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7TDH

Rabbit RyR1 with AMP-PCP and high Ca2+ embedded in nanodisc in open conformation

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0003151biological_processoutflow tract morphogenesis
A0005216molecular_functionmonoatomic ion channel activity
A0005219molecular_functionryanodine-sensitive calcium-release channel activity
A0005245molecular_functionvoltage-gated calcium channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005790cellular_componentsmooth endoplasmic reticulum
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006936biological_processmuscle contraction
A0006941biological_processstriated muscle contraction
A0008144molecular_functionobsolete drug binding
A0014802cellular_componentterminal cisterna
A0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0015278molecular_functionintracellularly gated calcium channel activity
A0015643molecular_functiontoxic substance binding
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0019722biological_processcalcium-mediated signaling
A0030018cellular_componentZ disc
A0031090cellular_componentorganelle membrane
A0033017cellular_componentsarcoplasmic reticulum membrane
A0034704cellular_componentcalcium channel complex
A0035381molecular_functionATP-gated ion channel activity
A0042383cellular_componentsarcolemma
A0042802molecular_functionidentical protein binding
A0043588biological_processskin development
A0043931biological_processossification involved in bone maturation
A0044325molecular_functiontransmembrane transporter binding
A0046872molecular_functionmetal ion binding
A0048741biological_processskeletal muscle fiber development
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0071277biological_processcellular response to calcium ion
A0071313biological_processcellular response to caffeine
A0097718molecular_functiondisordered domain specific binding
A1990425cellular_componentryanodine receptor complex
B0003151biological_processoutflow tract morphogenesis
B0005216molecular_functionmonoatomic ion channel activity
B0005219molecular_functionryanodine-sensitive calcium-release channel activity
B0005245molecular_functionvoltage-gated calcium channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005524molecular_functionATP binding
B0005790cellular_componentsmooth endoplasmic reticulum
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006936biological_processmuscle contraction
B0006941biological_processstriated muscle contraction
B0008144molecular_functionobsolete drug binding
B0014802cellular_componentterminal cisterna
B0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0015278molecular_functionintracellularly gated calcium channel activity
B0015643molecular_functiontoxic substance binding
B0016020cellular_componentmembrane
B0016529cellular_componentsarcoplasmic reticulum
B0019722biological_processcalcium-mediated signaling
B0030018cellular_componentZ disc
B0031090cellular_componentorganelle membrane
B0033017cellular_componentsarcoplasmic reticulum membrane
B0034704cellular_componentcalcium channel complex
B0035381molecular_functionATP-gated ion channel activity
B0042383cellular_componentsarcolemma
B0042802molecular_functionidentical protein binding
B0043588biological_processskin development
B0043931biological_processossification involved in bone maturation
B0044325molecular_functiontransmembrane transporter binding
B0046872molecular_functionmetal ion binding
B0048741biological_processskeletal muscle fiber development
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0071277biological_processcellular response to calcium ion
B0071313biological_processcellular response to caffeine
B0097718molecular_functiondisordered domain specific binding
B1990425cellular_componentryanodine receptor complex
C0003151biological_processoutflow tract morphogenesis
C0005216molecular_functionmonoatomic ion channel activity
C0005219molecular_functionryanodine-sensitive calcium-release channel activity
C0005245molecular_functionvoltage-gated calcium channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005790cellular_componentsmooth endoplasmic reticulum
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006874biological_processintracellular calcium ion homeostasis
C0006936biological_processmuscle contraction
C0006941biological_processstriated muscle contraction
C0008144molecular_functionobsolete drug binding
C0014802cellular_componentterminal cisterna
C0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0015278molecular_functionintracellularly gated calcium channel activity
C0015643molecular_functiontoxic substance binding
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0019722biological_processcalcium-mediated signaling
C0030018cellular_componentZ disc
C0031090cellular_componentorganelle membrane
C0033017cellular_componentsarcoplasmic reticulum membrane
C0034704cellular_componentcalcium channel complex
C0035381molecular_functionATP-gated ion channel activity
C0042383cellular_componentsarcolemma
C0042802molecular_functionidentical protein binding
C0043588biological_processskin development
C0043931biological_processossification involved in bone maturation
C0044325molecular_functiontransmembrane transporter binding
C0046872molecular_functionmetal ion binding
C0048741biological_processskeletal muscle fiber development
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0071277biological_processcellular response to calcium ion
C0071313biological_processcellular response to caffeine
C0097718molecular_functiondisordered domain specific binding
C1990425cellular_componentryanodine receptor complex
D0003151biological_processoutflow tract morphogenesis
D0005216molecular_functionmonoatomic ion channel activity
D0005219molecular_functionryanodine-sensitive calcium-release channel activity
D0005245molecular_functionvoltage-gated calcium channel activity
D0005262molecular_functioncalcium channel activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005524molecular_functionATP binding
D0005790cellular_componentsmooth endoplasmic reticulum
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0006936biological_processmuscle contraction
D0006941biological_processstriated muscle contraction
D0008144molecular_functionobsolete drug binding
D0014802cellular_componentterminal cisterna
D0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0015278molecular_functionintracellularly gated calcium channel activity
D0015643molecular_functiontoxic substance binding
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0019722biological_processcalcium-mediated signaling
D0030018cellular_componentZ disc
D0031090cellular_componentorganelle membrane
D0033017cellular_componentsarcoplasmic reticulum membrane
D0034704cellular_componentcalcium channel complex
D0035381molecular_functionATP-gated ion channel activity
D0042383cellular_componentsarcolemma
D0042802molecular_functionidentical protein binding
D0043588biological_processskin development
D0043931biological_processossification involved in bone maturation
D0044325molecular_functiontransmembrane transporter binding
D0046872molecular_functionmetal ion binding
D0048741biological_processskeletal muscle fiber development
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
D0071277biological_processcellular response to calcium ion
D0071313biological_processcellular response to caffeine
D0097718molecular_functiondisordered domain specific binding
D1990425cellular_componentryanodine receptor complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues19136
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
CASN4662-LYS4779
CLYS4821-LYS4835
CGLY4941-SER5037
DMET1-ASN4558
DASN4662-LYS4779
DLYS4821-LYS4835
DGLY4941-SER5037
BMET1-ASN4558
BASN4662-LYS4779
BLYS4821-LYS4835
BGLY4941-SER5037
CMET1-ASN4558
AMET1-ASN4558
AASN4662-LYS4779
ALYS4821-LYS4835
AGLY4941-SER5037

