7QTT

Structural organization of a late activated human spliceosome (Baqr, core region)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000124	cellular_component	SAGA complex
A	0000375	biological_process	RNA splicing, via transesterification reactions
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003676	molecular_function	nucleic acid binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005681	cellular_component	spliceosomal complex
A	0005684	cellular_component	U2-type spliceosomal complex
A	0005686	cellular_component	U2 snRNP
A	0005689	cellular_component	U12-type spliceosomal complex
A	0005730	cellular_component	nucleolus
A	0006282	biological_process	regulation of DNA repair
A	0006397	biological_process	mRNA processing
A	0008380	biological_process	RNA splicing
A	0030620	molecular_function	U2 snRNA binding
A	0042177	biological_process	negative regulation of protein catabolic process
A	0043484	biological_process	regulation of RNA splicing
A	0044877	molecular_function	protein-containing complex binding
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0071005	cellular_component	U2-type precatalytic spliceosome
A	0071013	cellular_component	catalytic step 2 spliceosome
A	1903241	biological_process	U2-type prespliceosome assembly
B	0000124	cellular_component	SAGA complex
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005681	cellular_component	spliceosomal complex
B	0005684	cellular_component	U2-type spliceosomal complex
B	0005686	cellular_component	U2 snRNP
B	0005689	cellular_component	U12-type spliceosomal complex
B	0006282	biological_process	regulation of DNA repair
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0043484	biological_process	regulation of RNA splicing
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0071005	cellular_component	U2-type precatalytic spliceosome
B	0071011	cellular_component	precatalytic spliceosome
B	1903241	biological_process	U2-type prespliceosome assembly
B	1990935	molecular_function	splicing factor binding
C	0000245	biological_process	spliceosomal complex assembly
C	0000375	biological_process	RNA splicing, via transesterification reactions
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0000785	cellular_component	chromatin
C	0003723	molecular_function	RNA binding
C	0003729	molecular_function	mRNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005681	cellular_component	spliceosomal complex
C	0005684	cellular_component	U2-type spliceosomal complex
C	0005686	cellular_component	U2 snRNP
C	0005689	cellular_component	U12-type spliceosomal complex
C	0005730	cellular_component	nucleolus
C	0006338	biological_process	chromatin remodeling
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0016607	cellular_component	nuclear speck
C	0031981	cellular_component	nuclear lumen
C	0034693	cellular_component	U11/U12 snRNP
C	0045943	biological_process	positive regulation of transcription by RNA polymerase I
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0045945	biological_process	positive regulation of transcription by RNA polymerase III
C	0071004	cellular_component	U2-type prespliceosome
C	0071005	cellular_component	U2-type precatalytic spliceosome
C	0071013	cellular_component	catalytic step 2 spliceosome
C	0110016	cellular_component	B-WICH complex
C	1903241	biological_process	U2-type prespliceosome assembly
C	1990935	molecular_function	splicing factor binding
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0003677	molecular_function	DNA binding
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005681	cellular_component	spliceosomal complex
D	0005684	cellular_component	U2-type spliceosomal complex
D	0005686	cellular_component	U2 snRNP
D	0005689	cellular_component	U12-type spliceosomal complex
D	0006397	biological_process	mRNA processing
D	0008270	molecular_function	zinc ion binding
D	0008380	biological_process	RNA splicing
D	0016363	cellular_component	nuclear matrix
D	0016607	cellular_component	nuclear speck
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0046872	molecular_function	metal ion binding
D	0048863	biological_process	stem cell differentiation
D	0071005	cellular_component	U2-type precatalytic spliceosome
D	0071011	cellular_component	precatalytic spliceosome
D	1903241	biological_process	U2-type prespliceosome assembly
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005681	cellular_component	spliceosomal complex
E	0005684	cellular_component	U2-type spliceosomal complex
E	0005686	cellular_component	U2 snRNP
E	0005689	cellular_component	U12-type spliceosomal complex
E	0006397	biological_process	mRNA processing
E	0008380	biological_process	RNA splicing
E	0016607	cellular_component	nuclear speck
E	0071005	cellular_component	U2-type precatalytic spliceosome
E	0071011	cellular_component	precatalytic spliceosome
E	0071013	cellular_component	catalytic step 2 spliceosome
E	1903241	biological_process	U2-type prespliceosome assembly
F	0000375	biological_process	RNA splicing, via transesterification reactions
