7T3B

GATOR1-RAG-RAGULATOR - GAP Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005096	molecular_function	GTPase activator activity
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005829	cellular_component	cytosol
A	0010508	biological_process	positive regulation of autophagy
A	0016020	cellular_component	membrane
A	0031267	molecular_function	small GTPase binding
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
A	0034198	biological_process	cellular response to amino acid starvation
A	0035556	biological_process	intracellular signal transduction
A	0044877	molecular_function	protein-containing complex binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1990130	cellular_component	GATOR1 complex
B	0005096	molecular_function	GTPase activator activity
B	0005515	molecular_function	protein binding
B	0005764	cellular_component	lysosome
B	0005765	cellular_component	lysosomal membrane
B	0005774	cellular_component	vacuolar membrane
B	0010508	biological_process	positive regulation of autophagy
B	0016020	cellular_component	membrane
B	0033673	biological_process	negative regulation of kinase activity
B	0034198	biological_process	cellular response to amino acid starvation
B	1904262	biological_process	negative regulation of TORC1 signaling
B	1990130	cellular_component	GATOR1 complex
C	0003281	biological_process	ventricular septum development
C	0005096	molecular_function	GTPase activator activity
C	0005515	molecular_function	protein binding
C	0005764	cellular_component	lysosome
C	0005765	cellular_component	lysosomal membrane
C	0010508	biological_process	positive regulation of autophagy
C	0016020	cellular_component	membrane
C	0032007	biological_process	negative regulation of TOR signaling
C	0034198	biological_process	cellular response to amino acid starvation
C	0035909	biological_process	aorta morphogenesis
C	0038202	biological_process	TORC1 signaling
C	0048738	biological_process	cardiac muscle tissue development
C	0060021	biological_process	roof of mouth development
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1990130	cellular_component	GATOR1 complex
D	0003924	molecular_function	GTPase activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005765	cellular_component	lysosomal membrane
D	0005829	cellular_component	cytosol
D	0006915	biological_process	apoptotic process
D	0008104	biological_process	protein localization
D	0009267	biological_process	cellular response to starvation
D	0010507	biological_process	negative regulation of autophagy
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0031669	biological_process	cellular response to nutrient levels
D	0032008	biological_process	positive regulation of TOR signaling
D	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
D	0034198	biological_process	cellular response to amino acid starvation
D	0035556	biological_process	intracellular signal transduction
D	0042593	biological_process	glucose homeostasis
D	0042803	molecular_function	protein homodimerization activity
D	0043495	molecular_function	protein-membrane adaptor activity
D	0046982	molecular_function	protein heterodimerization activity
D	0051219	molecular_function	phosphoprotein binding
D	0061462	biological_process	protein localization to lysosome
D	0071230	biological_process	cellular response to amino acid stimulus
D	0072657	biological_process	protein localization to membrane
D	1904263	biological_process	positive regulation of TORC1 signaling
D	1990130	cellular_component	GATOR1 complex
D	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
D	1990877	cellular_component	FNIP-folliculin RagC/D GAP
E	0000287	molecular_function	magnesium ion binding
E	0003924	molecular_function	GTPase activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005764	cellular_component	lysosome
E	0005765	cellular_component	lysosomal membrane
E	0005829	cellular_component	cytosol
E	0006351	biological_process	DNA-templated transcription
E	0006915	biological_process	apoptotic process
E	0007264	biological_process	small GTPase-mediated signal transduction
E	0008104	biological_process	protein localization
E	0008380	biological_process	RNA splicing
E	0009267	biological_process	cellular response to starvation
E	0010507	biological_process	negative regulation of autophagy
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0019003	molecular_function	GDP binding
E	0031669	biological_process	cellular response to nutrient levels
E	0032006	biological_process	regulation of TOR signaling
E	0034198	biological_process	cellular response to amino acid starvation
E	0043200	biological_process	response to amino acid
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0043495	molecular_function	protein-membrane adaptor activity
E	0046982	molecular_function	protein heterodimerization activity
E	0051020	molecular_function	GTPase binding
E	0060090	molecular_function	molecular adaptor activity
E	0061462	biological_process	protein localization to lysosome
E	0071230	biological_process	cellular response to amino acid stimulus
E	0072657	biological_process	protein localization to membrane
E	0140767	molecular_function	enzyme-substrate adaptor activity
E	1903432	biological_process	regulation of TORC1 signaling
E	1904263	biological_process	positive regulation of TORC1 signaling
E	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
E	1990877	cellular_component	FNIP-folliculin RagC/D GAP
F	0001558	biological_process	regulation of cell growth
F	0001919	biological_process	regulation of receptor recycling
F	0005085	molecular_function	guanyl-nucleotide exchange factor activity
F	0005515	molecular_function	protein binding
F	0005764	cellular_component	lysosome
F	0005765	cellular_component	lysosomal membrane
F	0005768	cellular_component	endosome
F	0005886	cellular_component	plasma membrane
F	0007032	biological_process	endosome organization
F	0007040	biological_process	lysosome organization
F	0008104	biological_process	protein localization
F	0010874	biological_process	regulation of cholesterol efflux
F	0016020	cellular_component	membrane
F	0016197	biological_process	endosomal transport
F	0031669	biological_process	cellular response to nutrient levels
F	0031902	cellular_component	late endosome membrane
