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7TW6

Cryo-EM structure of human ankyrin complex (B4P1A1) from red blood cell

Functional Information from GO Data
ChainGOidnamespacecontents
A0005452molecular_functionsolute:inorganic anion antiporter activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006820biological_processmonoatomic anion transport
A0006821biological_processchloride transport
A0006873biological_processintracellular monoatomic ion homeostasis
A0007596biological_processblood coagulation
A0008509molecular_functionmonoatomic anion transmembrane transporter activity
A0009898cellular_componentcytoplasmic side of plasma membrane
A0015075molecular_functionmonoatomic ion transmembrane transporter activity
A0015106molecular_functionbicarbonate transmembrane transporter activity
A0015108molecular_functionchloride transmembrane transporter activity
A0015297molecular_functionantiporter activity
A0015701biological_processbicarbonate transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0017121biological_processplasma membrane phospholipid scrambling
A0030018cellular_componentZ disc
A0030492molecular_functionhemoglobin binding
A0030506molecular_functionankyrin binding
A0030863cellular_componentcortical cytoskeleton
A0035811biological_processnegative regulation of urine volume
A0042803molecular_functionprotein homodimerization activity
A0043495molecular_functionprotein-membrane adaptor activity
A0045852biological_processpH elevation
A0048821biological_processerythrocyte development
A0051453biological_processregulation of intracellular pH
A0055085biological_processtransmembrane transport
A0070062cellular_componentextracellular exosome
A0072562cellular_componentblood microparticle
A0072659biological_processprotein localization to plasma membrane
A0140900molecular_functionchloride:bicarbonate antiporter activity
A0170014cellular_componentankyrin-1 complex
A1902476biological_processchloride transmembrane transport
A1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
B0005452molecular_functionsolute:inorganic anion antiporter activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006820biological_processmonoatomic anion transport
B0006821biological_processchloride transport
B0006873biological_processintracellular monoatomic ion homeostasis
B0007596biological_processblood coagulation
B0008509molecular_functionmonoatomic anion transmembrane transporter activity
B0009898cellular_componentcytoplasmic side of plasma membrane
B0015075molecular_functionmonoatomic ion transmembrane transporter activity
B0015106molecular_functionbicarbonate transmembrane transporter activity
B0015108molecular_functionchloride transmembrane transporter activity
B0015297molecular_functionantiporter activity
B0015701biological_processbicarbonate transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0017121biological_processplasma membrane phospholipid scrambling
B0030018cellular_componentZ disc
B0030492molecular_functionhemoglobin binding
B0030506molecular_functionankyrin binding
B0030863cellular_componentcortical cytoskeleton
B0035811biological_processnegative regulation of urine volume
B0042803molecular_functionprotein homodimerization activity
B0043495molecular_functionprotein-membrane adaptor activity
B0045852biological_processpH elevation
B0048821biological_processerythrocyte development
B0051453biological_processregulation of intracellular pH
B0055085biological_processtransmembrane transport
B0070062cellular_componentextracellular exosome
B0072562cellular_componentblood microparticle
B0072659biological_processprotein localization to plasma membrane
B0140900molecular_functionchloride:bicarbonate antiporter activity
B0170014cellular_componentankyrin-1 complex
B1902476biological_processchloride transmembrane transport
B1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
E0000902biological_processcell morphogenesis
E0003810molecular_functionprotein-glutamine gamma-glutamyltransferase activity
E0005200molecular_functionstructural constituent of cytoskeleton
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005856cellular_componentcytoskeleton
E0005886cellular_componentplasma membrane
E0007010biological_processcytoskeleton organization
E0008360biological_processregulation of cell shape
E0016020cellular_componentmembrane
E0018149biological_processpeptide cross-linking
E0020027biological_processhemoglobin metabolic process
E0030863cellular_componentcortical cytoskeleton
E0043249biological_processerythrocyte maturation
E0048536biological_processspleen development
E0050801biological_processmonoatomic ion homeostasis
E0060586biological_processmulticellular organismal-level iron ion homeostasis
E0170014cellular_componentankyrin-1 complex
G0005198molecular_functionstructural molecule activity
G0005200molecular_functionstructural constituent of cytoskeleton
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005886cellular_componentplasma membrane
G0006887biological_processexocytosis
G0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
G0007010biological_processcytoskeleton organization
G0007165biological_processsignal transduction
