7Q3L
Human 17S U2 snRNP 5' domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| 9 | 0000375 | biological_process | RNA splicing, via transesterification reactions |
| 9 | 0000389 | biological_process | mRNA 3'-splice site recognition |
| 9 | 0000398 | biological_process | mRNA splicing, via spliceosome |
| 9 | 0003676 | molecular_function | nucleic acid binding |
| 9 | 0003723 | molecular_function | RNA binding |
| 9 | 0005515 | molecular_function | protein binding |
| 9 | 0005634 | cellular_component | nucleus |
| 9 | 0005654 | cellular_component | nucleoplasm |
| 9 | 0005681 | cellular_component | spliceosomal complex |
| 9 | 0005684 | cellular_component | U2-type spliceosomal complex |
| 9 | 0005686 | cellular_component | U2 snRNP |
| 9 | 0006397 | biological_process | mRNA processing |
| 9 | 0008270 | molecular_function | zinc ion binding |
| 9 | 0008380 | biological_process | RNA splicing |
| 9 | 0016607 | cellular_component | nuclear speck |
| 9 | 0046872 | molecular_function | metal ion binding |
| 9 | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| 9 | 0071013 | cellular_component | catalytic step 2 spliceosome |
| 9 | 1903241 | biological_process | U2-type prespliceosome assembly |
| A | 0000245 | biological_process | spliceosomal complex assembly |
| A | 0000375 | biological_process | RNA splicing, via transesterification reactions |
| A | 0000398 | biological_process | mRNA splicing, via spliceosome |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003729 | molecular_function | mRNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005681 | cellular_component | spliceosomal complex |
| A | 0005684 | cellular_component | U2-type spliceosomal complex |
| A | 0005686 | cellular_component | U2 snRNP |
| A | 0005689 | cellular_component | U12-type spliceosomal complex |
| A | 0005730 | cellular_component | nucleolus |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006397 | biological_process | mRNA processing |
| A | 0008380 | biological_process | RNA splicing |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0034693 | cellular_component | U11/U12 snRNP |
| A | 0045943 | biological_process | positive regulation of transcription by RNA polymerase I |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0045945 | biological_process | positive regulation of transcription by RNA polymerase III |
| A | 0071004 | cellular_component | U2-type prespliceosome |
| A | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| A | 0071013 | cellular_component | catalytic step 2 spliceosome |
| A | 0110016 | cellular_component | B-WICH complex |
| A | 1903241 | biological_process | U2-type prespliceosome assembly |
| A | 1990935 | molecular_function | splicing factor binding |
| B | 0000398 | biological_process | mRNA splicing, via spliceosome |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005681 | cellular_component | spliceosomal complex |
| B | 0005684 | cellular_component | U2-type spliceosomal complex |
| B | 0005686 | cellular_component | U2 snRNP |
| B | 0005689 | cellular_component | U12-type spliceosomal complex |
| B | 0006397 | biological_process | mRNA processing |
| B | 0008380 | biological_process | RNA splicing |
| B | 0016607 | cellular_component | nuclear speck |
| B | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| B | 0071011 | cellular_component | precatalytic spliceosome |
| B | 0071013 | cellular_component | catalytic step 2 spliceosome |
| B | 1903241 | biological_process | U2-type prespliceosome assembly |
| C | 0000124 | cellular_component | SAGA complex |
| C | 0000375 | biological_process | RNA splicing, via transesterification reactions |
| C | 0000398 | biological_process | mRNA splicing, via spliceosome |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005681 | cellular_component | spliceosomal complex |
| C | 0005684 | cellular_component | U2-type spliceosomal complex |
| C | 0005686 | cellular_component | U2 snRNP |
| C | 0005689 | cellular_component | U12-type spliceosomal complex |
| C | 0005730 | cellular_component | nucleolus |
| C | 0006282 | biological_process | regulation of DNA repair |
| C | 0006397 | biological_process | mRNA processing |
| C | 0008380 | biological_process | RNA splicing |
| C | 0030620 | molecular_function | U2 snRNA binding |
| C | 0042177 | biological_process | negative regulation of protein catabolic process |
| C | 0043484 | biological_process | regulation of RNA splicing |
| C | 0044877 | molecular_function | protein-containing complex binding |
