7SEP

Cryo-EM Structure of the RT component of the HIV-1 Pol Polyprotein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0004521	molecular_function	RNA endonuclease activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0006278	biological_process	RNA-templated DNA biosynthetic process
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding
A	0015074	biological_process	DNA integration
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003964	molecular_function	RNA-directed DNA polymerase activity
B	0004190	molecular_function	aspartic-type endopeptidase activity
B	0004521	molecular_function	RNA endonuclease activity
B	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
B	0006278	biological_process	RNA-templated DNA biosynthetic process
B	0006508	biological_process	proteolysis
B	0008270	molecular_function	zinc ion binding
B	0015074	biological_process	DNA integration

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Region: {"description":"RT 'primer grip'"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	32
Details	Motif: {"description":"Tryptophan repeat motif"}

Chain

Residue

Details

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Essential for RT p66/p51 heterodimerization"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Site: {"description":"Cleavage; by viral protease; partial"}

Chain

Residue

Details