7R6K

State E2 nucleolar 60S ribosomal intermediate - Model for Noc2/Noc3 region

Functional Information from GO Data

Chain	GOid	namespace	contents
7	0000055	biological_process	ribosomal large subunit export from nucleus
7	0000447	biological_process	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
7	0000472	biological_process	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
7	0000480	biological_process	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
7	0003729	molecular_function	mRNA binding
7	0005515	molecular_function	protein binding
7	0005634	cellular_component	nucleus
7	0005730	cellular_component	nucleolus
7	0005737	cellular_component	cytoplasm
7	0008298	biological_process	intracellular mRNA localization
7	0017148	biological_process	negative regulation of translation
7	0019843	molecular_function	rRNA binding
7	0030687	cellular_component	preribosome, large subunit precursor
7	0033592	molecular_function	RNA strand annealing activity
7	0034337	biological_process	RNA folding
7	0042273	biological_process	ribosomal large subunit biogenesis
7	0042802	molecular_function	identical protein binding
7	0043022	molecular_function	ribosome binding
7	0101031	cellular_component	protein folding chaperone complex
7	0140691	molecular_function	RNA folding chaperone
7	0140693	molecular_function	molecular condensate scaffold activity
8	0003729	molecular_function	mRNA binding
8	0005515	molecular_function	protein binding
8	0005634	cellular_component	nucleus
8	0005654	cellular_component	nucleoplasm
8	0005730	cellular_component	nucleolus
8	0005739	cellular_component	mitochondrion
8	0030687	cellular_component	preribosome, large subunit precursor
8	0030690	cellular_component	Noc1p-Noc2p complex
8	0030691	cellular_component	Noc2p-Noc3p complex
8	0042273	biological_process	ribosomal large subunit biogenesis
A	0000027	biological_process	ribosomal large subunit assembly
A	0000464	biological_process	endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A	0000465	biological_process	exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005730	cellular_component	nucleolus
A	0006364	biological_process	rRNA processing
A	0008097	molecular_function	5S rRNA binding
A	0019843	molecular_function	rRNA binding
A	0030687	cellular_component	preribosome, large subunit precursor
A	0042134	molecular_function	rRNA primary transcript binding
A	0042254	biological_process	ribosome biogenesis
g	0002181	biological_process	cytoplasmic translation
g	0003735	molecular_function	structural constituent of ribosome
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0005840	cellular_component	ribosome
g	0006412	biological_process	translation
g	0022625	cellular_component	cytosolic large ribosomal subunit
g	0030687	cellular_component	preribosome, large subunit precursor
g	0042254	biological_process	ribosome biogenesis
G	0000470	biological_process	maturation of LSU-rRNA
G	0002181	biological_process	cytoplasmic translation
G	0003723	molecular_function	RNA binding
G	0003735	molecular_function	structural constituent of ribosome
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006364	biological_process	rRNA processing
G	0022625	cellular_component	cytosolic large ribosomal subunit
G	0042254	biological_process	ribosome biogenesis
G	1990904	cellular_component	ribonucleoprotein complex
i	0000470	biological_process	maturation of LSU-rRNA
i	0002181	biological_process	cytoplasmic translation
i	0003723	molecular_function	RNA binding
i	0003735	molecular_function	structural constituent of ribosome
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0005840	cellular_component	ribosome
i	0006412	biological_process	translation
i	0022625	cellular_component	cytosolic large ribosomal subunit
i	0180023	biological_process	cytosolic large ribosomal subunit assembly
I	0003682	molecular_function	chromatin binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005656	cellular_component	nuclear pre-replicative complex
I	0005730	cellular_component	nucleolus
I	0006267	biological_process	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
I	0006270	biological_process	DNA replication initiation
I	0006364	biological_process	rRNA processing
I	0030691	cellular_component	Noc2p-Noc3p complex
I	0042273	biological_process	ribosomal large subunit biogenesis
J	0000280	biological_process	nuclear division
J	0003729	molecular_function	mRNA binding
J	0005515	molecular_function	protein binding
J	0005730	cellular_component	nucleolus
J	0006364	biological_process	rRNA processing
J	0030687	cellular_component	preribosome, large subunit precursor
J	0034399	cellular_component	nuclear periphery
J	0042802	molecular_function	identical protein binding
l	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
l	0003674	molecular_function	molecular_function
l	0003723	molecular_function	RNA binding
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005730	cellular_component	nucleolus
l	0005737	cellular_component	cytoplasm
l	0030687	cellular_component	preribosome, large subunit precursor