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0003676	molecular_function	nucleic acid binding
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005681	cellular_component	spliceosomal complex
F	0005684	cellular_component	U2-type spliceosomal complex
F	0005686	cellular_component	U2 snRNP
F	0005689	cellular_component	U12-type spliceosomal complex
F	0006397	biological_process	mRNA processing
F	0008380	biological_process	RNA splicing
F	0071005	cellular_component	U2-type precatalytic spliceosome
F	0071011	cellular_component	precatalytic spliceosome
F	1903241	biological_process	U2-type prespliceosome assembly
F	1990935	molecular_function	splicing factor binding
G	0000398	biological_process	mRNA splicing, via spliceosome
G	0003676	molecular_function	nucleic acid binding
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005681	cellular_component	spliceosomal complex
G	0006397	biological_process	mRNA processing
G	0008380	biological_process	RNA splicing
I	0000245	biological_process	spliceosomal complex assembly
I	0000389	biological_process	mRNA 3'-splice site recognition
I	0000398	biological_process	mRNA splicing, via spliceosome
I	0003676	molecular_function	nucleic acid binding
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005681	cellular_component	spliceosomal complex
I	0005684	cellular_component	U2-type spliceosomal complex
I	0005686	cellular_component	U2 snRNP
I	0006397	biological_process	mRNA processing
I	0008270	molecular_function	zinc ion binding
I	0008380	biological_process	RNA splicing
I	0010976	biological_process	positive regulation of neuron projection development
I	0016607	cellular_component	nuclear speck
I	0046872	molecular_function	metal ion binding
I	0071004	cellular_component	U2-type prespliceosome
I	0071005	cellular_component	U2-type precatalytic spliceosome
I	0071013	cellular_component	catalytic step 2 spliceosome
I	1903241	biological_process	U2-type prespliceosome assembly
J	0000375	biological_process	RNA splicing, via transesterification reactions
J	0000389	biological_process	mRNA 3'-splice site recognition
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0003676	molecular_function	nucleic acid binding
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005681	cellular_component	spliceosomal complex
J	0005684	cellular_component	U2-type spliceosomal complex
J	0005686	cellular_component	U2 snRNP
J	0006397	biological_process	mRNA processing
J	0008270	molecular_function	zinc ion binding
J	0008380	biological_process	RNA splicing
J	0016607	cellular_component	nuclear speck
J	0046872	molecular_function	metal ion binding
J	0071005	cellular_component	U2-type precatalytic spliceosome
J	0071013	cellular_component	catalytic step 2 spliceosome
J	1903241	biological_process	U2-type prespliceosome assembly
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0003723	molecular_function	RNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005681	cellular_component	spliceosomal complex
L	0005684	cellular_component	U2-type spliceosomal complex
L	0005686	cellular_component	U2 snRNP
L	0006397	biological_process	mRNA processing
L	0008380	biological_process	RNA splicing
L	0070274	cellular_component	RES complex
L	0071005	cellular_component	U2-type precatalytic spliceosome
L	1903241	biological_process	U2-type prespliceosome assembly
N	0000166	molecular_function	nucleotide binding
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0002376	biological_process	immune system process
N	0003676	molecular_function	nucleic acid binding
N	0003723	molecular_function	RNA binding
N	0003724	molecular_function	RNA helicase activity
N	0004386	molecular_function	helicase activity
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005681	cellular_component	spliceosomal complex
N	0005737	cellular_component	cytoplasm
N	0006397	biological_process	mRNA processing
N	0008186	molecular_function	ATP-dependent activity, acting on RNA
N	0008380	biological_process	RNA splicing
N	0016787	molecular_function	hydrolase activity
N	0016887	molecular_function	ATP hydrolysis activity
N	0038187	molecular_function	pattern recognition receptor activity
N	0043130	molecular_function	ubiquitin binding
N	0045087	biological_process	innate immune response
N	0060090	molecular_function	molecular adaptor activity
N	0071005	cellular_component	U2-type precatalytic spliceosome
N	0140374	biological_process	antiviral innate immune response
N	1990904	cellular_component	ribonucleoprotein complex
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0000974	cellular_component	Prp19 complex
O	0001650	cellular_component	fibrillar center
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005662	cellular_component	DNA replication factor A complex
O	0005681	cellular_component	spliceosomal complex
O	0006397	biological_process	mRNA processing
O	0008380	biological_process	RNA splicing
O	0016607	cellular_component	nuclear speck
O	0031965	cellular_component	nuclear membrane
O	0034504	biological_process	protein localization to nucleus
