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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7QSC

GTPase IN COMPLEX WITH GDP.MGF3-

Functional Information from GO Data
ChainGOidnamespacecontents
A0007165biological_processsignal transduction
B0000166molecular_functionnucleotide binding
B0000281biological_processmitotic cytokinesis
B0002363biological_processalpha-beta T cell lineage commitment
B0003189biological_processaortic valve formation
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0005938cellular_componentcell cortex
B0007264biological_processsmall GTPase-mediated signal transduction
B0007266biological_processRho protein signal transduction
B0009898cellular_componentcytoplasmic side of plasma membrane
B0010812biological_processnegative regulation of cell-substrate adhesion
B0016477biological_processcell migration
B0016787molecular_functionhydrolase activity
B0017022molecular_functionmyosin binding
B0019901molecular_functionprotein kinase binding
B0021762biological_processsubstantia nigra development
B0030027cellular_componentlamellipodium
B0030036biological_processactin cytoskeleton organization
B0030054cellular_componentcell junction
B0030334biological_processregulation of cell migration
B0030335biological_processpositive regulation of cell migration
B0030425cellular_componentdendrite
B0030496cellular_componentmidbody
B0030667cellular_componentsecretory granule membrane
B0031122biological_processcytoplasmic microtubule organization
B0031982cellular_componentvesicle
B0032154cellular_componentcleavage furrow
B0032467biological_processpositive regulation of cytokinesis
B0032587cellular_componentruffle membrane
B0032956biological_processregulation of actin cytoskeleton organization
B0033688biological_processregulation of osteoblast proliferation
B0034329biological_processcell junction assembly
B0034446biological_processsubstrate adhesion-dependent cell spreading
B0035385biological_processRoundabout signaling pathway
B0036089biological_processcleavage furrow formation
B0038027biological_processapolipoprotein A-I-mediated signaling pathway
B0042476biological_processodontogenesis
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043149biological_processstress fiber assembly
B0043197cellular_componentdendritic spine
B0043296cellular_componentapical junction complex
B0043297biological_processapical junction assembly
B0043366biological_processbeta selection
B0043542biological_processendothelial cell migration
B0043931biological_processossification involved in bone maturation
B0044319biological_processwound healing, spreading of cells
B0045198biological_processestablishment of epithelial cell apical/basal polarity
B0045666biological_processpositive regulation of neuron differentiation
B0045792biological_processnegative regulation of cell size
B0046638biological_processpositive regulation of alpha-beta T cell differentiation
B0050919biological_processnegative chemotaxis
B0051301biological_processcell division
B0051496biological_processpositive regulation of stress fiber assembly
B0051893biological_processregulation of focal adhesion assembly
B0060071biological_processWnt signaling pathway, planar cell polarity pathway
B0060193biological_processpositive regulation of lipase activity
B0061430biological_processbone trabecula morphogenesis
B0070062cellular_componentextracellular exosome
B0070507biological_processregulation of microtubule cytoskeleton organization
B0071222biological_processcellular response to lipopolysaccharide
B0071345biological_processcellular response to cytokine stimulus
B0071526biological_processsemaphorin-plexin signaling pathway
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0071944cellular_componentcell periphery
B0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
B0090307biological_processmitotic spindle assembly
B0090324biological_processnegative regulation of oxidative phosphorylation
B0097498biological_processendothelial tube lumen extension
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099159biological_processregulation of modification of postsynaptic structure
B0101003cellular_componentficolin-1-rich granule membrane
B1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
B1902766biological_processskeletal muscle satellite cell migration
B1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
B1903673biological_processmitotic cleavage furrow formation
B1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
B1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
B1990869biological_processcellular response to chemokine
B2000406biological_processpositive regulation of T cell migration
C0007165biological_processsignal transduction
D0000166molecular_functionnucleotide binding
D0000281biological_processmitotic cytokinesis
D0002363biological_processalpha-beta T cell lineage commitment
D0003189biological_processaortic valve formation
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005768cellular_componentendosome
D0005789cellular_componentendoplasmic reticulum membrane
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0005938cellular_componentcell cortex
D0007264biological_processsmall GTPase-mediated signal transduction
D0007266biological_processRho protein signal transduction
D0009898cellular_componentcytoplasmic side of plasma membrane
