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7PXH

Emodepside-bound Drosophila Slo channel

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0007623biological_processcircadian rhythm
A0008582biological_processregulation of synaptic assembly at neuromuscular junction
A0009410biological_processresponse to xenobiotic stimulus
A0015269molecular_functioncalcium-activated potassium channel activity
A0016020cellular_componentmembrane
A0034702cellular_componentmonoatomic ion channel complex
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0045211cellular_componentpostsynaptic membrane
A0045433biological_processmale courtship behavior, veined wing generated song production
A0048512biological_processcircadian behavior
A0055085biological_processtransmembrane transport
A0060072molecular_functionlarge conductance calcium-activated potassium channel activity
A0071805biological_processpotassium ion transmembrane transport
A1900074biological_processnegative regulation of neuromuscular synaptic transmission
B0005216molecular_functionmonoatomic ion channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0007623biological_processcircadian rhythm
B0008582biological_processregulation of synaptic assembly at neuromuscular junction
B0009410biological_processresponse to xenobiotic stimulus
B0015269molecular_functioncalcium-activated potassium channel activity
B0016020cellular_componentmembrane
B0034702cellular_componentmonoatomic ion channel complex
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0045211cellular_componentpostsynaptic membrane
B0045433biological_processmale courtship behavior, veined wing generated song production
B0048512biological_processcircadian behavior
B0055085biological_processtransmembrane transport
B0060072molecular_functionlarge conductance calcium-activated potassium channel activity
B0071805biological_processpotassium ion transmembrane transport
B1900074biological_processnegative regulation of neuromuscular synaptic transmission
C0005216molecular_functionmonoatomic ion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0007623biological_processcircadian rhythm
C0008582biological_processregulation of synaptic assembly at neuromuscular junction
C0009410biological_processresponse to xenobiotic stimulus
C0015269molecular_functioncalcium-activated potassium channel activity
C0016020cellular_componentmembrane
C0034702cellular_componentmonoatomic ion channel complex
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0045211cellular_componentpostsynaptic membrane
C0045433biological_processmale courtship behavior, veined wing generated song production
C0048512biological_processcircadian behavior
C0055085biological_processtransmembrane transport
C0060072molecular_functionlarge conductance calcium-activated potassium channel activity
C0071805biological_processpotassium ion transmembrane transport
C1900074biological_processnegative regulation of neuromuscular synaptic transmission
D0005216molecular_functionmonoatomic ion channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0007623biological_processcircadian rhythm
D0008582biological_processregulation of synaptic assembly at neuromuscular junction
D0009410biological_processresponse to xenobiotic stimulus
D0015269molecular_functioncalcium-activated potassium channel activity
D0016020cellular_componentmembrane
D0034702cellular_componentmonoatomic ion channel complex
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0045211cellular_componentpostsynaptic membrane
D0045433biological_processmale courtship behavior, veined wing generated song production
D0048512biological_processcircadian behavior
D0055085biological_processtransmembrane transport
D0060072molecular_functionlarge conductance calcium-activated potassium channel activity
D0071805biological_processpotassium ion transmembrane transport
D1900074biological_processnegative regulation of neuromuscular synaptic transmission
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues336
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AMET1-LYS48
BTYR308-THR316
CMET1-LYS48
CSER150-THR164
CSER211-LEU214
CGLU272-HIS284
CTYR308-THR316
DMET1-LYS48
DSER150-THR164
DSER211-LEU214
DGLU272-HIS284
ASER150-THR164
DTYR308-THR316
ASER211-LEU214
AGLU272-HIS284
ATYR308-THR316
BMET1-LYS48
BSER150-THR164
BSER211-LEU214
BGLU272-HIS284

site_idSWS_FT_FI2
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S0 => ECO:0000255
ChainResidueDetails
ATYR49-LEU69
BTYR49-LEU69
CTYR49-LEU69
DTYR49-LEU69

site_idSWS_FT_FI3
Number of Residues296
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
ATRP70-ARG127
DTRP70-ARG127
DALA186-LYS189
DLEU236-LEU250
AALA186-LYS189
ALEU236-LEU250
BTRP70-ARG127
BALA186-LYS189
BLEU236-LEU250
CTRP70-ARG127
CALA186-LYS189
CLEU236-LEU250

site_idSWS_FT_FI4
Number of Residues84
DetailsTRANSMEM: Helical; Name=Segment S1 => ECO:0000255
ChainResidueDetails
AILE128-SER149
BILE128-SER149
CILE128-SER149
DILE128-SER149

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S2 => ECO:0000255
ChainResidueDetails
AGLN165-ALA185
BGLN165-ALA185
CGLN165-ALA185
DGLN165-ALA185

site_idSWS_FT_FI6
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S3 => ECO:0000255
ChainResidueDetails
ALEU190-VAL210
BLEU190-VAL210
CLEU190-VAL210
DLEU190-VAL210

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000255
ChainResidueDetails
AASP215-ILE235
BASP215-ILE235
CASP215-ILE235
DASP215-ILE235

site_idSWS_FT_FI8
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S5 => ECO:0000255
ChainResidueDetails
AALA251-LEU271
BALA251-LEU271
CALA251-LEU271
DALA251-LEU271

site_idSWS_FT_FI9
Number of Residues88
DetailsINTRAMEM: Pore-forming; Name=P region => ECO:0000255
ChainResidueDetails
AARG285-VAL307
BARG285-VAL307
CARG285-VAL307
DARG285-VAL307

site_idSWS_FT_FI10
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S6 => ECO:0000255
ChainResidueDetails
APHE317-ILE337
BPHE317-ILE337
CPHE317-ILE337
DPHE317-ILE337

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10234050
ChainResidueDetails
APHE978
BPHE978
CPHE978
DPHE978

227344

PDB entries from 2024-11-13

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