O	0071007	cellular_component	U2-type catalytic step 2 spliceosome
O	0071013	cellular_component	catalytic step 2 spliceosome
O	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
P	0000077	biological_process	DNA damage checkpoint signaling
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0000974	cellular_component	Prp19 complex
P	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
P	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
P	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
P	0003677	molecular_function	DNA binding
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005662	cellular_component	DNA replication factor A complex
P	0005681	cellular_component	spliceosomal complex
P	0005737	cellular_component	cytoplasm
P	0006281	biological_process	DNA repair
P	0006355	biological_process	regulation of DNA-templated transcription
P	0006357	biological_process	regulation of transcription by RNA polymerase II
P	0006397	biological_process	mRNA processing
P	0006974	biological_process	DNA damage response
P	0008380	biological_process	RNA splicing
P	0016020	cellular_component	membrane
P	0016607	cellular_component	nuclear speck
P	0019904	molecular_function	protein domain specific binding
P	0042802	molecular_function	identical protein binding
P	0045944	biological_process	positive regulation of transcription by RNA polymerase II
P	0071007	cellular_component	U2-type catalytic step 2 spliceosome
P	0071013	cellular_component	catalytic step 2 spliceosome
P	0071987	molecular_function	WD40-repeat domain binding
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0000974	cellular_component	Prp19 complex
Q	0003723	molecular_function	RNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005681	cellular_component	spliceosomal complex
Q	0005739	cellular_component	mitochondrion
Q	0006397	biological_process	mRNA processing
Q	0008380	biological_process	RNA splicing
Q	0016607	cellular_component	nuclear speck
Q	0045292	biological_process	mRNA cis splicing, via spliceosome
Q	0071007	cellular_component	U2-type catalytic step 2 spliceosome
Q	0071013	cellular_component	catalytic step 2 spliceosome
T	0000398	biological_process	mRNA splicing, via spliceosome
T	0000785	cellular_component	chromatin
T	0003713	molecular_function	transcription coactivator activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005681	cellular_component	spliceosomal complex
T	0005813	cellular_component	centrosome
T	0006397	biological_process	mRNA processing
T	0008380	biological_process	RNA splicing
T	0015630	cellular_component	microtubule cytoskeleton
T	0016922	molecular_function	nuclear receptor binding
T	0045893	biological_process	positive regulation of DNA-templated transcription
T	0071007	cellular_component	U2-type catalytic step 2 spliceosome
U	0000398	biological_process	mRNA splicing, via spliceosome
U	0000974	cellular_component	Prp19 complex
U	0003676	molecular_function	nucleic acid binding
U	0003723	molecular_function	RNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005681	cellular_component	spliceosomal complex
U	0005737	cellular_component	cytoplasm
U	0006397	biological_process	mRNA processing
U	0008270	molecular_function	zinc ion binding
U	0008380	biological_process	RNA splicing
U	0017070	molecular_function	U6 snRNA binding
U	0033120	biological_process	positive regulation of RNA splicing
U	0036002	molecular_function	pre-mRNA binding
U	0042307	biological_process	positive regulation of protein import into nucleus
U	0045292	biological_process	mRNA cis splicing, via spliceosome
U	0046827	biological_process	positive regulation of protein export from nucleus
U	0046872	molecular_function	metal ion binding
U	0048306	molecular_function	calcium-dependent protein binding
U	0071006	cellular_component	U2-type catalytic step 1 spliceosome
U	0071007	cellular_component	U2-type catalytic step 2 spliceosome
U	0071013	cellular_component	catalytic step 2 spliceosome
U	0071466	biological_process	cellular response to xenobiotic stimulus
V	0000413	biological_process	protein peptidyl-prolyl isomerization
V	0003676	molecular_function	nucleic acid binding
V	0003723	molecular_function	RNA binding
V	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005829	cellular_component	cytosol
V	0016853	molecular_function	isomerase activity
W	0000398	biological_process	mRNA splicing, via spliceosome
W	0003723	molecular_function	RNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005681	cellular_component	spliceosomal complex
W	0005829	cellular_component	cytosol
W	0006397	biological_process	mRNA processing
W	0008380	biological_process	RNA splicing
W	0016607	cellular_component	nuclear speck
W	0048024	biological_process	regulation of mRNA splicing, via spliceosome
W	0071005	cellular_component	U2-type precatalytic spliceosome
W	0071006	cellular_component	U2-type catalytic step 1 spliceosome
W	0071007	cellular_component	U2-type catalytic step 2 spliceosome
W	0071013	cellular_component	catalytic step 2 spliceosome