l	0042255	biological_process	ribosome assembly
l	0042273	biological_process	ribosomal large subunit biogenesis
l	1902626	biological_process	assembly of large subunit precursor of preribosome
m	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
m	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
m	0003674	molecular_function	molecular_function
m	0003677	molecular_function	DNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005730	cellular_component	nucleolus
m	0006364	biological_process	rRNA processing
m	0030687	cellular_component	preribosome, large subunit precursor
m	0042254	biological_process	ribosome biogenesis
m	0042273	biological_process	ribosomal large subunit biogenesis
m	0043021	molecular_function	ribonucleoprotein complex binding
m	0070180	molecular_function	large ribosomal subunit rRNA binding
m	0070545	cellular_component	PeBoW complex
N	0000470	biological_process	maturation of LSU-rRNA
N	0002181	biological_process	cytoplasmic translation
N	0003723	molecular_function	RNA binding
N	0003735	molecular_function	structural constituent of ribosome
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005840	cellular_component	ribosome
N	0006412	biological_process	translation
N	0022625	cellular_component	cytosolic large ribosomal subunit
N	0180023	biological_process	cytosolic large ribosomal subunit assembly
q	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
q	0000470	biological_process	maturation of LSU-rRNA
q	0001510	biological_process	RNA methylation
q	0003723	molecular_function	RNA binding
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005730	cellular_component	nucleolus
q	0006396	biological_process	RNA processing
q	0008168	molecular_function	methyltransferase activity
q	0008173	molecular_function	RNA methyltransferase activity
q	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
q	0009383	molecular_function	rRNA (cytosine-C5-)-methyltransferase activity
q	0030687	cellular_component	preribosome, large subunit precursor
q	0031167	biological_process	rRNA methylation
q	0042273	biological_process	ribosomal large subunit biogenesis
q	0070475	biological_process	rRNA base methylation
q	1902626	biological_process	assembly of large subunit precursor of preribosome
r	0000460	biological_process	maturation of 5.8S rRNA
r	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
r	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
r	0000470	biological_process	maturation of LSU-rRNA
r	0003674	molecular_function	molecular_function
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005730	cellular_component	nucleolus
r	0030684	cellular_component	preribosome
r	0030687	cellular_component	preribosome, large subunit precursor
r	0042273	biological_process	ribosomal large subunit biogenesis
w	0000451	biological_process	rRNA 2'-O-methylation
w	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
w	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
w	0001510	biological_process	RNA methylation
w	0005515	molecular_function	protein binding
w	0005634	cellular_component	nucleus
w	0005730	cellular_component	nucleolus
w	0006364	biological_process	rRNA processing
w	0008168	molecular_function	methyltransferase activity
w	0008649	molecular_function	rRNA methyltransferase activity
w	0008650	molecular_function	rRNA (uridine-2'-O-ribose)-methyltransferase activity
w	0016435	molecular_function	rRNA (guanine) methyltransferase activity
w	0030687	cellular_component	preribosome, large subunit precursor
w	0031167	biological_process	rRNA methylation
w	0032259	biological_process	methylation
w	0062105	molecular_function	RNA 2'-O-methyltransferase activity
w	0070039	molecular_function	rRNA (guanosine-2'-O-ribose)-methyltransferase activity

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATGsdDgTVRVWEI

Chain	Residue	Details
m	LEU452-ILE466

---

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CkkmgVPYaiVkGKarLG

Chain	Residue	Details
G	CYS170-GLY187

---

site_id	PS01145
Number of Residues	14
Details	RIBOSOMAL_L34E Ribosomal protein L34e signature. TrSnKikvvKTPGG

Chain	Residue	Details
g	THR15-GLY28

---

site_id	PS01153
Number of Residues	12
Details	NOL1_NOP2_SUN NOL1/NOP2/sun family signature. FDRILlDAPCSG

Chain	Residue	Details
q	PHE415-GLY426

---

site_id	PS01190
Number of Residues	11
Details	RIBOSOMAL_L36E Ribosomal protein L36e signature. PYERRlIDLIR

Chain	Residue	Details
i	PRO52-ARG62

---

site_id	PS01194
Number of Residues	24
Details	RIBOSOMAL_L15E Ribosomal protein L15e signature. DKARrLGYkAkqGFVIYRvRVrRG

Chain	Residue	Details
N	ASP46-GLY69

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	13
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	76
Details	Domain: {"description":"PUA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00161","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU01023","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01023","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	12
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---