7SZA

Crystal Structure Analysis of human PRPK complex with a compound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000408	cellular_component	EKC/KEOPS complex
A	0002039	molecular_function	p53 binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006468	biological_process	protein phosphorylation
A	0008033	biological_process	tRNA processing
A	0016787	molecular_function	hydrolase activity
A	0070525	biological_process	tRNA threonylcarbamoyladenosine metabolic process
A	0106310	molecular_function	protein serine kinase activity
A	1901796	biological_process	regulation of signal transduction by p53 class mediator
B	0000408	cellular_component	EKC/KEOPS complex
B	0002949	biological_process	tRNA threonylcarbamoyladenosine modification
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008033	biological_process	tRNA processing
B	0019901	molecular_function	protein kinase binding
C	0000408	cellular_component	EKC/KEOPS complex
C	0002039	molecular_function	p53 binding
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006468	biological_process	protein phosphorylation
C	0008033	biological_process	tRNA processing
C	0016787	molecular_function	hydrolase activity
C	0070525	biological_process	tRNA threonylcarbamoyladenosine metabolic process
C	0106310	molecular_function	protein serine kinase activity
C	1901796	biological_process	regulation of signal transduction by p53 class mediator
D	0000408	cellular_component	EKC/KEOPS complex
D	0002949	biological_process	tRNA threonylcarbamoyladenosine modification
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008033	biological_process	tRNA processing
D	0019901	molecular_function	protein kinase binding

Functional Information from PROSITE/UniProt

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LIHgDLTTSNMLL

Chain	Residue	Details
A	LEU158-LEU170

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP162
C	ASP162

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	VAL39
A	LYS60
C	VAL39
C	LYS60

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	SER34
C	SER34

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	THR135
C	THR135

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