7R2G

USP15 D1D2 in catalytically-competent state bound to mitoxantrone stack (isoform 2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0016579	biological_process	protein deubiquitination
B	0004843	molecular_function	cysteine-type deubiquitinase activity
B	0016579	biological_process	protein deubiquitination

Functional Information from PROSITE/UniProt

site_id	PS00972
Number of Residues	16
Details	USP_1 Ubiquitin specific protease (USP) domain signature 1. GLsnlGNtCFMNSaIQ

Chain	Residue	Details
A	GLY261-GLN276

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site_id	PS00973
Number of Residues	18
Details	USP_2 Ubiquitin specific protease (USP) domain signature 2. YnLiAVsnHyGgmgg..GHY

Chain	Residue	Details
A	TYR846-TYR863

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU01035, ECO:0000305|PubMed:19553310, ECO:0000305|PubMed:21947082, ECO:0000305|PubMed:22344298, ECO:0000305|PubMed:24852371, ECO:0000305|PubMed:27368102, ECO:0000305|PubMed:33093067

Chain	Residue	Details
A	CYS269
B	CYS269

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8R5H1

Chain	Residue	Details
A	THR885
B	THR885

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