Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7QSM

Bovine complex I in lipid nanodisc, Deactive-ligand (composite)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0006120biological_processmitochondrial electron transport, NADH to ubiquinone
A0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
A0045271cellular_componentrespiratory chain complex I
A1902600biological_processproton transmembrane transport
B0003954molecular_functionNADH dehydrogenase activity
B0005739cellular_componentmitochondrion
B0005743cellular_componentmitochondrial inner membrane
B0006120biological_processmitochondrial electron transport, NADH to ubiquinone
B0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
B0009060biological_processaerobic respiration
B0015990biological_processelectron transport coupled proton transport
B0016491molecular_functionoxidoreductase activity
B0032981biological_processmitochondrial respiratory chain complex I assembly
B0045271cellular_componentrespiratory chain complex I
B0046872molecular_functionmetal ion binding
B0048038molecular_functionquinone binding
B0051536molecular_functioniron-sulfur cluster binding
B0051539molecular_function4 iron, 4 sulfur cluster binding
C0003954molecular_functionNADH dehydrogenase activity
C0005739cellular_componentmitochondrion
C0005743cellular_componentmitochondrial inner membrane
C0006120biological_processmitochondrial electron transport, NADH to ubiquinone
C0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
C0016491molecular_functionoxidoreductase activity
C0016651molecular_functionoxidoreductase activity, acting on NAD(P)H
C0031966cellular_componentmitochondrial membrane
C0032981biological_processmitochondrial respiratory chain complex I assembly
C0045271cellular_componentrespiratory chain complex I
C0072593biological_processreactive oxygen species metabolic process
C1902600biological_processproton transmembrane transport
D0003954molecular_functionNADH dehydrogenase activity
D0005654cellular_componentnucleoplasm
D0005739cellular_componentmitochondrion
D0005743cellular_componentmitochondrial inner membrane
D0006120biological_processmitochondrial electron transport, NADH to ubiquinone
D0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
D0016491molecular_functionoxidoreductase activity
D0016651molecular_functionoxidoreductase activity, acting on NAD(P)H
D0019826molecular_functionoxygen sensor activity
D0022008biological_processneurogenesis
D0031625molecular_functionubiquitin protein ligase binding
D0032981biological_processmitochondrial respiratory chain complex I assembly
D0042063biological_processgliogenesis
D0042775biological_processmitochondrial ATP synthesis coupled electron transport
D0045271cellular_componentrespiratory chain complex I
D0046872molecular_functionmetal ion binding
D0048038molecular_functionquinone binding
D0051287molecular_functionNAD binding
D0051539molecular_function4 iron, 4 sulfur cluster binding
D0061351biological_processneural precursor cell proliferation
D0071453biological_processcellular response to oxygen levels
D1902600biological_processproton transmembrane transport
E0003954molecular_functionNADH dehydrogenase activity
E0005739cellular_componentmitochondrion
E0005743cellular_componentmitochondrial inner membrane
E0006120biological_processmitochondrial electron transport, NADH to ubiquinone
E0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
E0016491molecular_functionoxidoreductase activity
E0045271cellular_componentrespiratory chain complex I
E0046872molecular_functionmetal ion binding
E0051537molecular_function2 iron, 2 sulfur cluster binding
E1902600biological_processproton transmembrane transport
F0005739cellular_componentmitochondrion
F0005743cellular_componentmitochondrial inner membrane
F0006120biological_processmitochondrial electron transport, NADH to ubiquinone
F0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
F0010181molecular_functionFMN binding
F0016491molecular_functionoxidoreductase activity
F0045271cellular_componentrespiratory chain complex I
F0046872molecular_functionmetal ion binding
F0051287molecular_functionNAD binding
F0051539molecular_function4 iron, 4 sulfur cluster binding
F1902600biological_processproton transmembrane transport
G0005739cellular_componentmitochondrion
G0005743cellular_componentmitochondrial inner membrane
G0005758cellular_componentmitochondrial intermembrane space
G0006120biological_processmitochondrial electron transport, NADH to ubiquinone
G0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
G0009055molecular_functionelectron transfer activity
G0016020cellular_componentmembrane
G0016491molecular_functionoxidoreductase activity
G0016651molecular_functionoxidoreductase activity, acting on NAD(P)H
G0032981biological_processmitochondrial respiratory chain complex I assembly
G0042773biological_processATP synthesis coupled electron transport
