7UNF

CryoEM structure of a mEAK7 bound human V-ATPase complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000139	cellular_component	Golgi membrane
0	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
0	0005515	molecular_function	protein binding
0	0005765	cellular_component	lysosomal membrane
0	0005886	cellular_component	plasma membrane
0	0005925	cellular_component	focal adhesion
0	0006811	biological_process	monoatomic ion transport
0	0007035	biological_process	vacuolar acidification
0	0007042	biological_process	lysosomal lumen acidification
0	0010008	cellular_component	endosome membrane
0	0015078	molecular_function	proton transmembrane transporter activity
0	0015986	biological_process	proton motive force-driven ATP synthesis
0	0016020	cellular_component	membrane
0	0016241	biological_process	regulation of macroautophagy
0	0030177	biological_process	positive regulation of Wnt signaling pathway
0	0030665	cellular_component	clathrin-coated vesicle membrane
0	0030670	cellular_component	phagocytic vesicle membrane
0	0030672	cellular_component	synaptic vesicle membrane
0	0031410	cellular_component	cytoplasmic vesicle
0	0031625	molecular_function	ubiquitin protein ligase binding
0	0033176	cellular_component	proton-transporting V-type ATPase complex
0	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
0	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
0	0035577	cellular_component	azurophil granule membrane
0	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
0	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
0	0048388	biological_process	endosomal lumen acidification
0	0051452	biological_process	intracellular pH reduction
0	0061795	biological_process	Golgi lumen acidification
0	0070062	cellular_component	extracellular exosome
0	0070821	cellular_component	tertiary granule membrane
0	0097401	biological_process	synaptic vesicle lumen acidification
0	0098588	cellular_component	bounding membrane of organelle
0	0101003	cellular_component	ficolin-1-rich granule membrane
0	1902600	biological_process	proton transmembrane transport
1	0000139	cellular_component	Golgi membrane
1	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
1	0005515	molecular_function	protein binding
1	0005765	cellular_component	lysosomal membrane
1	0005768	cellular_component	endosome
1	0005886	cellular_component	plasma membrane
1	0006811	biological_process	monoatomic ion transport
1	0007035	biological_process	vacuolar acidification
1	0007042	biological_process	lysosomal lumen acidification
1	0010008	cellular_component	endosome membrane
1	0015078	molecular_function	proton transmembrane transporter activity
1	0016020	cellular_component	membrane
1	0016241	biological_process	regulation of macroautophagy
1	0030665	cellular_component	clathrin-coated vesicle membrane
1	0030670	cellular_component	phagocytic vesicle membrane
1	0031410	cellular_component	cytoplasmic vesicle
1	0033176	cellular_component	proton-transporting V-type ATPase complex
1	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
1	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
1	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
1	0048388	biological_process	endosomal lumen acidification
1	0051452	biological_process	intracellular pH reduction
1	0061795	biological_process	Golgi lumen acidification
1	1902600	biological_process	proton transmembrane transport
2	0000139	cellular_component	Golgi membrane
2	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
2	0005515	molecular_function	protein binding
2	0005765	cellular_component	lysosomal membrane
2	0005886	cellular_component	plasma membrane
2	0005925	cellular_component	focal adhesion
2	0006811	biological_process	monoatomic ion transport
2	0007035	biological_process	vacuolar acidification
2	0007042	biological_process	lysosomal lumen acidification
2	0010008	cellular_component	endosome membrane
2	0015078	molecular_function	proton transmembrane transporter activity
2	0015986	biological_process	proton motive force-driven ATP synthesis
2	0016020	cellular_component	membrane
2	0016241	biological_process	regulation of macroautophagy
2	0030177	biological_process	positive regulation of Wnt signaling pathway
2	0030665	cellular_component	clathrin-coated vesicle membrane
2	0030670	cellular_component	phagocytic vesicle membrane
2	0030672	cellular_component	synaptic vesicle membrane
2	0031410	cellular_component	cytoplasmic vesicle
2	0031625	molecular_function	ubiquitin protein ligase binding
2	0033176	cellular_component	proton-transporting V-type ATPase complex
2	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
2	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
2	0035577	cellular_component	azurophil granule membrane
2	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
2	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
2	0048388	biological_process	endosomal lumen acidification
2	0051452	biological_process	intracellular pH reduction
2	0061795	biological_process	Golgi lumen acidification
2	0070062	cellular_component	extracellular exosome
2	0070821	cellular_component	tertiary granule membrane
2	0097401	biological_process	synaptic vesicle lumen acidification
2	0098588	cellular_component	bounding membrane of organelle
2	0101003	cellular_component	ficolin-1-rich granule membrane
2	1902600	biological_process	proton transmembrane transport
3	0000139	cellular_component	Golgi membrane
3	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
3	0005515	molecular_function	protein binding
3	0005765	cellular_component	lysosomal membrane
3	0005886	cellular_component	plasma membrane
3	0005925	cellular_component	focal adhesion
3	0006811	biological_process	monoatomic ion transport
3	0007035	biological_process	vacuolar acidification
3	0007042	biological_process	lysosomal lumen acidification
3	0010008	cellular_component	endosome membrane
3	0015078	molecular_function	proton transmembrane transporter activity
3	0015986	biological_process	proton motive force-driven ATP synthesis
3	0016020	cellular_component	membrane
3	0016241	biological_process	regulation of macroautophagy
