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7S3H

Cas9:sgRNA:DNA (S. pyogenes) with 0 RNA:DNA base pairs, open-protein/linear-DNA conformation

Functional Information from GO Data
ChainGOidnamespacecontents
P0003676molecular_functionnucleic acid binding
P0003677molecular_functionDNA binding
P0003723molecular_functionRNA binding
P0004519molecular_functionendonuclease activity
P0004520molecular_functionDNA endonuclease activity
P0004527molecular_functionexonuclease activity
P0008408molecular_function3'-5' exonuclease activity
P0043571biological_processmaintenance of CRISPR repeat elements
P0046872molecular_functionmetal ion binding
P0051607biological_processdefense response to virus
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: For RuvC-like nuclease domain => ECO:0000305|PubMed:24529477
ChainResidueDetails
PASP10

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Proton acceptor for HNH nuclease domain => ECO:0000305|PubMed:24529477
ChainResidueDetails
PHIS840

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:24505130
ChainResidueDetails
PASP10
PGLU762
PGLU766
PHIS983
PHIS1297
PASP1328

223532

PDB entries from 2024-08-07

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