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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7PXH

Emodepside-bound Drosophila Slo channel

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0007623biological_processcircadian rhythm
A0008582biological_processregulation of synaptic assembly at neuromuscular junction
A0009410biological_processresponse to xenobiotic stimulus
A0015269molecular_functioncalcium-activated potassium channel activity
A0016020cellular_componentmembrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0045211cellular_componentpostsynaptic membrane
A0045433biological_processmale courtship behavior, veined wing generated song production
A0048512biological_processcircadian behavior
A0050804biological_processmodulation of chemical synaptic transmission
A0055085biological_processtransmembrane transport
A0060072molecular_functionlarge conductance calcium-activated potassium channel activity
A0071805biological_processpotassium ion transmembrane transport
A1900074biological_processnegative regulation of neuromuscular synaptic transmission
B0005216molecular_functionmonoatomic ion channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0007623biological_processcircadian rhythm
B0008582biological_processregulation of synaptic assembly at neuromuscular junction
B0009410biological_processresponse to xenobiotic stimulus
B0015269molecular_functioncalcium-activated potassium channel activity
B0016020cellular_componentmembrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0045211cellular_componentpostsynaptic membrane
B0045433biological_processmale courtship behavior, veined wing generated song production
B0048512biological_processcircadian behavior
B0050804biological_processmodulation of chemical synaptic transmission
B0055085biological_processtransmembrane transport
B0060072molecular_functionlarge conductance calcium-activated potassium channel activity
B0071805biological_processpotassium ion transmembrane transport
B1900074biological_processnegative regulation of neuromuscular synaptic transmission
C0005216molecular_functionmonoatomic ion channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0007623biological_processcircadian rhythm
C0008582biological_processregulation of synaptic assembly at neuromuscular junction
C0009410biological_processresponse to xenobiotic stimulus
C0015269molecular_functioncalcium-activated potassium channel activity
C0016020cellular_componentmembrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0045211cellular_componentpostsynaptic membrane
C0045433biological_processmale courtship behavior, veined wing generated song production
C0048512biological_processcircadian behavior
C0050804biological_processmodulation of chemical synaptic transmission
C0055085biological_processtransmembrane transport
C0060072molecular_functionlarge conductance calcium-activated potassium channel activity
C0071805biological_processpotassium ion transmembrane transport
C1900074biological_processnegative regulation of neuromuscular synaptic transmission
D0005216molecular_functionmonoatomic ion channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0007623biological_processcircadian rhythm
D0008582biological_processregulation of synaptic assembly at neuromuscular junction
D0009410biological_processresponse to xenobiotic stimulus
D0015269molecular_functioncalcium-activated potassium channel activity
D0016020cellular_componentmembrane
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0045211cellular_componentpostsynaptic membrane
D0045433biological_processmale courtship behavior, veined wing generated song production
D0048512biological_processcircadian behavior
D0050804biological_processmodulation of chemical synaptic transmission
D0055085biological_processtransmembrane transport
D0060072molecular_functionlarge conductance calcium-activated potassium channel activity
D0071805biological_processpotassium ion transmembrane transport
D1900074biological_processnegative regulation of neuromuscular synaptic transmission
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S0","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues148
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues68
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues88
DetailsIntramembrane: {"description":"Pore-forming; Name=P region","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues568
DetailsDomain: {"description":"RCK N-terminal 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00543","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues80
DetailsRegion: {"description":"Segment S7"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues80
DetailsRegion: {"description":"Segment S8"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues80
DetailsRegion: {"description":"Segment S9"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues80
DetailsRegion: {"description":"Segment S10"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues12
DetailsMotif: {"description":"Selectivity for potassium"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues88
DetailsMotif: {"description":"Calcium bowl"}
ChainResidueDetails

245011

PDB entries from 2025-11-19

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