Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7QO1

complex of DNA ligase I and FEN1 on PCNA and DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003909	molecular_function	DNA ligase activity
A	0003910	molecular_function	DNA ligase (ATP) activity
A	0005524	molecular_function	ATP binding
A	0006281	biological_process	DNA repair
A	0006310	biological_process	DNA recombination
A	0071897	biological_process	DNA biosynthetic process
B	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
B	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
B	0000781	cellular_component	chromosome, telomeric region
B	0000785	cellular_component	chromatin
B	0003677	molecular_function	DNA binding
B	0003682	molecular_function	chromatin binding
B	0003684	molecular_function	damaged DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005652	cellular_component	nuclear lamina
B	0005654	cellular_component	nucleoplasm
B	0005657	cellular_component	replication fork
B	0005813	cellular_component	centrosome
B	0006260	biological_process	DNA replication
B	0006272	biological_process	leading strand elongation
B	0006275	biological_process	regulation of DNA replication
B	0006281	biological_process	DNA repair
B	0006298	biological_process	mismatch repair
B	0006325	biological_process	chromatin organization
B	0006974	biological_process	DNA damage response
B	0006979	biological_process	response to oxidative stress
B	0007507	biological_process	heart development
B	0019899	molecular_function	enzyme binding
B	0019985	biological_process	translesion synthesis
B	0030331	molecular_function	nuclear estrogen receptor binding
B	0030337	molecular_function	DNA polymerase processivity factor activity
B	0030855	biological_process	epithelial cell differentiation
B	0030894	cellular_component	replisome
B	0030971	molecular_function	receptor tyrosine kinase binding
B	0031297	biological_process	replication fork processing
B	0032139	molecular_function	dinucleotide insertion or deletion binding
B	0032355	biological_process	response to estradiol
B	0032405	molecular_function	MutLalpha complex binding
B	0033993	biological_process	response to lipid
B	0034644	biological_process	cellular response to UV
B	0035035	molecular_function	histone acetyltransferase binding
B	0042802	molecular_function	identical protein binding
B	0043596	cellular_component	nuclear replication fork
B	0043626	cellular_component	PCNA complex
B	0044849	biological_process	estrous cycle
B	0044877	molecular_function	protein-containing complex binding
B	0045739	biological_process	positive regulation of DNA repair
B	0045740	biological_process	positive regulation of DNA replication
B	0046686	biological_process	response to cadmium ion
B	0070062	cellular_component	extracellular exosome
B	0070182	molecular_function	DNA polymerase binding
B	0070301	biological_process	cellular response to hydrogen peroxide
B	0070557	cellular_component	PCNA-p21 complex
B	0071548	biological_process	response to dexamethasone
B	0097421	biological_process	liver regeneration
B	0140861	biological_process	DNA repair-dependent chromatin remodeling
B	1902065	biological_process	response to L-glutamate
B	1902969	biological_process	mitotic DNA replication
B	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication
F	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
F	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
F	0000781	cellular_component	chromosome, telomeric region
F	0000785	cellular_component	chromatin
F	0003677	molecular_function	DNA binding
F	0003682	molecular_function	chromatin binding
F	0003684	molecular_function	damaged DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005652	cellular_component	nuclear lamina
F	0005654	cellular_component	nucleoplasm
F	0005657	cellular_component	replication fork
F	0005813	cellular_component	centrosome
F	0006260	biological_process	DNA replication
F	0006272	biological_process	leading strand elongation
F	0006275	biological_process	regulation of DNA replication
F	0006281	biological_process	DNA repair
F	0006298	biological_process	mismatch repair
F	0006325	biological_process	chromatin organization
F	0006974	biological_process	DNA damage response
F	0006979	biological_process	response to oxidative stress
F	0007507	biological_process	heart development
F	0019899	molecular_function	enzyme binding
F	0019985	biological_process	translesion synthesis
F	0030331	molecular_function	nuclear estrogen receptor binding
F	0030337	molecular_function	DNA polymerase processivity factor activity
F	0030855	biological_process	epithelial cell differentiation
F	0030894	cellular_component	replisome
F	0030971	molecular_function	receptor tyrosine kinase binding
F	0031297	biological_process	replication fork processing
F	0032139	molecular_function	dinucleotide insertion or deletion binding
F	0032355	biological_process	response to estradiol
F	0032405	molecular_function	MutLalpha complex binding
F	0033993	biological_process	response to lipid
F	0034644	biological_process	cellular response to UV
F	0035035	molecular_function	histone acetyltransferase binding
F	0042802	molecular_function	identical protein binding
F	0043596	cellular_component	nuclear replication fork
F	0043626	cellular_component	PCNA complex
F	0044849	biological_process	estrous cycle
F	0044877	molecular_function	protein-containing complex binding
F	0045739	biological_process	positive regulation of DNA repair
F	0045740	biological_process	positive regulation of DNA replication
