Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7RS5

Cryo-EM structure of Kip3 (AMPPNP) bound to Taxol-Stabilized Microtubules

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0003777	molecular_function	microtubule motor activity
a	0005524	molecular_function	ATP binding
a	0007018	biological_process	microtubule-based movement
a	0008017	molecular_function	microtubule binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0007017	biological_process	microtubule-based process
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
b	0003777	molecular_function	microtubule motor activity
b	0005524	molecular_function	ATP binding
b	0007018	biological_process	microtubule-based movement
b	0008017	molecular_function	microtubule binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0046872	molecular_function	metal ion binding
c	0003777	molecular_function	microtubule motor activity
c	0005524	molecular_function	ATP binding
c	0007018	biological_process	microtubule-based movement
c	0008017	molecular_function	microtubule binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0007017	biological_process	microtubule-based process
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
d	0003777	molecular_function	microtubule motor activity
d	0005524	molecular_function	ATP binding
d	0007018	biological_process	microtubule-based movement
d	0008017	molecular_function	microtubule binding
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0003924	molecular_function	GTPase activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0007017	biological_process	microtubule-based process
D	0046872	molecular_function	metal ion binding
e	0003777	molecular_function	microtubule motor activity
e	0005524	molecular_function	ATP binding
e	0007018	biological_process	microtubule-based movement
e	0008017	molecular_function	microtubule binding
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000278	biological_process	mitotic cell cycle
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0007017	biological_process	microtubule-based process
E	0016787	molecular_function	hydrolase activity
E	0046872	molecular_function	metal ion binding
f	0003777	molecular_function	microtubule motor activity
f	0005524	molecular_function	ATP binding
f	0007018	biological_process	microtubule-based movement
f	0008017	molecular_function	microtubule binding
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000278	biological_process	mitotic cell cycle
F	0003924	molecular_function	GTPase activity
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0007017	biological_process	microtubule-based process
F	0046872	molecular_function	metal ion binding
g	0003777	molecular_function	microtubule motor activity
g	0005524	molecular_function	ATP binding
g	0007018	biological_process	microtubule-based movement
g	0008017	molecular_function	microtubule binding
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000278	biological_process	mitotic cell cycle
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0007017	biological_process	microtubule-based process
G	0016787	molecular_function	hydrolase activity
G	0046872	molecular_function	metal ion binding
h	0003777	molecular_function	microtubule motor activity
h	0005524	molecular_function	ATP binding
h	0007018	biological_process	microtubule-based movement
h	0008017	molecular_function	microtubule binding
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000278	biological_process	mitotic cell cycle
H	0003924	molecular_function	GTPase activity
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0007017	biological_process	microtubule-based process
H	0046872	molecular_function	metal ion binding
I	0000226	biological_process	microtubule cytoskeleton organization
I	0000278	biological_process	mitotic cell cycle
I	0005200	molecular_function	structural constituent of cytoskeleton
I	0005525	molecular_function	GTP binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005874	cellular_component	microtubule
I	0007017	biological_process	microtubule-based process
I	0016787	molecular_function	hydrolase activity
I	0046872	molecular_function	metal ion binding
J	0000226	biological_process	microtubule cytoskeleton organization
J	0000278	biological_process	mitotic cell cycle
J	0003924	molecular_function	GTPase activity
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0007017	biological_process	microtubule-based process