3	0030177	biological_process	positive regulation of Wnt signaling pathway
3	0030665	cellular_component	clathrin-coated vesicle membrane
3	0030670	cellular_component	phagocytic vesicle membrane
3	0030672	cellular_component	synaptic vesicle membrane
3	0031410	cellular_component	cytoplasmic vesicle
3	0031625	molecular_function	ubiquitin protein ligase binding
3	0033176	cellular_component	proton-transporting V-type ATPase complex
3	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
3	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
3	0035577	cellular_component	azurophil granule membrane
3	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
3	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
3	0048388	biological_process	endosomal lumen acidification
3	0051452	biological_process	intracellular pH reduction
3	0061795	biological_process	Golgi lumen acidification
3	0070062	cellular_component	extracellular exosome
3	0070821	cellular_component	tertiary granule membrane
3	0097401	biological_process	synaptic vesicle lumen acidification
3	0098588	cellular_component	bounding membrane of organelle
3	0101003	cellular_component	ficolin-1-rich granule membrane
3	1902600	biological_process	proton transmembrane transport
4	0000139	cellular_component	Golgi membrane
4	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
4	0005515	molecular_function	protein binding
4	0005765	cellular_component	lysosomal membrane
4	0005886	cellular_component	plasma membrane
4	0005925	cellular_component	focal adhesion
4	0006811	biological_process	monoatomic ion transport
4	0007035	biological_process	vacuolar acidification
4	0007042	biological_process	lysosomal lumen acidification
4	0010008	cellular_component	endosome membrane
4	0015078	molecular_function	proton transmembrane transporter activity
4	0015986	biological_process	proton motive force-driven ATP synthesis
4	0016020	cellular_component	membrane
4	0016241	biological_process	regulation of macroautophagy
4	0030177	biological_process	positive regulation of Wnt signaling pathway
4	0030665	cellular_component	clathrin-coated vesicle membrane
4	0030670	cellular_component	phagocytic vesicle membrane
4	0030672	cellular_component	synaptic vesicle membrane
4	0031410	cellular_component	cytoplasmic vesicle
4	0031625	molecular_function	ubiquitin protein ligase binding
4	0033176	cellular_component	proton-transporting V-type ATPase complex
4	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
4	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
4	0035577	cellular_component	azurophil granule membrane
4	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
4	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
4	0048388	biological_process	endosomal lumen acidification
4	0051452	biological_process	intracellular pH reduction
4	0061795	biological_process	Golgi lumen acidification
4	0070062	cellular_component	extracellular exosome
4	0070821	cellular_component	tertiary granule membrane
4	0097401	biological_process	synaptic vesicle lumen acidification
4	0098588	cellular_component	bounding membrane of organelle
4	0101003	cellular_component	ficolin-1-rich granule membrane
4	1902600	biological_process	proton transmembrane transport
5	0000139	cellular_component	Golgi membrane
5	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
5	0005515	molecular_function	protein binding
5	0005765	cellular_component	lysosomal membrane
5	0005886	cellular_component	plasma membrane
5	0005925	cellular_component	focal adhesion
5	0006811	biological_process	monoatomic ion transport
5	0007035	biological_process	vacuolar acidification
5	0007042	biological_process	lysosomal lumen acidification
5	0010008	cellular_component	endosome membrane
5	0015078	molecular_function	proton transmembrane transporter activity
5	0015986	biological_process	proton motive force-driven ATP synthesis
5	0016020	cellular_component	membrane
5	0016241	biological_process	regulation of macroautophagy
5	0030177	biological_process	positive regulation of Wnt signaling pathway
5	0030665	cellular_component	clathrin-coated vesicle membrane
5	0030670	cellular_component	phagocytic vesicle membrane
5	0030672	cellular_component	synaptic vesicle membrane
5	0031410	cellular_component	cytoplasmic vesicle
5	0031625	molecular_function	ubiquitin protein ligase binding
5	0033176	cellular_component	proton-transporting V-type ATPase complex
5	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
5	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
5	0035577	cellular_component	azurophil granule membrane
5	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
5	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
5	0048388	biological_process	endosomal lumen acidification
5	0051452	biological_process	intracellular pH reduction
5	0061795	biological_process	Golgi lumen acidification
5	0070062	cellular_component	extracellular exosome
5	0070821	cellular_component	tertiary granule membrane
5	0097401	biological_process	synaptic vesicle lumen acidification
5	0098588	cellular_component	bounding membrane of organelle
5	0101003	cellular_component	ficolin-1-rich granule membrane
5	1902600	biological_process	proton transmembrane transport
6	0000139	cellular_component	Golgi membrane
6	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
6	0005515	molecular_function	protein binding
6	0005765	cellular_component	lysosomal membrane
6	0005886	cellular_component	plasma membrane
6	0005925	cellular_component	focal adhesion
6	0006811	biological_process	monoatomic ion transport
6	0007035	biological_process	vacuolar acidification
6	0007042	biological_process	lysosomal lumen acidification
6	0010008	cellular_component	endosome membrane
6	0015078	molecular_function	proton transmembrane transporter activity
6	0015986	biological_process	proton motive force-driven ATP synthesis
6	0016020	cellular_component	membrane
6	0016241	biological_process	regulation of macroautophagy
6	0030177	biological_process	positive regulation of Wnt signaling pathway
6	0030665	cellular_component	clathrin-coated vesicle membrane
6	0030670	cellular_component	phagocytic vesicle membrane