F	0046686	biological_process	response to cadmium ion
F	0070062	cellular_component	extracellular exosome
F	0070182	molecular_function	DNA polymerase binding
F	0070301	biological_process	cellular response to hydrogen peroxide
F	0070557	cellular_component	PCNA-p21 complex
F	0071548	biological_process	response to dexamethasone
F	0097421	biological_process	liver regeneration
F	0140861	biological_process	DNA repair-dependent chromatin remodeling
F	1902065	biological_process	response to L-glutamate
F	1902969	biological_process	mitotic DNA replication
F	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication
G	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
G	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
G	0000781	cellular_component	chromosome, telomeric region
G	0000785	cellular_component	chromatin
G	0003677	molecular_function	DNA binding
G	0003682	molecular_function	chromatin binding
G	0003684	molecular_function	damaged DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005652	cellular_component	nuclear lamina
G	0005654	cellular_component	nucleoplasm
G	0005657	cellular_component	replication fork
G	0005813	cellular_component	centrosome
G	0006260	biological_process	DNA replication
G	0006272	biological_process	leading strand elongation
G	0006275	biological_process	regulation of DNA replication
G	0006281	biological_process	DNA repair
G	0006298	biological_process	mismatch repair
G	0006325	biological_process	chromatin organization
G	0006974	biological_process	DNA damage response
G	0006979	biological_process	response to oxidative stress
G	0007507	biological_process	heart development
G	0019899	molecular_function	enzyme binding
G	0019985	biological_process	translesion synthesis
G	0030331	molecular_function	nuclear estrogen receptor binding
G	0030337	molecular_function	DNA polymerase processivity factor activity
G	0030855	biological_process	epithelial cell differentiation
G	0030894	cellular_component	replisome
G	0030971	molecular_function	receptor tyrosine kinase binding
G	0031297	biological_process	replication fork processing
G	0032139	molecular_function	dinucleotide insertion or deletion binding
G	0032355	biological_process	response to estradiol
G	0032405	molecular_function	MutLalpha complex binding
G	0033993	biological_process	response to lipid
G	0034644	biological_process	cellular response to UV
G	0035035	molecular_function	histone acetyltransferase binding
G	0042802	molecular_function	identical protein binding
G	0043596	cellular_component	nuclear replication fork
G	0043626	cellular_component	PCNA complex
G	0044849	biological_process	estrous cycle
G	0044877	molecular_function	protein-containing complex binding
G	0045739	biological_process	positive regulation of DNA repair
G	0045740	biological_process	positive regulation of DNA replication
G	0046686	biological_process	response to cadmium ion
G	0070062	cellular_component	extracellular exosome
G	0070182	molecular_function	DNA polymerase binding
G	0070301	biological_process	cellular response to hydrogen peroxide
G	0070557	cellular_component	PCNA-p21 complex
G	0071548	biological_process	response to dexamethasone
G	0097421	biological_process	liver regeneration
G	0140861	biological_process	DNA repair-dependent chromatin remodeling
G	1902065	biological_process	response to L-glutamate
G	1902969	biological_process	mitotic DNA replication
G	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication
Y	0000287	molecular_function	magnesium ion binding
Y	0000724	biological_process	double-strand break repair via homologous recombination
Y	0000781	cellular_component	chromosome, telomeric region
Y	0003677	molecular_function	DNA binding
Y	0003684	molecular_function	damaged DNA binding
Y	0003690	molecular_function	double-stranded DNA binding
Y	0003824	molecular_function	catalytic activity
Y	0004518	molecular_function	nuclease activity
Y	0004519	molecular_function	endonuclease activity
Y	0004520	molecular_function	DNA endonuclease activity
Y	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
Y	0004527	molecular_function	exonuclease activity
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005730	cellular_component	nucleolus
Y	0005739	cellular_component	mitochondrion
Y	0006260	biological_process	DNA replication
Y	0006281	biological_process	DNA repair
Y	0006284	biological_process	base-excision repair
Y	0006287	biological_process	base-excision repair, gap-filling
Y	0006302	biological_process	double-strand break repair
Y	0006310	biological_process	DNA recombination
Y	0006974	biological_process	DNA damage response
Y	0007613	biological_process	memory
Y	0008309	molecular_function	double-stranded DNA exodeoxyribonuclease activity
Y	0008409	molecular_function	5'-3' exonuclease activity
Y	0009650	biological_process	UV protection
Y	0016020	cellular_component	membrane
Y	0016787	molecular_function	hydrolase activity
Y	0016788	molecular_function	hydrolase activity, acting on ester bonds
Y	0017108	molecular_function	5'-flap endonuclease activity
Y	0030145	molecular_function	manganese ion binding
Y	0032201	biological_process	telomere maintenance via semi-conservative replication
Y	0032991	cellular_component	protein-containing complex
Y	0043137	biological_process	DNA replication, removal of RNA primer
Y	0045876	biological_process	positive regulation of sister chromatid cohesion
Y	0046872	molecular_function	metal ion binding
Y	0048256	molecular_function	flap endonuclease activity

