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7QO1

complex of DNA ligase I and FEN1 on PCNA and DNA

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003909molecular_functionDNA ligase activity
A0003910molecular_functionDNA ligase (ATP) activity
A0005524molecular_functionATP binding
A0006281biological_processDNA repair
A0006310biological_processDNA recombination
A0071897biological_processDNA biosynthetic process
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
B0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
B0000781cellular_componentchromosome, telomeric region
B0000785cellular_componentchromatin
B0001673cellular_componentmale germ cell nucleus
B0003677molecular_functionDNA binding
B0003682molecular_functionchromatin binding
B0003684molecular_functiondamaged DNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005652cellular_componentnuclear lamina
B0005654cellular_componentnucleoplasm
B0005657cellular_componentreplication fork
B0005813cellular_componentcentrosome
B0006260biological_processDNA replication
B0006272biological_processleading strand elongation
B0006275biological_processregulation of DNA replication
B0006281biological_processDNA repair
B0006287biological_processbase-excision repair, gap-filling
B0006298biological_processmismatch repair
B0006979biological_processresponse to oxidative stress
B0007507biological_processheart development
B0016604cellular_componentnuclear body
B0019899molecular_functionenzyme binding
B0019985biological_processtranslesion synthesis
B0030331molecular_functionnuclear estrogen receptor binding
B0030337molecular_functionDNA polymerase processivity factor activity
B0030855biological_processepithelial cell differentiation
B0030894cellular_componentreplisome
B0030971molecular_functionreceptor tyrosine kinase binding
B0031297biological_processreplication fork processing
B0032077biological_processpositive regulation of deoxyribonuclease activity
B0032139molecular_functiondinucleotide insertion or deletion binding
B0032355biological_processresponse to estradiol
B0032405molecular_functionMutLalpha complex binding
B0033993biological_processresponse to lipid
B0034644biological_processcellular response to UV
B0035035molecular_functionhistone acetyltransferase binding
B0042802molecular_functionidentical protein binding
B0043596cellular_componentnuclear replication fork
B0043626cellular_componentPCNA complex
B0044849biological_processestrous cycle
B0044877molecular_functionprotein-containing complex binding
B0045739biological_processpositive regulation of DNA repair
B0045740biological_processpositive regulation of DNA replication
B0046686biological_processresponse to cadmium ion
B0070062cellular_componentextracellular exosome
B0070182molecular_functionDNA polymerase binding
B0070301biological_processcellular response to hydrogen peroxide
B0070557cellular_componentPCNA-p21 complex
B0071466biological_processcellular response to xenobiotic stimulus
B0071548biological_processresponse to dexamethasone
B0097421biological_processliver regeneration
B1900264biological_processpositive regulation of DNA-directed DNA polymerase activity
B1902065biological_processresponse to L-glutamate
B1902990biological_processmitotic telomere maintenance via semi-conservative replication
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
F0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
F0000781cellular_componentchromosome, telomeric region
F0000785cellular_componentchromatin
F0001673cellular_componentmale germ cell nucleus
F0003677molecular_functionDNA binding
F0003682molecular_functionchromatin binding
F0003684molecular_functiondamaged DNA binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005652cellular_componentnuclear lamina
F0005654cellular_componentnucleoplasm
F0005657cellular_componentreplication fork
F0005813cellular_componentcentrosome
F0006260biological_processDNA replication
F0006272biological_processleading strand elongation
F0006275biological_processregulation of DNA replication
F0006281biological_processDNA repair
F0006287biological_processbase-excision repair, gap-filling
F0006298biological_processmismatch repair
F0006979biological_processresponse to oxidative stress
F0007507biological_processheart development
F0016604cellular_componentnuclear body
F0019899molecular_functionenzyme binding
F0019985biological_processtranslesion synthesis
F0030331molecular_functionnuclear estrogen receptor binding
F0030337molecular_functionDNA polymerase processivity factor activity
F0030855biological_processepithelial cell differentiation
F0030894cellular_componentreplisome
F0030971molecular_functionreceptor tyrosine kinase binding
F0031297biological_processreplication fork processing
F0032077biological_processpositive regulation of deoxyribonuclease activity
F0032139molecular_functiondinucleotide insertion or deletion binding
F0032355biological_processresponse to estradiol
F0032405molecular_functionMutLalpha complex binding
F0033993biological_processresponse to lipid
F0034644biological_processcellular response to UV
F0035035molecular_functionhistone acetyltransferase binding
F0042802molecular_functionidentical protein binding
F0043596cellular_componentnuclear replication fork
F0043626cellular_componentPCNA complex
F0044849biological_processestrous cycle
F0044877molecular_functionprotein-containing complex binding
F0045739biological_processpositive regulation of DNA repair
F0045740biological_processpositive regulation of DNA replication
F0046686biological_processresponse to cadmium ion
