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7QEW

human Connexin 26 class 2 hexamer at 90mmHg PCO2, pH7.4

Functional Information from GO Data
ChainGOidnamespacecontents
G0002931biological_processresponse to ischemia
G0005243molecular_functiongap junction channel activity
G0005509molecular_functioncalcium ion binding
G0005515molecular_functionprotein binding
G0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
G0005886cellular_componentplasma membrane
G0005921cellular_componentgap junction
G0005922cellular_componentconnexin complex
G0007154biological_processcell communication
G0007267biological_processcell-cell signaling
G0007565biological_processfemale pregnancy
G0007605biological_processsensory perception of sound
G0010644biological_processcell communication by electrical coupling
G0016264biological_processgap junction assembly
G0016328cellular_componentlateral plasma membrane
G0030054cellular_componentcell junction
G0032355biological_processresponse to estradiol
G0032496biological_processresponse to lipopolysaccharide
G0032526biological_processresponse to retinoic acid
G0032570biological_processresponse to progesterone
G0034599biological_processcellular response to oxidative stress
G0042802molecular_functionidentical protein binding
G0044297cellular_componentcell body
G0044752biological_processresponse to human chorionic gonadotropin
G0046697biological_processdecidualization
G0046872molecular_functionmetal ion binding
G0048471cellular_componentperinuclear region of cytoplasm
G0048839biological_processinner ear development
G0055085biological_processtransmembrane transport
G0071377biological_processcellular response to glucagon stimulus
G0071549biological_processcellular response to dexamethasone stimulus
G0097449cellular_componentastrocyte projection
G1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
G1905867biological_processepididymis development
G1990349biological_processgap junction-mediated intercellular transport
H0002931biological_processresponse to ischemia
H0005243molecular_functiongap junction channel activity
H0005509molecular_functioncalcium ion binding
H0005515molecular_functionprotein binding
H0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
H0005886cellular_componentplasma membrane
H0005921cellular_componentgap junction
H0005922cellular_componentconnexin complex
H0007154biological_processcell communication
H0007267biological_processcell-cell signaling
H0007565biological_processfemale pregnancy
H0007605biological_processsensory perception of sound
H0010644biological_processcell communication by electrical coupling
H0016264biological_processgap junction assembly
H0016328cellular_componentlateral plasma membrane
H0030054cellular_componentcell junction
H0032355biological_processresponse to estradiol
H0032496biological_processresponse to lipopolysaccharide
H0032526biological_processresponse to retinoic acid
H0032570biological_processresponse to progesterone
H0034599biological_processcellular response to oxidative stress
H0042802molecular_functionidentical protein binding
H0044297cellular_componentcell body
H0044752biological_processresponse to human chorionic gonadotropin
H0046697biological_processdecidualization
H0046872molecular_functionmetal ion binding
H0048471cellular_componentperinuclear region of cytoplasm
H0048839biological_processinner ear development
H0055085biological_processtransmembrane transport
H0071377biological_processcellular response to glucagon stimulus
H0071549biological_processcellular response to dexamethasone stimulus
H0097449cellular_componentastrocyte projection
H1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
H1905867biological_processepididymis development
H1990349biological_processgap junction-mediated intercellular transport
I0002931biological_processresponse to ischemia
I0005243molecular_functiongap junction channel activity
I0005509molecular_functioncalcium ion binding
I0005515molecular_functionprotein binding
I0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
I0005886cellular_componentplasma membrane
I0005921cellular_componentgap junction
I0005922cellular_componentconnexin complex
I0007154biological_processcell communication
I0007267biological_processcell-cell signaling
I0007565biological_processfemale pregnancy
I0007605biological_processsensory perception of sound
I0010644biological_processcell communication by electrical coupling
I0016264biological_processgap junction assembly
I0016328cellular_componentlateral plasma membrane
I0030054cellular_componentcell junction
I0032355biological_processresponse to estradiol
I0032496biological_processresponse to lipopolysaccharide
I0032526biological_processresponse to retinoic acid
I0032570biological_processresponse to progesterone
I0034599biological_processcellular response to oxidative stress
I0042802molecular_functionidentical protein binding
I0044297cellular_componentcell body
I0044752biological_processresponse to human chorionic gonadotropin
I0046697biological_processdecidualization
I0046872molecular_functionmetal ion binding
I0048471cellular_componentperinuclear region of cytoplasm
I0048839biological_processinner ear development
I0055085biological_processtransmembrane transport
I0071377biological_processcellular response to glucagon stimulus
I0071549biological_processcellular response to dexamethasone stimulus
I0097449cellular_componentastrocyte projection
I1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
I1905867biological_processepididymis development
I1990349biological_processgap junction-mediated intercellular transport
