7U6D
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM459
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1460 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| C | HIS1-VAL731 | |
| B | HIS1-VAL731 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Insulin-binding => ECO:0000305 |
| Chain | Residue | Details |
| C | PHE39 | |
| B | PHE39 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| C | SER373 | |
| C | SER380 | |
| B | SER373 | |
| B | SER380 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| C | TYR374 | |
| B | TYR374 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862, ECO:0000269|PubMed:2983222 |
| Chain | Residue | Details |
| C | ASN16 | |
| B | ASN16 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862 |
| Chain | Residue | Details |
| C | ASN25 | |
| C | ASN111 | |
| C | ASN255 | |
| B | ASN25 | |
| B | ASN111 | |
| B | ASN255 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 14 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| C | ASN78 | |
| C | ASN295 | |
| C | ASN606 | |
| C | ASN624 | |
| C | ASN671 | |
| C | GLU755 | |
| C | THR906 | |
| B | ASN78 | |
| B | ASN295 | |
| B | ASN606 | |
| B | ASN624 | |
| B | ASN671 | |
| B | GLU755 | |
| B | THR906 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:23302862 |
| Chain | Residue | Details |
| C | ASN215 | |
| B | ASN215 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147 |
| Chain | Residue | Details |
| C | ASN337 | |
| C | ASN397 | |
| B | ASN337 | |
| B | ASN397 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| C | ASN418 | |
| B | ASN418 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1472036, ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| C | ASN514 | |
| B | ASN514 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2983222 |
| Chain | Residue | Details |
| C | PRO742 | |
| B | PRO742 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| C | GLY893 | |
| B | GLY893 |
