7SJX
Cryo-EM Structure of the PR-RT components of the HIV-1 Pol Polyprotein
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0004521 | molecular_function | RNA endonuclease activity |
| A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| A | 0006508 | biological_process | proteolysis |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0015074 | biological_process | DNA integration |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0004521 | molecular_function | RNA endonuclease activity |
| B | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| B | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| B | 0006508 | biological_process | proteolysis |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0015074 | biological_process | DNA integration |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 82 |
| Details | ZN_FING: Integrase-type => ECO:0000255|PROSITE-ProRule:PRU00450 |
| Chain | Residue | Details |
| A | ASP644-GLN685 | |
| B | ASP638-GLN679 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 94 |
| Details | DNA_BIND: Integrase-type => ECO:0000255|PROSITE-ProRule:PRU00506 |
| Chain | Residue | Details |
| A | PHE864-ASP911 | |
| B | PHE858-ASP905 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:12924029 |
| Chain | Residue | Details |
| A | ALA25 | |
| B | ALA25 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP204 | |
| A | ASP271 | |
| A | ASP272 | |
| B | ASP209 | |
| B | ASP284 | |
| B | ASP285 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | ASP524 | |
| A | GLU559 | |
| A | ASP579 | |
| A | ASP630 | |
| B | ASP518 | |
| B | GLU553 | |
| B | ASP573 | |
| B | ASP624 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00450 |
| Chain | Residue | Details |
| A | HIS653 | |
| A | HIS657 | |
| A | CYS681 | |
| A | CYS684 | |
| B | HIS647 | |
| B | HIS651 | |
| B | CYS675 | |
| B | CYS678 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP705 | |
| A | ASP757 | |
| B | ASP699 | |
| B | ASP751 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P04585 |
| Chain | Residue | Details |
| A | GLU793 | |
| B | GLU787 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by viral protease |
| Chain | Residue | Details |
| A | PHE0 | |
| B | PHE0 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by viral protease => ECO:0000269|PubMed:2476069 |
| Chain | Residue | Details |
| A | PHE99 | |
| B | PHE99 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | SITE: Essential for RT p66/p51 heterodimerization |
| Chain | Residue | Details |
| A | TRP482 | |
| A | TRP495 | |
| B | TRP476 | |
| B | TRP489 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by viral protease; partial |
| Chain | Residue | Details |
| A | PHE521 | |
| B | PHE515 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by viral protease => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP641 | |
| B | ASP635 |
