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7PMK

S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
20000166molecular_functionnucleotide binding
20000727biological_processdouble-strand break repair via break-induced replication
20003677molecular_functionDNA binding
20003678molecular_functionDNA helicase activity
20003682molecular_functionchromatin binding
20003688molecular_functionDNA replication origin binding
20003697molecular_functionsingle-stranded DNA binding
20004386molecular_functionhelicase activity
20005515molecular_functionprotein binding
20005524molecular_functionATP binding
20005634cellular_componentnucleus
20005654cellular_componentnucleoplasm
20005656cellular_componentnuclear pre-replicative complex
20005737cellular_componentcytoplasm
20006260biological_processDNA replication
20006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
20006270biological_processDNA replication initiation
20006271biological_processDNA strand elongation involved in DNA replication
20006279biological_processpremeiotic DNA replication
20006974biological_processDNA damage response
20008270molecular_functionzinc ion binding
20016787molecular_functionhydrolase activity
20016887molecular_functionATP hydrolysis activity
20017116molecular_functionsingle-stranded DNA helicase activity
20031261cellular_componentDNA replication preinitiation complex
20042555cellular_componentMCM complex
20043138molecular_function3'-5' DNA helicase activity
20043596cellular_componentnuclear replication fork
20046872molecular_functionmetal ion binding
20071162cellular_componentCMG complex
21902975biological_processmitotic DNA replication initiation
30000166molecular_functionnucleotide binding
30000727biological_processdouble-strand break repair via break-induced replication
30000781cellular_componentchromosome, telomeric region
30003677molecular_functionDNA binding
30003678molecular_functionDNA helicase activity
30003682molecular_functionchromatin binding
30003688molecular_functionDNA replication origin binding
30003697molecular_functionsingle-stranded DNA binding
30004386molecular_functionhelicase activity
30005515molecular_functionprotein binding
30005524molecular_functionATP binding
30005634cellular_componentnucleus
30005654cellular_componentnucleoplasm
30005656cellular_componentnuclear pre-replicative complex
30005737cellular_componentcytoplasm
30006260biological_processDNA replication
30006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
30006270biological_processDNA replication initiation
30006271biological_processDNA strand elongation involved in DNA replication
30006279biological_processpremeiotic DNA replication
30016787molecular_functionhydrolase activity
30016887molecular_functionATP hydrolysis activity
30017116molecular_functionsingle-stranded DNA helicase activity
30030466biological_processsilent mating-type cassette heterochromatin formation
30031261cellular_componentDNA replication preinitiation complex
30031509biological_processsubtelomeric heterochromatin formation
30042555cellular_componentMCM complex
30043596cellular_componentnuclear replication fork
30071162cellular_componentCMG complex
31902975biological_processmitotic DNA replication initiation
31904931molecular_functionMCM complex binding
40000166molecular_functionnucleotide binding
40000727biological_processdouble-strand break repair via break-induced replication
40003677molecular_functionDNA binding
40003678molecular_functionDNA helicase activity
40003688molecular_functionDNA replication origin binding
40003697molecular_functionsingle-stranded DNA binding
40004386molecular_functionhelicase activity
40005515molecular_functionprotein binding
40005524molecular_functionATP binding
40005634cellular_componentnucleus
40005654cellular_componentnucleoplasm
40005656cellular_componentnuclear pre-replicative complex
40005737cellular_componentcytoplasm
40006260biological_processDNA replication
40006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
40006270biological_processDNA replication initiation
40006271biological_processDNA strand elongation involved in DNA replication
40006279biological_processpremeiotic DNA replication
40008270molecular_functionzinc ion binding
40009378molecular_functionfour-way junction helicase activity
40016787molecular_functionhydrolase activity
40016887molecular_functionATP hydrolysis activity
40017116molecular_functionsingle-stranded DNA helicase activity
40031261cellular_componentDNA replication preinitiation complex
40033260biological_processnuclear DNA replication
40042555cellular_componentMCM complex
40043138molecular_function3'-5' DNA helicase activity
40043596cellular_componentnuclear replication fork
40071162cellular_componentCMG complex
40097373cellular_componentMCM core complex