D0010812biological_processnegative regulation of cell-substrate adhesion
D0016477biological_processcell migration
D0016787molecular_functionhydrolase activity
D0017022molecular_functionmyosin binding
D0019901molecular_functionprotein kinase binding
D0021762biological_processsubstantia nigra development
D0030027cellular_componentlamellipodium
D0030036biological_processactin cytoskeleton organization
D0030054cellular_componentcell junction
D0030334biological_processregulation of cell migration
D0030335biological_processpositive regulation of cell migration
D0030425cellular_componentdendrite
D0030496cellular_componentmidbody
D0030667cellular_componentsecretory granule membrane
D0031122biological_processcytoplasmic microtubule organization
D0031982cellular_componentvesicle
D0032154cellular_componentcleavage furrow
D0032467biological_processpositive regulation of cytokinesis
D0032587cellular_componentruffle membrane
D0032956biological_processregulation of actin cytoskeleton organization
D0033688biological_processregulation of osteoblast proliferation
D0034329biological_processcell junction assembly
D0034446biological_processsubstrate adhesion-dependent cell spreading
D0035385biological_processRoundabout signaling pathway
D0036089biological_processcleavage furrow formation
D0038027biological_processapolipoprotein A-I-mediated signaling pathway
D0042476biological_processodontogenesis
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043149biological_processstress fiber assembly
D0043197cellular_componentdendritic spine
D0043296cellular_componentapical junction complex
D0043297biological_processapical junction assembly
D0043366biological_processbeta selection
D0043542biological_processendothelial cell migration
D0043931biological_processossification involved in bone maturation
D0044319biological_processwound healing, spreading of cells
D0045198biological_processestablishment of epithelial cell apical/basal polarity
D0045666biological_processpositive regulation of neuron differentiation
D0045792biological_processnegative regulation of cell size
D0046638biological_processpositive regulation of alpha-beta T cell differentiation
D0050919biological_processnegative chemotaxis
D0051301biological_processcell division
D0051496biological_processpositive regulation of stress fiber assembly
D0051893biological_processregulation of focal adhesion assembly
D0060071biological_processWnt signaling pathway, planar cell polarity pathway
D0060193biological_processpositive regulation of lipase activity
D0061430biological_processbone trabecula morphogenesis
D0070062cellular_componentextracellular exosome
D0070507biological_processregulation of microtubule cytoskeleton organization
D0071222biological_processcellular response to lipopolysaccharide
D0071345biological_processcellular response to cytokine stimulus
D0071526biological_processsemaphorin-plexin signaling pathway
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0071944cellular_componentcell periphery
D0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
D0090307biological_processmitotic spindle assembly
D0090324biological_processnegative regulation of oxidative phosphorylation
D0097498biological_processendothelial tube lumen extension
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099159biological_processregulation of modification of postsynaptic structure
D0101003cellular_componentficolin-1-rich granule membrane
D1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
D1902766biological_processskeletal muscle satellite cell migration
D1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
D1903673biological_processmitotic cleavage furrow formation
D1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
D1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
D1990869biological_processcellular response to chemokine
D2000406biological_processpositive regulation of T cell migration
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSite: {"description":"Arginine finger; crucial for GTP hydrolysis by stabilizing the transition state","evidences":[{"source":"PROSITE-ProRule","id":"PRU00172","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues34
DetailsRegion: {"description":"Switch II region; involved in RAP1GDS1 isoform 2 binding","evidences":[{"source":"PubMed","id":"30190425","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZHX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10748207","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12777804","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate","evidences":[{"source":"PubMed","id":"19362538","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) O-AMP-threonine; by Vibrio VopS","evidences":[{"source":"PubMed","id":"19039103","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) ADP-ribosylasparagine; by botulinum toxin","evidences":[{"source":"PubMed","id":"1328215","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"5-glutamyl serotonin","evidences":[{"source":"UniProtKB","id":"Q9QUI0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7775453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7777059","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23871831","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

245663

PDB entries from 2025-12-03

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