F0070062cellular_componentextracellular exosome
F0070182molecular_functionDNA polymerase binding
F0070301biological_processcellular response to hydrogen peroxide
F0070557cellular_componentPCNA-p21 complex
F0071466biological_processcellular response to xenobiotic stimulus
F0071548biological_processresponse to dexamethasone
F0097421biological_processliver regeneration
F1900264biological_processpositive regulation of DNA-directed DNA polymerase activity
F1902065biological_processresponse to L-glutamate
F1902990biological_processmitotic telomere maintenance via semi-conservative replication
G0000122biological_processnegative regulation of transcription by RNA polymerase II
G0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
G0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
G0000781cellular_componentchromosome, telomeric region
G0000785cellular_componentchromatin
G0001673cellular_componentmale germ cell nucleus
G0003677molecular_functionDNA binding
G0003682molecular_functionchromatin binding
G0003684molecular_functiondamaged DNA binding
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005652cellular_componentnuclear lamina
G0005654cellular_componentnucleoplasm
G0005657cellular_componentreplication fork
G0005813cellular_componentcentrosome
G0006260biological_processDNA replication
G0006272biological_processleading strand elongation
G0006275biological_processregulation of DNA replication
G0006281biological_processDNA repair
G0006287biological_processbase-excision repair, gap-filling
G0006298biological_processmismatch repair
G0006979biological_processresponse to oxidative stress
G0007507biological_processheart development
G0016604cellular_componentnuclear body
G0019899molecular_functionenzyme binding
G0019985biological_processtranslesion synthesis
G0030331molecular_functionnuclear estrogen receptor binding
G0030337molecular_functionDNA polymerase processivity factor activity
G0030855biological_processepithelial cell differentiation
G0030894cellular_componentreplisome
G0030971molecular_functionreceptor tyrosine kinase binding
G0031297biological_processreplication fork processing
G0032077biological_processpositive regulation of deoxyribonuclease activity
G0032139molecular_functiondinucleotide insertion or deletion binding
G0032355biological_processresponse to estradiol
G0032405molecular_functionMutLalpha complex binding
G0033993biological_processresponse to lipid
G0034644biological_processcellular response to UV
G0035035molecular_functionhistone acetyltransferase binding
G0042802molecular_functionidentical protein binding
G0043596cellular_componentnuclear replication fork
G0043626cellular_componentPCNA complex
G0044849biological_processestrous cycle
G0044877molecular_functionprotein-containing complex binding
G0045739biological_processpositive regulation of DNA repair
G0045740biological_processpositive regulation of DNA replication
G0046686biological_processresponse to cadmium ion
G0070062cellular_componentextracellular exosome
G0070182molecular_functionDNA polymerase binding
G0070301biological_processcellular response to hydrogen peroxide
G0070557cellular_componentPCNA-p21 complex
G0071466biological_processcellular response to xenobiotic stimulus
G0071548biological_processresponse to dexamethasone
G0097421biological_processliver regeneration
G1900264biological_processpositive regulation of DNA-directed DNA polymerase activity
G1902065biological_processresponse to L-glutamate
G1902990biological_processmitotic telomere maintenance via semi-conservative replication
Y0000287molecular_functionmagnesium ion binding
Y0000724biological_processdouble-strand break repair via homologous recombination
Y0000781cellular_componentchromosome, telomeric region
Y0003677molecular_functionDNA binding
Y0003684molecular_functiondamaged DNA binding
Y0003690molecular_functiondouble-stranded DNA binding
Y0003824molecular_functioncatalytic activity
Y0004518molecular_functionnuclease activity
Y0004519molecular_functionendonuclease activity
Y0004523molecular_functionRNA-DNA hybrid ribonuclease activity
Y0004527molecular_functionexonuclease activity
Y0005515molecular_functionprotein binding
Y0005634cellular_componentnucleus
Y0005654cellular_componentnucleoplasm
Y0005730cellular_componentnucleolus
Y0005739cellular_componentmitochondrion
Y0006260biological_processDNA replication
Y0006281biological_processDNA repair
Y0006284biological_processbase-excision repair
Y0006287biological_processbase-excision repair, gap-filling
Y0006302biological_processdouble-strand break repair
Y0007613biological_processmemory
Y0008309molecular_functiondouble-stranded DNA exodeoxyribonuclease activity
Y0008409molecular_function5'-3' exonuclease activity
Y0009650biological_processUV protection
Y0016020cellular_componentmembrane
Y0016788molecular_functionhydrolase activity, acting on ester bonds
Y0017108molecular_function5'-flap endonuclease activity
Y0030145molecular_functionmanganese ion binding
Y0032201biological_processtelomere maintenance via semi-conservative replication
Y0032991cellular_componentprotein-containing complex
Y0043137biological_processDNA replication, removal of RNA primer
Y0045876biological_processpositive regulation of sister chromatid cohesion
Y0046872molecular_functionmetal ion binding
Y0048256molecular_functionflap endonuclease activity
Y0090304biological_processnucleic acid metabolic process
Functional Information from PROSITE/UniProt
site_idPS00293
Number of Residues19
DetailsPCNA_2 Proliferating cell nuclear antigen signature 2. RCDRnlaMgvnLtSMsKIL
ChainResidueDetails
BARG61-LEU79

