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7SAQ

Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0003674molecular_functionmolecular_function
A0005515molecular_functionprotein binding
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005886cellular_componentplasma membrane
A0007040biological_processlysosome organization
A0007041biological_processlysosomal transport
A0007042biological_processlysosomal lumen acidification
A0031902cellular_componentlate endosome membrane
A0032418biological_processlysosome localization
A0048813biological_processdendrite morphogenesis
A0051117molecular_functionATPase binding
A0070050biological_processneuron cellular homeostasis
A1900006biological_processpositive regulation of dendrite development
A1905146biological_processlysosomal protein catabolic process
A1905671biological_processregulation of lysosome organization
B0003674molecular_functionmolecular_function
B0005515molecular_functionprotein binding
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005768cellular_componentendosome
B0005886cellular_componentplasma membrane
B0007040biological_processlysosome organization
B0007041biological_processlysosomal transport
B0007042biological_processlysosomal lumen acidification
B0031902cellular_componentlate endosome membrane
B0032418biological_processlysosome localization
B0048813biological_processdendrite morphogenesis
B0051117molecular_functionATPase binding
B0070050biological_processneuron cellular homeostasis
B1900006biological_processpositive regulation of dendrite development
B1905146biological_processlysosomal protein catabolic process
B1905671biological_processregulation of lysosome organization
C0003674molecular_functionmolecular_function
C0005515molecular_functionprotein binding
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005768cellular_componentendosome
C0005886cellular_componentplasma membrane
C0007040biological_processlysosome organization
C0007041biological_processlysosomal transport
C0007042biological_processlysosomal lumen acidification
C0031902cellular_componentlate endosome membrane
C0032418biological_processlysosome localization
C0048813biological_processdendrite morphogenesis
C0051117molecular_functionATPase binding
C0070050biological_processneuron cellular homeostasis
C1900006biological_processpositive regulation of dendrite development
C1905146biological_processlysosomal protein catabolic process
C1905671biological_processregulation of lysosome organization
D0003674molecular_functionmolecular_function
D0005515molecular_functionprotein binding
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005768cellular_componentendosome
D0005886cellular_componentplasma membrane
D0007040biological_processlysosome organization
D0007041biological_processlysosomal transport
D0007042biological_processlysosomal lumen acidification
D0031902cellular_componentlate endosome membrane
D0032418biological_processlysosome localization
D0048813biological_processdendrite morphogenesis
D0051117molecular_functionATPase binding
D0070050biological_processneuron cellular homeostasis
D1900006biological_processpositive regulation of dendrite development
D1905146biological_processlysosomal protein catabolic process
D1905671biological_processregulation of lysosome organization
E0003674molecular_functionmolecular_function
E0005515molecular_functionprotein binding
E0005764cellular_componentlysosome
E0005765cellular_componentlysosomal membrane
E0005768cellular_componentendosome
E0005886cellular_componentplasma membrane
E0007040biological_processlysosome organization
E0007041biological_processlysosomal transport
E0007042biological_processlysosomal lumen acidification
E0031902cellular_componentlate endosome membrane
E0032418biological_processlysosome localization
E0048813biological_processdendrite morphogenesis
E0051117molecular_functionATPase binding
E0070050biological_processneuron cellular homeostasis
E1900006biological_processpositive regulation of dendrite development
E1905146biological_processlysosomal protein catabolic process
E1905671biological_processregulation of lysosome organization
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues470
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:22511793, ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:25066864
ChainResidueDetails
AGLY2-LEU96
BGLY2-LEU96
CGLY2-LEU96
DGLY2-LEU96
EGLY2-LEU96

site_idSWS_FT_FI2
Number of Residues100
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ATYR97-PHE117
BTYR97-PHE117
CTYR97-PHE117
DTYR97-PHE117
ETYR97-PHE117

site_idSWS_FT_FI3
Number of Residues780
DetailsTOPO_DOM: Lumenal => ECO:0000269|PubMed:22511793, ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:25066864
ChainResidueDetails
APRO118-GLN274
BPRO118-GLN274
CPRO118-GLN274
DPRO118-GLN274
EPRO118-GLN274

site_idSWS_FT_FI4
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER33
BSER33
CSER33
DSER33
ESER33

site_idSWS_FT_FI5
Number of Residues5
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805
ChainResidueDetails
AGLY2
BGLY2
CGLY2
DGLY2
EGLY2

site_idSWS_FT_FI6
Number of Residues20
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22511793
ChainResidueDetails
AASN145
CASN151
CASN164
CASN256
DASN145
DASN151
DASN164
DASN256
EASN145
EASN151
EASN164
AASN151
EASN256
AASN164
AASN256
BASN145
BASN151
BASN164
BASN256
CASN145

site_idSWS_FT_FI7
Number of Residues5
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22511793, ECO:0000269|PubMed:23742080
ChainResidueDetails
AASN183
BASN183
CASN183
DASN183
EASN183

220113

PDB entries from 2024-05-22

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