6	0030672	cellular_component	synaptic vesicle membrane
6	0031410	cellular_component	cytoplasmic vesicle
6	0031625	molecular_function	ubiquitin protein ligase binding
6	0033176	cellular_component	proton-transporting V-type ATPase complex
6	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
6	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
6	0035577	cellular_component	azurophil granule membrane
6	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
6	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
6	0048388	biological_process	endosomal lumen acidification
6	0051452	biological_process	intracellular pH reduction
6	0061795	biological_process	Golgi lumen acidification
6	0070062	cellular_component	extracellular exosome
6	0070821	cellular_component	tertiary granule membrane
6	0097401	biological_process	synaptic vesicle lumen acidification
6	0098588	cellular_component	bounding membrane of organelle
6	0101003	cellular_component	ficolin-1-rich granule membrane
6	1902600	biological_process	proton transmembrane transport
7	0000139	cellular_component	Golgi membrane
7	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
7	0005515	molecular_function	protein binding
7	0005765	cellular_component	lysosomal membrane
7	0005886	cellular_component	plasma membrane
7	0005925	cellular_component	focal adhesion
7	0006811	biological_process	monoatomic ion transport
7	0007035	biological_process	vacuolar acidification
7	0007042	biological_process	lysosomal lumen acidification
7	0010008	cellular_component	endosome membrane
7	0015078	molecular_function	proton transmembrane transporter activity
7	0015986	biological_process	proton motive force-driven ATP synthesis
7	0016020	cellular_component	membrane
7	0016241	biological_process	regulation of macroautophagy
7	0030177	biological_process	positive regulation of Wnt signaling pathway
7	0030665	cellular_component	clathrin-coated vesicle membrane
7	0030670	cellular_component	phagocytic vesicle membrane
7	0030672	cellular_component	synaptic vesicle membrane
7	0031410	cellular_component	cytoplasmic vesicle
7	0031625	molecular_function	ubiquitin protein ligase binding
7	0033176	cellular_component	proton-transporting V-type ATPase complex
7	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
7	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
7	0035577	cellular_component	azurophil granule membrane
7	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
7	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
7	0048388	biological_process	endosomal lumen acidification
7	0051452	biological_process	intracellular pH reduction
7	0061795	biological_process	Golgi lumen acidification
7	0070062	cellular_component	extracellular exosome
7	0070821	cellular_component	tertiary granule membrane
7	0097401	biological_process	synaptic vesicle lumen acidification
7	0098588	cellular_component	bounding membrane of organelle
7	0101003	cellular_component	ficolin-1-rich granule membrane
7	1902600	biological_process	proton transmembrane transport
8	0000139	cellular_component	Golgi membrane
8	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
8	0005515	molecular_function	protein binding
8	0005765	cellular_component	lysosomal membrane
8	0005886	cellular_component	plasma membrane
8	0005925	cellular_component	focal adhesion
8	0006811	biological_process	monoatomic ion transport
8	0007035	biological_process	vacuolar acidification
8	0007042	biological_process	lysosomal lumen acidification
8	0010008	cellular_component	endosome membrane
8	0015078	molecular_function	proton transmembrane transporter activity
8	0015986	biological_process	proton motive force-driven ATP synthesis
8	0016020	cellular_component	membrane
8	0016241	biological_process	regulation of macroautophagy
8	0030177	biological_process	positive regulation of Wnt signaling pathway
8	0030665	cellular_component	clathrin-coated vesicle membrane
8	0030670	cellular_component	phagocytic vesicle membrane
8	0030672	cellular_component	synaptic vesicle membrane
8	0031410	cellular_component	cytoplasmic vesicle
8	0031625	molecular_function	ubiquitin protein ligase binding
8	0033176	cellular_component	proton-transporting V-type ATPase complex
8	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
8	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
8	0035577	cellular_component	azurophil granule membrane
8	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
8	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
8	0048388	biological_process	endosomal lumen acidification
8	0051452	biological_process	intracellular pH reduction
8	0061795	biological_process	Golgi lumen acidification
8	0070062	cellular_component	extracellular exosome
8	0070821	cellular_component	tertiary granule membrane
8	0097401	biological_process	synaptic vesicle lumen acidification
8	0098588	cellular_component	bounding membrane of organelle
8	0101003	cellular_component	ficolin-1-rich granule membrane
8	1902600	biological_process	proton transmembrane transport
9	0000139	cellular_component	Golgi membrane
9	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
9	0005515	molecular_function	protein binding
9	0005765	cellular_component	lysosomal membrane
9	0005886	cellular_component	plasma membrane
9	0005925	cellular_component	focal adhesion
9	0006811	biological_process	monoatomic ion transport
9	0007035	biological_process	vacuolar acidification
9	0007042	biological_process	lysosomal lumen acidification
9	0010008	cellular_component	endosome membrane
9	0015078	molecular_function	proton transmembrane transporter activity
9	0015986	biological_process	proton motive force-driven ATP synthesis
9	0016020	cellular_component	membrane
9	0016241	biological_process	regulation of macroautophagy
9	0030177	biological_process	positive regulation of Wnt signaling pathway
9	0030665	cellular_component	clathrin-coated vesicle membrane
9	0030670	cellular_component	phagocytic vesicle membrane
9	0030672	cellular_component	synaptic vesicle membrane
9	0031410	cellular_component	cytoplasmic vesicle
9	0031625	molecular_function	ubiquitin protein ligase binding
