7T37

Activated state of 2-APB and CBD-bound wildtype rat TRPV2 in nanodiscs

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0006915	biological_process	apoptotic process
A	0008285	biological_process	negative regulation of cell population proliferation
A	0009266	biological_process	response to temperature stimulus
A	0009986	cellular_component	cell surface
A	0012505	cellular_component	endomembrane system
A	0016020	cellular_component	membrane
A	0030027	cellular_component	lamellipodium
A	0030424	cellular_component	axon
A	0032584	cellular_component	growth cone membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042470	cellular_component	melanosome
A	0043025	cellular_component	neuronal cell body
A	0044295	cellular_component	axonal growth cone
A	0044297	cellular_component	cell body
A	0045773	biological_process	positive regulation of axon extension
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0090280	biological_process	positive regulation of calcium ion import
A	0098703	biological_process	calcium ion import across plasma membrane
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
B	0005216	molecular_function	monoatomic ion channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0006915	biological_process	apoptotic process
B	0008285	biological_process	negative regulation of cell population proliferation
B	0009266	biological_process	response to temperature stimulus
B	0009986	cellular_component	cell surface
B	0012505	cellular_component	endomembrane system
B	0016020	cellular_component	membrane
B	0030027	cellular_component	lamellipodium
B	0030424	cellular_component	axon
B	0032584	cellular_component	growth cone membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042470	cellular_component	melanosome
B	0043025	cellular_component	neuronal cell body
B	0044295	cellular_component	axonal growth cone
B	0044297	cellular_component	cell body
B	0045773	biological_process	positive regulation of axon extension
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0090280	biological_process	positive regulation of calcium ion import
B	0098703	biological_process	calcium ion import across plasma membrane
B	0120162	biological_process	positive regulation of cold-induced thermogenesis
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0006915	biological_process	apoptotic process
C	0008285	biological_process	negative regulation of cell population proliferation
C	0009266	biological_process	response to temperature stimulus
C	0009986	cellular_component	cell surface
C	0012505	cellular_component	endomembrane system
C	0016020	cellular_component	membrane
C	0030027	cellular_component	lamellipodium
C	0030424	cellular_component	axon
C	0032584	cellular_component	growth cone membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042470	cellular_component	melanosome
C	0043025	cellular_component	neuronal cell body
C	0044295	cellular_component	axonal growth cone
C	0044297	cellular_component	cell body
C	0045773	biological_process	positive regulation of axon extension
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0090280	biological_process	positive regulation of calcium ion import
C	0098703	biological_process	calcium ion import across plasma membrane
C	0120162	biological_process	positive regulation of cold-induced thermogenesis
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0006915	biological_process	apoptotic process
D	0008285	biological_process	negative regulation of cell population proliferation
D	0009266	biological_process	response to temperature stimulus
D	0009986	cellular_component	cell surface
D	0012505	cellular_component	endomembrane system
D	0016020	cellular_component	membrane
D	0030027	cellular_component	lamellipodium
D	0030424	cellular_component	axon
D	0032584	cellular_component	growth cone membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042470	cellular_component	melanosome
D	0043025	cellular_component	neuronal cell body
D	0044295	cellular_component	axonal growth cone
D	0044297	cellular_component	cell body
D	0045773	biological_process	positive regulation of axon extension
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0090280	biological_process	positive regulation of calcium ion import
D	0098703	biological_process	calcium ion import across plasma membrane
D	0120162	biological_process	positive regulation of cold-induced thermogenesis

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	72
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	76
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	168
Details	Repeat: {"description":"ANK 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16809337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	184
Details	Repeat: {"description":"ANK 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16809337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	180
Details	Repeat: {"description":"ANK 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16809337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	140
Details	Repeat: {"description":"ANK 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16809337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	192
Details	Repeat: {"description":"ANK 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16809337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	132
Details	Repeat: {"description":"ANK 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16809337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39972168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---