7RUC

Metazoan pre-targeting GET complex with SGTA (cBUGGS)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0006620	biological_process	post-translational protein targeting to endoplasmic reticulum membrane
A	0007416	biological_process	synapse assembly
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0043529	cellular_component	GET complex
A	0045048	biological_process	protein insertion into ER membrane
A	0046872	molecular_function	metal ion binding
A	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
A	0090150	biological_process	establishment of protein localization to membrane
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0006620	biological_process	post-translational protein targeting to endoplasmic reticulum membrane
B	0007416	biological_process	synapse assembly
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0043529	cellular_component	GET complex
B	0045048	biological_process	protein insertion into ER membrane
B	0046872	molecular_function	metal ion binding
B	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
B	0090150	biological_process	establishment of protein localization to membrane
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006620	biological_process	post-translational protein targeting to endoplasmic reticulum membrane
C	0031647	biological_process	regulation of protein stability
C	0036503	biological_process	ERAD pathway
C	0036506	biological_process	maintenance of unfolded protein
C	0045048	biological_process	protein insertion into ER membrane
C	0051087	molecular_function	protein-folding chaperone binding
C	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
C	0071818	cellular_component	BAT3 complex
C	0140597	molecular_function	protein carrier chaperone
F	0005515	molecular_function	protein binding
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0005730	cellular_component	nucleolus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0006620	biological_process	post-translational protein targeting to endoplasmic reticulum membrane
F	0031647	biological_process	regulation of protein stability
F	0036503	biological_process	ERAD pathway
F	0036506	biological_process	maintenance of unfolded protein
F	0045048	biological_process	protein insertion into ER membrane
F	0051087	molecular_function	protein-folding chaperone binding
F	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
F	0071818	cellular_component	BAT3 complex
F	0140597	molecular_function	protein carrier chaperone
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0006620	biological_process	post-translational protein targeting to endoplasmic reticulum membrane
H	0016020	cellular_component	membrane
H	0019787	molecular_function	ubiquitin-like protein transferase activity
H	0031647	biological_process	regulation of protein stability
H	0036211	biological_process	protein modification process
H	0051087	molecular_function	protein-folding chaperone binding
H	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
H	0071818	cellular_component	BAT3 complex

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KqlVsEklnVPvrqQrLLFkGkalaD

Chain	Residue	Details
H	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03112","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03112","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34887561","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RU9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RUA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RUC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34887561","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RU9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RUA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RUC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	152
Details	Region: {"description":"Interacts with BAG6","evidences":[{"source":"PubMed","id":"25535373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29042515","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	60
Details	Region: {"description":"Required for interaction with GET4","evidences":[{"source":"PubMed","id":"25535373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29042515","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	10
Details	Compositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	42
Details	Region: {"description":"Required and sufficient for interaction with BAG6","evidences":[{"source":"PubMed","id":"25535373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25713138","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---