9	0033176	cellular_component	proton-transporting V-type ATPase complex
9	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
9	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
9	0035577	cellular_component	azurophil granule membrane
9	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
9	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
9	0048388	biological_process	endosomal lumen acidification
9	0051452	biological_process	intracellular pH reduction
9	0061795	biological_process	Golgi lumen acidification
9	0070062	cellular_component	extracellular exosome
9	0070821	cellular_component	tertiary granule membrane
9	0097401	biological_process	synaptic vesicle lumen acidification
9	0098588	cellular_component	bounding membrane of organelle
9	0101003	cellular_component	ficolin-1-rich granule membrane
9	1902600	biological_process	proton transmembrane transport
a	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
a	0001503	biological_process	ossification
a	0005515	molecular_function	protein binding
a	0005765	cellular_component	lysosomal membrane
a	0005768	cellular_component	endosome
a	0005886	cellular_component	plasma membrane
a	0005903	cellular_component	brush border
a	0006811	biological_process	monoatomic ion transport
a	0006885	biological_process	regulation of pH
a	0007035	biological_process	vacuolar acidification
a	0007605	biological_process	sensory perception of sound
a	0010008	cellular_component	endosome membrane
a	0016323	cellular_component	basolateral plasma membrane
a	0016324	cellular_component	apical plasma membrane
a	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
a	0030670	cellular_component	phagocytic vesicle membrane
a	0030672	cellular_component	synaptic vesicle membrane
a	0031526	cellular_component	brush border membrane
a	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
a	0045177	cellular_component	apical part of cell
a	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
a	0051117	molecular_function	ATPase binding
a	0051452	biological_process	intracellular pH reduction
a	0070062	cellular_component	extracellular exosome
a	0097254	biological_process	renal tubular secretion
a	0097401	biological_process	synaptic vesicle lumen acidification
a	1902600	biological_process	proton transmembrane transport
b	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
b	0005515	molecular_function	protein binding
b	0005737	cellular_component	cytoplasm
b	0005765	cellular_component	lysosomal membrane
b	0005768	cellular_component	endosome
b	0005829	cellular_component	cytosol
b	0005902	cellular_component	microvillus
b	0006811	biological_process	monoatomic ion transport
b	0016241	biological_process	regulation of macroautophagy
b	0016324	cellular_component	apical plasma membrane
b	0016469	cellular_component	proton-transporting two-sector ATPase complex
b	0030665	cellular_component	clathrin-coated vesicle membrane
b	0030672	cellular_component	synaptic vesicle membrane
b	0031410	cellular_component	cytoplasmic vesicle
b	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
b	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
b	0051117	molecular_function	ATPase binding
b	0070062	cellular_component	extracellular exosome
b	0097401	biological_process	synaptic vesicle lumen acidification
b	1902600	biological_process	proton transmembrane transport
c	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
c	0005515	molecular_function	protein binding
c	0005737	cellular_component	cytoplasm
c	0005765	cellular_component	lysosomal membrane
c	0005768	cellular_component	endosome
c	0005829	cellular_component	cytosol
c	0005902	cellular_component	microvillus
c	0006811	biological_process	monoatomic ion transport
c	0016241	biological_process	regulation of macroautophagy
c	0016324	cellular_component	apical plasma membrane
c	0016469	cellular_component	proton-transporting two-sector ATPase complex
c	0030665	cellular_component	clathrin-coated vesicle membrane
c	0030672	cellular_component	synaptic vesicle membrane
c	0031410	cellular_component	cytoplasmic vesicle
c	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
c	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
c	0051117	molecular_function	ATPase binding
c	0070062	cellular_component	extracellular exosome
c	0097401	biological_process	synaptic vesicle lumen acidification
c	1902600	biological_process	proton transmembrane transport
C	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
C	0005515	molecular_function	protein binding
C	0005765	cellular_component	lysosomal membrane
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0015078	molecular_function	proton transmembrane transporter activity
C	0016020	cellular_component	membrane
C	0016241	biological_process	regulation of macroautophagy
C	0016469	cellular_component	proton-transporting two-sector ATPase complex
C	0030665	cellular_component	clathrin-coated vesicle membrane
C	0030672	cellular_component	synaptic vesicle membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0033176	cellular_component	proton-transporting V-type ATPase complex
C	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
C	0045177	cellular_component	apical part of cell
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	0070062	cellular_component	extracellular exosome
C	0097401	biological_process	synaptic vesicle lumen acidification
C	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
C	1902600	biological_process	proton transmembrane transport
d	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
d	0005515	molecular_function	protein binding
d	0005737	cellular_component	cytoplasm
d	0005765	cellular_component	lysosomal membrane
d	0005768	cellular_component	endosome
d	0005829	cellular_component	cytosol
d	0005902	cellular_component	microvillus
d	0006811	biological_process	monoatomic ion transport
d	0016241	biological_process	regulation of macroautophagy
d	0016324	cellular_component	apical plasma membrane
d	0016469	cellular_component	proton-transporting two-sector ATPase complex
d	0030665	cellular_component	clathrin-coated vesicle membrane
d	0030672	cellular_component	synaptic vesicle membrane
