7QTI

SARS-CoV-2 S Omicron Spike B.1.1.529 - 3-P2G3 and 1-P5C3 Fabs (Global)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
A	0019031	cellular_component	viral envelope
A	0019064	biological_process	fusion of virus membrane with host plasma membrane
A	0039654	biological_process	fusion of virus membrane with host endosome membrane
A	0046813	biological_process	receptor-mediated virion attachment to host cell
A	0055036	cellular_component	virion membrane
A	0075509	biological_process	endocytosis involved in viral entry into host cell
D	0016020	cellular_component	membrane
D	0019031	cellular_component	viral envelope
D	0019064	biological_process	fusion of virus membrane with host plasma membrane
D	0039654	biological_process	fusion of virus membrane with host endosome membrane
D	0046813	biological_process	receptor-mediated virion attachment to host cell
D	0055036	cellular_component	virion membrane
D	0075509	biological_process	endocytosis involved in viral entry into host cell
K	0016020	cellular_component	membrane
K	0019031	cellular_component	viral envelope
K	0019064	biological_process	fusion of virus membrane with host plasma membrane
K	0039654	biological_process	fusion of virus membrane with host endosome membrane
K	0046813	biological_process	receptor-mediated virion attachment to host cell
K	0055036	cellular_component	virion membrane
K	0075509	biological_process	endocytosis involved in viral entry into host cell

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
F	TYR204-HIS210
H	TYR192-HIS198
E	TYR193-HIS199
G	TYR206-HIS212

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616

Chain	Residue	Details
D	SER682
K	SER682
A	SER682

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site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616

Chain	Residue	Details
D	ARG812
K	ARG812
A	ARG812

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site_id	SWS_FT_FI3
Number of Residues	9
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
D	ASN17
D	ASN1155
D	ASN1170
K	ASN17
K	ASN1155
K	ASN1170
A	ASN17
A	ASN1155
A	ASN1170

---

site_id	SWS_FT_FI4
Number of Residues	15
Details	CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
D	ASN61
K	ASN1071
A	ASN61
A	THR122
A	ASN714
A	ASN798
A	ASN1071
D	THR122
D	ASN714
D	ASN798
D	ASN1071
K	ASN61
K	THR122
K	ASN714
K	ASN798

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
D	THR74
D	GLU149
D	ASN1191
K	THR74
K	GLU149
K	ASN1191
A	THR74
A	GLU149
A	ASN1191

---

site_id	SWS_FT_FI6
Number of Residues	21
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
D	TYR165
K	ASN328
K	ASN340
K	ASN613
K	ASN654
K	ASN1095
A	TYR165
A	ASN279
A	ASN328
A	ASN340
A	ASN613
D	ASN279
A	ASN654
A	ASN1095
D	ASN328
D	ASN340
D	ASN613
D	ASN654
D	ASN1095
K	TYR165
K	ASN279

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
D	ASN231
D	ASN706
K	ASN231
K	ASN706
A	ASN231
A	ASN706

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391

Chain	Residue	Details
D	THR320
K	THR320
A	THR320

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391

Chain	Residue	Details
D	SER322
K	SER322
A	SER322

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site_id	SWS_FT_FI10
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
D	ASN600
K	ASN600
A	ASN600

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site_id	SWS_FT_FI11
Number of Residues	6
Details	CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583

Chain	Residue	Details
D	THR673
D	THR675
K	THR673
K	THR675
A	THR673
A	THR675

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site_id	SWS_FT_FI12
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
D	ASN1131
K	ASN1131
A	ASN1131

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