7QGM

Human CD73 (ecto 5'-nucleotidase) in complex with MRS4598 (a 3-methyl-CMPCP derivative, compound 16 in paper) in the closed state (crystal form III)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0009166	biological_process	nucleotide catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016788	molecular_function	hydrolase activity, acting on ester bonds
A	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00785
Number of Residues	13
Details	5_NUCLEOTIDASE_1 5'-nucleotidase signature 1. LtILHTnDvHSrL

Chain	Residue	Details
A	LEU29-LEU41

---

site_id	PS00786
Number of Residues	12
Details	5_NUCLEOTIDASE_2 5'-nucleotidase signature 2. YdamaLGNHEFD

Chain	Residue	Details
A	TYR110-ASP121

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:22997138, ECO:0000269|PubMed:23142347, ECO:0000269|PubMed:34403084, ECO:0007744|PDB:4H1S, ECO:0007744|PDB:7P9N

Chain	Residue	Details
A	ASP36

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:22997138, ECO:0000269|PubMed:23142347, ECO:0000269|PubMed:34403084, ECO:0007744|PDB:4H1S, ECO:0007744|PDB:4H1Y, ECO:0007744|PDB:4H2B, ECO:0007744|PDB:4H2G, ECO:0007744|PDB:4H2I, ECO:0007744|PDB:7P9N

Chain	Residue	Details
A	HIS38

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:22997138, ECO:0000269|PubMed:23142347, ECO:0000269|PubMed:34403084, ECO:0007744|PDB:4H1S, ECO:0007744|PDB:4H1Y, ECO:0007744|PDB:4H2B, ECO:0007744|PDB:4H2F, ECO:0007744|PDB:4H2G, ECO:0007744|PDB:4H2I, ECO:0007744|PDB:7P9N

Chain	Residue	Details
A	ASP85
A	ASN117
A	HIS220
A	HIS243

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:34403084, ECO:0007744|PDB:7PBA

Chain	Residue	Details
A	ARG354
A	ASN390
A	ARG395
A	PHE417
A	PHE500
A	ASP506

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000269|PubMed:23142347

Chain	Residue	Details
A	HIS118

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000305|PubMed:23142347

Chain	Residue	Details
A	ASP121

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	LIPID: GPI-anchor amidated serine => ECO:0000269|PubMed:2129526

Chain	Residue	Details
A	SER549

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASP53

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22997138, ECO:0000269|PubMed:23142347

Chain	Residue	Details
A	ASP311

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973

Chain	Residue	Details
A	ASP333

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASP403

---