7U0F

HIV-1 Rev in complex with tubulin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005929	cellular_component	cilium
A	0007017	biological_process	microtubule-based process
A	0016787	molecular_function	hydrolase activity
A	0031514	cellular_component	motile cilium
A	0042995	cellular_component	cell projection
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0001764	biological_process	neuron migration
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005929	cellular_component	cilium
C	0007017	biological_process	microtubule-based process
C	0016787	molecular_function	hydrolase activity
C	0031514	cellular_component	motile cilium
C	0042995	cellular_component	cell projection
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0001764	biological_process	neuron migration
D	0003924	molecular_function	GTPase activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0007017	biological_process	microtubule-based process
D	0046872	molecular_function	metal ion binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0003723	molecular_function	RNA binding
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006611	biological_process	protein export from nucleus
E	0016032	biological_process	viral process
E	0030430	cellular_component	host cell cytoplasm
E	0042025	cellular_component	host cell nucleus
E	0044196	cellular_component	host cell nucleolus
E	0051028	biological_process	mRNA transport
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0003723	molecular_function	RNA binding
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006611	biological_process	protein export from nucleus
F	0016032	biological_process	viral process
F	0030430	cellular_component	host cell cytoplasm
F	0042025	cellular_component	host cell nucleus
F	0044196	cellular_component	host cell nucleolus
F	0051028	biological_process	mRNA transport
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0003723	molecular_function	RNA binding
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006611	biological_process	protein export from nucleus
G	0016032	biological_process	viral process
G	0030430	cellular_component	host cell cytoplasm
G	0042025	cellular_component	host cell nucleus
G	0044196	cellular_component	host cell nucleolus
G	0051028	biological_process	mRNA transport
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0003723	molecular_function	RNA binding
H	0006355	biological_process	regulation of DNA-templated transcription
H	0006611	biological_process	protein export from nucleus
H	0016032	biological_process	viral process
H	0030430	cellular_component	host cell cytoplasm
H	0042025	cellular_component	host cell nucleus
H	0044196	cellular_component	host cell nucleolus
H	0051028	biological_process	mRNA transport
I	0003700	molecular_function	DNA-binding transcription factor activity
I	0003723	molecular_function	RNA binding
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006611	biological_process	protein export from nucleus
I	0016032	biological_process	viral process
I	0030430	cellular_component	host cell cytoplasm
I	0042025	cellular_component	host cell nucleus
I	0044196	cellular_component	host cell nucleolus
I	0051028	biological_process	mRNA transport
J	0003700	molecular_function	DNA-binding transcription factor activity
J	0003723	molecular_function	RNA binding
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006611	biological_process	protein export from nucleus
J	0016032	biological_process	viral process
J	0030430	cellular_component	host cell cytoplasm
J	0042025	cellular_component	host cell nucleus
J	0044196	cellular_component	host cell nucleolus
J	0051028	biological_process	mRNA transport

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
B	GLY140-GLY146
A	GLY142-GLY148

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	MOD_RES: Phosphoserine; by host CK2 => ECO:0000255|HAMAP-Rule:MF_04077

Chain	Residue	Details
E	SER5
I	SER8
J	SER5
J	SER8
D	ASN204
D	ASN226
E	SER8
F	SER5
F	SER8
G	SER5
G	SER8
H	SER5
H	SER8
I	SER5

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	MOD_RES: Phosphoserine; by host => ECO:0000255|HAMAP-Rule:MF_04077

Chain	Residue	Details
E	SER92
I	SER99
J	SER92
J	SER99
C	THR145
C	THR179
C	ASN206
C	ASN228
E	SER99
F	SER92
F	SER99
G	SER92
G	SER99
H	SER92
H	SER99
I	SER92

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P99024

Chain	Residue	Details
B	SER40
D	SER40

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P99024

Chain	Residue	Details
B	LYS58
D	LYS58

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CDK1 => ECO:0000250|UniProtKB:Q13885

Chain	Residue	Details
B	SER172
D	SER172

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P07437

Chain	Residue	Details
B	THR285
B	THR290
D	THR285
D	THR290

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P07437

Chain	Residue	Details
B	ARG318
D	ARG318

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:Q2T9S0

Chain	Residue	Details
B	GLU438
D	GLU438

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P07437

Chain	Residue	Details
B	LYS58
D	LYS58

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P07437

Chain	Residue	Details
B	LYS324
D	LYS324

---