Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7UKH

Human Kv4.2-KChIP2-DPP6 channel complex in an open state, intracellular region

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0016020	cellular_component	membrane
A	0051260	biological_process	protein homooligomerization
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0016020	cellular_component	membrane
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0016020	cellular_component	membrane
C	0051260	biological_process	protein homooligomerization
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0016020	cellular_component	membrane
D	0051260	biological_process	protein homooligomerization
D	0055085	biological_process	transmembrane transport
I	0001508	biological_process	action potential
I	0005250	molecular_function	A-type (transient outward) potassium channel activity
I	0005267	molecular_function	potassium channel activity
I	0005509	molecular_function	calcium ion binding
I	0005513	biological_process	detection of calcium ion
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005886	cellular_component	plasma membrane
I	0006811	biological_process	monoatomic ion transport
I	0006813	biological_process	potassium ion transport
I	0006936	biological_process	muscle contraction
I	0007165	biological_process	signal transduction
I	0007268	biological_process	chemical synaptic transmission
I	0008016	biological_process	regulation of heart contraction
I	0008076	cellular_component	voltage-gated potassium channel complex
I	0009966	biological_process	regulation of signal transduction
I	0015459	molecular_function	potassium channel regulator activity
I	0030425	cellular_component	dendrite
I	0034220	biological_process	monoatomic ion transmembrane transport
I	0034702	cellular_component	monoatomic ion channel complex
I	0044325	molecular_function	transmembrane transporter binding
I	0044877	molecular_function	protein-containing complex binding
I	0045163	biological_process	clustering of voltage-gated potassium channels
I	0045202	cellular_component	synapse
I	0046872	molecular_function	metal ion binding
I	0046923	molecular_function	ER retention sequence binding
I	0060306	biological_process	regulation of membrane repolarization
I	0071805	biological_process	potassium ion transmembrane transport
I	0086009	biological_process	membrane repolarization
I	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
I	1901379	biological_process	regulation of potassium ion transmembrane transport
I	1903764	biological_process	regulation of potassium ion export across plasma membrane
I	1903766	biological_process	positive regulation of potassium ion export across plasma membrane
J	0001508	biological_process	action potential
J	0005250	molecular_function	A-type (transient outward) potassium channel activity
J	0005267	molecular_function	potassium channel activity
J	0005509	molecular_function	calcium ion binding
J	0005513	biological_process	detection of calcium ion
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005886	cellular_component	plasma membrane
J	0006811	biological_process	monoatomic ion transport
J	0006813	biological_process	potassium ion transport
J	0006936	biological_process	muscle contraction
J	0007165	biological_process	signal transduction
J	0007268	biological_process	chemical synaptic transmission
J	0008016	biological_process	regulation of heart contraction
J	0008076	cellular_component	voltage-gated potassium channel complex
J	0009966	biological_process	regulation of signal transduction
J	0015459	molecular_function	potassium channel regulator activity
J	0030425	cellular_component	dendrite
J	0034220	biological_process	monoatomic ion transmembrane transport
J	0034702	cellular_component	monoatomic ion channel complex
J	0044325	molecular_function	transmembrane transporter binding
J	0044877	molecular_function	protein-containing complex binding
J	0045163	biological_process	clustering of voltage-gated potassium channels
J	0045202	cellular_component	synapse
J	0046872	molecular_function	metal ion binding
J	0046923	molecular_function	ER retention sequence binding
J	0060306	biological_process	regulation of membrane repolarization
J	0071805	biological_process	potassium ion transmembrane transport
J	0086009	biological_process	membrane repolarization
J	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
J	1901379	biological_process	regulation of potassium ion transmembrane transport
J	1903764	biological_process	regulation of potassium ion export across plasma membrane
J	1903766	biological_process	positive regulation of potassium ion export across plasma membrane
K	0001508	biological_process	action potential
K	0005250	molecular_function	A-type (transient outward) potassium channel activity
K	0005267	molecular_function	potassium channel activity
K	0005509	molecular_function	calcium ion binding
K	0005513	biological_process	detection of calcium ion
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005886	cellular_component	plasma membrane
K	0006811	biological_process	monoatomic ion transport
K	0006813	biological_process	potassium ion transport
K	0006936	biological_process	muscle contraction
K	0007165	biological_process	signal transduction
K	0007268	biological_process	chemical synaptic transmission
K	0008016	biological_process	regulation of heart contraction
K	0008076	cellular_component	voltage-gated potassium channel complex
K	0009966	biological_process	regulation of signal transduction
K	0015459	molecular_function	potassium channel regulator activity
K	0030425	cellular_component	dendrite
K	0034220	biological_process	monoatomic ion transmembrane transport
K	0034702	cellular_component	monoatomic ion channel complex
K	0044325	molecular_function	transmembrane transporter binding
K	0044877	molecular_function	protein-containing complex binding
K	0045163	biological_process	clustering of voltage-gated potassium channels
K	0045202	cellular_component	synapse
K	0046872	molecular_function	metal ion binding
K	0046923	molecular_function	ER retention sequence binding
K	0060306	biological_process	regulation of membrane repolarization
K	0071805	biological_process	potassium ion transmembrane transport
K	0086009	biological_process	membrane repolarization
K	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
K	1901379	biological_process	regulation of potassium ion transmembrane transport
K	1903764	biological_process	regulation of potassium ion export across plasma membrane
K	1903766	biological_process	positive regulation of potassium ion export across plasma membrane
L	0001508	biological_process	action potential
L	0005250	molecular_function	A-type (transient outward) potassium channel activity
L	0005267	molecular_function	potassium channel activity
L	0005509	molecular_function	calcium ion binding
L	0005513	biological_process	detection of calcium ion
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005886	cellular_component	plasma membrane
L	0006811	biological_process	monoatomic ion transport
L	0006813	biological_process	potassium ion transport
L	0006936	biological_process	muscle contraction
L	0007165	biological_process	signal transduction
L	0007268	biological_process	chemical synaptic transmission
L	0008016	biological_process	regulation of heart contraction
L	0008076	cellular_component	voltage-gated potassium channel complex
L	0009966	biological_process	regulation of signal transduction
L	0015459	molecular_function	potassium channel regulator activity
L	0030425	cellular_component	dendrite
L	0034220	biological_process	monoatomic ion transmembrane transport
L	0034702	cellular_component	monoatomic ion channel complex
L	0044325	molecular_function	transmembrane transporter binding
L	0044877	molecular_function	protein-containing complex binding
L	0045163	biological_process	clustering of voltage-gated potassium channels
L	0045202	cellular_component	synapse
L	0046872	molecular_function	metal ion binding
L	0046923	molecular_function	ER retention sequence binding
L	0060306	biological_process	regulation of membrane repolarization
L	0071805	biological_process	potassium ion transmembrane transport
L	0086009	biological_process	membrane repolarization
L	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
L	1901379	biological_process	regulation of potassium ion transmembrane transport
L	1903764	biological_process	regulation of potassium ion export across plasma membrane
L	1903766	biological_process	positive regulation of potassium ion export across plasma membrane

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DTNHDGSVSfeDF

Chain	Residue	Details
I	ASP135-PHE147
I	ASP171-MET183
I	ASP219-PHE231

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	Region: {"description":"Interaction with KCNIP1","evidences":[{"source":"UniProtKB","id":"Q63881","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	60
Details	Region: {"description":"Required for dendritic targeting","evidences":[{"source":"UniProtKB","id":"Q63881","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q63881","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q63881","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	140
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	140
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	140
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	52
Details	Region: {"description":"Interaction with KCND2","evidences":[{"source":"UniProtKB","id":"Q8R426","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)