7QEW

human Connexin 26 class 2 hexamer at 90mmHg PCO2, pH7.4

Functional Information from GO Data

Chain	GOid	namespace	contents
G	0005922	cellular_component	connexin complex
G	0007154	biological_process	cell communication
H	0005922	cellular_component	connexin complex
H	0007154	biological_process	cell communication
I	0005922	cellular_component	connexin complex
I	0007154	biological_process	cell communication
J	0005922	cellular_component	connexin complex
J	0007154	biological_process	cell communication
K	0005922	cellular_component	connexin complex
K	0007154	biological_process	cell communication
L	0005922	cellular_component	connexin complex
L	0007154	biological_process	cell communication

Functional Information from PROSITE/UniProt

site_id	PS00407
Number of Residues	14
Details	CONNEXINS_1 Connexins signature 1. CNTlQPGCknVCYD

Chain	Residue	Details
G	CYS53-ASP66

---

site_id	PS00408
Number of Residues	17
Details	CONNEXINS_2 Connexins signature 2. Cnaw.PCpntVDCFVSRP

Chain	Residue	Details
G	CYS169-PRO185

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	66
Details	INTRAMEM: INTRAMEM => ECO:0000269|PubMed:26753910

Chain	Residue	Details
G	ASP2-VAL13
H	ASP2-VAL13
I	ASP2-VAL13
J	ASP2-VAL13
K	ASP2-VAL13
L	ASP2-VAL13

---

site_id	SWS_FT_FI2
Number of Residues	366
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26753910

Chain	Residue	Details
G	ASN14-ILE20
J	ASN14-ILE20
J	VAL95-THR135
J	CYS211-VAL226
K	ASN14-ILE20
K	VAL95-THR135
K	CYS211-VAL226
L	ASN14-ILE20
L	VAL95-THR135
L	CYS211-VAL226
G	VAL95-THR135
G	CYS211-VAL226
H	ASN14-ILE20
H	VAL95-THR135
H	CYS211-VAL226
I	ASN14-ILE20
I	VAL95-THR135
I	CYS211-VAL226

---

site_id	SWS_FT_FI3
Number of Residues	474
Details	TRANSMEM: Helical => ECO:0000269|PubMed:26753910

Chain	Residue	Details
G	GLY21-ALA40
I	ILE74-HIS94
I	TYR136-VAL156
I	VAL190-LEU210
J	GLY21-ALA40
J	ILE74-HIS94
J	TYR136-VAL156
J	VAL190-LEU210
K	GLY21-ALA40
K	ILE74-HIS94
K	TYR136-VAL156
G	ILE74-HIS94
K	VAL190-LEU210
L	GLY21-ALA40
L	ILE74-HIS94
L	TYR136-VAL156
L	VAL190-LEU210
G	TYR136-VAL156
G	VAL190-LEU210
H	GLY21-ALA40
H	ILE74-HIS94
H	TYR136-VAL156
H	VAL190-LEU210
I	GLY21-ALA40

---

site_id	SWS_FT_FI4
Number of Residues	384
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:26753910

Chain	Residue	Details
G	LYS41-HIS73
K	MET157-THR189
L	LYS41-HIS73
L	MET157-THR189
G	MET157-THR189
H	LYS41-HIS73
H	MET157-THR189
I	LYS41-HIS73
I	MET157-THR189
J	LYS41-HIS73
J	MET157-THR189
K	LYS41-HIS73

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: in other chain => ECO:0000305|PubMed:26753910, ECO:0007744|PDB:5ER7

Chain	Residue	Details
G	GLU42
H	GLU42
I	GLU42
J	GLU42
K	GLU42
L	GLU42

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305|PubMed:26753910, ECO:0007744|PDB:5ER7

Chain	Residue	Details
G	GLY45
K	GLU47
L	GLY45
L	GLU47
G	GLU47
H	GLY45
H	GLU47
I	GLY45
I	GLU47
J	GLY45
J	GLU47
K	GLY45

---