G0045271cellular_componentrespiratory chain complex I
G0045333biological_processcellular respiration
G0046872molecular_functionmetal ion binding
G0051536molecular_functioniron-sulfur cluster binding
G0051537molecular_function2 iron, 2 sulfur cluster binding
G0051539molecular_function4 iron, 4 sulfur cluster binding
G1902600biological_processproton transmembrane transport
H0003954molecular_functionNADH dehydrogenase activity
H0005739cellular_componentmitochondrion
H0005743cellular_componentmitochondrial inner membrane
H0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
H0009060biological_processaerobic respiration
H0016020cellular_componentmembrane
H0032981biological_processmitochondrial respiratory chain complex I assembly
H0045271cellular_componentrespiratory chain complex I
H1902600biological_processproton transmembrane transport
I0003954molecular_functionNADH dehydrogenase activity
I0005739cellular_componentmitochondrion
I0005743cellular_componentmitochondrial inner membrane
I0006120biological_processmitochondrial electron transport, NADH to ubiquinone
I0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
I0016020cellular_componentmembrane
I0016491molecular_functionoxidoreductase activity
I0016651molecular_functionoxidoreductase activity, acting on NAD(P)H
I0032981biological_processmitochondrial respiratory chain complex I assembly
I0045271cellular_componentrespiratory chain complex I
I0046872molecular_functionmetal ion binding
I0051539molecular_function4 iron, 4 sulfur cluster binding
I1902600biological_processproton transmembrane transport
J0005739cellular_componentmitochondrion
J0005743cellular_componentmitochondrial inner membrane
J0006120biological_processmitochondrial electron transport, NADH to ubiquinone
J0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
J0032981biological_processmitochondrial respiratory chain complex I assembly
J1902600biological_processproton transmembrane transport
K0005739cellular_componentmitochondrion
K0005743cellular_componentmitochondrial inner membrane
K0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
K0016651molecular_functionoxidoreductase activity, acting on NAD(P)H
K0042773biological_processATP synthesis coupled electron transport
K0045271cellular_componentrespiratory chain complex I
K1902600biological_processproton transmembrane transport
L0003954molecular_functionNADH dehydrogenase activity
L0005739cellular_componentmitochondrion
L0005743cellular_componentmitochondrial inner membrane
L0006120biological_processmitochondrial electron transport, NADH to ubiquinone
L0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
L0015990biological_processelectron transport coupled proton transport
L0032981biological_processmitochondrial respiratory chain complex I assembly
L0042773biological_processATP synthesis coupled electron transport
L0045271cellular_componentrespiratory chain complex I
M0003954molecular_functionNADH dehydrogenase activity
M0005739cellular_componentmitochondrion
M0005743cellular_componentmitochondrial inner membrane
M0006120biological_processmitochondrial electron transport, NADH to ubiquinone
M0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
M0009060biological_processaerobic respiration
M0015990biological_processelectron transport coupled proton transport
M0032981biological_processmitochondrial respiratory chain complex I assembly
M0042773biological_processATP synthesis coupled electron transport
M0045271cellular_componentrespiratory chain complex I
M0048039molecular_functionubiquinone binding
N0005739cellular_componentmitochondrion
N0005743cellular_componentmitochondrial inner membrane
N0006120biological_processmitochondrial electron transport, NADH to ubiquinone
N0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
N0032981biological_processmitochondrial respiratory chain complex I assembly
N0045271cellular_componentrespiratory chain complex I
N1902600biological_processproton transmembrane transport
O0005737cellular_componentcytoplasm
O0005739cellular_componentmitochondrion
O0005759cellular_componentmitochondrial matrix
O0006120biological_processmitochondrial electron transport, NADH to ubiquinone
O0032981biological_processmitochondrial respiratory chain complex I assembly
O0045271cellular_componentrespiratory chain complex I
P0005739cellular_componentmitochondrion
P0005759cellular_componentmitochondrial matrix
P0032981biological_processmitochondrial respiratory chain complex I assembly
P0044877molecular_functionprotein-containing complex binding
P0045271cellular_componentrespiratory chain complex I
P1901006biological_processubiquinone-6 biosynthetic process
Q0001932biological_processregulation of protein phosphorylation
Q0005739cellular_componentmitochondrion
Q0005743cellular_componentmitochondrial inner membrane
Q0007420biological_processbrain development
Q0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
