Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7Q5N

Crystal structure of Chaetomium thermophilum Ahp1-Urm1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005777	cellular_component	peroxisome
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0034599	biological_process	cellular response to oxidative stress
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0045454	biological_process	cell redox homeostasis
A	0046872	molecular_function	metal ion binding
A	0098869	biological_process	cellular oxidant detoxification
A	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
B	0004601	molecular_function	peroxidase activity
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005777	cellular_component	peroxisome
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0034599	biological_process	cellular response to oxidative stress
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0045454	biological_process	cell redox homeostasis
B	0046872	molecular_function	metal ion binding
B	0098869	biological_process	cellular oxidant detoxification
B	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
C	0004601	molecular_function	peroxidase activity
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005777	cellular_component	peroxisome
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0034599	biological_process	cellular response to oxidative stress
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0045454	biological_process	cell redox homeostasis
C	0046872	molecular_function	metal ion binding
C	0098869	biological_process	cellular oxidant detoxification
C	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
D	0004601	molecular_function	peroxidase activity
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005777	cellular_component	peroxisome
D	0008379	molecular_function	thioredoxin peroxidase activity
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0034599	biological_process	cellular response to oxidative stress
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0045454	biological_process	cell redox homeostasis
D	0046872	molecular_function	metal ion binding
D	0098869	biological_process	cellular oxidant detoxification
D	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
E	0004601	molecular_function	peroxidase activity
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005777	cellular_component	peroxisome
E	0008379	molecular_function	thioredoxin peroxidase activity
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0034599	biological_process	cellular response to oxidative stress
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0045454	biological_process	cell redox homeostasis
E	0046872	molecular_function	metal ion binding
E	0098869	biological_process	cellular oxidant detoxification
E	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
F	0004601	molecular_function	peroxidase activity
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005777	cellular_component	peroxisome
F	0008379	molecular_function	thioredoxin peroxidase activity
F	0016209	molecular_function	antioxidant activity
F	0016491	molecular_function	oxidoreductase activity
F	0034599	biological_process	cellular response to oxidative stress
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0045454	biological_process	cell redox homeostasis
F	0046872	molecular_function	metal ion binding
F	0098869	biological_process	cellular oxidant detoxification
F	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
G	0002098	biological_process	tRNA wobble uridine modification
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0008033	biological_process	tRNA processing
G	0032447	biological_process	protein urmylation
G	0034227	biological_process	tRNA thio-modification
G	0046872	molecular_function	metal ion binding
H	0002098	biological_process	tRNA wobble uridine modification
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0008033	biological_process	tRNA processing
H	0032447	biological_process	protein urmylation
H	0034227	biological_process	tRNA thio-modification
H	0046872	molecular_function	metal ion binding
I	0002098	biological_process	tRNA wobble uridine modification
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0008033	biological_process	tRNA processing
I	0032447	biological_process	protein urmylation
I	0034227	biological_process	tRNA thio-modification
I	0046872	molecular_function	metal ion binding
J	0002098	biological_process	tRNA wobble uridine modification
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0008033	biological_process	tRNA processing
J	0032447	biological_process	protein urmylation
J	0034227	biological_process	tRNA thio-modification
J	0046872	molecular_function	metal ion binding
K	0002098	biological_process	tRNA wobble uridine modification
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0008033	biological_process	tRNA processing
K	0032447	biological_process	protein urmylation
K	0034227	biological_process	tRNA thio-modification
K	0046872	molecular_function	metal ion binding
L	0002098	biological_process	tRNA wobble uridine modification
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0008033	biological_process	tRNA processing
L	0032447	biological_process	protein urmylation
L	0034227	biological_process	tRNA thio-modification
L	0046872	molecular_function	metal ion binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"UniProtKB","id":"P38013","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Modified residue: {"description":"Cysteine persulfide","evidences":[{"source":"PubMed","id":"36102610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	36
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in URM1)","evidences":[{"source":"PubMed","id":"36102610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"1-thioglycine","evidences":[{"source":"HAMAP-Rule","id":"MF_03048","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32901956","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)","evidences":[{"source":"HAMAP-Rule","id":"MF_03048","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36102610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)