X	0000245	biological_process	spliceosomal complex assembly
X	0000398	biological_process	mRNA splicing, via spliceosome
X	0000974	cellular_component	Prp19 complex
X	0003723	molecular_function	RNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005681	cellular_component	spliceosomal complex
X	0006396	biological_process	RNA processing
X	0006397	biological_process	mRNA processing
X	0008380	biological_process	RNA splicing
X	0016607	cellular_component	nuclear speck
X	0071007	cellular_component	U2-type catalytic step 2 spliceosome
X	0071013	cellular_component	catalytic step 2 spliceosome
X	0071014	cellular_component	post-mRNA release spliceosomal complex
Y	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Y	0000398	biological_process	mRNA splicing, via spliceosome
Y	0003713	molecular_function	transcription coactivator activity
Y	0003714	molecular_function	transcription corepressor activity
Y	0003723	molecular_function	RNA binding
Y	0005112	molecular_function	Notch binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005681	cellular_component	spliceosomal complex
Y	0006357	biological_process	regulation of transcription by RNA polymerase II
Y	0006397	biological_process	mRNA processing
Y	0008024	cellular_component	cyclin/CDK positive transcription elongation factor complex
Y	0008380	biological_process	RNA splicing
Y	0016363	cellular_component	nuclear matrix
Y	0016604	cellular_component	nuclear body
Y	0016607	cellular_component	nuclear speck
Y	0016922	molecular_function	nuclear receptor binding
Y	0019899	molecular_function	enzyme binding
Y	0030511	biological_process	positive regulation of transforming growth factor beta receptor signaling pathway
Y	0042771	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Y	0042809	molecular_function	nuclear vitamin D receptor binding
Y	0042974	molecular_function	nuclear retinoic acid receptor binding
Y	0043923	biological_process	host-mediated activation of viral transcription
Y	0045892	biological_process	negative regulation of DNA-templated transcription
Y	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Y	0046332	molecular_function	SMAD binding
Y	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
Y	0048384	biological_process	retinoic acid receptor signaling pathway
Y	0048385	biological_process	regulation of retinoic acid receptor signaling pathway
Y	0050681	molecular_function	nuclear androgen receptor binding
Y	0050769	biological_process	positive regulation of neurogenesis
Y	0070562	biological_process	regulation of vitamin D receptor signaling pathway
Y	0070564	biological_process	positive regulation of vitamin D receptor signaling pathway
Y	0071007	cellular_component	U2-type catalytic step 2 spliceosome
Y	0071013	cellular_component	catalytic step 2 spliceosome
Y	0071300	biological_process	cellular response to retinoic acid
Z	0000398	biological_process	mRNA splicing, via spliceosome
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005681	cellular_component	spliceosomal complex
Z	0005684	cellular_component	U2-type spliceosomal complex
Z	0006281	biological_process	DNA repair
Z	0006397	biological_process	mRNA processing
Z	0006974	biological_process	DNA damage response
Z	0008270	molecular_function	zinc ion binding
Z	0008380	biological_process	RNA splicing
Z	0016567	biological_process	protein ubiquitination
Z	0016607	cellular_component	nuclear speck
Z	0016740	molecular_function	transferase activity
Z	0034247	biological_process	snoRNA splicing
Z	0046872	molecular_function	metal ion binding
Z	0061630	molecular_function	ubiquitin protein ligase activity
Z	0070100	biological_process	negative regulation of chemokine-mediated signaling pathway
Z	0071005	cellular_component	U2-type precatalytic spliceosome
a	0000244	biological_process	spliceosomal tri-snRNP complex assembly
a	0000375	biological_process	RNA splicing, via transesterification reactions
a	0000398	biological_process	mRNA splicing, via spliceosome
a	0003723	molecular_function	RNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005681	cellular_component	spliceosomal complex
a	0005682	cellular_component	U5 snRNP
a	0006397	biological_process	mRNA processing
a	0008233	molecular_function	peptidase activity
a	0008237	molecular_function	metallopeptidase activity
a	0008380	biological_process	RNA splicing
a	0016020	cellular_component	membrane
a	0016607	cellular_component	nuclear speck
a	0017070	molecular_function	U6 snRNA binding
a	0030532	cellular_component	small nuclear ribonucleoprotein complex
a	0030619	molecular_function	U1 snRNA binding
a	0030620	molecular_function	U2 snRNA binding
a	0030623	molecular_function	U5 snRNA binding
a	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
a	0070530	molecular_function	K63-linked polyubiquitin modification-dependent protein binding
a	0071005	cellular_component	U2-type precatalytic spliceosome
a	0071006	cellular_component	U2-type catalytic step 1 spliceosome
a	0071007	cellular_component	U2-type catalytic step 2 spliceosome