Q0022900biological_processelectron transport chain
Q0032981biological_processmitochondrial respiratory chain complex I assembly
Q0045271cellular_componentrespiratory chain complex I
Q0051591biological_processresponse to cAMP
Q0072593biological_processreactive oxygen species metabolic process
Q1902600biological_processproton transmembrane transport
R0005739cellular_componentmitochondrion
R0005743cellular_componentmitochondrial inner membrane
R0006120biological_processmitochondrial electron transport, NADH to ubiquinone
R0045271cellular_componentrespiratory chain complex I
S0005739cellular_componentmitochondrion
S0005743cellular_componentmitochondrial inner membrane
S0031966cellular_componentmitochondrial membrane
S0032981biological_processmitochondrial respiratory chain complex I assembly
S0045271cellular_componentrespiratory chain complex I
T0000035molecular_functionacyl binding
T0000036molecular_functionacyl carrier activity
T0005504molecular_functionfatty acid binding
T0005739cellular_componentmitochondrion
T0005759cellular_componentmitochondrial matrix
T0006120biological_processmitochondrial electron transport, NADH to ubiquinone
T0006633biological_processfatty acid biosynthetic process
T0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
T0016491molecular_functionoxidoreductase activity
T0031966cellular_componentmitochondrial membrane
T0032981biological_processmitochondrial respiratory chain complex I assembly
T0044571biological_process[2Fe-2S] cluster assembly
T0045271cellular_componentrespiratory chain complex I
T0140978molecular_functionmitochondrial large ribosomal subunit binding
T1902494cellular_componentcatalytic complex
T1902600biological_processproton transmembrane transport
U0000035molecular_functionacyl binding
U0000036molecular_functionacyl carrier activity
U0005504molecular_functionfatty acid binding
U0005739cellular_componentmitochondrion
U0005759cellular_componentmitochondrial matrix
U0006120biological_processmitochondrial electron transport, NADH to ubiquinone
U0006633biological_processfatty acid biosynthetic process
U0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
U0016491molecular_functionoxidoreductase activity
U0031966cellular_componentmitochondrial membrane
U0032981biological_processmitochondrial respiratory chain complex I assembly
U0044571biological_process[2Fe-2S] cluster assembly
U0045271cellular_componentrespiratory chain complex I
U0140978molecular_functionmitochondrial large ribosomal subunit binding
U1902494cellular_componentcatalytic complex
U1902600biological_processproton transmembrane transport
V0005739cellular_componentmitochondrion
V0005743cellular_componentmitochondrial inner membrane
V0022904biological_processrespiratory electron transport chain
V0032981biological_processmitochondrial respiratory chain complex I assembly
V0045271cellular_componentrespiratory chain complex I
W0005739cellular_componentmitochondrion
W0005743cellular_componentmitochondrial inner membrane
W0006979biological_processresponse to oxidative stress
W0032981biological_processmitochondrial respiratory chain complex I assembly
W0045271cellular_componentrespiratory chain complex I
X0005739cellular_componentmitochondrion
X0005743cellular_componentmitochondrial inner membrane
X0005758cellular_componentmitochondrial intermembrane space
X0006120biological_processmitochondrial electron transport, NADH to ubiquinone
X0032981biological_processmitochondrial respiratory chain complex I assembly
X0045271cellular_componentrespiratory chain complex I
Y0005739cellular_componentmitochondrion
Y0005743cellular_componentmitochondrial inner membrane
Y0032981biological_processmitochondrial respiratory chain complex I assembly
Y0045271cellular_componentrespiratory chain complex I
Z0005634cellular_componentnucleus
Z0005654cellular_componentnucleoplasm
Z0005737cellular_componentcytoplasm
Z0005739cellular_componentmitochondrion
Z0005743cellular_componentmitochondrial inner membrane
Z0006915biological_processapoptotic process
Z0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
Z0032981biological_processmitochondrial respiratory chain complex I assembly
Z0045271cellular_componentrespiratory chain complex I
Z0045892biological_processnegative regulation of DNA-templated transcription
Z1902600biological_processproton transmembrane transport
a0005739cellular_componentmitochondrion
a0005743cellular_componentmitochondrial inner membrane
a0032981biological_processmitochondrial respiratory chain complex I assembly
a0045271cellular_componentrespiratory chain complex I
b0005739cellular_componentmitochondrion
b0005743cellular_componentmitochondrial inner membrane
b0032981biological_processmitochondrial respiratory chain complex I assembly
b0045271cellular_componentrespiratory chain complex I
c0005739cellular_componentmitochondrion
c0005743cellular_componentmitochondrial inner membrane
