7SRV
Metal dependent activation of Plasmodium falciparum M17 aminopeptidase (inactive form), spacegroup P22121
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006508 | biological_process | proteolysis |
| A | 0019538 | biological_process | protein metabolic process |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006508 | biological_process | proteolysis |
| B | 0019538 | biological_process | protein metabolic process |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070006 | molecular_function | metalloaminopeptidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006508 | biological_process | proteolysis |
| C | 0019538 | biological_process | protein metabolic process |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070006 | molecular_function | metalloaminopeptidase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006508 | biological_process | proteolysis |
| D | 0019538 | biological_process | protein metabolic process |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070006 | molecular_function | metalloaminopeptidase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006508 | biological_process | proteolysis |
| E | 0019538 | biological_process | protein metabolic process |
| E | 0030145 | molecular_function | manganese ion binding |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0070006 | molecular_function | metalloaminopeptidase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006508 | biological_process | proteolysis |
| F | 0019538 | biological_process | protein metabolic process |
| F | 0030145 | molecular_function | manganese ion binding |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00631 |
| Number of Residues | 8 |
| Details | CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL |
| Chain | Residue | Details |
| A | ASN457-LEU464 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P00727 |
| Chain | Residue | Details |
| A | LYS386 | |
| A | ARG463 | |
| B | LYS386 | |
| B | ARG463 | |
| C | LYS386 | |
| C | ARG463 | |
| D | LYS386 | |
| D | ARG463 | |
| E | LYS386 | |
| E | ARG463 | |
| F | LYS386 | |
| F | ARG463 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20133789, ECO:0000269|PubMed:21844374, ECO:0000269|PubMed:23713488, ECO:0000269|PubMed:25299353, ECO:0000269|PubMed:25645579, ECO:0000269|PubMed:35691342, ECO:0000269|Ref.13, ECO:0000312|PDB:3T8W, ECO:0007744|PDB:3KQX, ECO:0007744|PDB:3KQZ, ECO:0007744|PDB:3KR4, ECO:0007744|PDB:3KR5, ECO:0007744|PDB:4K3N, ECO:0007744|PDB:4R6T, ECO:0007744|PDB:4R76, ECO:0007744|PDB:4R7M, ECO:0007744|PDB:4X2T, ECO:0007744|PDB:7RIE, ECO:0007744|PDB:7T3V |
| Chain | Residue | Details |
| A | LYS374 | |
| A | ASP379 | |
| A | GLU461 | |
| B | LYS374 | |
| B | ASP379 | |
| B | GLU461 | |
| C | LYS374 | |
| C | ASP379 | |
| C | GLU461 | |
| D | LYS374 | |
| D | ASP379 | |
| D | GLU461 | |
| E | LYS374 | |
| E | ASP379 | |
| E | GLU461 | |
| F | LYS374 | |
| F | ASP379 | |
| F | GLU461 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:20133789, ECO:0000305|PubMed:23713488, ECO:0007744|PDB:3KR5, ECO:0007744|PDB:4K3N |
| Chain | Residue | Details |
| A | LYS386 | |
| B | LYS386 | |
| C | LYS386 | |
| D | LYS386 | |
| E | LYS386 | |
| F | LYS386 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35691342, ECO:0007744|PDB:7SRV |
| Chain | Residue | Details |
| A | ASP394 | |
| A | MET396 | |
| A | ASP399 | |
| B | ASP394 | |
| B | MET396 | |
| B | ASP399 | |
| C | ASP394 | |
| C | MET396 | |
| C | ASP399 | |
| D | ASP394 | |
| D | MET396 | |
| D | ASP399 | |
| E | ASP394 | |
| E | MET396 | |
| E | ASP399 | |
| F | ASP394 | |
| F | MET396 | |
| F | ASP399 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20133789, ECO:0000269|PubMed:21844374, ECO:0000269|PubMed:23713488, ECO:0000269|PubMed:25299353, ECO:0000269|PubMed:25645579, ECO:0000269|PubMed:35691342, ECO:0000269|Ref.13, ECO:0000312|PDB:3KQZ, ECO:0000312|PDB:3T8W, ECO:0007744|PDB:3KR4, ECO:0007744|PDB:3KR5, ECO:0007744|PDB:4K3N, ECO:0007744|PDB:4R6T, ECO:0007744|PDB:4R76, ECO:0007744|PDB:4R7M, ECO:0007744|PDB:4X2T, ECO:0007744|PDB:7RIE, ECO:0007744|PDB:7T3V |
| Chain | Residue | Details |
| A | ASP459 | |
| B | ASP459 | |
| C | ASP459 | |
| D | ASP459 | |
| E | ASP459 | |
| F | ASP459 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | SITE: Essential for hexamer stabilization => ECO:0000269|PubMed:35691342 |
| Chain | Residue | Details |
| A | LYS386 | |
| B | LYS386 | |
| C | LYS386 | |
| D | LYS386 | |
| E | LYS386 | |
| F | LYS386 |