J	0046872	molecular_function	metal ion binding
K	0003777	molecular_function	microtubule motor activity
K	0005524	molecular_function	ATP binding
K	0007018	biological_process	microtubule-based movement
K	0008017	molecular_function	microtubule binding
L	0000226	biological_process	microtubule cytoskeleton organization
L	0000278	biological_process	mitotic cell cycle
L	0005200	molecular_function	structural constituent of cytoskeleton
L	0005525	molecular_function	GTP binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005874	cellular_component	microtubule
L	0007017	biological_process	microtubule-based process
L	0016787	molecular_function	hydrolase activity
L	0046872	molecular_function	metal ion binding
M	0000226	biological_process	microtubule cytoskeleton organization
M	0000278	biological_process	mitotic cell cycle
M	0003924	molecular_function	GTPase activity
M	0005200	molecular_function	structural constituent of cytoskeleton
M	0005515	molecular_function	protein binding
M	0005525	molecular_function	GTP binding
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005874	cellular_component	microtubule
M	0007017	biological_process	microtubule-based process
M	0046872	molecular_function	metal ion binding
N	0000226	biological_process	microtubule cytoskeleton organization
N	0000278	biological_process	mitotic cell cycle
N	0005200	molecular_function	structural constituent of cytoskeleton
N	0005525	molecular_function	GTP binding
N	0005737	cellular_component	cytoplasm
N	0005856	cellular_component	cytoskeleton
N	0005874	cellular_component	microtubule
N	0007017	biological_process	microtubule-based process
N	0016787	molecular_function	hydrolase activity
N	0046872	molecular_function	metal ion binding
O	0000226	biological_process	microtubule cytoskeleton organization
O	0000278	biological_process	mitotic cell cycle
O	0003924	molecular_function	GTPase activity
O	0005200	molecular_function	structural constituent of cytoskeleton
O	0005515	molecular_function	protein binding
O	0005525	molecular_function	GTP binding
O	0005737	cellular_component	cytoplasm
O	0005856	cellular_component	cytoskeleton
O	0005874	cellular_component	microtubule
O	0007017	biological_process	microtubule-based process
O	0046872	molecular_function	metal ion binding
P	0000226	biological_process	microtubule cytoskeleton organization
P	0000278	biological_process	mitotic cell cycle
P	0005200	molecular_function	structural constituent of cytoskeleton
P	0005525	molecular_function	GTP binding
P	0005737	cellular_component	cytoplasm
P	0005856	cellular_component	cytoskeleton
P	0005874	cellular_component	microtubule
P	0007017	biological_process	microtubule-based process
P	0016787	molecular_function	hydrolase activity
P	0046872	molecular_function	metal ion binding
Q	0000226	biological_process	microtubule cytoskeleton organization
Q	0000278	biological_process	mitotic cell cycle
Q	0003924	molecular_function	GTPase activity
Q	0005200	molecular_function	structural constituent of cytoskeleton
Q	0005515	molecular_function	protein binding
Q	0005525	molecular_function	GTP binding
Q	0005737	cellular_component	cytoplasm
Q	0005856	cellular_component	cytoskeleton
Q	0005874	cellular_component	microtubule
Q	0007017	biological_process	microtubule-based process
Q	0046872	molecular_function	metal ion binding
R	0000226	biological_process	microtubule cytoskeleton organization
R	0000278	biological_process	mitotic cell cycle
R	0005200	molecular_function	structural constituent of cytoskeleton
R	0005525	molecular_function	GTP binding
R	0005737	cellular_component	cytoplasm
R	0005856	cellular_component	cytoskeleton
R	0005874	cellular_component	microtubule
R	0007017	biological_process	microtubule-based process
R	0016787	molecular_function	hydrolase activity
R	0046872	molecular_function	metal ion binding
S	0000226	biological_process	microtubule cytoskeleton organization
S	0000278	biological_process	mitotic cell cycle
S	0003924	molecular_function	GTPase activity
S	0005200	molecular_function	structural constituent of cytoskeleton
S	0005515	molecular_function	protein binding
S	0005525	molecular_function	GTP binding
S	0005737	cellular_component	cytoplasm
S	0005856	cellular_component	cytoskeleton
S	0005874	cellular_component	microtubule
S	0007017	biological_process	microtubule-based process
S	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
A	GLY142-GLY148
B	GLY142-GLY148

