7Q12

Human GYS1-GYG1 complex activated state bound to glucose-6-phosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004373	molecular_function	alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity
A	0005515	molecular_function	protein binding
A	0005536	molecular_function	D-glucose binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005977	biological_process	glycogen metabolic process
A	0005978	biological_process	glycogen biosynthetic process
A	0007507	biological_process	heart development
A	0016020	cellular_component	membrane
A	0016234	cellular_component	inclusion body
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0061547	molecular_function	glycogen synthase activity, transferring glucose-1-phosphate
B	0003824	molecular_function	catalytic activity
B	0004373	molecular_function	alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity
B	0005515	molecular_function	protein binding
B	0005536	molecular_function	D-glucose binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005977	biological_process	glycogen metabolic process
B	0005978	biological_process	glycogen biosynthetic process
B	0007507	biological_process	heart development
B	0016020	cellular_component	membrane
B	0016234	cellular_component	inclusion body
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0061547	molecular_function	glycogen synthase activity, transferring glucose-1-phosphate
C	0003824	molecular_function	catalytic activity
C	0004373	molecular_function	alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity
C	0005515	molecular_function	protein binding
C	0005536	molecular_function	D-glucose binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005977	biological_process	glycogen metabolic process
C	0005978	biological_process	glycogen biosynthetic process
C	0007507	biological_process	heart development
C	0016020	cellular_component	membrane
C	0016234	cellular_component	inclusion body
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0061547	molecular_function	glycogen synthase activity, transferring glucose-1-phosphate
D	0003824	molecular_function	catalytic activity
D	0004373	molecular_function	alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity
D	0005515	molecular_function	protein binding
D	0005536	molecular_function	D-glucose binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005977	biological_process	glycogen metabolic process
D	0005978	biological_process	glycogen biosynthetic process
D	0007507	biological_process	heart development
D	0016020	cellular_component	membrane
D	0016234	cellular_component	inclusion body
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0061547	molecular_function	glycogen synthase activity, transferring glucose-1-phosphate
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005978	biological_process	glycogen biosynthetic process
E	0008466	molecular_function	glycogenin glucosyltransferase activity
E	0016020	cellular_component	membrane
E	0016740	molecular_function	transferase activity
E	0016757	molecular_function	glycosyltransferase activity
E	0030145	molecular_function	manganese ion binding
E	0034774	cellular_component	secretory granule lumen
E	0042803	molecular_function	protein homodimerization activity
E	0043202	cellular_component	lysosomal lumen
E	0046872	molecular_function	metal ion binding
E	0160249	biological_process	glycogen biosynthetic process via UDP-glucose
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005978	biological_process	glycogen biosynthetic process
F	0008466	molecular_function	glycogenin glucosyltransferase activity
F	0016020	cellular_component	membrane
F	0016740	molecular_function	transferase activity
F	0016757	molecular_function	glycosyltransferase activity
F	0030145	molecular_function	manganese ion binding
F	0034774	cellular_component	secretory granule lumen
F	0042803	molecular_function	protein homodimerization activity
F	0043202	cellular_component	lysosomal lumen
F	0046872	molecular_function	metal ion binding
F	0160249	biological_process	glycogen biosynthetic process via UDP-glucose
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005978	biological_process	glycogen biosynthetic process
G	0008466	molecular_function	glycogenin glucosyltransferase activity
G	0016020	cellular_component	membrane
G	0016740	molecular_function	transferase activity
G	0016757	molecular_function	glycosyltransferase activity
G	0030145	molecular_function	manganese ion binding
G	0034774	cellular_component	secretory granule lumen
G	0042803	molecular_function	protein homodimerization activity
G	0043202	cellular_component	lysosomal lumen
G	0046872	molecular_function	metal ion binding
G	0160249	biological_process	glycogen biosynthetic process via UDP-glucose
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005978	biological_process	glycogen biosynthetic process
H	0008466	molecular_function	glycogenin glucosyltransferase activity
H	0016020	cellular_component	membrane
H	0016740	molecular_function	transferase activity
H	0016757	molecular_function	glycosyltransferase activity
H	0030145	molecular_function	manganese ion binding
H	0034774	cellular_component	secretory granule lumen
H	0042803	molecular_function	protein homodimerization activity
H	0043202	cellular_component	lysosomal lumen
H	0046872	molecular_function	metal ion binding
H	0160249	biological_process	glycogen biosynthetic process via UDP-glucose
H	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35835870","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Q13","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35835870","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7Q13","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"35835870","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Q13","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35835870","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Q12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Q13","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"35690592","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---