7TPT

Single-particle Cryo-EM structure of Arp2/3 complex at branched-actin junction.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003779	molecular_function	actin binding
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005885	cellular_component	Arp2/3 protein complex
A	0010592	biological_process	positive regulation of lamellipodium assembly
A	0030030	biological_process	cell projection organization
A	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
A	0035861	cellular_component	site of double-strand break
A	0042995	cellular_component	cell projection
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0051015	molecular_function	actin filament binding
A	0060271	biological_process	cilium assembly
B	0000166	molecular_function	nucleotide binding
B	0003779	molecular_function	actin binding
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005885	cellular_component	Arp2/3 protein complex
B	0005938	cellular_component	cell cortex
B	0010592	biological_process	positive regulation of lamellipodium assembly
B	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
B	0035861	cellular_component	site of double-strand break
B	0042995	cellular_component	cell projection
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0051015	molecular_function	actin filament binding
B	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
B	2001032	biological_process	regulation of double-strand break repair via nonhomologous end joining
C	0003779	molecular_function	actin binding
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005885	cellular_component	Arp2/3 protein complex
C	0015629	cellular_component	actin cytoskeleton
C	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
C	0051015	molecular_function	actin filament binding
D	0003779	molecular_function	actin binding
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005768	cellular_component	endosome
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005885	cellular_component	Arp2/3 protein complex
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0010592	biological_process	positive regulation of lamellipodium assembly
D	0015629	cellular_component	actin cytoskeleton
D	0030027	cellular_component	lamellipodium
D	0030041	biological_process	actin filament polymerization
D	0030672	cellular_component	synaptic vesicle membrane
D	0031252	cellular_component	cell leading edge
D	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
D	0035861	cellular_component	site of double-strand break
D	0036195	cellular_component	muscle cell projection membrane
D	0042995	cellular_component	cell projection
D	0043005	cellular_component	neuron projection
D	0045202	cellular_component	synapse
D	0051015	molecular_function	actin filament binding
D	0098793	cellular_component	presynapse
D	0098794	cellular_component	postsynapse
D	0098978	cellular_component	glutamatergic synapse
E	0003779	molecular_function	actin binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005885	cellular_component	Arp2/3 protein complex
E	0030833	biological_process	regulation of actin filament polymerization
E	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
E	0035861	cellular_component	site of double-strand break
E	0042995	cellular_component	cell projection
E	0051015	molecular_function	actin filament binding
F	0003779	molecular_function	actin binding
F	0005634	cellular_component	nucleus
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005885	cellular_component	Arp2/3 protein complex
F	0015629	cellular_component	actin cytoskeleton
F	0030041	biological_process	actin filament polymerization
F	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
F	0035861	cellular_component	site of double-strand break
F	0042995	cellular_component	cell projection
F	0051015	molecular_function	actin filament binding
G	0003779	molecular_function	actin binding
G	0005634	cellular_component	nucleus
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005885	cellular_component	Arp2/3 protein complex
G	0015629	cellular_component	actin cytoskeleton
G	0016477	biological_process	cell migration
G	0030674	molecular_function	protein-macromolecule adaptor activity
G	0030833	biological_process	regulation of actin filament polymerization
G	0030863	cellular_component	cortical cytoskeleton
G	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
G	0035861	cellular_component	site of double-strand break
G	0042995	cellular_component	cell projection
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0001725	cellular_component	stress fiber
H	0003785	molecular_function	actin monomer binding
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005523	molecular_function	tropomyosin binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005865	cellular_component	striated muscle thin filament
H	0005884	cellular_component	actin filament
H	0010628	biological_process	positive regulation of gene expression