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

site_id	PS00411
Number of Residues	12
Details	KINESIN_MOTOR_1 Kinesin motor domain signature. ATLsIIDLAGSE

Chain	Residue	Details
h	ALA251-GLU262

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	63
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q13509

Chain	Residue	Details
B	GLN11
D	GLY144
D	THR145
D	GLY146
D	ASN206
D	ASN228
F	GLN11
F	SER140
F	GLY144
F	THR145
F	GLY146
B	SER140
F	ASN206
F	ASN228
H	GLN11
H	SER140
H	GLY144
H	THR145
H	GLY146
H	ASN206
H	ASN228
J	GLN11
B	GLY144
J	SER140
J	GLY144
J	THR145
J	GLY146
J	ASN206
J	ASN228
M	GLN11
M	SER140
M	GLY144
M	THR145
B	THR145
M	GLY146
M	ASN206
M	ASN228
O	GLN11
O	SER140
O	GLY144
O	THR145
O	GLY146
O	ASN206
O	ASN228
B	GLY146
Q	GLN11
Q	SER140
Q	GLY144
Q	THR145
Q	GLY146
Q	ASN206
Q	ASN228
S	GLN11
S	SER140
S	GLY144
B	ASN206
S	THR145
S	GLY146
S	ASN206
S	ASN228
B	ASN228
D	GLN11
D	SER140

site_id	SWS_FT_FI2
Number of Residues	9
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
B	GLU71
C	GLU71
C	SER140
C	GLY144
C	THR145
C	THR179
C	ASN206
C	ASN228
E	GLN11
E	GLU71
E	SER140
D	GLU71
E	GLY144
E	THR145
E	THR179
E	ASN206
E	ASN228
G	GLN11
G	GLU71
G	SER140
G	GLY144
G	THR145
F	GLU71
G	THR179
G	ASN206
G	ASN228
I	GLN11
I	GLU71
I	SER140
I	GLY144
I	THR145
I	THR179
I	ASN206
H	GLU71
I	ASN228
L	GLN11
L	GLU71
L	SER140
L	GLY144
L	THR145
L	THR179
L	ASN206
L	ASN228
N	GLN11
J	GLU71
N	GLU71
N	SER140
N	GLY144
N	THR145
N	THR179
N	ASN206
N	ASN228
P	GLN11
P	GLU71
P	SER140
M	GLU71
P	GLY144
P	THR145
P	THR179
P	ASN206
P	ASN228
R	GLN11
R	GLU71
R	SER140
R	GLY144
R	THR145
O	GLU71
R	THR179
R	ASN206
R	ASN228
Q	GLU71
S	GLU71

site_id	SWS_FT_FI3
Number of Residues	9
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P99024

Chain	Residue	Details
B	SER40
D	SER40
F	SER40
H	SER40
J	SER40
M	SER40
O	SER40
Q	SER40
S	SER40

site_id	SWS_FT_FI4
Number of Residues	9
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P99024

Chain	Residue	Details
B	LYS60
D	LYS60
F	LYS60
H	LYS60
J	LYS60
M	LYS60
O	LYS60
Q	LYS60
S	LYS60

site_id	SWS_FT_FI5
Number of Residues	9
Details	MOD_RES: Phosphoserine; by CDK1 => ECO:0000250\|UniProtKB:Q13885

Chain	Residue	Details
B	SER174
D	SER174
F	SER174
H	SER174
J	SER174
M	SER174
O	SER174
Q	SER174
S	SER174

site_id	SWS_FT_FI6
Number of Residues	18
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
B	THR287
J	THR292
M	THR287
M	THR292
O	THR287
O	THR292
Q	THR287
Q	THR292
S	THR287
S	THR292
B	THR292
D	THR287
D	THR292
F	THR287
F	THR292
H	THR287
H	THR292
J	THR287

site_id	SWS_FT_FI7
Number of Residues	9
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
B	ARG320
D	ARG320
F	ARG320
H	ARG320
J	ARG320
M	ARG320
O	ARG320
Q	ARG320
S	ARG320

site_id	SWS_FT_FI8
Number of Residues	9
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000250\|UniProtKB:Q2T9S0

Chain	Residue	Details
B	GLU448
D	GLU448
F	GLU448
H	GLU448
J	GLU448
M	GLU448
O	GLU448
Q	GLU448
S	GLU448

site_id	SWS_FT_FI9
Number of Residues	9
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
B	LYS60
D	LYS60
F	LYS60
H	LYS60
J	LYS60
M	LYS60
O	LYS60
Q	LYS60
S	LYS60

site_id	SWS_FT_FI10
Number of Residues	18
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
J	LYS326
M	LYS326
O	LYS326
Q	LYS326
S	LYS326
B	LYS326
D	LYS326
F	LYS326
H	LYS326

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)