a	0071013	cellular_component	catalytic step 2 spliceosome
a	0071222	biological_process	cellular response to lipopolysaccharide
a	0071356	biological_process	cellular response to tumor necrosis factor
a	0097157	molecular_function	pre-mRNA intronic binding
a	0140492	molecular_function	metal-dependent deubiquitinase activity
a	1990904	cellular_component	ribonucleoprotein complex
b	0000166	molecular_function	nucleotide binding
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0003723	molecular_function	RNA binding
b	0003924	molecular_function	GTPase activity
b	0005515	molecular_function	protein binding
b	0005525	molecular_function	GTP binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005681	cellular_component	spliceosomal complex
b	0005829	cellular_component	cytosol
b	0006397	biological_process	mRNA processing
b	0008380	biological_process	RNA splicing
b	0015030	cellular_component	Cajal body
b	0016020	cellular_component	membrane
b	0016607	cellular_component	nuclear speck
b	0030623	molecular_function	U5 snRNA binding
b	0042220	biological_process	response to cocaine
b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
b	0071005	cellular_component	U2-type precatalytic spliceosome
b	0071007	cellular_component	U2-type catalytic step 2 spliceosome
b	0071013	cellular_component	catalytic step 2 spliceosome
b	0071466	biological_process	cellular response to xenobiotic stimulus
h	0000387	biological_process	spliceosomal snRNP assembly
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0003723	molecular_function	RNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005681	cellular_component	spliceosomal complex
h	0005682	cellular_component	U5 snRNP
h	0005683	cellular_component	U7 snRNP
h	0005684	cellular_component	U2-type spliceosomal complex
h	0005685	cellular_component	U1 snRNP
h	0005686	cellular_component	U2 snRNP
h	0005687	cellular_component	U4 snRNP
h	0005689	cellular_component	U12-type spliceosomal complex
h	0005829	cellular_component	cytosol
h	0006397	biological_process	mRNA processing
h	0008380	biological_process	RNA splicing
h	0022618	biological_process	protein-RNA complex assembly
h	0030532	cellular_component	small nuclear ribonucleoprotein complex
h	0034709	cellular_component	methylosome
h	0034715	cellular_component	pICln-Sm protein complex
h	0034719	cellular_component	SMN-Sm protein complex
h	0036261	biological_process	7-methylguanosine cap hypermethylation
h	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
h	0071005	cellular_component	U2-type precatalytic spliceosome
h	0071007	cellular_component	U2-type catalytic step 2 spliceosome
h	0071013	cellular_component	catalytic step 2 spliceosome
h	1903241	biological_process	U2-type prespliceosome assembly
h	1990904	cellular_component	ribonucleoprotein complex
i	0000245	biological_process	spliceosomal complex assembly
i	0000387	biological_process	spliceosomal snRNP assembly
i	0000398	biological_process	mRNA splicing, via spliceosome
i	0003723	molecular_function	RNA binding
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005681	cellular_component	spliceosomal complex
i	0005682	cellular_component	U5 snRNP
i	0005683	cellular_component	U7 snRNP
i	0005684	cellular_component	U2-type spliceosomal complex
i	0005685	cellular_component	U1 snRNP
i	0005686	cellular_component	U2 snRNP
i	0005687	cellular_component	U4 snRNP
i	0005689	cellular_component	U12-type spliceosomal complex
i	0005697	cellular_component	telomerase holoenzyme complex
i	0005829	cellular_component	cytosol
i	0006397	biological_process	mRNA processing
i	0008380	biological_process	RNA splicing
i	0030532	cellular_component	small nuclear ribonucleoprotein complex
i	0034709	cellular_component	methylosome
i	0034715	cellular_component	pICln-Sm protein complex
i	0034719	cellular_component	SMN-Sm protein complex
i	0036261	biological_process	7-methylguanosine cap hypermethylation
i	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
i	0071005	cellular_component	U2-type precatalytic spliceosome
i	0071007	cellular_component	U2-type catalytic step 2 spliceosome
i	0071011	cellular_component	precatalytic spliceosome
i	0071013	cellular_component	catalytic step 2 spliceosome
i	1903241	biological_process	U2-type prespliceosome assembly
i	1990904	cellular_component	ribonucleoprotein complex
j	0000243	cellular_component	commitment complex
j	0000387	biological_process	spliceosomal snRNP assembly
j	0000398	biological_process	mRNA splicing, via spliceosome
j	0003723	molecular_function	RNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005681	cellular_component	spliceosomal complex
j	0005682	cellular_component	U5 snRNP
j	0005683	cellular_component	U7 snRNP
j	0005684	cellular_component	U2-type spliceosomal complex
j	0005685	cellular_component	U1 snRNP
j	0005686	cellular_component	U2 snRNP
j	0005687	cellular_component	U4 snRNP
j	0005689	cellular_component	U12-type spliceosomal complex
j	0005697	cellular_component	telomerase holoenzyme complex
