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7RMI

SP6-11 biased agonist bound to active human neurokinin 1 receptor in complex with miniGs/q70

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007186biological_processG protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0002118biological_processaggressive behavior
R0002687biological_processpositive regulation of leukocyte migration
R0003051biological_processangiotensin-mediated drinking behavior
R0004930molecular_functionG protein-coupled receptor activity
R0004995molecular_functiontachykinin receptor activity
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0006954biological_processinflammatory response
R0007186biological_processG protein-coupled receptor signaling pathway
R0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0007217biological_processtachykinin receptor signaling pathway
R0007611biological_processlearning or memory
R0007616biological_processlong-term memory
R0008217biological_processregulation of blood pressure
R0008306biological_processassociative learning
R0009582biological_processdetection of abiotic stimulus
R0009725biological_processresponse to hormone
R0009986cellular_componentcell surface
R0010193biological_processresponse to ozone
R0010634biological_processpositive regulation of epithelial cell migration
R0010996biological_processresponse to auditory stimulus
R0014070biological_processresponse to organic cyclic compound
R0014910biological_processregulation of smooth muscle cell migration
R0016020cellular_componentmembrane
R0016496molecular_functionsubstance P receptor activity
R0030425cellular_componentdendrite
R0032224biological_processpositive regulation of synaptic transmission, cholinergic
R0032230biological_processpositive regulation of synaptic transmission, GABAergic
R0032355biological_processresponse to estradiol
R0032570biological_processresponse to progesterone
R0035094biological_processresponse to nicotine
R0035106biological_processoperant conditioning
R0036126cellular_componentsperm flagellum
R0042713biological_processsperm ejaculation
R0042755biological_processeating behavior
R0043117biological_processpositive regulation of vascular permeability
R0044297cellular_componentcell body
R0045471biological_processresponse to ethanol
R0045760biological_processpositive regulation of action potential
R0045777biological_processpositive regulation of blood pressure
R0045778biological_processpositive regulation of ossification
R0045907biological_processpositive regulation of vasoconstriction
R0046887biological_processpositive regulation of hormone secretion
R0048265biological_processresponse to pain
R0048266biological_processbehavioral response to pain
R0048660biological_processregulation of smooth muscle cell proliferation
R0050671biological_processpositive regulation of lymphocyte proliferation
R0050679biological_processpositive regulation of epithelial cell proliferation
R0051496biological_processpositive regulation of stress fiber assembly
R0051602biological_processresponse to electrical stimulus
R0060083biological_processsmooth muscle contraction involved in micturition
R0061827cellular_componentsperm head
R0070472biological_processregulation of uterine smooth muscle contraction
R0070474biological_processpositive regulation of uterine smooth muscle contraction
R0071944cellular_componentcell periphery
R0097225cellular_componentsperm midpiece
R1902093biological_processpositive regulation of flagellated sperm motility
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIySMTAVAFDRYMaI
ChainResidueDetails
RALA118-ILE134

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
RVAL87-LYS106
RTHR170-LYS194
RPRO271-ILE283
ALEU302
APHE376
GALA2

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
GCYS68

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
RASP129-LYS148
RGLY220-LYS248
RASN309-SER407
GCYS68

site_idSWS_FT_FI4
Number of Residues21
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
RTHR65-THR86

site_idSWS_FT_FI5
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RPHE107-PHE128

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RVAL149-SER169

site_idSWS_FT_FI7
Number of Residues24
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RVAL195-VAL219

site_idSWS_FT_FI8
Number of Residues21
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RMET249-LEU270

site_idSWS_FT_FI9
Number of Residues24
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RGLN284-LEU308

site_idSWS_FT_FI10
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:8384323
ChainResidueDetails
RHIS197

site_idSWS_FT_FI11
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000255
ChainResidueDetails
RCYS322

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN14
RASN18

221051

PDB entries from 2024-06-12

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