7QAA
Crystal structure of RARalpha/RXRalpha ligand binding domain heterodimer in complex with BMS614 and oleic acid
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0003707 | molecular_function | nuclear steroid receptor activity |
A | 0005634 | cellular_component | nucleus |
A | 0006355 | biological_process | regulation of DNA-templated transcription |
A | 0008270 | molecular_function | zinc ion binding |
B | 0003677 | molecular_function | DNA binding |
B | 0004879 | molecular_function | nuclear receptor activity |
B | 0005634 | cellular_component | nucleus |
B | 0006355 | biological_process | regulation of DNA-templated transcription |
B | 0048384 | biological_process | retinoic acid receptor signaling pathway |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 65 |
Details | DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 |
Chain | Residue | Details |
B | GLY185-THR250 | |
A | ALA332 |
site_id | SWS_FT_FI2 |
Number of Residues | 44 |
Details | ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 |
Chain | Residue | Details |
B | GLY185-LEU205 | |
B | ASP221-GLN245 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by PKB/AKT1 => ECO:0000269|PubMed:16417524 |
Chain | Residue | Details |
B | LYS193 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:20215566 |
Chain | Residue | Details |
B | LEU316 |
site_id | SWS_FT_FI5 |
Number of Residues | 3 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:19850744 |
Chain | Residue | Details |
B | ALA263 | |
B | ILE268 |