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0006396	biological_process	RNA processing
j	0006397	biological_process	mRNA processing
j	0006479	biological_process	protein methylation
j	0008380	biological_process	RNA splicing
j	0016604	cellular_component	nuclear body
j	0019899	molecular_function	enzyme binding
j	0030532	cellular_component	small nuclear ribonucleoprotein complex
j	0034709	cellular_component	methylosome
j	0034715	cellular_component	pICln-Sm protein complex
j	0034719	cellular_component	SMN-Sm protein complex
j	0036261	biological_process	7-methylguanosine cap hypermethylation
j	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
j	0070034	molecular_function	telomerase RNA binding
j	0071005	cellular_component	U2-type precatalytic spliceosome
j	0071007	cellular_component	U2-type catalytic step 2 spliceosome
j	0071011	cellular_component	precatalytic spliceosome
j	0071013	cellular_component	catalytic step 2 spliceosome
j	0071208	molecular_function	histone pre-mRNA DCP binding
j	0071209	molecular_function	U7 snRNA binding
j	0097526	cellular_component	spliceosomal tri-snRNP complex
j	1903241	biological_process	U2-type prespliceosome assembly
j	1990904	cellular_component	ribonucleoprotein complex
k	0000243	cellular_component	commitment complex
k	0000245	biological_process	spliceosomal complex assembly
k	0000387	biological_process	spliceosomal snRNP assembly
k	0000398	biological_process	mRNA splicing, via spliceosome
k	0003723	molecular_function	RNA binding
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005681	cellular_component	spliceosomal complex
k	0005682	cellular_component	U5 snRNP
k	0005684	cellular_component	U2-type spliceosomal complex
k	0005685	cellular_component	U1 snRNP
k	0005686	cellular_component	U2 snRNP
k	0005687	cellular_component	U4 snRNP
k	0005689	cellular_component	U12-type spliceosomal complex
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0006396	biological_process	RNA processing
k	0006397	biological_process	mRNA processing
k	0008380	biological_process	RNA splicing
k	0030532	cellular_component	small nuclear ribonucleoprotein complex
k	0034709	cellular_component	methylosome
k	0034715	cellular_component	pICln-Sm protein complex
k	0034719	cellular_component	SMN-Sm protein complex
k	0036261	biological_process	7-methylguanosine cap hypermethylation
k	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
k	0071005	cellular_component	U2-type precatalytic spliceosome
k	0071007	cellular_component	U2-type catalytic step 2 spliceosome
k	0071011	cellular_component	precatalytic spliceosome
k	0071013	cellular_component	catalytic step 2 spliceosome
k	0097526	cellular_component	spliceosomal tri-snRNP complex
k	1903241	biological_process	U2-type prespliceosome assembly
k	1990446	molecular_function	U1 snRNP binding
k	1990904	cellular_component	ribonucleoprotein complex
l	0000245	biological_process	spliceosomal complex assembly
l	0000387	biological_process	spliceosomal snRNP assembly
l	0000398	biological_process	mRNA splicing, via spliceosome
l	0003723	molecular_function	RNA binding
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005681	cellular_component	spliceosomal complex
l	0005682	cellular_component	U5 snRNP
l	0005684	cellular_component	U2-type spliceosomal complex
l	0005685	cellular_component	U1 snRNP
l	0005686	cellular_component	U2 snRNP
l	0005687	cellular_component	U4 snRNP
l	0005689	cellular_component	U12-type spliceosomal complex
l	0005829	cellular_component	cytosol
l	0006397	biological_process	mRNA processing
l	0008380	biological_process	RNA splicing
l	0030532	cellular_component	small nuclear ribonucleoprotein complex
l	0034709	cellular_component	methylosome
l	0034715	cellular_component	pICln-Sm protein complex
l	0034719	cellular_component	SMN-Sm protein complex
l	0036261	biological_process	7-methylguanosine cap hypermethylation
l	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
l	0070062	cellular_component	extracellular exosome
l	0071005	cellular_component	U2-type precatalytic spliceosome
l	0071007	cellular_component	U2-type catalytic step 2 spliceosome
l	0071011	cellular_component	precatalytic spliceosome
l	0071013	cellular_component	catalytic step 2 spliceosome
l	0097525	cellular_component	spliceosomal snRNP complex
l	1903241	biological_process	U2-type prespliceosome assembly
l	1990904	cellular_component	ribonucleoprotein complex
m	0000245	biological_process	spliceosomal complex assembly
m	0000387	biological_process	spliceosomal snRNP assembly
m	0000398	biological_process	mRNA splicing, via spliceosome
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005681	cellular_component	spliceosomal complex
m	0005682	cellular_component	U5 snRNP
m	0005683	cellular_component	U7 snRNP
m	0005684	cellular_component	U2-type spliceosomal complex
m	0005685	cellular_component	U1 snRNP
m	0005686	cellular_component	U2 snRNP
m	0005687	cellular_component	U4 snRNP
m	0005689	cellular_component	U12-type spliceosomal complex
m	0005829	cellular_component	cytosol
m	0006397	biological_process	mRNA processing