d	0031410	cellular_component	cytoplasmic vesicle
d	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
d	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
d	0051117	molecular_function	ATPase binding
d	0070062	cellular_component	extracellular exosome
d	0097401	biological_process	synaptic vesicle lumen acidification
d	1902600	biological_process	proton transmembrane transport
D	0000139	cellular_component	Golgi membrane
D	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
D	0005515	molecular_function	protein binding
D	0005765	cellular_component	lysosomal membrane
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005929	cellular_component	cilium
D	0006811	biological_process	monoatomic ion transport
D	0007035	biological_process	vacuolar acidification
D	0007042	biological_process	lysosomal lumen acidification
D	0010008	cellular_component	endosome membrane
D	0015078	molecular_function	proton transmembrane transporter activity
D	0016020	cellular_component	membrane
D	0016241	biological_process	regulation of macroautophagy
D	0030030	biological_process	cell projection organization
D	0030665	cellular_component	clathrin-coated vesicle membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0033176	cellular_component	proton-transporting V-type ATPase complex
D	0035579	cellular_component	specific granule membrane
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	0048388	biological_process	endosomal lumen acidification
D	0051452	biological_process	intracellular pH reduction
D	0060271	biological_process	cilium assembly
D	0061512	biological_process	protein localization to cilium
D	0061795	biological_process	Golgi lumen acidification
D	0070062	cellular_component	extracellular exosome
D	0097401	biological_process	synaptic vesicle lumen acidification
D	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
D	1902600	biological_process	proton transmembrane transport
e	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
e	0005515	molecular_function	protein binding
e	0005765	cellular_component	lysosomal membrane
e	0005829	cellular_component	cytosol
e	0005886	cellular_component	plasma membrane
e	0006811	biological_process	monoatomic ion transport
e	0006879	biological_process	intracellular iron ion homeostasis
e	0015078	molecular_function	proton transmembrane transporter activity
e	0016241	biological_process	regulation of macroautophagy
e	0016324	cellular_component	apical plasma membrane
e	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
e	0030672	cellular_component	synaptic vesicle membrane
e	0033176	cellular_component	proton-transporting V-type ATPase complex
e	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
e	0036295	biological_process	cellular response to increased oxygen levels
e	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
e	0051117	molecular_function	ATPase binding
e	0070062	cellular_component	extracellular exosome
e	0097401	biological_process	synaptic vesicle lumen acidification
e	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
e	1902600	biological_process	proton transmembrane transport
f	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
f	0005515	molecular_function	protein binding
f	0005765	cellular_component	lysosomal membrane
f	0005829	cellular_component	cytosol
f	0005886	cellular_component	plasma membrane
f	0006811	biological_process	monoatomic ion transport
f	0006879	biological_process	intracellular iron ion homeostasis
f	0015078	molecular_function	proton transmembrane transporter activity
f	0016241	biological_process	regulation of macroautophagy
f	0016324	cellular_component	apical plasma membrane
f	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
f	0030672	cellular_component	synaptic vesicle membrane
f	0033176	cellular_component	proton-transporting V-type ATPase complex
f	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
f	0036295	biological_process	cellular response to increased oxygen levels
f	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
f	0051117	molecular_function	ATPase binding
f	0070062	cellular_component	extracellular exosome
f	0097401	biological_process	synaptic vesicle lumen acidification
f	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
f	1902600	biological_process	proton transmembrane transport
F	0000139	cellular_component	Golgi membrane
F	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
F	0005515	molecular_function	protein binding
F	0005765	cellular_component	lysosomal membrane
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0007035	biological_process	vacuolar acidification
F	0007042	biological_process	lysosomal lumen acidification
F	0010008	cellular_component	endosome membrane
F	0015078	molecular_function	proton transmembrane transporter activity
F	0016020	cellular_component	membrane
F	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
F	0030665	cellular_component	clathrin-coated vesicle membrane
F	0030672	cellular_component	synaptic vesicle membrane
F	0031410	cellular_component	cytoplasmic vesicle
F	0033176	cellular_component	proton-transporting V-type ATPase complex
F	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0042625	molecular_function	ATPase-coupled ion transmembrane transporter activity
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	0048388	biological_process	endosomal lumen acidification
F	0051452	biological_process	intracellular pH reduction
F	0061795	biological_process	Golgi lumen acidification
F	0070062	cellular_component	extracellular exosome
F	0097401	biological_process	synaptic vesicle lumen acidification
F	1902600	biological_process	proton transmembrane transport
g	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
g	0005515	molecular_function	protein binding
g	0005765	cellular_component	lysosomal membrane
g	0005829	cellular_component	cytosol
g	0005886	cellular_component	plasma membrane
g	0006811	biological_process	monoatomic ion transport
g	0006879	biological_process	intracellular iron ion homeostasis
g	0015078	molecular_function	proton transmembrane transporter activity
g	0016241	biological_process	regulation of macroautophagy