c0032981biological_processmitochondrial respiratory chain complex I assembly
c0045271cellular_componentrespiratory chain complex I
d0005739cellular_componentmitochondrion
d0005743cellular_componentmitochondrial inner membrane
d0006120biological_processmitochondrial electron transport, NADH to ubiquinone
d0032981biological_processmitochondrial respiratory chain complex I assembly
d0045271cellular_componentrespiratory chain complex I
e0005739cellular_componentmitochondrion
e0005743cellular_componentmitochondrial inner membrane
e0005758cellular_componentmitochondrial intermembrane space
e0032981biological_processmitochondrial respiratory chain complex I assembly
e0045271cellular_componentrespiratory chain complex I
f0005739cellular_componentmitochondrion
f0005743cellular_componentmitochondrial inner membrane
f0032981biological_processmitochondrial respiratory chain complex I assembly
f0045271cellular_componentrespiratory chain complex I
g0005739cellular_componentmitochondrion
g0005743cellular_componentmitochondrial inner membrane
g0032981biological_processmitochondrial respiratory chain complex I assembly
g0045271cellular_componentrespiratory chain complex I
h0005739cellular_componentmitochondrion
h0005743cellular_componentmitochondrial inner membrane
h0032981biological_processmitochondrial respiratory chain complex I assembly
h0045271cellular_componentrespiratory chain complex I
i0005654cellular_componentnucleoplasm
i0005739cellular_componentmitochondrion
i0005743cellular_componentmitochondrial inner membrane
i0006120biological_processmitochondrial electron transport, NADH to ubiquinone
i0031966cellular_componentmitochondrial membrane
i0032981biological_processmitochondrial respiratory chain complex I assembly
i0042775biological_processmitochondrial ATP synthesis coupled electron transport
i0045271cellular_componentrespiratory chain complex I
j0005739cellular_componentmitochondrion
j0005743cellular_componentmitochondrial inner membrane
j0032981biological_processmitochondrial respiratory chain complex I assembly
j0045271cellular_componentrespiratory chain complex I
k0005739cellular_componentmitochondrion
k0005743cellular_componentmitochondrial inner membrane
k0022900biological_processelectron transport chain
k0032981biological_processmitochondrial respiratory chain complex I assembly
k0045271cellular_componentrespiratory chain complex I
l0005739cellular_componentmitochondrion
l0005743cellular_componentmitochondrial inner membrane
l0006120biological_processmitochondrial electron transport, NADH to ubiquinone
l0032981biological_processmitochondrial respiratory chain complex I assembly
l0045271cellular_componentrespiratory chain complex I
m0005739cellular_componentmitochondrion
m0005743cellular_componentmitochondrial inner membrane
m0032981biological_processmitochondrial respiratory chain complex I assembly
m0045271cellular_componentrespiratory chain complex I
n0005739cellular_componentmitochondrion
n0005743cellular_componentmitochondrial inner membrane
n0006120biological_processmitochondrial electron transport, NADH to ubiquinone
n0032981biological_processmitochondrial respiratory chain complex I assembly
n0045271cellular_componentrespiratory chain complex I
o0005739cellular_componentmitochondrion
o0005743cellular_componentmitochondrial inner membrane
o0005758cellular_componentmitochondrial intermembrane space
o0008137molecular_functionNADH dehydrogenase (ubiquinone) activity
o0032981biological_processmitochondrial respiratory chain complex I assembly
o0045271cellular_componentrespiratory chain complex I
o1902600biological_processproton transmembrane transport
p0005739cellular_componentmitochondrion
p0005743cellular_componentmitochondrial inner membrane
p0032981biological_processmitochondrial respiratory chain complex I assembly
p0045271cellular_componentrespiratory chain complex I
q0005739cellular_componentmitochondrion
q0005743cellular_componentmitochondrial inner membrane
q0006979biological_processresponse to oxidative stress
q0016020cellular_componentmembrane
q0032981biological_processmitochondrial respiratory chain complex I assembly
q0045271cellular_componentrespiratory chain complex I
r0005739cellular_componentmitochondrion
r0005743cellular_componentmitochondrial inner membrane
r0006120biological_processmitochondrial electron transport, NADH to ubiquinone
r0016491molecular_functionoxidoreductase activity
r0042773biological_processATP synthesis coupled electron transport
r0045271cellular_componentrespiratory chain complex I
s0005739cellular_componentmitochondrion
s0005743cellular_componentmitochondrial inner membrane
s0042775biological_processmitochondrial ATP synthesis coupled electron transport
s0045271cellular_componentrespiratory chain complex I
Functional Information from PROSITE/UniProt
site_idPS00012
Number of Residues16
DetailsPHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM
ChainResidueDetails
TASP39-MET54