F	0032008	biological_process	positive regulation of TOR signaling
F	0032418	biological_process	lysosome localization
F	0035577	cellular_component	azurophil granule membrane
F	0035579	cellular_component	specific granule membrane
F	0038202	biological_process	TORC1 signaling
F	0042632	biological_process	cholesterol homeostasis
F	0043410	biological_process	positive regulation of MAPK cascade
F	0043495	molecular_function	protein-membrane adaptor activity
F	0045121	cellular_component	membrane raft
F	0051020	molecular_function	GTPase binding
F	0060090	molecular_function	molecular adaptor activity
F	0060620	biological_process	regulation of cholesterol import
F	0070062	cellular_component	extracellular exosome
F	0071230	biological_process	cellular response to amino acid stimulus
F	0071986	cellular_component	Ragulator complex
F	0072657	biological_process	protein localization to membrane
F	0101003	cellular_component	ficolin-1-rich granule membrane
F	0150032	biological_process	positive regulation of protein localization to lysosome
F	1904263	biological_process	positive regulation of TORC1 signaling
F	1990877	cellular_component	FNIP-folliculin RagC/D GAP
G	0001558	biological_process	regulation of cell growth
G	0005085	molecular_function	guanyl-nucleotide exchange factor activity
G	0005515	molecular_function	protein binding
G	0005764	cellular_component	lysosome
G	0005765	cellular_component	lysosomal membrane
G	0005768	cellular_component	endosome
G	0005770	cellular_component	late endosome
G	0005886	cellular_component	plasma membrane
G	0008104	biological_process	protein localization
G	0010008	cellular_component	endosome membrane
G	0010761	biological_process	fibroblast migration
G	0016020	cellular_component	membrane
G	0031902	cellular_component	late endosome membrane
G	0032008	biological_process	positive regulation of TOR signaling
G	0035579	cellular_component	specific granule membrane
G	0038202	biological_process	TORC1 signaling
G	0043410	biological_process	positive regulation of MAPK cascade
G	0060090	molecular_function	molecular adaptor activity
G	0070821	cellular_component	tertiary granule membrane
G	0071230	biological_process	cellular response to amino acid stimulus
G	0071986	cellular_component	Ragulator complex
G	0150116	biological_process	regulation of cell-substrate junction organization
G	1902414	biological_process	protein localization to cell junction
G	1904263	biological_process	positive regulation of TORC1 signaling
G	1990877	cellular_component	FNIP-folliculin RagC/D GAP
H	0005085	molecular_function	guanyl-nucleotide exchange factor activity
H	0005515	molecular_function	protein binding
H	0005765	cellular_component	lysosomal membrane
H	0005768	cellular_component	endosome
H	0005770	cellular_component	late endosome
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0008104	biological_process	protein localization
H	0010008	cellular_component	endosome membrane
H	0016020	cellular_component	membrane
H	0019209	molecular_function	kinase activator activity
H	0031902	cellular_component	late endosome membrane
H	0032006	biological_process	regulation of TOR signaling
H	0032008	biological_process	positive regulation of TOR signaling
H	0035579	cellular_component	specific granule membrane
H	0038202	biological_process	TORC1 signaling
H	0043410	biological_process	positive regulation of MAPK cascade
H	0060090	molecular_function	molecular adaptor activity
H	0070062	cellular_component	extracellular exosome
H	0070821	cellular_component	tertiary granule membrane
H	0071230	biological_process	cellular response to amino acid stimulus
H	0071986	cellular_component	Ragulator complex
H	1902414	biological_process	protein localization to cell junction
H	1904263	biological_process	positive regulation of TORC1 signaling
H	1990877	cellular_component	FNIP-folliculin RagC/D GAP
I	0005085	molecular_function	guanyl-nucleotide exchange factor activity
I	0005515	molecular_function	protein binding
I	0005764	cellular_component	lysosome
I	0005765	cellular_component	lysosomal membrane
I	0008361	biological_process	regulation of cell size
I	0031902	cellular_component	late endosome membrane
I	0032008	biological_process	positive regulation of TOR signaling
I	0038202	biological_process	TORC1 signaling
I	0043231	cellular_component	intracellular membrane-bounded organelle
I	0060090	molecular_function	molecular adaptor activity
I	0061462	biological_process	protein localization to lysosome
I	0071230	biological_process	cellular response to amino acid stimulus
I	0071986	cellular_component	Ragulator complex
I	1904263	biological_process	positive regulation of TORC1 signaling
I	1990877	cellular_component	FNIP-folliculin RagC/D GAP
J	0005085	molecular_function	guanyl-nucleotide exchange factor activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005764	cellular_component	lysosome
J	0005765	cellular_component	lysosomal membrane
J	0005829	cellular_component	cytosol
J	0008361	biological_process	regulation of cell size
J	0009615	biological_process	response to virus
J	0010628	biological_process	positive regulation of gene expression
J	0019079	biological_process	viral genome replication
J	0031902	cellular_component	late endosome membrane
J	0032008	biological_process	positive regulation of TOR signaling
J	0032757	biological_process	positive regulation of interleukin-8 production
J	0032991	cellular_component	protein-containing complex
J	0038202	biological_process	TORC1 signaling
J	0043066	biological_process	negative regulation of apoptotic process
J	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
J	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
J	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
J	0060090	molecular_function	molecular adaptor activity
J	0061462	biological_process	protein localization to lysosome
J	0071230	biological_process	cellular response to amino acid stimulus
J	0071986	cellular_component	Ragulator complex
J	1900182	biological_process	positive regulation of protein localization to nucleus
J	1904263	biological_process	positive regulation of TORC1 signaling
J	1905636	biological_process	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
J	1990877	cellular_component	FNIP-folliculin RagC/D GAP