| C | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| C | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| C | 0071013 | cellular_component | catalytic step 2 spliceosome |
| C | 1903241 | biological_process | U2-type prespliceosome assembly |
| E | 0000124 | cellular_component | SAGA complex |
| E | 0000398 | biological_process | mRNA splicing, via spliceosome |
| E | 0003723 | molecular_function | RNA binding |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005654 | cellular_component | nucleoplasm |
| E | 0005681 | cellular_component | spliceosomal complex |
| E | 0005684 | cellular_component | U2-type spliceosomal complex |
| E | 0005686 | cellular_component | U2 snRNP |
| E | 0005689 | cellular_component | U12-type spliceosomal complex |
| E | 0006282 | biological_process | regulation of DNA repair |
| E | 0006397 | biological_process | mRNA processing |
| E | 0008380 | biological_process | RNA splicing |
| E | 0043484 | biological_process | regulation of RNA splicing |
| E | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| E | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| E | 0071011 | cellular_component | precatalytic spliceosome |
| E | 1903241 | biological_process | U2-type prespliceosome assembly |
| E | 1990935 | molecular_function | splicing factor binding |
| G | 0000398 | biological_process | mRNA splicing, via spliceosome |
| G | 0003677 | molecular_function | DNA binding |
| G | 0003723 | molecular_function | RNA binding |
| G | 0005515 | molecular_function | protein binding |
| G | 0005634 | cellular_component | nucleus |
| G | 0005654 | cellular_component | nucleoplasm |
| G | 0005681 | cellular_component | spliceosomal complex |
| G | 0005684 | cellular_component | U2-type spliceosomal complex |
| G | 0005686 | cellular_component | U2 snRNP |
| G | 0005689 | cellular_component | U12-type spliceosomal complex |
| G | 0006397 | biological_process | mRNA processing |
| G | 0008270 | molecular_function | zinc ion binding |
| G | 0008380 | biological_process | RNA splicing |
| G | 0016363 | cellular_component | nuclear matrix |
| G | 0016607 | cellular_component | nuclear speck |
| G | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0048863 | biological_process | stem cell differentiation |
| G | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| G | 0071011 | cellular_component | precatalytic spliceosome |
| G | 1903241 | biological_process | U2-type prespliceosome assembly |
| p | 0000398 | biological_process | mRNA splicing, via spliceosome |
| p | 0001650 | cellular_component | fibrillar center |
| p | 0003676 | molecular_function | nucleic acid binding |
| p | 0003723 | molecular_function | RNA binding |
| p | 0003724 | molecular_function | RNA helicase activity |
| p | 0004386 | molecular_function | helicase activity |
| p | 0005515 | molecular_function | protein binding |
| p | 0005524 | molecular_function | ATP binding |
| p | 0005634 | cellular_component | nucleus |
| p | 0005654 | cellular_component | nucleoplasm |
| p | 0005681 | cellular_component | spliceosomal complex |
| p | 0005684 | cellular_component | U2-type spliceosomal complex |
| p | 0005686 | cellular_component | U2 snRNP |
| p | 0006397 | biological_process | mRNA processing |
| p | 0008380 | biological_process | RNA splicing |
| p | 0015030 | cellular_component | Cajal body |
| p | 0016607 | cellular_component | nuclear speck |
| p | 0016787 | molecular_function | hydrolase activity |
| p | 0016887 | molecular_function | ATP hydrolysis activity |
| p | 1903241 | biological_process | U2-type prespliceosome assembly |
| q | 0000398 | biological_process | mRNA splicing, via spliceosome |
| q | 0000724 | biological_process | double-strand break repair via homologous recombination |
| q | 0003676 | molecular_function | nucleic acid binding |
| q | 0003723 | molecular_function | RNA binding |
| q | 0005515 | molecular_function | protein binding |
| q | 0005634 | cellular_component | nucleus |
| q | 0005654 | cellular_component | nucleoplasm |
| q | 0005681 | cellular_component | spliceosomal complex |
| q | 0005684 | cellular_component | U2-type spliceosomal complex |
| q | 0005686 | cellular_component | U2 snRNP |
| q | 0005694 | cellular_component | chromosome |
| q | 0006281 | biological_process | DNA repair |
| q | 0006325 | biological_process | chromatin organization |
| q | 0006397 | biological_process | mRNA processing |
| q | 0008380 | biological_process | RNA splicing |
| q | 0035861 | cellular_component | site of double-strand break |
| q | 0140463 | molecular_function | chromatin-protein adaptor activity |