g	0016324	cellular_component	apical plasma membrane
g	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
g	0030672	cellular_component	synaptic vesicle membrane
g	0033176	cellular_component	proton-transporting V-type ATPase complex
g	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
g	0036295	biological_process	cellular response to increased oxygen levels
g	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
g	0051117	molecular_function	ATPase binding
g	0070062	cellular_component	extracellular exosome
g	0097401	biological_process	synaptic vesicle lumen acidification
g	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
g	1902600	biological_process	proton transmembrane transport
H	0000139	cellular_component	Golgi membrane
H	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
H	0005515	molecular_function	protein binding
H	0005765	cellular_component	lysosomal membrane
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006811	biological_process	monoatomic ion transport
H	0006897	biological_process	endocytosis
H	0007035	biological_process	vacuolar acidification
H	0007042	biological_process	lysosomal lumen acidification
H	0010008	cellular_component	endosome membrane
H	0016020	cellular_component	membrane
H	0016241	biological_process	regulation of macroautophagy
H	0016887	molecular_function	ATP hydrolysis activity
H	0030234	molecular_function	enzyme regulator activity
H	0030665	cellular_component	clathrin-coated vesicle membrane
H	0031410	cellular_component	cytoplasmic vesicle
H	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
H	0048388	biological_process	endosomal lumen acidification
H	0051452	biological_process	intracellular pH reduction
H	0061795	biological_process	Golgi lumen acidification
H	0070062	cellular_component	extracellular exosome
H	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
H	1902600	biological_process	proton transmembrane transport
k	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
k	0005515	molecular_function	protein binding
k	0005765	cellular_component	lysosomal membrane
k	0005769	cellular_component	early endosome
k	0005813	cellular_component	centrosome
k	0006811	biological_process	monoatomic ion transport
k	0006879	biological_process	intracellular iron ion homeostasis
k	0007034	biological_process	vacuolar transport
k	0007035	biological_process	vacuolar acidification
k	0008021	cellular_component	synaptic vesicle
k	0010008	cellular_component	endosome membrane
k	0015078	molecular_function	proton transmembrane transporter activity
k	0016020	cellular_component	membrane
k	0016241	biological_process	regulation of macroautophagy
k	0016324	cellular_component	apical plasma membrane
k	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
k	0030030	biological_process	cell projection organization
k	0030665	cellular_component	clathrin-coated vesicle membrane
k	0030670	cellular_component	phagocytic vesicle membrane
k	0030672	cellular_component	synaptic vesicle membrane
k	0031410	cellular_component	cytoplasmic vesicle
k	0032991	cellular_component	protein-containing complex
k	0033176	cellular_component	proton-transporting V-type ATPase complex
k	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
k	0033181	cellular_component	plasma membrane proton-transporting V-type ATPase complex
k	0036295	biological_process	cellular response to increased oxygen levels
k	0042592	biological_process	homeostatic process
k	0043679	cellular_component	axon terminus
k	0044877	molecular_function	protein-containing complex binding
k	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
k	0060271	biological_process	cilium assembly
k	0070062	cellular_component	extracellular exosome
k	0097401	biological_process	synaptic vesicle lumen acidification
k	1902600	biological_process	proton transmembrane transport
L	0000139	cellular_component	Golgi membrane
L	0000166	molecular_function	nucleotide binding
L	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005764	cellular_component	lysosome
L	0005765	cellular_component	lysosomal membrane
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0005902	cellular_component	microvillus
L	0006811	biological_process	monoatomic ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0007035	biological_process	vacuolar acidification
L	0007042	biological_process	lysosomal lumen acidification
L	0010008	cellular_component	endosome membrane
L	0015078	molecular_function	proton transmembrane transporter activity
L	0016020	cellular_component	membrane
L	0016241	biological_process	regulation of macroautophagy
L	0016324	cellular_component	apical plasma membrane
L	0016469	cellular_component	proton-transporting two-sector ATPase complex
L	0016887	molecular_function	ATP hydrolysis activity
L	0030133	cellular_component	transport vesicle
L	0030141	cellular_component	secretory granule
L	0030665	cellular_component	clathrin-coated vesicle membrane
L	0031410	cellular_component	cytoplasmic vesicle
L	0033176	cellular_component	proton-transporting V-type ATPase complex
L	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
L	0036295	biological_process	cellular response to increased oxygen levels
L	0042592	biological_process	homeostatic process
L	0046034	biological_process	ATP metabolic process
L	0046612	cellular_component	lysosomal proton-transporting V-type ATPase, V1 domain
L	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
L	0048388	biological_process	endosomal lumen acidification
L	0051452	biological_process	intracellular pH reduction
L	0061795	biological_process	Golgi lumen acidification
L	0070062	cellular_component	extracellular exosome
L	0097401	biological_process	synaptic vesicle lumen acidification
L	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
L	1902600	biological_process	proton transmembrane transport
m	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
m	0005515	molecular_function	protein binding
m	0005765	cellular_component	lysosomal membrane
m	0006811	biological_process	monoatomic ion transport
m	0007035	biological_process	vacuolar acidification
m	0010008	cellular_component	endosome membrane