H	0016787	molecular_function	hydrolase activity
H	0019904	molecular_function	protein domain specific binding
H	0030027	cellular_component	lamellipodium
H	0030041	biological_process	actin filament polymerization
H	0030175	cellular_component	filopodium
H	0030240	biological_process	skeletal muscle thin filament assembly
H	0031013	molecular_function	troponin I binding
H	0031432	molecular_function	titin binding
H	0031941	cellular_component	filamentous actin
H	0032036	molecular_function	myosin heavy chain binding
H	0032432	cellular_component	actin filament bundle
H	0042802	molecular_function	identical protein binding
H	0044297	cellular_component	cell body
H	0048306	molecular_function	calcium-dependent protein binding
H	0048741	biological_process	skeletal muscle fiber development
H	0051017	biological_process	actin filament bundle assembly
H	0090131	biological_process	mesenchyme migration
H	0098723	cellular_component	skeletal muscle myofibril
H	0140660	molecular_function	cytoskeletal motor activator activity
I	0000166	molecular_function	nucleotide binding
I	0000287	molecular_function	magnesium ion binding
I	0001725	cellular_component	stress fiber
I	0003785	molecular_function	actin monomer binding
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005523	molecular_function	tropomyosin binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005865	cellular_component	striated muscle thin filament
I	0005884	cellular_component	actin filament
I	0010628	biological_process	positive regulation of gene expression
I	0016787	molecular_function	hydrolase activity
I	0019904	molecular_function	protein domain specific binding
I	0030027	cellular_component	lamellipodium
I	0030041	biological_process	actin filament polymerization
I	0030175	cellular_component	filopodium
I	0030240	biological_process	skeletal muscle thin filament assembly
I	0031013	molecular_function	troponin I binding
I	0031432	molecular_function	titin binding
I	0031941	cellular_component	filamentous actin
I	0032036	molecular_function	myosin heavy chain binding
I	0032432	cellular_component	actin filament bundle
I	0042802	molecular_function	identical protein binding
I	0044297	cellular_component	cell body
I	0048306	molecular_function	calcium-dependent protein binding
I	0048741	biological_process	skeletal muscle fiber development
I	0051017	biological_process	actin filament bundle assembly
I	0090131	biological_process	mesenchyme migration
I	0098723	cellular_component	skeletal muscle myofibril
I	0140660	molecular_function	cytoskeletal motor activator activity
J	0000166	molecular_function	nucleotide binding
J	0000287	molecular_function	magnesium ion binding
J	0001725	cellular_component	stress fiber
J	0003785	molecular_function	actin monomer binding
J	0005509	molecular_function	calcium ion binding
J	0005515	molecular_function	protein binding
J	0005523	molecular_function	tropomyosin binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005865	cellular_component	striated muscle thin filament
J	0005884	cellular_component	actin filament
J	0010628	biological_process	positive regulation of gene expression
J	0016787	molecular_function	hydrolase activity
J	0019904	molecular_function	protein domain specific binding
J	0030027	cellular_component	lamellipodium
J	0030041	biological_process	actin filament polymerization
J	0030175	cellular_component	filopodium
J	0030240	biological_process	skeletal muscle thin filament assembly
J	0031013	molecular_function	troponin I binding
J	0031432	molecular_function	titin binding
J	0031941	cellular_component	filamentous actin
J	0032036	molecular_function	myosin heavy chain binding
J	0032432	cellular_component	actin filament bundle
J	0042802	molecular_function	identical protein binding
J	0044297	cellular_component	cell body
J	0048306	molecular_function	calcium-dependent protein binding
J	0048741	biological_process	skeletal muscle fiber development
J	0051017	biological_process	actin filament bundle assembly
J	0090131	biological_process	mesenchyme migration
J	0098723	cellular_component	skeletal muscle myofibril
J	0140660	molecular_function	cytoskeletal motor activator activity
K	0000166	molecular_function	nucleotide binding
K	0000287	molecular_function	magnesium ion binding
K	0001725	cellular_component	stress fiber
K	0003785	molecular_function	actin monomer binding
K	0005509	molecular_function	calcium ion binding
K	0005515	molecular_function	protein binding
K	0005523	molecular_function	tropomyosin binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005865	cellular_component	striated muscle thin filament
K	0005884	cellular_component	actin filament
K	0010628	biological_process	positive regulation of gene expression
K	0016787	molecular_function	hydrolase activity
K	0019904	molecular_function	protein domain specific binding
K	0030027	cellular_component	lamellipodium
K	0030041	biological_process	actin filament polymerization
K	0030175	cellular_component	filopodium
