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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7U0F

HIV-1 Rev in complex with tubulin

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000226biological_processmicrotubule cytoskeleton organization
A0000278biological_processmitotic cell cycle
A0005200molecular_functionstructural constituent of cytoskeleton
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0007017biological_processmicrotubule-based process
A0016787molecular_functionhydrolase activity
A0030182biological_processneuron differentiation
A0046872molecular_functionmetal ion binding
B0000166molecular_functionnucleotide binding
B0000226biological_processmicrotubule cytoskeleton organization
B0000278biological_processmitotic cell cycle
B0001764biological_processneuron migration
B0003924molecular_functionGTPase activity
B0005200molecular_functionstructural constituent of cytoskeleton
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0007017biological_processmicrotubule-based process
B0046872molecular_functionmetal ion binding
C0000166molecular_functionnucleotide binding
C0000226biological_processmicrotubule cytoskeleton organization
C0000278biological_processmitotic cell cycle
C0005200molecular_functionstructural constituent of cytoskeleton
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005856cellular_componentcytoskeleton
C0005874cellular_componentmicrotubule
C0007017biological_processmicrotubule-based process
C0016787molecular_functionhydrolase activity
C0030182biological_processneuron differentiation
C0046872molecular_functionmetal ion binding
D0000166molecular_functionnucleotide binding
D0000226biological_processmicrotubule cytoskeleton organization
D0000278biological_processmitotic cell cycle
D0001764biological_processneuron migration
D0003924molecular_functionGTPase activity
D0005200molecular_functionstructural constituent of cytoskeleton
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005856cellular_componentcytoskeleton
D0005874cellular_componentmicrotubule
D0007017biological_processmicrotubule-based process
D0046872molecular_functionmetal ion binding
E0003700molecular_functionDNA-binding transcription factor activity
E0003723molecular_functionRNA binding
E0006355biological_processregulation of DNA-templated transcription
E0006611biological_processprotein export from nucleus
E0016032biological_processviral process
E0030430cellular_componenthost cell cytoplasm
E0042025cellular_componenthost cell nucleus
E0044196cellular_componenthost cell nucleolus
E0051028biological_processmRNA transport
F0003700molecular_functionDNA-binding transcription factor activity
F0003723molecular_functionRNA binding
F0006355biological_processregulation of DNA-templated transcription
F0006611biological_processprotein export from nucleus
F0016032biological_processviral process
F0030430cellular_componenthost cell cytoplasm
F0042025cellular_componenthost cell nucleus
F0044196cellular_componenthost cell nucleolus
F0051028biological_processmRNA transport
G0003700molecular_functionDNA-binding transcription factor activity
G0003723molecular_functionRNA binding
G0006355biological_processregulation of DNA-templated transcription
G0006611biological_processprotein export from nucleus
G0016032biological_processviral process
G0030430cellular_componenthost cell cytoplasm
G0042025cellular_componenthost cell nucleus
G0044196cellular_componenthost cell nucleolus
G0051028biological_processmRNA transport
H0003700molecular_functionDNA-binding transcription factor activity
H0003723molecular_functionRNA binding
H0006355biological_processregulation of DNA-templated transcription
H0006611biological_processprotein export from nucleus
H0016032biological_processviral process
H0030430cellular_componenthost cell cytoplasm
H0042025cellular_componenthost cell nucleus
H0044196cellular_componenthost cell nucleolus
H0051028biological_processmRNA transport
I0003700molecular_functionDNA-binding transcription factor activity
I0003723molecular_functionRNA binding
I0006355biological_processregulation of DNA-templated transcription
I0006611biological_processprotein export from nucleus
I0016032biological_processviral process
I0030430cellular_componenthost cell cytoplasm
I0042025cellular_componenthost cell nucleus
I0044196cellular_componenthost cell nucleolus
I0051028biological_processmRNA transport
J0003700molecular_functionDNA-binding transcription factor activity
J0003723molecular_functionRNA binding
J0006355biological_processregulation of DNA-templated transcription
J0006611biological_processprotein export from nucleus
J0016032biological_processviral process
J0030430cellular_componenthost cell cytoplasm
J0042025cellular_componenthost cell nucleus
J0044196cellular_componenthost cell nucleolus
J0051028biological_processmRNA transport
Functional Information from PROSITE/UniProt
site_idPS00227
Number of Residues7
DetailsTUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG
ChainResidueDetails
BGLY140-GLY146
AGLY142-GLY148
site_idPS00228
Number of Residues4
DetailsTUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI
ChainResidueDetails
BMET1-ILE4
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues36
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q71U36","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsSite: {"description":"Involved in polymerization"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"5-glutamyl polyglutamate","evidences":[{"source":"UniProtKB","id":"Q71U36","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"5-glutamyl polyglutamate","evidences":[{"source":"UniProtKB","id":"P68369","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"Q71U36","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues6
DetailsMotif: {"description":"MREI motif","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"UniProtKB","id":"Q13885","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsModified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsModified residue: {"description":"5-glutamyl polyglutamate","evidences":[{"source":"UniProtKB","id":"Q2T9S0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues48
DetailsRegion: {"description":"Homomultimerization","evidences":[{"source":"HAMAP-Rule","id":"MF_04077","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues156
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues96
DetailsMotif: {"description":"Nuclear localization signal and RNA-binding (RRE)","evidences":[{"source":"HAMAP-Rule","id":"MF_04077","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues66
DetailsCompositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

248636

PDB entries from 2026-02-04

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