G0008093molecular_functioncytoskeletal anchor activity
G0009898cellular_componentcytoplasmic side of plasma membrane
G0010638biological_processpositive regulation of organelle organization
G0014731cellular_componentspectrin-associated cytoskeleton
G0016020cellular_componentmembrane
G0016323cellular_componentbasolateral plasma membrane
G0016529cellular_componentsarcoplasmic reticulum
G0019899molecular_functionenzyme binding
G0019903molecular_functionprotein phosphatase binding
G0030018cellular_componentZ disc
G0030507molecular_functionspectrin binding
G0030673cellular_componentaxolemma
G0031430cellular_componentM band
G0031672cellular_componentA band
G0042383cellular_componentsarcolemma
G0043005cellular_componentneuron projection
G0044325molecular_functiontransmembrane transporter binding
G0045199biological_processmaintenance of epithelial cell apical/basal polarity
G0045211cellular_componentpostsynaptic membrane
G0051117molecular_functionATPase binding
G0072659biological_processprotein localization to plasma membrane
G0170014cellular_componentankyrin-1 complex
J0005452molecular_functionsolute:inorganic anion antiporter activity
J0005515molecular_functionprotein binding
J0005886cellular_componentplasma membrane
J0006811biological_processmonoatomic ion transport
J0006820biological_processmonoatomic anion transport
J0006821biological_processchloride transport
J0006873biological_processintracellular monoatomic ion homeostasis
J0007596biological_processblood coagulation
J0008509molecular_functionmonoatomic anion transmembrane transporter activity
J0009898cellular_componentcytoplasmic side of plasma membrane
J0015075molecular_functionmonoatomic ion transmembrane transporter activity
J0015106molecular_functionbicarbonate transmembrane transporter activity
J0015108molecular_functionchloride transmembrane transporter activity
J0015297molecular_functionantiporter activity
J0015701biological_processbicarbonate transport
J0016020cellular_componentmembrane
J0016323cellular_componentbasolateral plasma membrane
J0017121biological_processplasma membrane phospholipid scrambling
J0030018cellular_componentZ disc
J0030492molecular_functionhemoglobin binding
J0030506molecular_functionankyrin binding
J0030863cellular_componentcortical cytoskeleton
J0035811biological_processnegative regulation of urine volume
J0042803molecular_functionprotein homodimerization activity
J0043495molecular_functionprotein-membrane adaptor activity
J0045852biological_processpH elevation
J0048821biological_processerythrocyte development
J0051453biological_processregulation of intracellular pH
J0055085biological_processtransmembrane transport
J0070062cellular_componentextracellular exosome
J0072562cellular_componentblood microparticle
J0072659biological_processprotein localization to plasma membrane
J0140900molecular_functionchloride:bicarbonate antiporter activity
J0170014cellular_componentankyrin-1 complex
J1902476biological_processchloride transmembrane transport
J1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
K0005452molecular_functionsolute:inorganic anion antiporter activity
K0005515molecular_functionprotein binding
K0005886cellular_componentplasma membrane
K0006811biological_processmonoatomic ion transport
K0006820biological_processmonoatomic anion transport
K0006821biological_processchloride transport
K0006873biological_processintracellular monoatomic ion homeostasis
K0007596biological_processblood coagulation
K0008509molecular_functionmonoatomic anion transmembrane transporter activity
K0009898cellular_componentcytoplasmic side of plasma membrane
K0015075molecular_functionmonoatomic ion transmembrane transporter activity
K0015106molecular_functionbicarbonate transmembrane transporter activity
K0015108molecular_functionchloride transmembrane transporter activity
K0015297molecular_functionantiporter activity
K0015701biological_processbicarbonate transport
K0016020cellular_componentmembrane
K0016323cellular_componentbasolateral plasma membrane
K0017121biological_processplasma membrane phospholipid scrambling
K0030018cellular_componentZ disc
K0030492molecular_functionhemoglobin binding
K0030506molecular_functionankyrin binding
K0030863cellular_componentcortical cytoskeleton
K0035811biological_processnegative regulation of urine volume
K0042803molecular_functionprotein homodimerization activity
K0043495molecular_functionprotein-membrane adaptor activity
K0045852biological_processpH elevation
K0048821biological_processerythrocyte development
K0051453biological_processregulation of intracellular pH
K0055085biological_processtransmembrane transport
K0070062cellular_componentextracellular exosome
K0072562cellular_componentblood microparticle
K0072659biological_processprotein localization to plasma membrane
K0140900molecular_functionchloride:bicarbonate antiporter activity
K0170014cellular_componentankyrin-1 complex
K1902476biological_processchloride transmembrane transport
K1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
Functional Information from PROSITE/UniProt
site_idPS00219
Number of Residues12
DetailsANION_EXCHANGER_1 Anion exchangers family signature 1. FGGLVRDIRRRY
ChainResidueDetails
APHE379-TYR390