K	0030240	biological_process	skeletal muscle thin filament assembly
K	0031013	molecular_function	troponin I binding
K	0031432	molecular_function	titin binding
K	0031941	cellular_component	filamentous actin
K	0032036	molecular_function	myosin heavy chain binding
K	0032432	cellular_component	actin filament bundle
K	0042802	molecular_function	identical protein binding
K	0044297	cellular_component	cell body
K	0048306	molecular_function	calcium-dependent protein binding
K	0048741	biological_process	skeletal muscle fiber development
K	0051017	biological_process	actin filament bundle assembly
K	0090131	biological_process	mesenchyme migration
K	0098723	cellular_component	skeletal muscle myofibril
K	0140660	molecular_function	cytoskeletal motor activator activity
L	0000166	molecular_function	nucleotide binding
L	0000287	molecular_function	magnesium ion binding
L	0001725	cellular_component	stress fiber
L	0003785	molecular_function	actin monomer binding
L	0005509	molecular_function	calcium ion binding
L	0005515	molecular_function	protein binding
L	0005523	molecular_function	tropomyosin binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005865	cellular_component	striated muscle thin filament
L	0005884	cellular_component	actin filament
L	0010628	biological_process	positive regulation of gene expression
L	0016787	molecular_function	hydrolase activity
L	0019904	molecular_function	protein domain specific binding
L	0030027	cellular_component	lamellipodium
L	0030041	biological_process	actin filament polymerization
L	0030175	cellular_component	filopodium
L	0030240	biological_process	skeletal muscle thin filament assembly
L	0031013	molecular_function	troponin I binding
L	0031432	molecular_function	titin binding
L	0031941	cellular_component	filamentous actin
L	0032036	molecular_function	myosin heavy chain binding
L	0032432	cellular_component	actin filament bundle
L	0042802	molecular_function	identical protein binding
L	0044297	cellular_component	cell body
L	0048306	molecular_function	calcium-dependent protein binding
L	0048741	biological_process	skeletal muscle fiber development
L	0051017	biological_process	actin filament bundle assembly
L	0090131	biological_process	mesenchyme migration
L	0098723	cellular_component	skeletal muscle myofibril
L	0140660	molecular_function	cytoskeletal motor activator activity
M	0000166	molecular_function	nucleotide binding
M	0000287	molecular_function	magnesium ion binding
M	0001725	cellular_component	stress fiber
M	0003785	molecular_function	actin monomer binding
M	0005509	molecular_function	calcium ion binding
M	0005515	molecular_function	protein binding
M	0005523	molecular_function	tropomyosin binding
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005865	cellular_component	striated muscle thin filament
M	0005884	cellular_component	actin filament
M	0010628	biological_process	positive regulation of gene expression
M	0016787	molecular_function	hydrolase activity
M	0019904	molecular_function	protein domain specific binding
M	0030027	cellular_component	lamellipodium
M	0030041	biological_process	actin filament polymerization
M	0030175	cellular_component	filopodium
M	0030240	biological_process	skeletal muscle thin filament assembly
M	0031013	molecular_function	troponin I binding
M	0031432	molecular_function	titin binding
M	0031941	cellular_component	filamentous actin
M	0032036	molecular_function	myosin heavy chain binding
M	0032432	cellular_component	actin filament bundle
M	0042802	molecular_function	identical protein binding
M	0044297	cellular_component	cell body
M	0048306	molecular_function	calcium-dependent protein binding
M	0048741	biological_process	skeletal muscle fiber development
M	0051017	biological_process	actin filament bundle assembly
M	0090131	biological_process	mesenchyme migration
M	0098723	cellular_component	skeletal muscle myofibril
M	0140660	molecular_function	cytoskeletal motor activator activity
N	0000166	molecular_function	nucleotide binding
N	0000287	molecular_function	magnesium ion binding
N	0001725	cellular_component	stress fiber
N	0003785	molecular_function	actin monomer binding
N	0005509	molecular_function	calcium ion binding
N	0005515	molecular_function	protein binding
N	0005523	molecular_function	tropomyosin binding
N	0005524	molecular_function	ATP binding
N	0005737	cellular_component	cytoplasm
N	0005856	cellular_component	cytoskeleton
N	0005865	cellular_component	striated muscle thin filament
N	0005884	cellular_component	actin filament
N	0010628	biological_process	positive regulation of gene expression
N	0016787	molecular_function	hydrolase activity
N	0019904	molecular_function	protein domain specific binding
N	0030027	cellular_component	lamellipodium
N	0030041	biological_process	actin filament polymerization
N	0030175	cellular_component	filopodium
N	0030240	biological_process	skeletal muscle thin filament assembly
