7TUI
Structure of C. albicans FAS in an inhibited state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004312 | molecular_function | fatty acid synthase activity |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| A | 0004321 | molecular_function | fatty-acyl-CoA synthase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005835 | cellular_component | fatty acid synthase complex |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0008897 | molecular_function | holo-[acyl-carrier-protein] synthase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0042759 | biological_process | long-chain fatty acid biosynthetic process |
| A | 0101026 | biological_process | mitotic nuclear membrane biogenesis |
| A | 1900535 | biological_process | palmitic acid biosynthetic process |
| B | 0004312 | molecular_function | fatty acid synthase activity |
| B | 0004313 | molecular_function | [acyl-carrier-protein] S-acetyltransferase activity |
| B | 0004314 | molecular_function | [acyl-carrier-protein] S-malonyltransferase activity |
| B | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| B | 0004321 | molecular_function | fatty-acyl-CoA synthase activity |
| B | 0005835 | cellular_component | fatty acid synthase complex |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016297 | molecular_function | fatty acyl-[ACP] hydrolase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| B | 0042759 | biological_process | long-chain fatty acid biosynthetic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 540 |
| Details | Domain: {"description":"Ketosynthase family 3 (KS3)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 128 |
| Details | Domain: {"description":"MaoC-like"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 333 |
| Details | Region: {"description":"Enoyl reductase","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 480 |
| Details | Region: {"description":"Dehydratase","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 220 |
| Details | Region: {"description":"Malonyl/palmitoyl transferase","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For acetyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For malonyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