site_idPS00220
Number of Residues15
DetailsANION_EXCHANGER_2 Anion exchangers family signature 2. FLISLIFIYETFsKL
ChainResidueDetails
APHE526-LEU540

site_idPS00547
Number of Residues18
DetailsTRANSGLUTAMINASES Transglutaminases active site. GQAWVlAAVacTvLRCLG
ChainResidueDetails
EGLY266-GLY283

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsMOD_RES: (3S)-3-hydroxyasparagine; by HIF1AN; partial => ECO:0000269|PubMed:21177872
ChainResidueDetails
GASN105
BGLN457-LEU459
BPHE507-ARG518
BLYS592-ARG602
BTHR685-SER700
BLEU738-ARG760
BSER801-GLY838
BARG870-VAL911
KMET1-PRO403
KGLN457-LEU459
KPHE507-ARG518
GASN233
KLYS592-ARG602
KTHR685-SER700
KLEU738-ARG760
KSER801-GLY838
KARG870-VAL911
JMET1-PRO403
JGLN457-LEU459
JPHE507-ARG518
JLYS592-ARG602
JTHR685-SER700
GASN431
JLEU738-ARG760
JSER801-GLY838
JARG870-VAL911
GASN464
GASN629
GASN662
GASN728
GASN761
BMET1-PRO403

site_idSWS_FT_FI2
Number of Residues9
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
GSER429
GSER759
GSER1396
GSER1486
GSER1666
GSER1671
GSER1686
GSER1690
GSER1696

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: (3S)-3-hydroxyaspartate; by HIF1AN; partial => ECO:0000269|PubMed:21177872
ChainResidueDetails
GASP695
KSER477-GLU485
KLYS542-THR570
KILE624-MET663
JGLY428-MET435
JSER477-GLU485
JLYS542-THR570
JILE624-MET663
ASER477-GLU485
ALYS542-THR570
AILE624-MET663
BGLY428-MET435
BSER477-GLU485
BLYS542-THR570
BILE624-MET663
KGLY428-MET435

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
GSER781
GSER856
KGLY436-ALA456
JGLY436-ALA456

site_idSWS_FT_FI5
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
GSER817
GSER834
GSER1428
GSER1523
GSER1533

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q02357
ChainResidueDetails
GTHR961
GTHR1400
KTYR486-ALA506
JTYR486-ALA506

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q02357
ChainResidueDetails
GTYR1073
BTYR519-ILE541
KTYR519-ILE541
JTYR519-ILE541

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q02357
ChainResidueDetails
GSER1082
GSER1390
GSER1392
GSER1617

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
GTHR1378
GTHR1380
KARG603-PHE623
JARG603-PHE623

site_idSWS_FT_FI10
Number of Residues80
DetailsTRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:26542571
ChainResidueDetails
AMET664-ILE684
BMET664-ILE684
KMET664-ILE684
JMET664-ILE684

site_idSWS_FT_FI11
Number of Residues72
DetailsTRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:26542571
ChainResidueDetails
AGLY701-PHE719
BGLY701-PHE719
KGLY701-PHE719
JGLY701-PHE719

site_idSWS_FT_FI12
Number of Residues68
DetailsTRANSMEM: Discontinuously helical; Name=10 => ECO:0000269|PubMed:26542571
ChainResidueDetails
AGLY720-ALA737
BGLY720-ALA737
KGLY720-ALA737
JGLY720-ALA737

site_idSWS_FT_FI13
Number of Residues80
DetailsTRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:26542571
ChainResidueDetails
AILE761-SER781
BILE761-SER781
KILE761-SER781
JILE761-SER781

site_idSWS_FT_FI14
Number of Residues72
DetailsTRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:26542571
ChainResidueDetails
AARG782-LEU800
BARG782-LEU800
KARG782-LEU800
JARG782-LEU800

site_idSWS_FT_FI15
Number of Residues120
DetailsINTRAMEM: Discontinuously helical => ECO:0000269|PubMed:26542571
ChainResidueDetails
AILE839-LEU869
BILE839-LEU869
KILE839-LEU869
JILE839-LEU869

site_idSWS_FT_FI16
Number of Residues4
DetailsSITE: Important for anion transport
ChainResidueDetails
ALYS590
BLYS590
KLYS590
JLYS590

site_idSWS_FT_FI17
Number of Residues4
DetailsSITE: Important for anion-proton cotransport
ChainResidueDetails
AGLU681
BGLU681
KGLU681
JGLU681

site_idSWS_FT_FI18
Number of Residues4
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:2790053, ECO:0000269|PubMed:701248
ChainResidueDetails
AMET1
BMET1
KMET1
JMET1

site_idSWS_FT_FI19
Number of Residues8
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:10942405, ECO:0000269|PubMed:1998697
ChainResidueDetails
ATYR8
ATYR21
BTYR8
BTYR21
KTYR8
KTYR21
JTYR8
JTYR21

site_idSWS_FT_FI20
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:1998697
ChainResidueDetails
ATYR46
BTYR46
KTYR46
JTYR46

site_idSWS_FT_FI21
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23562
ChainResidueDetails
ASER185
BSER185
KSER185
JSER185

site_idSWS_FT_FI22
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P04919
ChainResidueDetails
ASER350
BSER350
KSER350
JSER350

site_idSWS_FT_FI23
Number of Residues8
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:10942405
ChainResidueDetails
ATYR359
ATYR904
BTYR359
BTYR904
KTYR359
KTYR904
JTYR359
JTYR904

site_idSWS_FT_FI24
Number of Residues4
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:1885574
ChainResidueDetails
ACYS843
BCYS843
KCYS843
JCYS843

site_idSWS_FT_FI25
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:10861210, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:35835865
ChainResidueDetails
AASN642
BASN642
KASN642
JASN642

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PDB entries from 2024-07-31

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