41902975biological_processmitotic DNA replication initiation
50000166molecular_functionnucleotide binding
50000727biological_processdouble-strand break repair via break-induced replication
50000781cellular_componentchromosome, telomeric region
50003677molecular_functionDNA binding
50003678molecular_functionDNA helicase activity
50003682molecular_functionchromatin binding
50003688molecular_functionDNA replication origin binding
50003697molecular_functionsingle-stranded DNA binding
50004386molecular_functionhelicase activity
50005515molecular_functionprotein binding
50005524molecular_functionATP binding
50005634cellular_componentnucleus
50005654cellular_componentnucleoplasm
50005656cellular_componentnuclear pre-replicative complex
50005737cellular_componentcytoplasm
50006260biological_processDNA replication
50006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
50006270biological_processDNA replication initiation
50006279biological_processpremeiotic DNA replication
50006368biological_processtranscription elongation by RNA polymerase II
50008270molecular_functionzinc ion binding
50016787molecular_functionhydrolase activity
50016887molecular_functionATP hydrolysis activity
50017116molecular_functionsingle-stranded DNA helicase activity
50030174biological_processregulation of DNA-templated DNA replication initiation
50031261cellular_componentDNA replication preinitiation complex
50031507biological_processheterochromatin formation
50031509biological_processsubtelomeric heterochromatin formation
50033260biological_processnuclear DNA replication
50042555cellular_componentMCM complex
50043138molecular_function3'-5' DNA helicase activity
50043596cellular_componentnuclear replication fork
50071162cellular_componentCMG complex
60000166molecular_functionnucleotide binding
60000727biological_processdouble-strand break repair via break-induced replication
60003677molecular_functionDNA binding
60003678molecular_functionDNA helicase activity
60003688molecular_functionDNA replication origin binding
60003697molecular_functionsingle-stranded DNA binding
60004386molecular_functionhelicase activity
60005515molecular_functionprotein binding
60005524molecular_functionATP binding
60005634cellular_componentnucleus
60005654cellular_componentnucleoplasm
60005656cellular_componentnuclear pre-replicative complex
60005737cellular_componentcytoplasm
60005777cellular_componentperoxisome
60006260biological_processDNA replication
60006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
60006270biological_processDNA replication initiation
60006271biological_processDNA strand elongation involved in DNA replication
60006279biological_processpremeiotic DNA replication
60008270molecular_functionzinc ion binding
60009378molecular_functionfour-way junction helicase activity
60016787molecular_functionhydrolase activity
60016887molecular_functionATP hydrolysis activity
60017116molecular_functionsingle-stranded DNA helicase activity
60031261cellular_componentDNA replication preinitiation complex
60042555cellular_componentMCM complex
60043138molecular_function3'-5' DNA helicase activity
60043596cellular_componentnuclear replication fork
60071162cellular_componentCMG complex
60097373cellular_componentMCM core complex
61902969biological_processmitotic DNA replication
61990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
70000166molecular_functionnucleotide binding
70000727biological_processdouble-strand break repair via break-induced replication
70000781cellular_componentchromosome, telomeric region
70003677molecular_functionDNA binding
70003678molecular_functionDNA helicase activity
70003682molecular_functionchromatin binding
70003688molecular_functionDNA replication origin binding
70003697molecular_functionsingle-stranded DNA binding
70004386molecular_functionhelicase activity
70005515molecular_functionprotein binding
70005524molecular_functionATP binding
70005634cellular_componentnucleus
70005654cellular_componentnucleoplasm
70005656cellular_componentnuclear pre-replicative complex
70005737cellular_componentcytoplasm
70006260biological_processDNA replication
70006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
70006270biological_processDNA replication initiation
70006271biological_processDNA strand elongation involved in DNA replication
70006279biological_processpremeiotic DNA replication
70008270molecular_functionzinc ion binding
70009378molecular_functionfour-way junction helicase activity
70016787molecular_functionhydrolase activity
70016887molecular_functionATP hydrolysis activity
70017116molecular_functionsingle-stranded DNA helicase activity
70030466biological_processsilent mating-type cassette heterochromatin formation
70031261cellular_componentDNA replication preinitiation complex
