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7TRD

Human telomerase catalytic core structure at 3.3 Angstrom

Functional Information from GO Data
ChainGOidnamespacecontents
A0000049molecular_functiontRNA binding
A0000333cellular_componenttelomerase catalytic core complex
A0000723biological_processtelomere maintenance
A0000781cellular_componentchromosome, telomeric region
A0000783cellular_componentnuclear telomere cap complex
A0001172biological_processRNA-templated transcription
A0001223molecular_functiontranscription coactivator binding
A0003677molecular_functionDNA binding
A0003720molecular_functiontelomerase activity
A0003721molecular_functiontelomerase RNA reverse transcriptase activity
A0003723molecular_functionRNA binding
A0003964molecular_functionRNA-directed DNA polymerase activity
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005697cellular_componenttelomerase holoenzyme complex
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006278biological_processRNA-templated DNA biosynthetic process
A0007004biological_processtelomere maintenance via telomerase
A0007005biological_processmitochondrion organization
A0010629biological_processnegative regulation of gene expression
A0016605cellular_componentPML body
A0016607cellular_componentnuclear speck
A0022616biological_processDNA strand elongation
A0030177biological_processpositive regulation of Wnt signaling pathway
A0030422biological_processsiRNA processing
A0031379cellular_componentRNA-directed RNA polymerase complex
A0031647biological_processregulation of protein stability
A0032092biological_processpositive regulation of protein binding
A0042162molecular_functiontelomeric DNA binding
A0042635biological_processpositive regulation of hair cycle
A0042645cellular_componentmitochondrial nucleoid
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043066biological_processnegative regulation of apoptotic process
A0043231cellular_componentintracellular membrane-bounded organelle
A0043524biological_processnegative regulation of neuron apoptotic process
A0045766biological_processpositive regulation of angiogenesis
A0046326biological_processpositive regulation of glucose import
A0046686biological_processresponse to cadmium ion
A0046872molecular_functionmetal ion binding
A0051000biological_processpositive regulation of nitric-oxide synthase activity
A0051087molecular_functionprotein-folding chaperone binding
A0070034molecular_functiontelomerase RNA binding
A0070200biological_processestablishment of protein localization to telomere
A0071456biological_processcellular response to hypoxia
A0071897biological_processDNA biosynthetic process
A0090399biological_processreplicative senescence
A0098680molecular_functiontemplate-free RNA nucleotidyltransferase
A0140745biological_processsiRNA transcription
A1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
A1902895biological_processpositive regulation of miRNA transcription
A1903620biological_processpositive regulation of transdifferentiation
A1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
A1904751biological_processpositive regulation of protein localization to nucleolus
A1904754biological_processpositive regulation of vascular associated smooth muscle cell migration
A1990572cellular_componentTERT-RMRP complex
A1990904cellular_componentribonucleoprotein complex
A2000352biological_processnegative regulation of endothelial cell apoptotic process
A2000648biological_processpositive regulation of stem cell proliferation
A2000773biological_processnegative regulation of cellular senescence
A2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00405
ChainResidueDetails
AASP712
AASP868
AASP869

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Required for optimal binding of telomeric ssDNA and incorporation of nucleotides at the second position of the template
ChainResidueDetails
AGLN169

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Required for nucleotide incorporation and primer extension rate
ChainResidueDetails
AVAL867

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKB/AKT1 => ECO:0000269|PubMed:22366458
ChainResidueDetails
ASER227

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by DYRK2 => ECO:0000269|PubMed:23362280
ChainResidueDetails
ASER457

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by SRC-type Tyr-kinases => ECO:0000269|PubMed:12808100, ECO:0000269|PubMed:18829466
ChainResidueDetails
ATYR707

220113

PDB entries from 2024-05-22

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