7THT
CryoEM structure of SARS-CoV-2 S protein in complex with Receptor Binding Domain antibody DH1042
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0016020 | cellular_component | membrane |
| C | 0019031 | cellular_component | viral envelope |
| C | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| C | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| C | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| C | 0055036 | cellular_component | virion membrane |
| C | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| S | 0016020 | cellular_component | membrane |
| S | 0019031 | cellular_component | viral envelope |
| S | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| S | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| S | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| S | 0055036 | cellular_component | virion membrane |
| S | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| V | 0016020 | cellular_component | membrane |
| V | 0019031 | cellular_component | viral envelope |
| V | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| V | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| V | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| V | 0055036 | cellular_component | virion membrane |
| V | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| S | ARG685 | |
| V | ARG685 | |
| C | ARG685 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| S | ARG815 | |
| V | ARG815 | |
| C | ARG815 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 15 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| S | ASN61 | |
| V | ASN1074 | |
| C | ASN61 | |
| C | ASN122 | |
| C | ASN717 | |
| C | ASN801 | |
| C | ASN1074 | |
| S | ASN122 | |
| S | ASN717 | |
| S | ASN801 | |
| S | ASN1074 | |
| V | ASN61 | |
| V | ASN122 | |
| V | ASN717 | |
| V | ASN801 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| S | ASN74 | |
| S | ASN149 | |
| V | ASN74 | |
| V | ASN149 | |
| C | ASN74 | |
| C | ASN149 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| S | ASN165 | |
| V | ASN331 | |
| V | ASN343 | |
| V | ASN616 | |
| V | ASN657 | |
| V | ASN1098 | |
| C | ASN165 | |
| C | ASN282 | |
| C | ASN331 | |
| C | ASN343 | |
| C | ASN616 | |
| S | ASN282 | |
| C | ASN657 | |
| C | ASN1098 | |
| S | ASN331 | |
| S | ASN343 | |
| S | ASN616 | |
| S | ASN657 | |
| S | ASN1098 | |
| V | ASN165 | |
| V | ASN282 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| S | ASN234 | |
| S | ASN709 | |
| V | ASN234 | |
| V | ASN709 | |
| C | ASN234 | |
| C | ASN709 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| S | THR323 | |
| V | THR323 | |
| C | THR323 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| S | SER325 | |
| V | SER325 | |
| C | SER325 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| S | ASN603 | |
| V | ASN603 | |
| C | ASN603 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583 |
| Chain | Residue | Details |
| S | THR676 | |
| S | THR678 | |
| V | THR676 | |
| V | THR678 | |
| C | THR676 | |
| C | THR678 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| S | ASN1134 | |
| V | ASN1134 | |
| C | ASN1134 |