J0002931biological_processresponse to ischemia
J0005243molecular_functiongap junction channel activity
J0005509molecular_functioncalcium ion binding
J0005515molecular_functionprotein binding
J0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
J0005886cellular_componentplasma membrane
J0005921cellular_componentgap junction
J0005922cellular_componentconnexin complex
J0007154biological_processcell communication
J0007267biological_processcell-cell signaling
J0007565biological_processfemale pregnancy
J0007605biological_processsensory perception of sound
J0010644biological_processcell communication by electrical coupling
J0016264biological_processgap junction assembly
J0016328cellular_componentlateral plasma membrane
J0030054cellular_componentcell junction
J0032355biological_processresponse to estradiol
J0032496biological_processresponse to lipopolysaccharide
J0032526biological_processresponse to retinoic acid
J0032570biological_processresponse to progesterone
J0034599biological_processcellular response to oxidative stress
J0042802molecular_functionidentical protein binding
J0044297cellular_componentcell body
J0044752biological_processresponse to human chorionic gonadotropin
J0046697biological_processdecidualization
J0046872molecular_functionmetal ion binding
J0048471cellular_componentperinuclear region of cytoplasm
J0048839biological_processinner ear development
J0055085biological_processtransmembrane transport
J0071377biological_processcellular response to glucagon stimulus
J0071549biological_processcellular response to dexamethasone stimulus
J0097449cellular_componentastrocyte projection
J1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
J1905867biological_processepididymis development
J1990349biological_processgap junction-mediated intercellular transport
K0002931biological_processresponse to ischemia
K0005243molecular_functiongap junction channel activity
K0005509molecular_functioncalcium ion binding
K0005515molecular_functionprotein binding
K0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
K0005886cellular_componentplasma membrane
K0005921cellular_componentgap junction
K0005922cellular_componentconnexin complex
K0007154biological_processcell communication
K0007267biological_processcell-cell signaling
K0007565biological_processfemale pregnancy
K0007605biological_processsensory perception of sound
K0010644biological_processcell communication by electrical coupling
K0016264biological_processgap junction assembly
K0016328cellular_componentlateral plasma membrane
K0030054cellular_componentcell junction
K0032355biological_processresponse to estradiol
K0032496biological_processresponse to lipopolysaccharide
K0032526biological_processresponse to retinoic acid
K0032570biological_processresponse to progesterone
K0034599biological_processcellular response to oxidative stress
K0042802molecular_functionidentical protein binding
K0044297cellular_componentcell body
K0044752biological_processresponse to human chorionic gonadotropin
K0046697biological_processdecidualization
K0046872molecular_functionmetal ion binding
K0048471cellular_componentperinuclear region of cytoplasm
K0048839biological_processinner ear development
K0055085biological_processtransmembrane transport
K0071377biological_processcellular response to glucagon stimulus
K0071549biological_processcellular response to dexamethasone stimulus
K0097449cellular_componentastrocyte projection
K1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
K1905867biological_processepididymis development
K1990349biological_processgap junction-mediated intercellular transport
L0002931biological_processresponse to ischemia
L0005243molecular_functiongap junction channel activity
L0005509molecular_functioncalcium ion binding
L0005515molecular_functionprotein binding
L0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
L0005886cellular_componentplasma membrane
L0005921cellular_componentgap junction
L0005922cellular_componentconnexin complex
L0007154biological_processcell communication
L0007267biological_processcell-cell signaling
L0007565biological_processfemale pregnancy
L0007605biological_processsensory perception of sound
L0010644biological_processcell communication by electrical coupling
L0016264biological_processgap junction assembly
L0016328cellular_componentlateral plasma membrane
L0030054cellular_componentcell junction
L0032355biological_processresponse to estradiol
L0032496biological_processresponse to lipopolysaccharide
L0032526biological_processresponse to retinoic acid
L0032570biological_processresponse to progesterone
L0034599biological_processcellular response to oxidative stress
L0042802molecular_functionidentical protein binding
L0044297cellular_componentcell body
L0044752biological_processresponse to human chorionic gonadotropin
L0046697biological_processdecidualization
L0046872molecular_functionmetal ion binding
L0048471cellular_componentperinuclear region of cytoplasm
L0048839biological_processinner ear development
L0055085biological_processtransmembrane transport
L0071377biological_processcellular response to glucagon stimulus
L0071549biological_processcellular response to dexamethasone stimulus
L0097449cellular_componentastrocyte projection
L1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
L1905867biological_processepididymis development
L1990349biological_processgap junction-mediated intercellular transport
Functional Information from PROSITE/UniProt
site_idPS00407
Number of Residues14
DetailsCONNEXINS_1 Connexins signature 1. CNTlQPGCknVCYD
ChainResidueDetails
GCYS53-ASP66

