Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7R5S

Structure of the human CCAN bound to alpha satellite DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0000776	cellular_component	kinetochore
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005829	cellular_component	cytosol
H	0007052	biological_process	mitotic spindle organization
H	0007059	biological_process	chromosome segregation
H	0043515	molecular_function	kinetochore binding
H	0051382	biological_process	kinetochore assembly
H	0051383	biological_process	kinetochore organization
I	0000070	biological_process	mitotic sister chromatid segregation
I	0000775	cellular_component	chromosome, centromeric region
I	0000776	cellular_component	kinetochore
I	0000939	cellular_component	inner kinetochore
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005829	cellular_component	cytosol
I	0007059	biological_process	chromosome segregation
I	0007548	biological_process	sex differentiation
I	0016604	cellular_component	nuclear body
I	0034080	biological_process	CENP-A containing chromatin assembly
K	0000070	biological_process	mitotic sister chromatid segregation
K	0000775	cellular_component	chromosome, centromeric region
K	0000776	cellular_component	kinetochore
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005829	cellular_component	cytosol
K	0007059	biological_process	chromosome segregation
K	0051382	biological_process	kinetochore assembly
L	0000775	cellular_component	chromosome, centromeric region
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005829	cellular_component	cytosol
L	0007059	biological_process	chromosome segregation
M	0000776	cellular_component	kinetochore
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0007059	biological_process	chromosome segregation
N	0000776	cellular_component	kinetochore
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005829	cellular_component	cytosol
N	0007059	biological_process	chromosome segregation
N	0034080	biological_process	CENP-A containing chromatin assembly
O	0000775	cellular_component	chromosome, centromeric region
O	0000776	cellular_component	kinetochore
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005829	cellular_component	cytosol
O	0007059	biological_process	chromosome segregation
O	0016604	cellular_component	nuclear body
O	0031511	cellular_component	Mis6-Sim4 complex
O	0051382	biological_process	kinetochore assembly
P	0000775	cellular_component	chromosome, centromeric region
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005829	cellular_component	cytosol
P	0007059	biological_process	chromosome segregation
P	0034080	biological_process	CENP-A containing chromatin assembly
Q	0000775	cellular_component	chromosome, centromeric region
Q	0000939	cellular_component	inner kinetochore
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005829	cellular_component	cytosol
Q	0007059	biological_process	chromosome segregation
Q	0051310	biological_process	metaphase chromosome alignment
Q	1905342	biological_process	positive regulation of protein localization to kinetochore
R	0000775	cellular_component	chromosome, centromeric region
R	0000776	cellular_component	kinetochore
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006351	biological_process	DNA-templated transcription
R	0006355	biological_process	regulation of DNA-templated transcription
R	0006915	biological_process	apoptotic process
R	0007059	biological_process	chromosome segregation
R	0007155	biological_process	cell adhesion
R	0007165	biological_process	signal transduction
R	0016020	cellular_component	membrane
R	0034080	biological_process	CENP-A containing chromatin assembly
R	0051301	biological_process	cell division
S	0000712	biological_process	resolution of meiotic recombination intermediates
S	0000775	cellular_component	chromosome, centromeric region
S	0000776	cellular_component	kinetochore
S	0000785	cellular_component	chromatin
S	0003677	molecular_function	DNA binding
S	0003682	molecular_function	chromatin binding
S	0003690	molecular_function	double-stranded DNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005829	cellular_component	cytosol
S	0006281	biological_process	DNA repair
S	0006974	biological_process	DNA damage response
S	0007059	biological_process	chromosome segregation
S	0031297	biological_process	replication fork processing
S	0031398	biological_process	positive regulation of protein ubiquitination
S	0036297	biological_process	interstrand cross-link repair
S	0043240	cellular_component	Fanconi anaemia nuclear complex
S	0046982	molecular_function	protein heterodimerization activity
S	0051301	biological_process	cell division
S	0071821	cellular_component	FANCM-MHF complex
T	0000278	biological_process	mitotic cell cycle
T	0000775	cellular_component	chromosome, centromeric region
T	0000776	cellular_component	kinetochore
T	0003677	molecular_function	DNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005829	cellular_component	cytosol
T	0007059	biological_process	chromosome segregation
T	0016604	cellular_component	nuclear body
T	0046982	molecular_function	protein heterodimerization activity
T	0051276	biological_process	chromosome organization
T	0051301	biological_process	cell division
T	0051382	biological_process	kinetochore assembly
U	0000776	cellular_component	kinetochore
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0006351	biological_process	DNA-templated transcription
U	0007059	biological_process	chromosome segregation
U	0034451	cellular_component	centriolar satellite
W	0000278	biological_process	mitotic cell cycle
W	0000775	cellular_component	chromosome, centromeric region
W	0000776	cellular_component	kinetochore
W	0003677	molecular_function	DNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005730	cellular_component	nucleolus
W	0007059	biological_process	chromosome segregation
W	0016363	cellular_component	nuclear matrix
W	0034080	biological_process	CENP-A containing chromatin assembly
W	0046982	molecular_function	protein heterodimerization activity
W	0051276	biological_process	chromosome organization
W	0051301	biological_process	cell division
W	0051382	biological_process	kinetochore assembly
X	0000712	biological_process	resolution of meiotic recombination intermediates
X	0000775	cellular_component	chromosome, centromeric region
X	0000776	cellular_component	kinetochore
X	0000785	cellular_component	chromatin
X	0003677	molecular_function	DNA binding
X	0003690	molecular_function	double-stranded DNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005829	cellular_component	cytosol
X	0006281	biological_process	DNA repair
X	0006974	biological_process	DNA damage response
X	0007059	biological_process	chromosome segregation
X	0031297	biological_process	replication fork processing
X	0031398	biological_process	positive regulation of protein ubiquitination
X	0036297	biological_process	interstrand cross-link repair
X	0043240	cellular_component	Fanconi anaemia nuclear complex
X	0051301	biological_process	cell division
X	0051382	biological_process	kinetochore assembly
X	0071821	cellular_component	FANCM-MHF complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	99
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Breakpoint for translocation to form KMT2A/MLL1-CENPK oncogene"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	17
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Motif: {"description":"LXXIL motif"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)