7TJ2
SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Proton donor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | ALA235 | |
B | ALA235 | |
C | ALA235 | |
D | ALA235 | |
E | ALA235 | |
F | ALA235 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | ACT_SITE: Proton acceptor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | HIS250 | |
B | HIS250 | |
C | HIS250 | |
D | HIS250 | |
E | HIS250 | |
F | HIS250 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | ACT_SITE: For uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779 |
Chain | Residue | Details |
A | LYS290 | |
B | LYS290 | |
C | LYS290 | |
D | LYS290 | |
E | LYS290 | |
F | LYS290 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | LYS290 | |
B | LYS290 | |
C | LYS290 | |
D | LYS290 | |
E | LYS290 | |
F | LYS290 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | THR341 | |
B | THR341 | |
C | THR341 | |
D | THR341 | |
E | THR341 | |
F | THR341 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | SITE: Transition state stabilizer => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | LYS290 | |
B | LYS290 | |
C | LYS290 | |
D | LYS290 | |
E | LYS290 | |
F | LYS290 |
site_id | SWS_FT_FI7 |
Number of Residues | 6 |
Details | SITE: Uracil recognition site => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
Chain | Residue | Details |
A | SER294 | |
B | SER294 | |
C | SER294 | |
D | SER294 | |
E | SER294 | |
F | SER294 |
site_id | SWS_FT_FI8 |
Number of Residues | 6 |
Details | SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 |
Chain | Residue | Details |
A | GLN347 | |
B | GLN347 | |
C | GLN347 | |
D | GLN347 | |
E | GLN347 | |
F | GLN347 |