site_idPS00408
Number of Residues17
DetailsCONNEXINS_2 Connexins signature 2. Cnaw.PCpntVDCFVSRP
ChainResidueDetails
GCYS169-PRO185

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues66
DetailsINTRAMEM: INTRAMEM => ECO:0000269|PubMed:26753910
ChainResidueDetails
GASP2-VAL13
HASP2-VAL13
IASP2-VAL13
JASP2-VAL13
KASP2-VAL13
LASP2-VAL13

site_idSWS_FT_FI2
Number of Residues366
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26753910
ChainResidueDetails
GASN14-ILE20
JASN14-ILE20
JVAL95-THR135
JCYS211-VAL226
KASN14-ILE20
KVAL95-THR135
KCYS211-VAL226
LASN14-ILE20
LVAL95-THR135
LCYS211-VAL226
GVAL95-THR135
GCYS211-VAL226
HASN14-ILE20
HVAL95-THR135
HCYS211-VAL226
IASN14-ILE20
IVAL95-THR135
ICYS211-VAL226

site_idSWS_FT_FI3
Number of Residues474
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:26753910
ChainResidueDetails
GGLY21-ALA40
IILE74-HIS94
ITYR136-VAL156
IVAL190-LEU210
JGLY21-ALA40
JILE74-HIS94
JTYR136-VAL156
JVAL190-LEU210
KGLY21-ALA40
KILE74-HIS94
KTYR136-VAL156
GILE74-HIS94
KVAL190-LEU210
LGLY21-ALA40
LILE74-HIS94
LTYR136-VAL156
LVAL190-LEU210
GTYR136-VAL156
GVAL190-LEU210
HGLY21-ALA40
HILE74-HIS94
HTYR136-VAL156
HVAL190-LEU210
IGLY21-ALA40

site_idSWS_FT_FI4
Number of Residues384
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:26753910
ChainResidueDetails
GLYS41-HIS73
KMET157-THR189
LLYS41-HIS73
LMET157-THR189
GMET157-THR189
HLYS41-HIS73
HMET157-THR189
ILYS41-HIS73
IMET157-THR189
JLYS41-HIS73
JMET157-THR189
KLYS41-HIS73

site_idSWS_FT_FI5
Number of Residues6
DetailsBINDING: in other chain => ECO:0000305|PubMed:26753910, ECO:0007744|PDB:5ER7
ChainResidueDetails
GGLU42
HGLU42
IGLU42
JGLU42
KGLU42
LGLU42

site_idSWS_FT_FI6
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:26753910, ECO:0007744|PDB:5ER7
ChainResidueDetails
GGLY45
KGLU47
LGLY45
LGLU47
GGLU47
HGLY45
HGLU47
IGLY45
IGLU47
JGLY45
JGLU47
KGLY45

224931

PDB entries from 2024-09-11

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