site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI
ChainResidueDetails
TASP64-ILE76

site_idPS00198
Number of Residues12
Details4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP
ChainResidueDetails
ICYS77-PRO88
ICYS116-PRO127

site_idPS00535
Number of Residues12
DetailsCOMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK
ChainResidueDetails
DLEU83-LYS94

site_idPS00542
Number of Residues22
DetailsCOMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL
ChainResidueDetails
CGLU131-LEU152

site_idPS00641
Number of Residues18
DetailsCOMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC
ChainResidueDetails
GPRO38-CYS55

site_idPS00642
Number of Residues13
DetailsCOMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ
ChainResidueDetails
GCYS105-GLN117

site_idPS00643
Number of Residues11
DetailsCOMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF
ChainResidueDetails
GARG152-PHE162

site_idPS00644
Number of Residues16
DetailsCOMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES
ChainResidueDetails
FGLY180-SER195

site_idPS00645
Number of Residues12
DetailsCOMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG
ChainResidueDetails
FGLU357-GLY368

site_idPS00667
Number of Residues16
DetailsCOMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpIaDAIKLFiKE
ChainResidueDetails
HGLY44-GLU59

site_idPS00668
Number of Residues14
DetailsCOMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLTEGEseLVs.G
ChainResidueDetails
HPRO197-GLY210

site_idPS01099
Number of Residues19
DetailsCOMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP
ChainResidueDetails
EASP134-PRO152

site_idPS01150
Number of Residues17
DetailsCOMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP
ChainResidueDetails
BGLY135-PRO151

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues60
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ALEU3-TRP23
NASN274-MET294
NPHE325-VAL345
MILE393-MET413
MALA435-LEU455
LMET482-LEU502
LGLY582-PHE602
APHE55-LEU75
ALEU84-TYR104
NMET96-PRO116
NILE122-LEU142
NILE145-GLY165
NILE178-PRO198
NMET200-MET220
NILE239-GLY259

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-formylmethionine => ECO:0000269|PubMed:17060615
ChainResidueDetails
AFME1
VLYS59
GCYS108
GCYS114

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O95168
ChainResidueDetails
mSER25
kHIS6
kHIS8

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9CQZ6
ChainResidueDetails
kLYS22
FLYS355

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9CPP6
ChainResidueDetails
VLYS97

226707

PDB entries from 2024-10-30

PDB statisticsPDBj update infoContact PDBjnumon