m	0016020	cellular_component	membrane
m	0016241	biological_process	regulation of macroautophagy
m	0030670	cellular_component	phagocytic vesicle membrane
m	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
m	0042625	molecular_function	ATPase-coupled ion transmembrane transporter activity
m	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
m	1902600	biological_process	proton transmembrane transport
M	0000139	cellular_component	Golgi membrane
M	0000166	molecular_function	nucleotide binding
M	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0005764	cellular_component	lysosome
M	0005765	cellular_component	lysosomal membrane
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0005902	cellular_component	microvillus
M	0006811	biological_process	monoatomic ion transport
M	0006879	biological_process	intracellular iron ion homeostasis
M	0007035	biological_process	vacuolar acidification
M	0007042	biological_process	lysosomal lumen acidification
M	0010008	cellular_component	endosome membrane
M	0015078	molecular_function	proton transmembrane transporter activity
M	0016020	cellular_component	membrane
M	0016241	biological_process	regulation of macroautophagy
M	0016324	cellular_component	apical plasma membrane
M	0016469	cellular_component	proton-transporting two-sector ATPase complex
M	0016887	molecular_function	ATP hydrolysis activity
M	0030133	cellular_component	transport vesicle
M	0030141	cellular_component	secretory granule
M	0030665	cellular_component	clathrin-coated vesicle membrane
M	0031410	cellular_component	cytoplasmic vesicle
M	0033176	cellular_component	proton-transporting V-type ATPase complex
M	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
M	0036295	biological_process	cellular response to increased oxygen levels
M	0042592	biological_process	homeostatic process
M	0046034	biological_process	ATP metabolic process
M	0046612	cellular_component	lysosomal proton-transporting V-type ATPase, V1 domain
M	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
M	0048388	biological_process	endosomal lumen acidification
M	0051452	biological_process	intracellular pH reduction
M	0061795	biological_process	Golgi lumen acidification
M	0070062	cellular_component	extracellular exosome
M	0097401	biological_process	synaptic vesicle lumen acidification
M	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
M	1902600	biological_process	proton transmembrane transport
n	0000139	cellular_component	Golgi membrane
n	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
n	0004518	molecular_function	nuclease activity
n	0004519	molecular_function	endonuclease activity
n	0004521	molecular_function	RNA endonuclease activity
n	0005515	molecular_function	protein binding
n	0005765	cellular_component	lysosomal membrane
n	0005886	cellular_component	plasma membrane
n	0006811	biological_process	monoatomic ion transport
n	0006897	biological_process	endocytosis
n	0006898	biological_process	receptor-mediated endocytosis
n	0007035	biological_process	vacuolar acidification
n	0007042	biological_process	lysosomal lumen acidification
n	0010008	cellular_component	endosome membrane
n	0012505	cellular_component	endomembrane system
n	0016020	cellular_component	membrane
n	0016787	molecular_function	hydrolase activity
n	0019065	biological_process	receptor-mediated endocytosis of virus by host cell
n	0030665	cellular_component	clathrin-coated vesicle membrane
n	0031410	cellular_component	cytoplasmic vesicle
n	0048388	biological_process	endosomal lumen acidification
n	0051452	biological_process	intracellular pH reduction
n	0061795	biological_process	Golgi lumen acidification
n	0090304	biological_process	nucleic acid metabolic process
n	1902600	biological_process	proton transmembrane transport
N	0000139	cellular_component	Golgi membrane
N	0000166	molecular_function	nucleotide binding
N	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005737	cellular_component	cytoplasm
N	0005764	cellular_component	lysosome
N	0005765	cellular_component	lysosomal membrane
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0005902	cellular_component	microvillus
N	0006811	biological_process	monoatomic ion transport
N	0006879	biological_process	intracellular iron ion homeostasis
N	0007035	biological_process	vacuolar acidification
N	0007042	biological_process	lysosomal lumen acidification
N	0010008	cellular_component	endosome membrane
N	0015078	molecular_function	proton transmembrane transporter activity
N	0016020	cellular_component	membrane
N	0016241	biological_process	regulation of macroautophagy
N	0016324	cellular_component	apical plasma membrane
N	0016469	cellular_component	proton-transporting two-sector ATPase complex
N	0016887	molecular_function	ATP hydrolysis activity
N	0030133	cellular_component	transport vesicle
N	0030141	cellular_component	secretory granule
N	0030665	cellular_component	clathrin-coated vesicle membrane
N	0031410	cellular_component	cytoplasmic vesicle
N	0033176	cellular_component	proton-transporting V-type ATPase complex
N	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
N	0036295	biological_process	cellular response to increased oxygen levels
N	0042592	biological_process	homeostatic process
N	0046034	biological_process	ATP metabolic process
N	0046612	cellular_component	lysosomal proton-transporting V-type ATPase, V1 domain
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	0048388	biological_process	endosomal lumen acidification
N	0051452	biological_process	intracellular pH reduction
N	0061795	biological_process	Golgi lumen acidification
N	0070062	cellular_component	extracellular exosome
N	0097401	biological_process	synaptic vesicle lumen acidification
N	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
N	1902600	biological_process	proton transmembrane transport
O	0000166	molecular_function	nucleotide binding
O	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
O	0001726	cellular_component	ruffle
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005737	cellular_component	cytoplasm
O	0005765	cellular_component	lysosomal membrane
O	0005829	cellular_component	cytosol