N	0031013	molecular_function	troponin I binding
N	0031432	molecular_function	titin binding
N	0031941	cellular_component	filamentous actin
N	0032036	molecular_function	myosin heavy chain binding
N	0032432	cellular_component	actin filament bundle
N	0042802	molecular_function	identical protein binding
N	0044297	cellular_component	cell body
N	0048306	molecular_function	calcium-dependent protein binding
N	0048741	biological_process	skeletal muscle fiber development
N	0051017	biological_process	actin filament bundle assembly
N	0090131	biological_process	mesenchyme migration
N	0098723	cellular_component	skeletal muscle myofibril
N	0140660	molecular_function	cytoskeletal motor activator activity
O	0000166	molecular_function	nucleotide binding
O	0000287	molecular_function	magnesium ion binding
O	0001725	cellular_component	stress fiber
O	0003785	molecular_function	actin monomer binding
O	0005509	molecular_function	calcium ion binding
O	0005515	molecular_function	protein binding
O	0005523	molecular_function	tropomyosin binding
O	0005524	molecular_function	ATP binding
O	0005737	cellular_component	cytoplasm
O	0005856	cellular_component	cytoskeleton
O	0005865	cellular_component	striated muscle thin filament
O	0005884	cellular_component	actin filament
O	0010628	biological_process	positive regulation of gene expression
O	0016787	molecular_function	hydrolase activity
O	0019904	molecular_function	protein domain specific binding
O	0030027	cellular_component	lamellipodium
O	0030041	biological_process	actin filament polymerization
O	0030175	cellular_component	filopodium
O	0030240	biological_process	skeletal muscle thin filament assembly
O	0031013	molecular_function	troponin I binding
O	0031432	molecular_function	titin binding
O	0031941	cellular_component	filamentous actin
O	0032036	molecular_function	myosin heavy chain binding
O	0032432	cellular_component	actin filament bundle
O	0042802	molecular_function	identical protein binding
O	0044297	cellular_component	cell body
O	0048306	molecular_function	calcium-dependent protein binding
O	0048741	biological_process	skeletal muscle fiber development
O	0051017	biological_process	actin filament bundle assembly
O	0090131	biological_process	mesenchyme migration
O	0098723	cellular_component	skeletal muscle myofibril
O	0140660	molecular_function	cytoskeletal motor activator activity
P	0000166	molecular_function	nucleotide binding
P	0000287	molecular_function	magnesium ion binding
P	0001725	cellular_component	stress fiber
P	0003785	molecular_function	actin monomer binding
P	0005509	molecular_function	calcium ion binding
P	0005515	molecular_function	protein binding
P	0005523	molecular_function	tropomyosin binding
P	0005524	molecular_function	ATP binding
P	0005737	cellular_component	cytoplasm
P	0005856	cellular_component	cytoskeleton
P	0005865	cellular_component	striated muscle thin filament
P	0005884	cellular_component	actin filament
P	0010628	biological_process	positive regulation of gene expression
P	0016787	molecular_function	hydrolase activity
P	0019904	molecular_function	protein domain specific binding
P	0030027	cellular_component	lamellipodium
P	0030041	biological_process	actin filament polymerization
P	0030175	cellular_component	filopodium
P	0030240	biological_process	skeletal muscle thin filament assembly
P	0031013	molecular_function	troponin I binding
P	0031432	molecular_function	titin binding
P	0031941	cellular_component	filamentous actin
P	0032036	molecular_function	myosin heavy chain binding
P	0032432	cellular_component	actin filament bundle
P	0042802	molecular_function	identical protein binding
P	0044297	cellular_component	cell body
P	0048306	molecular_function	calcium-dependent protein binding
P	0048741	biological_process	skeletal muscle fiber development
P	0051017	biological_process	actin filament bundle assembly
P	0090131	biological_process	mesenchyme migration
P	0098723	cellular_component	skeletal muscle myofibril
P	0140660	molecular_function	cytoskeletal motor activator activity
Q	0000166	molecular_function	nucleotide binding
Q	0000287	molecular_function	magnesium ion binding
Q	0001725	cellular_component	stress fiber
Q	0003785	molecular_function	actin monomer binding
Q	0005509	molecular_function	calcium ion binding
Q	0005515	molecular_function	protein binding
Q	0005523	molecular_function	tropomyosin binding
Q	0005524	molecular_function	ATP binding
Q	0005737	cellular_component	cytoplasm
Q	0005856	cellular_component	cytoskeleton
Q	0005865	cellular_component	striated muscle thin filament
Q	0005884	cellular_component	actin filament
Q	0010628	biological_process	positive regulation of gene expression
Q	0016787	molecular_function	hydrolase activity
Q	0019904	molecular_function	protein domain specific binding
Q	0030027	cellular_component	lamellipodium
Q	0030041	biological_process	actin filament polymerization
Q	0030175	cellular_component	filopodium