site_idPS00333
Number of Residues27
DetailsDNA_LIGASE_A2 ATP-dependent DNA ligase signature 2. EGLMVKtldvdat.YEiakrs.Hnwl..KLK
ChainResidueDetails
AGLU720-LYS746

site_idPS00697
Number of Residues9
DetailsDNA_LIGASE_A1 ATP-dependent DNA ligase AMP-binding site. EYKYDGQRA
ChainResidueDetails
AGLU566-ALA574

site_idPS00841
Number of Residues15
DetailsXPG_1 XPG protein signature 1. IKPvYVFDGkpPqLK
ChainResidueDetails
YILE79-LYS93

site_idPS00842
Number of Residues15
DetailsXPG_2 XPG protein signature 2. GIPYLdAPsEAEASC
ChainResidueDetails
YGLY149-CYS163

site_idPS01251
Number of Residues24
DetailsPCNA_1 Proliferating cell nuclear antigen signature 1. GVnLqSMDsSHVsLVqLtLrsegF
ChainResidueDetails
BGLY34-PHE57

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:15616578, ECO:0007744|PDB:1UL1
ChainResidueDetails
YASP34
FARG61-LYS80
GARG61-LYS80

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING:
ChainResidueDetails
YARG47
YARG70
YGLY231
ALYS744

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:15616578, ECO:0007744|PDB:1UL1, ECO:0007744|PDB:5FV7
ChainResidueDetails
YASP86
YGLU158
BLYS248
FLYS77
FLYS80
FLYS248
GLYS77
GLYS80
GLYS248

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:15616578, ECO:0007744|PDB:1UL1, ECO:0007744|PDB:5FV7, ECO:0007744|PDB:5ZOD
ChainResidueDetails
YGLU160
YALA181
GTYR211
ALYS795

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:5FV7, ECO:0007744|PDB:5ZOD
ChainResidueDetails
YASP179
FLYS164
GLYS164

site_idSWS_FT_FI6
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:5ZOD
ChainResidueDetails
YASP233
BLYS254
ASER230
FLYS254
ASER819
GLYS254

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Symmetric dimethylarginine; by PRMT5 => ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:20729856
ChainResidueDetails
YARG19
YARG100
YARG104
YARG192

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
YLYS80
ATHR798

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK2 => ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:20729856
ChainResidueDetails
YSER187

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
YSER197

site_idSWS_FT_FI11
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
YSER255
YSER293
YSER335

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
YTHR336

site_idSWS_FT_FI13
Number of Residues3
DetailsMOD_RES: N6-acetyllysine => ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:11430825
ChainResidueDetails
YLYS354
YLYS377
YLYS380

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231
ChainResidueDetails
YTHR364

site_idSWS_FT_FI15
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:11430825, ECO:0007744|PubMed:19608861
ChainResidueDetails
YLYS375

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PDB entries from 2024-07-10

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