7TJ2
SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Proton donor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | ALA235 | |
| B | ALA235 | |
| C | ALA235 | |
| D | ALA235 | |
| E | ALA235 | |
| F | ALA235 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | ACT_SITE: Proton acceptor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | HIS250 | |
| B | HIS250 | |
| C | HIS250 | |
| D | HIS250 | |
| E | HIS250 | |
| F | HIS250 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | ACT_SITE: For uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779 |
| Chain | Residue | Details |
| A | LYS290 | |
| B | LYS290 | |
| C | LYS290 | |
| D | LYS290 | |
| E | LYS290 | |
| F | LYS290 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | LYS290 | |
| B | LYS290 | |
| C | LYS290 | |
| D | LYS290 | |
| E | LYS290 | |
| F | LYS290 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | THR341 | |
| B | THR341 | |
| C | THR341 | |
| D | THR341 | |
| E | THR341 | |
| F | THR341 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | SITE: Transition state stabilizer => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | LYS290 | |
| B | LYS290 | |
| C | LYS290 | |
| D | LYS290 | |
| E | LYS290 | |
| F | LYS290 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | SITE: Uracil recognition site => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | SER294 | |
| B | SER294 | |
| C | SER294 | |
| D | SER294 | |
| E | SER294 | |
| F | SER294 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 |
| Chain | Residue | Details |
| A | GLN347 | |
| B | GLN347 | |
| C | GLN347 | |
| D | GLN347 | |
| E | GLN347 | |
| F | GLN347 |