O	0005886	cellular_component	plasma membrane
O	0005902	cellular_component	microvillus
O	0006811	biological_process	monoatomic ion transport
O	0007035	biological_process	vacuolar acidification
O	0015078	molecular_function	proton transmembrane transporter activity
O	0016241	biological_process	regulation of macroautophagy
O	0016324	cellular_component	apical plasma membrane
O	0030665	cellular_component	clathrin-coated vesicle membrane
O	0030672	cellular_component	synaptic vesicle membrane
O	0031410	cellular_component	cytoplasmic vesicle
O	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
O	0042470	cellular_component	melanosome
O	0046034	biological_process	ATP metabolic process
O	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
O	0070062	cellular_component	extracellular exosome
O	0097401	biological_process	synaptic vesicle lumen acidification
O	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
O	1902600	biological_process	proton transmembrane transport
P	0000166	molecular_function	nucleotide binding
P	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
P	0001726	cellular_component	ruffle
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005737	cellular_component	cytoplasm
P	0005765	cellular_component	lysosomal membrane
P	0005829	cellular_component	cytosol
P	0005886	cellular_component	plasma membrane
P	0005902	cellular_component	microvillus
P	0006811	biological_process	monoatomic ion transport
P	0007035	biological_process	vacuolar acidification
P	0015078	molecular_function	proton transmembrane transporter activity
P	0016241	biological_process	regulation of macroautophagy
P	0016324	cellular_component	apical plasma membrane
P	0030665	cellular_component	clathrin-coated vesicle membrane
P	0030672	cellular_component	synaptic vesicle membrane
P	0031410	cellular_component	cytoplasmic vesicle
P	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
P	0042470	cellular_component	melanosome
P	0046034	biological_process	ATP metabolic process
P	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
P	0070062	cellular_component	extracellular exosome
P	0097401	biological_process	synaptic vesicle lumen acidification
P	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
P	1902600	biological_process	proton transmembrane transport
Q	0000166	molecular_function	nucleotide binding
Q	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
Q	0001726	cellular_component	ruffle
Q	0005515	molecular_function	protein binding
Q	0005524	molecular_function	ATP binding
Q	0005737	cellular_component	cytoplasm
Q	0005765	cellular_component	lysosomal membrane
Q	0005829	cellular_component	cytosol
Q	0005886	cellular_component	plasma membrane
Q	0005902	cellular_component	microvillus
Q	0006811	biological_process	monoatomic ion transport
Q	0007035	biological_process	vacuolar acidification
Q	0015078	molecular_function	proton transmembrane transporter activity
Q	0016241	biological_process	regulation of macroautophagy
Q	0016324	cellular_component	apical plasma membrane
Q	0030665	cellular_component	clathrin-coated vesicle membrane
Q	0030672	cellular_component	synaptic vesicle membrane
Q	0031410	cellular_component	cytoplasmic vesicle
Q	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
Q	0042470	cellular_component	melanosome
Q	0046034	biological_process	ATP metabolic process
Q	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Q	0070062	cellular_component	extracellular exosome
Q	0097401	biological_process	synaptic vesicle lumen acidification
Q	0098850	cellular_component	extrinsic component of synaptic vesicle membrane
Q	1902600	biological_process	proton transmembrane transport
r	0016020	cellular_component	membrane
r	0038023	molecular_function	signaling receptor activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005737	cellular_component	cytoplasm
U	0005764	cellular_component	lysosome
U	0005765	cellular_component	lysosomal membrane
U	0005829	cellular_component	cytosol
U	0006979	biological_process	response to oxidative stress
U	0016020	cellular_component	membrane
U	0030334	biological_process	regulation of cell migration
U	0031667	biological_process	response to nutrient levels
U	0031929	biological_process	TOR signaling
U	0032868	biological_process	response to insulin
U	0042127	biological_process	regulation of cell population proliferation
U	0043200	biological_process	response to amino acid
U	0150032	biological_process	positive regulation of protein localization to lysosome

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PPINVLPSLS

Chain	Residue	Details
O	PRO390-SER399
L	PRO446-SER455

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1130
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	129
Details	Topological domain: {"description":"Vacuolar","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	415
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	168
Details	Domain: {"description":"TLDc","evidences":[{"source":"PROSITE-ProRule","id":"PRU01234","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WLZ","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6WM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P50518","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2005","submissionDatabase":"UniProtKB","authors":["Kanor S.","Bienvenut W.V.","Quadroni M."]}},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P51863","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P51863","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WLW","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6WM2","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WLW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WLW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	188
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	9
Details	Site: {"description":"Essential for proton translocation","evidences":[{"source":"PubMed","id":"36074901","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	Site: {"description":"Essential for proton translocation","evidences":[{"source":"UniProtKB","id":"Q2TA24","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---