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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7Q4D

Local refinement structure of the two interacting N-domains of full-length, dimeric, soluble somatic angiotensin I-converting enzyme

Functional Information from GO Data
ChainGOidnamespacecontents
A0001822biological_processkidney development
A0001974biological_processblood vessel remodeling
A0002003biological_processangiotensin maturation
A0002019biological_processregulation of renal output by angiotensin
A0002446biological_processneutrophil mediated immunity
A0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
A0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
A0003084biological_processpositive regulation of systemic arterial blood pressure
A0004175molecular_functionendopeptidase activity
A0004180molecular_functioncarboxypeptidase activity
A0004181molecular_functionmetallocarboxypeptidase activity
A0004222molecular_functionmetalloendopeptidase activity
A0005516molecular_functioncalmodulin binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005768cellular_componentendosome
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0007283biological_processspermatogenesis
A0008217biological_processregulation of blood pressure
A0008233molecular_functionpeptidase activity
A0008237molecular_functionmetallopeptidase activity
A0008238molecular_functionexopeptidase activity
A0008240molecular_functiontripeptidyl-peptidase activity
A0008241molecular_functionpeptidyl-dipeptidase activity
A0008270molecular_functionzinc ion binding
A0008584biological_processmale gonad development
A0009897cellular_componentexternal side of plasma membrane
A0010608biological_processpost-transcriptional regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010814biological_processsubstance P catabolic process
A0010815biological_processbradykinin catabolic process
A0014910biological_processregulation of smooth muscle cell migration
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019229biological_processregulation of vasoconstriction
A0031404molecular_functionchloride ion binding
A0031434molecular_functionmitogen-activated protein kinase kinase binding
A0031711molecular_functionbradykinin receptor binding
A0032943biological_processmononuclear cell proliferation
A0038166biological_processangiotensin-activated signaling pathway
A0042445biological_processhormone metabolic process
A0042447biological_processhormone catabolic process
A0043171biological_processpeptide catabolic process
A0046872molecular_functionmetal ion binding
A0048167biological_processregulation of synaptic plasticity
A0050435biological_processamyloid-beta metabolic process
A0050482biological_processarachidonate secretion
A0051019molecular_functionmitogen-activated protein kinase binding
A0060047biological_processheart contraction
A0060177biological_processregulation of angiotensin metabolic process
A0060218biological_processhematopoietic stem cell differentiation
A0070062cellular_componentextracellular exosome
A0070573molecular_functionmetallodipeptidase activity
A0071838biological_processcell proliferation in bone marrow
A0086091biological_processregulation of heart rate by cardiac conduction
A0097746biological_processblood vessel diameter maintenance
A1902033biological_processregulation of hematopoietic stem cell proliferation
A1903597biological_processnegative regulation of gap junction assembly
B0001822biological_processkidney development
B0001974biological_processblood vessel remodeling
B0002003biological_processangiotensin maturation
B0002019biological_processregulation of renal output by angiotensin
B0002446biological_processneutrophil mediated immunity
B0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
B0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
B0003084biological_processpositive regulation of systemic arterial blood pressure
B0004175molecular_functionendopeptidase activity
B0004180molecular_functioncarboxypeptidase activity
B0004181molecular_functionmetallocarboxypeptidase activity
B0004222molecular_functionmetalloendopeptidase activity
B0005516molecular_functioncalmodulin binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005768cellular_componentendosome
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0007283biological_processspermatogenesis
B0008217biological_processregulation of blood pressure
B0008233molecular_functionpeptidase activity
B0008237molecular_functionmetallopeptidase activity
B0008238molecular_functionexopeptidase activity
B0008240molecular_functiontripeptidyl-peptidase activity
B0008241molecular_functionpeptidyl-dipeptidase activity
B0008270molecular_functionzinc ion binding
B0008584biological_processmale gonad development
B0009897cellular_componentexternal side of plasma membrane
B0010608biological_processpost-transcriptional regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0010814biological_processsubstance P catabolic process
B0010815biological_processbradykinin catabolic process
B0014910biological_processregulation of smooth muscle cell migration
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0019229biological_processregulation of vasoconstriction
B0031404molecular_functionchloride ion binding
B0031434molecular_functionmitogen-activated protein kinase kinase binding
B0031711molecular_functionbradykinin receptor binding
B0032943biological_processmononuclear cell proliferation
B0038166biological_processangiotensin-activated signaling pathway
B0042445biological_processhormone metabolic process
B0042447biological_processhormone catabolic process
B0043171biological_processpeptide catabolic process
B0046872molecular_functionmetal ion binding
B0048167biological_processregulation of synaptic plasticity
B0050435biological_processamyloid-beta metabolic process
B0050482biological_processarachidonate secretion
B0051019molecular_functionmitogen-activated protein kinase binding
B0060047biological_processheart contraction
B0060177biological_processregulation of angiotensin metabolic process
B0060218biological_processhematopoietic stem cell differentiation
B0070062cellular_componentextracellular exosome
B0070573molecular_functionmetallodipeptidase activity
B0071838biological_processcell proliferation in bone marrow
B0086091biological_processregulation of heart rate by cardiac conduction
B0097746biological_processblood vessel diameter maintenance
B1902033biological_processregulation of hematopoietic stem cell proliferation
B1903597biological_processnegative regulation of gap junction assembly
Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TVHHEMGHIQ
ChainResidueDetails
ATHR358-GLN367
AVAL956-GLN965
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1168
DetailsDomain: {"description":"Peptidase M2 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsActive site: {"description":"Proton acceptor 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12540854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16154999","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19773553","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsActive site: {"description":"Proton donor 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16476442","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16476442","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20826823","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26403559","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2OC2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NXQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24297181","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4C2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C2R","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsSite: {"description":"Not glycosylated","evidences":[{"source":"PubMed","id":"20826823","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"20826823","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9013598","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16476442","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20826823","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9013598","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16476442","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20826823","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26403559","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NXQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20826823","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9013598","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"20826823","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16476442","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20826823","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26403559","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NXQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16476442","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20826823","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26403559","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9013598","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NXQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21810173","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24297181","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626443","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4C2O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"8626443","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idMCSA1
Number of Residues
DetailsM-CSA 170
ChainResidueDetails
site_idMCSA2
Number of Residues
DetailsM-CSA 170
ChainResidueDetails

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PDB entries from 2026-01-14

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