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7SIT

Crystal structure of Voltage gated potassium ion channel, Kv 1.2 chimera-3m

Functional Information from GO Data
ChainGOidnamespacecontents
A0002244biological_processhematopoietic progenitor cell differentiation
A0004033molecular_functionaldo-keto reductase (NADPH) activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0005886cellular_componentplasma membrane
A0006813biological_processpotassium ion transport
A0008076cellular_componentvoltage-gated potassium channel complex
A0009898cellular_componentcytoplasmic side of plasma membrane
A0014069cellular_componentpostsynaptic density
A0015459molecular_functionpotassium channel regulator activity
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0030424cellular_componentaxon
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0034705cellular_componentpotassium channel complex
A0043005cellular_componentneuron projection
A0043194cellular_componentaxon initial segment
A0043679cellular_componentaxon terminus
A0044224cellular_componentjuxtaparanode region of axon
A0044325molecular_functiontransmembrane transporter binding
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0045445biological_processmyoblast differentiation
A0050905biological_processneuromuscular process
A0055085biological_processtransmembrane transport
A0055114biological_processobsolete oxidation-reduction process
A0070995biological_processNADPH oxidation
A0071805biological_processpotassium ion transmembrane transport
A0098839cellular_componentpostsynaptic density membrane
A0098900biological_processregulation of action potential
A0098978cellular_componentglutamatergic synapse
A1901379biological_processregulation of potassium ion transmembrane transport
A1990031cellular_componentpinceau fiber
A2000008biological_processregulation of protein localization to cell surface
B0001508biological_processaction potential
B0005216molecular_functionmonoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005251molecular_functiondelayed rectifier potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005768cellular_componentendosome
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0008076cellular_componentvoltage-gated potassium channel complex
B0014059biological_processregulation of dopamine secretion
B0015271molecular_functionoutward rectifier potassium channel activity
B0016020cellular_componentmembrane
B0019228biological_processneuronal action potential
B0019233biological_processsensory perception of pain
B0019894molecular_functionkinesin binding
B0021554biological_processoptic nerve development
B0021633biological_processoptic nerve structural organization
B0021987biological_processcerebral cortex development
B0022038biological_processcorpus callosum development
B0030027cellular_componentlamellipodium
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0031258cellular_componentlamellipodium membrane
B0032809cellular_componentneuronal cell body membrane
B0033010cellular_componentparanodal junction
B0034702cellular_componentmonoatomic ion channel complex
B0034705cellular_componentpotassium channel complex
B0042734cellular_componentpresynaptic membrane
B0043005cellular_componentneuron projection
B0043194cellular_componentaxon initial segment
B0043204cellular_componentperikaryon
B0043679cellular_componentaxon terminus
B0044224cellular_componentjuxtaparanode region of axon
B0044305cellular_componentcalyx of Held
B0045188biological_processregulation of circadian sleep/wake cycle, non-REM sleep
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0051260biological_processprotein homooligomerization
B0055085biological_processtransmembrane transport
B0060078biological_processregulation of postsynaptic membrane potential
B0070161cellular_componentanchoring junction
B0071805biological_processpotassium ion transmembrane transport
B0097623biological_processpotassium ion export across plasma membrane
B0098978cellular_componentglutamatergic synapse
B0099505biological_processregulation of presynaptic membrane potential
B0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C0002244biological_processhematopoietic progenitor cell differentiation
C0004033molecular_functionaldo-keto reductase (NADPH) activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005874cellular_componentmicrotubule
C0005886cellular_componentplasma membrane
C0006813biological_processpotassium ion transport
C0008076cellular_componentvoltage-gated potassium channel complex
C0009898cellular_componentcytoplasmic side of plasma membrane
C0014069cellular_componentpostsynaptic density
C0015459molecular_functionpotassium channel regulator activity
C0016020cellular_componentmembrane
C0016491molecular_functionoxidoreductase activity
C0030424cellular_componentaxon
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0034705cellular_componentpotassium channel complex
C0043005cellular_componentneuron projection
C0043194cellular_componentaxon initial segment
C0043679cellular_componentaxon terminus
C0044224cellular_componentjuxtaparanode region of axon
C0044325molecular_functiontransmembrane transporter binding
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0045445biological_processmyoblast differentiation
C0050905biological_processneuromuscular process
C0055085biological_processtransmembrane transport
C0055114biological_processobsolete oxidation-reduction process
C0070995biological_processNADPH oxidation
C0071805biological_processpotassium ion transmembrane transport
C0098839cellular_componentpostsynaptic density membrane
C0098900biological_processregulation of action potential
C0098978cellular_componentglutamatergic synapse
C1901379biological_processregulation of potassium ion transmembrane transport
C1990031cellular_componentpinceau fiber
C2000008biological_processregulation of protein localization to cell surface
D0001508biological_processaction potential
D0005216molecular_functionmonoatomic ion channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005251molecular_functiondelayed rectifier potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005768cellular_componentendosome
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0008076cellular_componentvoltage-gated potassium channel complex
D0014059biological_processregulation of dopamine secretion
D0015271molecular_functionoutward rectifier potassium channel activity
D0016020cellular_componentmembrane
D0019228biological_processneuronal action potential
D0019233biological_processsensory perception of pain
D0019894molecular_functionkinesin binding
D0021554biological_processoptic nerve development
D0021633biological_processoptic nerve structural organization
D0021987biological_processcerebral cortex development
D0022038biological_processcorpus callosum development
D0030027cellular_componentlamellipodium
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0031258cellular_componentlamellipodium membrane
D0032809cellular_componentneuronal cell body membrane
D0033010cellular_componentparanodal junction
D0034702cellular_componentmonoatomic ion channel complex
D0034705cellular_componentpotassium channel complex
D0042734cellular_componentpresynaptic membrane
D0043005cellular_componentneuron projection
D0043194cellular_componentaxon initial segment
D0043204cellular_componentperikaryon
D0043679cellular_componentaxon terminus
D0044224cellular_componentjuxtaparanode region of axon
D0044305cellular_componentcalyx of Held
D0045188biological_processregulation of circadian sleep/wake cycle, non-REM sleep
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0051260biological_processprotein homooligomerization
D0055085biological_processtransmembrane transport
D0060078biological_processregulation of postsynaptic membrane potential
D0070161cellular_componentanchoring junction
D0071805biological_processpotassium ion transmembrane transport
D0097623biological_processpotassium ion export across plasma membrane
D0098978cellular_componentglutamatergic synapse
D0099505biological_processregulation of presynaptic membrane potential
D0099508molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues366
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430
ChainResidueDetails
BGLN311-GLY325
DMET1-GLY160
DCYS244-ILE254
DGLN311-GLY325
BMET1-GLY160
BCYS244-ILE254

