7S6C

CryoEM structure of modular PKS holo-Lsd14 stalled at the condensation step and bound to antibody fragment 1B2, composite structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004312	molecular_function	fatty acid synthase activity
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006633	biological_process	fatty acid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0017000	biological_process	antibiotic biosynthetic process
A	0031177	molecular_function	phosphopantetheine binding
A	0033068	biological_process	macrolide biosynthetic process
A	0071770	biological_process	DIM/DIP cell wall layer assembly
B	0004312	molecular_function	fatty acid synthase activity
B	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0006633	biological_process	fatty acid biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0017000	biological_process	antibiotic biosynthetic process
B	0031177	molecular_function	phosphopantetheine binding
B	0033068	biological_process	macrolide biosynthetic process
B	0071770	biological_process	DIM/DIP cell wall layer assembly
C	0004312	molecular_function	fatty acid synthase activity
C	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0006633	biological_process	fatty acid biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0017000	biological_process	antibiotic biosynthetic process
C	0031177	molecular_function	phosphopantetheine binding
C	0033068	biological_process	macrolide biosynthetic process
C	0071770	biological_process	DIM/DIP cell wall layer assembly
D	0004312	molecular_function	fatty acid synthase activity
D	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0006633	biological_process	fatty acid biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0017000	biological_process	antibiotic biosynthetic process
D	0031177	molecular_function	phosphopantetheine binding
D	0033068	biological_process	macrolide biosynthetic process
D	0071770	biological_process	DIM/DIP cell wall layer assembly

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGFDSLMAVELRNRI

Chain	Residue	Details
A	ASP1521-ILE1536

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
E	TYR201-HIS207
F	TYR214-HIS220

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site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPAvtIDtACSSSlvAL

Chain	Residue	Details
A	GLY201-LEU217

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