Q	0030240	biological_process	skeletal muscle thin filament assembly
Q	0031013	molecular_function	troponin I binding
Q	0031432	molecular_function	titin binding
Q	0031941	cellular_component	filamentous actin
Q	0032036	molecular_function	myosin heavy chain binding
Q	0032432	cellular_component	actin filament bundle
Q	0042802	molecular_function	identical protein binding
Q	0044297	cellular_component	cell body
Q	0048306	molecular_function	calcium-dependent protein binding
Q	0048741	biological_process	skeletal muscle fiber development
Q	0051017	biological_process	actin filament bundle assembly
Q	0090131	biological_process	mesenchyme migration
Q	0098723	cellular_component	skeletal muscle myofibril
Q	0140660	molecular_function	cytoskeletal motor activator activity
R	0000166	molecular_function	nucleotide binding
R	0000287	molecular_function	magnesium ion binding
R	0001725	cellular_component	stress fiber
R	0003785	molecular_function	actin monomer binding
R	0005509	molecular_function	calcium ion binding
R	0005515	molecular_function	protein binding
R	0005523	molecular_function	tropomyosin binding
R	0005524	molecular_function	ATP binding
R	0005737	cellular_component	cytoplasm
R	0005856	cellular_component	cytoskeleton
R	0005865	cellular_component	striated muscle thin filament
R	0005884	cellular_component	actin filament
R	0010628	biological_process	positive regulation of gene expression
R	0016787	molecular_function	hydrolase activity
R	0019904	molecular_function	protein domain specific binding
R	0030027	cellular_component	lamellipodium
R	0030041	biological_process	actin filament polymerization
R	0030175	cellular_component	filopodium
R	0030240	biological_process	skeletal muscle thin filament assembly
R	0031013	molecular_function	troponin I binding
R	0031432	molecular_function	titin binding
R	0031941	cellular_component	filamentous actin
R	0032036	molecular_function	myosin heavy chain binding
R	0032432	cellular_component	actin filament bundle
R	0042802	molecular_function	identical protein binding
R	0044297	cellular_component	cell body
R	0048306	molecular_function	calcium-dependent protein binding
R	0048741	biological_process	skeletal muscle fiber development
R	0051017	biological_process	actin filament bundle assembly
R	0090131	biological_process	mesenchyme migration
R	0098723	cellular_component	skeletal muscle myofibril
R	0140660	molecular_function	cytoskeletal motor activator activity
S	0000166	molecular_function	nucleotide binding
S	0000287	molecular_function	magnesium ion binding
S	0001725	cellular_component	stress fiber
S	0003785	molecular_function	actin monomer binding
S	0005509	molecular_function	calcium ion binding
S	0005515	molecular_function	protein binding
S	0005523	molecular_function	tropomyosin binding
S	0005524	molecular_function	ATP binding
S	0005737	cellular_component	cytoplasm
S	0005856	cellular_component	cytoskeleton
S	0005865	cellular_component	striated muscle thin filament
S	0005884	cellular_component	actin filament
S	0010628	biological_process	positive regulation of gene expression
S	0016787	molecular_function	hydrolase activity
S	0019904	molecular_function	protein domain specific binding
S	0030027	cellular_component	lamellipodium
S	0030041	biological_process	actin filament polymerization
S	0030175	cellular_component	filopodium
S	0030240	biological_process	skeletal muscle thin filament assembly
S	0031013	molecular_function	troponin I binding
S	0031432	molecular_function	titin binding
S	0031941	cellular_component	filamentous actin
S	0032036	molecular_function	myosin heavy chain binding
S	0032432	cellular_component	actin filament bundle
S	0042802	molecular_function	identical protein binding
S	0044297	cellular_component	cell body
S	0048306	molecular_function	calcium-dependent protein binding
S	0048741	biological_process	skeletal muscle fiber development
S	0051017	biological_process	actin filament bundle assembly
S	0090131	biological_process	mesenchyme migration
S	0098723	cellular_component	skeletal muscle myofibril
S	0140660	molecular_function	cytoskeletal motor activator activity
T	0000166	molecular_function	nucleotide binding
T	0000287	molecular_function	magnesium ion binding
T	0001725	cellular_component	stress fiber
T	0003785	molecular_function	actin monomer binding
T	0005509	molecular_function	calcium ion binding
T	0005515	molecular_function	protein binding
T	0005523	molecular_function	tropomyosin binding
T	0005524	molecular_function	ATP binding
T	0005737	cellular_component	cytoplasm
T	0005856	cellular_component	cytoskeleton
T	0005865	cellular_component	striated muscle thin filament
T	0005884	cellular_component	actin filament
T	0010628	biological_process	positive regulation of gene expression
T	0016787	molecular_function	hydrolase activity
T	0019904	molecular_function	protein domain specific binding
T	0030027	cellular_component	lamellipodium
T	0030041	biological_process	actin filament polymerization