m	0008380	biological_process	RNA splicing
m	0030532	cellular_component	small nuclear ribonucleoprotein complex
m	0034709	cellular_component	methylosome
m	0034719	cellular_component	SMN-Sm protein complex
m	0036261	biological_process	7-methylguanosine cap hypermethylation
m	0043186	cellular_component	P granule
m	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
m	0071004	cellular_component	U2-type prespliceosome
m	0071005	cellular_component	U2-type precatalytic spliceosome
m	0071007	cellular_component	U2-type catalytic step 2 spliceosome
m	0071011	cellular_component	precatalytic spliceosome
m	0071013	cellular_component	catalytic step 2 spliceosome
m	0097526	cellular_component	spliceosomal tri-snRNP complex
m	1903241	biological_process	U2-type prespliceosome assembly
m	1990904	cellular_component	ribonucleoprotein complex
n	0000387	biological_process	spliceosomal snRNP assembly
n	0000398	biological_process	mRNA splicing, via spliceosome
n	0003723	molecular_function	RNA binding
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005681	cellular_component	spliceosomal complex
n	0005682	cellular_component	U5 snRNP
n	0005683	cellular_component	U7 snRNP
n	0005684	cellular_component	U2-type spliceosomal complex
n	0005685	cellular_component	U1 snRNP
n	0005686	cellular_component	U2 snRNP
n	0005687	cellular_component	U4 snRNP
n	0005689	cellular_component	U12-type spliceosomal complex
n	0005697	cellular_component	telomerase holoenzyme complex
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0006397	biological_process	mRNA processing
n	0006479	biological_process	protein methylation
n	0008380	biological_process	RNA splicing
n	0030532	cellular_component	small nuclear ribonucleoprotein complex
n	0034709	cellular_component	methylosome
n	0034719	cellular_component	SMN-Sm protein complex
n	0036261	biological_process	7-methylguanosine cap hypermethylation
n	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
n	0070034	molecular_function	telomerase RNA binding
n	0070990	molecular_function	snRNP binding
n	0071004	cellular_component	U2-type prespliceosome
n	0071005	cellular_component	U2-type precatalytic spliceosome
n	0071007	cellular_component	U2-type catalytic step 2 spliceosome
n	0071013	cellular_component	catalytic step 2 spliceosome
n	0071204	cellular_component	histone pre-mRNA 3'end processing complex
n	0071208	molecular_function	histone pre-mRNA DCP binding
n	1903241	biological_process	U2-type prespliceosome assembly
n	1990446	molecular_function	U1 snRNP binding
n	1990447	molecular_function	U2 snRNP binding
n	1990904	cellular_component	ribonucleoprotein complex
p	0000398	biological_process	mRNA splicing, via spliceosome
p	0000413	biological_process	protein peptidyl-prolyl isomerization
p	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0005681	cellular_component	spliceosomal complex
p	0006397	biological_process	mRNA processing
p	0006457	biological_process	protein folding
p	0008380	biological_process	RNA splicing
p	0016853	molecular_function	isomerase activity
p	0071007	cellular_component	U2-type catalytic step 2 spliceosome
p	0071013	cellular_component	catalytic step 2 spliceosome
p	0097718	molecular_function	disordered domain specific binding
p	1990403	biological_process	embryonic brain development
q	0000398	biological_process	mRNA splicing, via spliceosome
q	0003723	molecular_function	RNA binding
q	0003729	molecular_function	mRNA binding
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005681	cellular_component	spliceosomal complex
q	0006397	biological_process	mRNA processing
q	0008380	biological_process	RNA splicing
q	0015030	cellular_component	Cajal body
q	0016607	cellular_component	nuclear speck
q	0070742	molecular_function	C2H2 zinc finger domain binding
q	0071005	cellular_component	U2-type precatalytic spliceosome
q	0071007	cellular_component	U2-type catalytic step 2 spliceosome
q	0071013	cellular_component	catalytic step 2 spliceosome
u	0000209	biological_process	protein polyubiquitination
u	0000413	biological_process	protein peptidyl-prolyl isomerization
u	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
u	0004842	molecular_function	ubiquitin-protein transferase activity
u	0005515	molecular_function	protein binding
u	0005634	cellular_component	nucleus
u	0005654	cellular_component	nucleoplasm
u	0005681	cellular_component	spliceosomal complex
u	0005737	cellular_component	cytoplasm
u	0005796	cellular_component	Golgi lumen
u	0005886	cellular_component	plasma membrane
u	0006397	biological_process	mRNA processing
u	0006457	biological_process	protein folding
u	0008380	biological_process	RNA splicing
u	0016567	biological_process	protein ubiquitination
u	0016740	molecular_function	transferase activity
u	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
u	0061630	molecular_function	ubiquitin protein ligase activity
u	0071013	cellular_component	catalytic step 2 spliceosome
u	0072659	biological_process	protein localization to plasma membrane