| q | 0160004 | molecular_function | poly-ADP-D-ribose modification-dependent protein binding |
| q | 1903241 | biological_process | U2-type prespliceosome assembly |
| q | 1990166 | biological_process | protein localization to site of double-strand break |
Functional Information from PROSITE/UniProt
| site_id | PS00039 |
| Number of Residues | 9 |
| Details | DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmF |
| Chain | Residue | Details |
| p | VAL527-PHE535 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH |
| Chain | Residue | Details |
| C | PHE287-HIS293 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541 |
| Chain | Residue | Details |
| p | ALA416 | |
| G | CYS72 | |
| G | CYS75 | |
| G | CYS85 | |
| A | TYR587 | |
| A | CYS1035 | |
| A | TYR1049 | |
| A | LEU1141 | |
| G | CYS46 | |
| G | CYS49 | |
| G | CYS58 | |
| G | CYS61 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q62780 |
| Chain | Residue | Details |
| p | SER199 | |
| C | LYS1171 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| p | LYS263 | |
| p | LYS776 | |
| A | GLU1205 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| p | TYR294 | |
| A | THR235 | |
| A | THR426 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| p | SER295 | |
| p | SER296 | |
| 9 | SER369 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| p | SER346 | |
| p | SER928 | |
| A | LYS562 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| p | SER804 | |
| q | SER453 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q569Z5 |
| Chain | Residue | Details |
| p | LYS903 | |
| q | SER494 | |
| q | SER521 | |
| q | SER529 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | LIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805 |
| Chain | Residue | Details |
| p | GLY2 | |
| q | SER607 | |
| B | SER436 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| p | LYS186 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 5 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | THR207 | |
| p | LYS325 | |
| p | LYS779 | |
| p | LYS907 | |
| p | LYS915 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR211 | |
| B | LYS280 | |
| B | LYS492 | |
| B | LYS543 | |
| B | LYS770 | |
| B | LYS790 | |
| B | LYS843 | |
| B | LYS857 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q99NB9 |
| Chain | Residue | Details |
| A | LYS214 | |
| q | SER600 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:17924679, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR223 | |
| q | SER676 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR227 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q99NB9 |
| Chain | Residue | Details |
| A | SER229 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:12105215 |
| Chain | Residue | Details |
| A | THR244 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000305|PubMed:12105215 |
| Chain | Residue | Details |
| A | THR248 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 5 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR257 | |
| A | THR261 | |
| A | THR278 | |
| A | THR303 | |
| A | THR313 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR267 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR273 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER287 | |
| q | LYS430 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR296 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983 |
| Chain | Residue | Details |
| A | THR299 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER322 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR326 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | THR328 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER332 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| A | THR341 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| A | SER344 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| A | SER349 |
| site_id | SWS_FT_FI32 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR350 | |
| A | THR436 |
| site_id | SWS_FT_FI33 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR354 |
| site_id | SWS_FT_FI34 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER400 |
| site_id | SWS_FT_FI35 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by DYRK1A => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR434 |
| site_id | SWS_FT_FI36 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER488 |
| site_id | SWS_FT_FI37 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS214 |
| site_id | SWS_FT_FI38 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS430 |
| site_id | SWS_FT_FI39 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS413 |
