7SCD

Ternary complex of fixed-arm Trx-3ost5 (I299E) with 8mer-1 octasaccharide substrate and co-factor product PAP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008146	molecular_function	sulfotransferase activity
A	0015035	molecular_function	protein-disulfide reductase activity
A	0015036	molecular_function	disulfide oxidoreductase activity
A	0030337	molecular_function	DNA polymerase processivity factor activity
A	0045454	biological_process	cell redox homeostasis

Functional Information from PROSITE/UniProt

site_id	PS00194
Number of Residues	19
Details	THIOREDOXIN_1 Thioredoxin family active site. LVdFWaeWCGPCKmIapiL

Chain	Residue	Details
A	LEU25-LEU43

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile

Chain	Residue	Details
A	CYS33
A	CYS36

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Deprotonates C-terminal active site Cys

Chain	Residue	Details
A	ASP27

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Contributes to redox potential value

Chain	Residue	Details
A	GLY34
A	PRO35

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842

Chain	Residue	Details
A	LYS70

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site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	LYS1100
A	GLU1122
A	LYS1155
A	ARG1183
A	SER1191
A	TYR1226
A	TYR1293
A	LYS1309

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN1287

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