7SV9

Structure of EmrE-D3 mutant in complex with monobody L10 and TPP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006805	biological_process	xenobiotic metabolic process
A	0006970	biological_process	response to osmotic stress
A	0006974	biological_process	DNA damage response
A	0009410	biological_process	response to xenobiotic stimulus
A	0015199	molecular_function	amino-acid betaine transmembrane transporter activity
A	0015220	molecular_function	choline transmembrane transporter activity
A	0015297	molecular_function	antiporter activity
A	0015871	biological_process	choline transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0031460	biological_process	glycine betaine transport
A	0042802	molecular_function	identical protein binding
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	1990207	cellular_component	EmrE multidrug transporter complex
A	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
B	0005886	cellular_component	plasma membrane
B	0006805	biological_process	xenobiotic metabolic process
B	0006970	biological_process	response to osmotic stress
B	0006974	biological_process	DNA damage response
B	0009410	biological_process	response to xenobiotic stimulus
B	0015199	molecular_function	amino-acid betaine transmembrane transporter activity
B	0015220	molecular_function	choline transmembrane transporter activity
B	0015297	molecular_function	antiporter activity
B	0015871	biological_process	choline transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0031460	biological_process	glycine betaine transport
B	0042802	molecular_function	identical protein binding
B	0042908	biological_process	xenobiotic transport
B	0042910	molecular_function	xenobiotic transmembrane transporter activity
B	0055085	biological_process	transmembrane transport
B	0071466	biological_process	cellular response to xenobiotic stimulus
B	1990207	cellular_component	EmrE multidrug transporter complex
B	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane

Functional Information from PROSITE/UniProt

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GETGGNSP

Chain	Residue	Details
C	GLY40-PRO47

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	34
Details	TRANSMEM: Helical; Name=1 => ECO:0000305|PubMed:17005200

Chain	Residue	Details
B	TYR4-MET21
A	TYR4-MET21

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site_id	SWS_FT_FI2
Number of Residues	36
Details	TRANSMEM: Helical; Name=2 => ECO:0000305|PubMed:17005200

Chain	Residue	Details
B	MET34-ALA52
A	MET34-ALA52

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site_id	SWS_FT_FI3
Number of Residues	44
Details	TRANSMEM: Helical; Name=3 => ECO:0000305|PubMed:17005200

Chain	Residue	Details
B	ILE58-GLY80
A	ILE58-GLY80

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site_id	SWS_FT_FI4
Number of Residues	34
Details	TRANSMEM: Helical; Name=4 => ECO:0000305|PubMed:17005200

Chain	Residue	Details
B	ALA87-LEU104
A	ALA87-LEU104

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site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: Required for proper coupling between the substrate transport and the proton gradient

Chain	Residue	Details
B	TYR4
A	TYR4

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site_id	SWS_FT_FI6
Number of Residues	2
Details	SITE: Essential for translocation and for substrate and proton binding => ECO:0000305|PubMed:12590142, ECO:0000305|PubMed:29114048

Chain	Residue	Details
B	GLU14
A	GLU14

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site_id	SWS_FT_FI7
Number of Residues	6
Details	SITE: Involved in substrate binding

Chain	Residue	Details
B	TYR40
B	TYR60
B	TRP63
A	TYR40
A	TYR60
A	TRP63

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site_id	SWS_FT_FI8
Number of Residues	2
Details	SITE: Important for activity => ECO:0000305|PubMed:30287687

Chain	Residue	Details
B	HIS110
A	HIS110

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