site_idSWS_FT_FI2
Number of Residues80
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
APHE4559-PHE4579
BPHE4559-PHE4579
CPHE4559-PHE4579
DPHE4559-PHE4579

site_idSWS_FT_FI3
Number of Residues408
DetailsTOPO_DOM: Lumenal => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
CHIS4803
CASN4857-MET4879
CGLU4900-THR4919
DTYR4580-GLU4640
DHIS4803
DASN4857-MET4879
DGLU4900-THR4919
BTYR4580-GLU4640
BHIS4803
BASN4857-MET4879
BGLU4900-THR4919
CTYR4580-GLU4640
ATYR4580-GLU4640
AHIS4803
AASN4857-MET4879
AGLU4900-THR4919

site_idSWS_FT_FI4
Number of Residues80
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
APRO4641-TYR4661
BPRO4641-TYR4661
CPRO4641-TYR4661
DPRO4641-TYR4661

site_idSWS_FT_FI5
Number of Residues88
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
APHE4780-GLY4802
BPHE4780-GLY4802
CPHE4780-GLY4802
DPHE4780-GLY4802

site_idSWS_FT_FI6
Number of Residues64
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
ATYR4804-VAL4820
BTYR4804-VAL4820
CTYR4804-VAL4820
DTYR4804-VAL4820

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
AGLN4836-PHE4856
BGLN4836-PHE4856
CGLN4836-PHE4856
DGLN4836-PHE4856

site_idSWS_FT_FI8
Number of Residues76
DetailsINTRAMEM: Pore-forming => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
AMET4880-ASP4899
BMET4880-ASP4899
CMET4880-ASP4899
DMET4880-ASP4899

site_idSWS_FT_FI9
Number of Residues80
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:25470059, ECO:0000269|PubMed:25517095, ECO:0000269|PubMed:27468892, ECO:0000269|PubMed:27573175
ChainResidueDetails
APHE4920-PHE4940
BPHE4920-PHE4940
CPHE4920-PHE4940
DPHE4920-PHE4940

site_idSWS_FT_FI10
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5TA3, ECO:0007744|PDB:5TAL, ECO:0007744|PDB:5TAM, ECO:0007744|PDB:5TAN
ChainResidueDetails
AGLU3893
AGLU3967
ATHR5001
BGLU3893
BGLU3967
BTHR5001
CGLU3893
CGLU3967
CTHR5001
DGLU3893
DGLU3967
DTHR5001

site_idSWS_FT_FI11
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5T9V, ECO:0007744|PDB:5TA3, ECO:0007744|PDB:5TAL, ECO:0007744|PDB:5TAM, ECO:0007744|PDB:5TAN, ECO:0007744|PDB:5TAS, ECO:0007744|PDB:5TAT, ECO:0007744|PDB:5TAU
ChainResidueDetails
CTHR4979
DLYS4211
DMET4954
DTHR4979
ALYS4211
AMET4954
ATHR4979
BLYS4211
BMET4954
BTHR4979
CLYS4211
CMET4954

site_idSWS_FT_FI12
Number of Residues4
DetailsBINDING: BINDING => ECO:0000305|PubMed:27662087, ECO:0007744|PDB:5TAN
ChainResidueDetails
ATRP4716
BTRP4716
CTRP4716
DTRP4716

site_idSWS_FT_FI13
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:F1LMY4
ChainResidueDetails
BSER2345
BSER4470
CUNK1338
CSER2345
CSER4470
DUNK1338
DSER2345
DSER4470
AUNK1338
ASER2345
ASER4470
BUNK1338

site_idSWS_FT_FI14
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA and PKG => ECO:0000269|PubMed:8380342
ChainResidueDetails
ASER2843
BSER2843
CSER2843
DSER2843

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:10601232, ECO:0000269|PubMed:11562475, ECO:0000269|PubMed:22036948
ChainResidueDetails
ACYS3635
BCYS3635
CCYS3635
DCYS3635

site_idSWS_FT_FI16
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:F1LMY4
ChainResidueDetails
ATHR4466
BTHR4466
CTHR4466
DTHR4466

site_idSWS_FT_FI17
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P21817
ChainResidueDetails
ATYR4863
BTYR4863
CTYR4863
DTYR4863

site_idSWS_FT_FI18
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P21817
ChainResidueDetails
ASER4866
BSER4866
CSER4866
DSER4866

219869

PDB entries from 2024-05-15

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