7R2G

USP15 D1D2 in catalytically-competent state bound to mitoxantrone stack (isoform 2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0016579	biological_process	protein deubiquitination
B	0004843	molecular_function	cysteine-type deubiquitinase activity
B	0016579	biological_process	protein deubiquitination

Functional Information from PROSITE/UniProt

site_id	PS00972
Number of Residues	16
Details	USP_1 Ubiquitin specific protease (USP) domain signature 1. GLsnlGNtCFMNSaIQ

Chain	Residue	Details
A	GLY261-GLN276

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site_id	PS00973
Number of Residues	18
Details	USP_2 Ubiquitin specific protease (USP) domain signature 2. YnLiAVsnHyGgmgg..GHY

Chain	Residue	Details
A	TYR846-TYR863

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU01035","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19553310","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21947082","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22344298","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24852371","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27368102","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33093067","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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