site_idSWS_FT_FI2
Number of Residues42
DetailsTRANSMEM: Helical; Name=Segment S1 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430
ChainResidueDetails
BPRO161-LEU182
DPRO161-LEU182
CTHR56
CTRP57
CGLN63
CASP85
CSER188
CGLN214
CTRP243
CSER244
CLEU246
CLYS254
CARG264
CSER325
CGLN329
CASN333
AGLN63
AASP85
ASER188
AGLN214
ATRP243
ASER244
ALEU246
ALYS254
AARG264
ASER325
AGLN329
AASN333

site_idSWS_FT_FI3
Number of Residues76
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000305|PubMed:12151401
ChainResidueDetails
BGLU183-PRO221
DGLU183-PRO221

site_idSWS_FT_FI4
Number of Residues42
DetailsTRANSMEM: Helical; Name=Segment S2 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430
ChainResidueDetails
BPHE222-ALA243
DPHE222-ALA243

site_idSWS_FT_FI5
Number of Residues40
DetailsTRANSMEM: Helical; Name=Segment S3 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20534430
ChainResidueDetails
BMET255-SER275
DMET255-SER275

site_idSWS_FT_FI6
Number of Residues64
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430
ChainResidueDetails
BGLY382-SER388
DASN276-VAL289
DASP348-PHE361
DGLY382-SER388
BASN276-VAL289
BASP348-PHE361

site_idSWS_FT_FI7
Number of Residues40
DetailsTRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20534430
ChainResidueDetails
BGLN290-LEU310
DGLN290-LEU310

site_idSWS_FT_FI8
Number of Residues42
DetailsTRANSMEM: Helical; Name=Segment S5 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430
ChainResidueDetails
BLEU326-ALA347
DLEU326-ALA347

site_idSWS_FT_FI9
Number of Residues22
DetailsINTRAMEM: Helical; Name=Pore helix => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430
ChainResidueDetails
BPHE362-TYR373
DPHE362-TYR373

site_idSWS_FT_FI10
Number of Residues14
DetailsINTRAMEM: INTRAMEM => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430
ChainResidueDetails
BGLY374-ILE381
DGLY374-ILE381

site_idSWS_FT_FI11
Number of Residues56
DetailsTRANSMEM: Helical; Name=Segment S6 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430
ChainResidueDetails
BLEU389-THR417
DLEU389-THR417

site_idSWS_FT_FI12
Number of Residues162
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:12151401, ECO:0000305
ChainResidueDetails
ALYS124
CLYS124

site_idSWS_FT_FI13
Number of Residues2
DetailsSITE: Important for normal, slow channel gating => ECO:0000269|PubMed:17766348
ChainResidueDetails
BTHR252
DTHR252

site_idSWS_FT_FI14
Number of Residues2
DetailsSITE: Important for binding with the scorpion mesomartoxin; when the scorpion mesomartoxin-rKv1.2/KCNA2 interaction is modeled, this residue is close to the 'Y-57' residue of the toxin => ECO:0000305|PubMed:25514171
ChainResidueDetails
BILE381
DILE381

site_idSWS_FT_FI15
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P63141
ChainResidueDetails
BTHR429
DTHR429

site_idSWS_FT_FI16
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P63141
ChainResidueDetails
BILE434
DILE434

site_idSWS_FT_FI17
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:18003609, ECO:0007744|PubMed:22673903
ChainResidueDetails
BLEU440
DLEU440

site_idSWS_FT_FI18
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
BLYS441
BPHE468
DLYS441
DPHE468

site_idSWS_FT_FI19
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:18003609, ECO:0000269|PubMed:21602278
ChainResidueDetails
BILE449
DILE449

site_idSWS_FT_FI20
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000305|PubMed:21602278
ChainResidueDetails
BGLN458
DGLN458

site_idSWS_FT_FI21
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000255
ChainResidueDetails
BCYS244
DCYS244

site_idSWS_FT_FI22
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:16770729
ChainResidueDetails
BGLN207
DGLN207

221051

PDB entries from 2024-06-12

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