T	0030175	cellular_component	filopodium
T	0030240	biological_process	skeletal muscle thin filament assembly
T	0031013	molecular_function	troponin I binding
T	0031432	molecular_function	titin binding
T	0031941	cellular_component	filamentous actin
T	0032036	molecular_function	myosin heavy chain binding
T	0032432	cellular_component	actin filament bundle
T	0042802	molecular_function	identical protein binding
T	0044297	cellular_component	cell body
T	0048306	molecular_function	calcium-dependent protein binding
T	0048741	biological_process	skeletal muscle fiber development
T	0051017	biological_process	actin filament bundle assembly
T	0090131	biological_process	mesenchyme migration
T	0098723	cellular_component	skeletal muscle myofibril
T	0140660	molecular_function	cytoskeletal motor activator activity
U	0000166	molecular_function	nucleotide binding
U	0000287	molecular_function	magnesium ion binding
U	0001725	cellular_component	stress fiber
U	0003785	molecular_function	actin monomer binding
U	0005509	molecular_function	calcium ion binding
U	0005515	molecular_function	protein binding
U	0005523	molecular_function	tropomyosin binding
U	0005524	molecular_function	ATP binding
U	0005737	cellular_component	cytoplasm
U	0005856	cellular_component	cytoskeleton
U	0005865	cellular_component	striated muscle thin filament
U	0005884	cellular_component	actin filament
U	0010628	biological_process	positive regulation of gene expression
U	0016787	molecular_function	hydrolase activity
U	0019904	molecular_function	protein domain specific binding
U	0030027	cellular_component	lamellipodium
U	0030041	biological_process	actin filament polymerization
U	0030175	cellular_component	filopodium
U	0030240	biological_process	skeletal muscle thin filament assembly
U	0031013	molecular_function	troponin I binding
U	0031432	molecular_function	titin binding
U	0031941	cellular_component	filamentous actin
U	0032036	molecular_function	myosin heavy chain binding
U	0032432	cellular_component	actin filament bundle
U	0042802	molecular_function	identical protein binding
U	0044297	cellular_component	cell body
U	0048306	molecular_function	calcium-dependent protein binding
U	0048741	biological_process	skeletal muscle fiber development
U	0051017	biological_process	actin filament bundle assembly
U	0090131	biological_process	mesenchyme migration
U	0098723	cellular_component	skeletal muscle myofibril
U	0140660	molecular_function	cytoskeletal motor activator activity

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
H	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITKqEYDE

Chain	Residue	Details
H	TRP356-GLU364

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEPpLNTpeNR

Chain	Residue	Details
A	LEU111-ARG123
B	LEU108-ARG120
H	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P61158","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15505213","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17499050","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P61160","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	39
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	39
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	41
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	39
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	38
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O15144","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"O15145","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O15145","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"O15145","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine","evidences":[{"source":"UniProtKB","id":"P59998","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	350
Details	Region: {"description":"Interaction with alpha-actinin","evidences":[{"source":"PubMed","id":"8449927","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	28
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P68134","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	14
Details	Modified residue: {"description":"N6-malonyllysine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	14
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"1150665","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16905096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"213279","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2395459","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"499690","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ATN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NWK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	14
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68133","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	14
Details	Modified residue: {"description":"ADP-ribosylarginine; by SpvB","evidences":[{"source":"PubMed","id":"16905096","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---