Functional Information from PROSITE/UniProt

site_id	PS00293
Number of Residues	19
Details	PCNA_2 Proliferating cell nuclear antigen signature 2. RCDRnlaMgvnLtSMsKIL

Chain	Residue	Details
B	ARG61-LEU79

site_id	PS00333
Number of Residues	27
Details	DNA_LIGASE_A2 ATP-dependent DNA ligase signature 2. EGLMVKtldvdat.YEiakrs.Hnwl..KLK

Chain	Residue	Details
A	GLU720-LYS746

site_id	PS00697
Number of Residues	9
Details	DNA_LIGASE_A1 ATP-dependent DNA ligase AMP-binding site. EYKYDGQRA

Chain	Residue	Details
A	GLU566-ALA574

site_id	PS00841
Number of Residues	15
Details	XPG_1 XPG protein signature 1. IKPvYVFDGkpPqLK

Chain	Residue	Details
Y	ILE79-LYS93

site_id	PS00842
Number of Residues	15
Details	XPG_2 XPG protein signature 2. GIPYLdAPsEAEASC

Chain	Residue	Details
Y	GLY149-CYS163

site_id	PS01251
Number of Residues	24
Details	PCNA_1 Proliferating cell nuclear antigen signature 1. GVnLqSMDsSHVsLVqLtLrsegF

Chain	Residue	Details
B	GLY34-PHE57

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	11
Details	Region: {"description":"Interaction with target DNA"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"N6-AMP-lysine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10135","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15565146","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1X9N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Interaction with target DNA"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	57
Details	DNA binding: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	279
Details	Region: {"description":"Interaction with NUDT15","evidences":[{"source":"PubMed","id":"19419956","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19419956","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	10
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	3
Details	Modified residue: {"description":"Phosphotyrosine; by EGFR","evidences":[{"source":"PubMed","id":"17115032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38459011","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"17108083","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17130289","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	8
Details	Region: {"description":"Interaction with PCNA","evidences":[{"source":"PubMed","id":"9305916","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15616578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UL1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15616578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FV7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15616578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"5FV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"5ZOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	2
Details	Modified residue: {"description":"Symmetric dimethylarginine; by PRMT5","evidences":[{"source":"HAMAP-Rule","id":"MF_03140","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20729856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by CDK2","evidences":[{"source":"HAMAP-Rule","id":"MF_03140","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20729856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)