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. KAYkVnpDmNFEvFIHKV

Chain	Residue	Details
E	LYS163-VAL180

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
C	SER476
D	GLY17
D	HIS127

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
F	SER42
F	SER56
F	SER98
F	SER141

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site_id	SWS_FT_FI3
Number of Residues	1
Details	LIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:25807930, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:34999170

Chain	Residue	Details
F	GLY2
D	THR21
D	THR36
D	ILE164

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site_id	SWS_FT_FI4
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:34999170, ECO:0000269|PubMed:35893977

Chain	Residue	Details
F	CYS3
F	CYS4
B	LYS357

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site_id	SWS_FT_FI5
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36476874

Chain	Residue	Details
F	LYS20
F	LYS31
F	LYS60

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site_id	SWS_FT_FI6
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q9CQ22

Chain	Residue	Details
D	ASP130
F	LYS103
F	LYS104

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site_id	SWS_FT_FI7
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:31704029, ECO:0000269|PubMed:32868926, ECO:0007744|PDB:6ULG, ECO:0007744|PDB:6WJ2

Chain	Residue	Details
D	LEU148
E	THR96
E	ASP181

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site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER309

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site_id	SWS_FT_FI9
Number of Residues	5
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25936802

Chain	Residue	Details
D	LYS142
D	LYS220
D	LYS230
D	LYS244

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site_id	SWS_FT_FI10
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:35338845, ECO:0000269|PubMed:36697823, ECO:0007744|PDB:6U62, ECO:0007744|PDB:7T3B, ECO:0007744|PDB:7UX2, ECO:0007744|PDB:7UXC, ECO:0007744|PDB:7UXH

Chain	Residue	Details
E	LYS179
E	ILE220

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site_id	SWS_FT_FI11
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:35338845, ECO:0000269|PubMed:36697823, ECO:0007744|PDB:7T3B, ECO:0007744|PDB:7UX2, ECO:0007744|PDB:7UXC, ECO:0007744|PDB:7UXH

Chain	Residue	Details
E	SER219

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site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
E	SER2

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site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
E	SER15

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site_id	SWS_FT_FI14
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q99K70

Chain	Residue	Details
E	THR96

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