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7R7C

State E2 nucleolar 60S ribosomal biogenesis intermediate - L1 stalk local model

Functional Information from GO Data
ChainGOidnamespacecontents
70000055biological_processribosomal large subunit export from nucleus
70000447biological_processendonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
70000472biological_processendonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
70000480biological_processendonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
70003729molecular_functionmRNA binding
70005515molecular_functionprotein binding
70005634cellular_componentnucleus
70005730cellular_componentnucleolus
70005737cellular_componentcytoplasm
70008298biological_processintracellular mRNA localization
70017148biological_processnegative regulation of translation
70030687cellular_componentpreribosome, large subunit precursor
70042254biological_processribosome biogenesis
70042273biological_processribosomal large subunit biogenesis
70042802molecular_functionidentical protein binding
70051028biological_processmRNA transport
70101031cellular_componentprotein folding chaperone complex
A0000027biological_processribosomal large subunit assembly
A0000464biological_processendonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A0000465biological_processexonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005730cellular_componentnucleolus
A0006364biological_processrRNA processing
A0008097molecular_function5S rRNA binding
A0019843molecular_functionrRNA binding
A0030687cellular_componentpreribosome, large subunit precursor
A0042134molecular_functionrRNA primary transcript binding
A0042254biological_processribosome biogenesis
a0000055biological_processribosomal large subunit export from nucleus
a0002181biological_processcytoplasmic translation
a0003723molecular_functionRNA binding
a0003735molecular_functionstructural constituent of ribosome
a0005737cellular_componentcytoplasm
a0005829cellular_componentcytosol
a0005840cellular_componentribosome
a0006412biological_processtranslation
a0015934cellular_componentlarge ribosomal subunit
a0022625cellular_componentcytosolic large ribosomal subunit
a0042254biological_processribosome biogenesis
a1990904cellular_componentribonucleoprotein complex
l0000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
l0003674molecular_functionmolecular_function
l0003723molecular_functionRNA binding
l0005515molecular_functionprotein binding
l0005634cellular_componentnucleus
l0005730cellular_componentnucleolus
l0005737cellular_componentcytoplasm
l0030687cellular_componentpreribosome, large subunit precursor
l0042254biological_processribosome biogenesis
l0042255biological_processribosome assembly
l0042273biological_processribosomal large subunit biogenesis
l1902626biological_processassembly of large subunit precursor of preribosome
m0006364biological_processrRNA processing
m0042254biological_processribosome biogenesis
q0000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
q0000470biological_processmaturation of LSU-rRNA
q0001510biological_processRNA methylation
q0003723molecular_functionRNA binding
q0005515molecular_functionprotein binding
q0005634cellular_componentnucleus
q0005654cellular_componentnucleoplasm
q0005730cellular_componentnucleolus
q0006364biological_processrRNA processing
q0006396biological_processRNA processing
q0008168molecular_functionmethyltransferase activity
q0008173molecular_functionRNA methyltransferase activity
q0008757molecular_functionS-adenosylmethionine-dependent methyltransferase activity
q0009383molecular_functionrRNA (cytosine-C5-)-methyltransferase activity
q0030687cellular_componentpreribosome, large subunit precursor
q0031167biological_processrRNA methylation
q0032259biological_processmethylation
q0042254biological_processribosome biogenesis
q0042273biological_processribosomal large subunit biogenesis
q0070475biological_processrRNA base methylation
q1902626biological_processassembly of large subunit precursor of preribosome
Functional Information from PROSITE/UniProt
site_idPS01153
Number of Residues12
DetailsNOL1_NOP2_SUN NOL1/NOP2/sun family signature. FDRILlDAPCSG
ChainResidueDetails
qPHE415-GLY426

site_idPS01199
Number of Residues20
DetailsRIBOSOMAL_L1 Ribosomal protein L1 signature. IkqVprlLGpqLSKAGkFPT
ChainResidueDetails
aILE117-THR136

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylserine => ECO:0000269|PubMed:10601260, ECO:0007744|PubMed:22814378
ChainResidueDetails
aSER2

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-methyllysine; by RKM5 => ECO:0000269|PubMed:21460220
ChainResidueDetails
aLYS47
qASP377
qASP404
qASP421

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198
ChainResidueDetails
aSER79

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198
ChainResidueDetails
aSER86

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PDB entries from 2024-11-06

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