Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001696 | biological_process | gastric acid secretion |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004969 | molecular_function | histamine receptor activity |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0016020 | cellular_component | membrane |
| A | 0045907 | biological_process | positive regulation of vasoconstriction |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIlNLFMISLDRYCaV |
| Chain | Residue | Details |
| A | ALA104-VAL120 | |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR192-HIS198 | |
| H | TYR194-HIS200 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 59 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-THR22 | |
| A | CYS82-ASN92 | |
| A | SER160-GLU180 | |
| A | LEU259-GLU267 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL23-GLY44 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 100 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU45-ILE57 | |
| A | ASP115-ARG134 | |
| A | ALA290-ARG359 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL58-SER81 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE93-LEU114 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL135-ASN159 | |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL268-ALA289 | |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | SITE: Essential for histamine binding => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP98 | |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | SITE: Essential for tiotidine binding and implicated in H2 selectivity => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP186 | |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | SITE: Implicated in histamine binding => ECO:0000250 |
| Chain | Residue | Details |
| A | THR190 | |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS305 | |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 26 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| A | LEU204-ARG234 | |
