7QI1

Crystal structure of human 14-3-3 protein beta in complex with CFTR peptide pS753pS768 and PPI stabilizer CY007424

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG43-VAL53

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site_id	PS00797
Number of Residues	20
Details	1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS

Chain	Residue	Details
A	TYR213-SER232

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	SITE: Interaction with phosphoserine on interacting protein

Chain	Residue	Details
A	ARG58
A	ARG129
B	ARG58
B	ARG129
C	ARG58
C	ARG129
D	ARG58
D	ARG129

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N-acetylmethionine => ECO:0000269|Ref.8, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712

Chain	Residue	Details
A	MET3
B	MET3
C	MET3
D	MET3

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site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS5
D	LYS5
D	LYS70
D	LYS117
A	LYS70
A	LYS117
B	LYS5
B	LYS70
B	LYS117
C	LYS5
C	LYS70
C	LYS117

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS51
B	LYS51
C	LYS51
D	LYS51

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:Q9CQV8

Chain	Residue	Details
A	TYR84
A	TYR106
B	TYR84
B	TYR106
C	TYR84
C	TYR106
D	TYR84
D	TYR106

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site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68254

Chain	Residue	Details
A	ASP94
B	ASP94
C	ASP94
D	ASP94

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site_id	SWS_FT_FI7
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS51
B	LYS51
C	LYS51
D	LYS51

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