Functional Information from PROSITE/UniProt

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YngTkFHRIIkdFMiQGG

Chain	Residue	Details
p	TYR48-GLY65
u	TYR316-GLY333

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH

Chain	Residue	Details
A	PHE287-HIS293

---

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CrHyFCesCA

Chain	Residue	Details
Z	CYS277-ALA286

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVTCsrDsTARIWDV

Chain	Residue	Details
O	LEU303-VAL317
O	ILE345-LEU359

---

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. SvVMVDEAHE

Chain	Residue	Details
N	SER515-GLU524

---

site_id	PS00997
Number of Residues	23
Details	G10_1 G10 protein signature 1. LCClRCiqtrDtNfgtnCiCRVP

Chain	Residue	Details
T	LEU100-PRO122

---

site_id	PS00998
Number of Residues	10
Details	G10_2 G10 protein signature 2. CtHCGCRGCS

Chain	Residue	Details
T	CYS134-SER143

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	37
Details	Region: {"description":"Interaction with PHF5A, SF3B1 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	56
Details	Region: {"description":"Interaction with SF3B1 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	21
Details	Region: {"description":"Interaction with SF3B1","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	23
Details	Region: {"description":"Interaction with SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Site: {"description":"Interaction with SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Interaction with SF3B1","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	77
Details	Region: {"description":"Interaction with SF3B1 and SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	5
Details	Site: {"description":"Interaction with RNA","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	7
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	39
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	34
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	37
Details	Repeat: {"description":"HEAT 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	34
Details	Repeat: {"description":"HEAT 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	38
Details	Repeat: {"description":"HEAT 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	38
Details	Repeat: {"description":"HEAT 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	38
Details	Repeat: {"description":"HEAT 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	38
Details	Repeat: {"description":"HEAT 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	38
Details	Repeat: {"description":"HEAT 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	38
Details	Repeat: {"description":"HEAT 10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	38
Details	Repeat: {"description":"HEAT 11"}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	39
Details	Region: {"description":"Interaction with SF3B14"}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	4
Details	Region: {"description":"Interaction with PHF5A","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	56
Details	Region: {"description":"Interaction with SF3B3 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	1
Details	Site: {"description":"Interaction with PHF5A","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	4
Details	Site: {"description":"Interaction with SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	3
Details	Region: {"description":"Interaction with SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28541300","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IFE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SYB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	1
Details	Modified residue: {"description":"Symmetric dimethylarginine; by PRMT9; alternate","evidences":[{"source":"PubMed","id":"25737013","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	15
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	50
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q62203","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	31
Details	Zinc finger: {"description":"Matrin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00130","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	164
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	173
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	3
Details	Motif: {"description":"DEAH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	39
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	39
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	39
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	39
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	40
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	38
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	39
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI49
Number of Residues	51
Details	Domain: {"description":"HTH myb-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00625","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI50
Number of Residues	45
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00625","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI51
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18583928","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI52
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI53
Number of Residues	10
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI54
Number of Residues	8
Details	Region: {"description":"Interaction with AR","evidences":[{"source":"PubMed","id":"28076346","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI55
Number of Residues	8
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI56
Number of Residues	55
Details	Zinc finger: {"description":"C3H1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00723","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI57
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI58
Number of Residues	183
Details	Domain: {"description":"MIF4G","evidences":[{"source":"PROSITE-ProRule","id":"PRU00698","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI59
Number of Residues	116
Details	Domain: {"description":"MI","evidences":[{"source":"PROSITE-ProRule","id":"PRU00698","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI60
Number of Residues	32
Details	Repeat: {"description":"HAT 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI61
Number of Residues	32
Details	Repeat: {"description":"HAT 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI62
Number of Residues	32
Details	Repeat: {"description":"HAT 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI63
Number of Residues	31
Details	Repeat: {"description":"HAT 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI64
Number of Residues	31
Details	Repeat: {"description":"HAT 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI65
Number of Residues	35
Details	Repeat: {"description":"HAT 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI66
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI67
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI68
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI69
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI70
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI71
Number of Residues	38
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI72
Number of Residues	491
Details	Region: {"description":"Reverse transcriptase homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI73
Number of Residues	171
Details	Region: {"description":"Restriction endonuclease homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI74
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI75
Number of Residues	1
Details	Modified residue: {"description":"N6,N6-dimethyllysine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI76
Number of Residues	282
Details	Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI77
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI78
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI79
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI80
Number of Residues	309
Details	Domain: {"description":"PPIase cyclophilin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00156","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI81
Number of Residues	23
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16595688","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI82
Number of Residues	32
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI83
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Heiserich L.","Boulahbel H.","Gottlieb E."]}},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---