70031509biological_processsubtelomeric heterochromatin formation
70033260biological_processnuclear DNA replication
70042555cellular_componentMCM complex
70043138molecular_function3'-5' DNA helicase activity
70043596cellular_componentnuclear replication fork
70071162cellular_componentCMG complex
70097373cellular_componentMCM core complex
71904931molecular_functionMCM complex binding
A0000727biological_processdouble-strand break repair via break-induced replication
A0000811cellular_componentGINS complex
A0003674molecular_functionmolecular_function
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0006260biological_processDNA replication
A0006261biological_processDNA-templated DNA replication
A0031261cellular_componentDNA replication preinitiation complex
A0043596cellular_componentnuclear replication fork
A0071162cellular_componentCMG complex
A1902983biological_processDNA strand elongation involved in mitotic DNA replication
B0000228cellular_componentnuclear chromosome
B0000727biological_processdouble-strand break repair via break-induced replication
B0000811cellular_componentGINS complex
B0003674molecular_functionmolecular_function
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0006260biological_processDNA replication
B0006261biological_processDNA-templated DNA replication
B0031261cellular_componentDNA replication preinitiation complex
B0043596cellular_componentnuclear replication fork
B0071162cellular_componentCMG complex
C0000727biological_processdouble-strand break repair via break-induced replication
C0000811cellular_componentGINS complex
C0003674molecular_functionmolecular_function
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0006260biological_processDNA replication
C0006261biological_processDNA-templated DNA replication
C0006270biological_processDNA replication initiation
C0031261cellular_componentDNA replication preinitiation complex
C0043596cellular_componentnuclear replication fork
C0071162cellular_componentCMG complex
D0000727biological_processdouble-strand break repair via break-induced replication
D0000811cellular_componentGINS complex
D0003674molecular_functionmolecular_function
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0006260biological_processDNA replication
D0006261biological_processDNA-templated DNA replication
D0031261cellular_componentDNA replication preinitiation complex
D0043596cellular_componentnuclear replication fork
D0071162cellular_componentCMG complex
E0006270biological_processDNA replication initiation
F0000228cellular_componentnuclear chromosome
F0000278biological_processmitotic cell cycle
F0000727biological_processdouble-strand break repair via break-induced replication
F0003682molecular_functionchromatin binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0006260biological_processDNA replication
F0006261biological_processDNA-templated DNA replication
F0006270biological_processDNA replication initiation
F0006281biological_processDNA repair
F0006334biological_processnucleosome assembly
F0007064biological_processmitotic sister chromatid cohesion
F0034085biological_processestablishment of sister chromatid cohesion
F0042802molecular_functionidentical protein binding
F0043596cellular_componentnuclear replication fork
G0000228cellular_componentnuclear chromosome
G0000278biological_processmitotic cell cycle
G0000727biological_processdouble-strand break repair via break-induced replication
G0003682molecular_functionchromatin binding
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0006260biological_processDNA replication
G0006261biological_processDNA-templated DNA replication
G0006270biological_processDNA replication initiation
G0006281biological_processDNA repair
G0006334biological_processnucleosome assembly
G0007064biological_processmitotic sister chromatid cohesion
G0034085biological_processestablishment of sister chromatid cohesion
G0042802molecular_functionidentical protein binding
G0043596cellular_componentnuclear replication fork
H0000228cellular_componentnuclear chromosome
H0000278biological_processmitotic cell cycle
H0000727biological_processdouble-strand break repair via break-induced replication
H0003682molecular_functionchromatin binding
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0006260biological_processDNA replication
H0006261biological_processDNA-templated DNA replication
H0006270biological_processDNA replication initiation
H0006281biological_processDNA repair
H0006334biological_processnucleosome assembly
H0007064biological_processmitotic sister chromatid cohesion
H0034085biological_processestablishment of sister chromatid cohesion
H0042802molecular_functionidentical protein binding
H0043596cellular_componentnuclear replication fork
K0000082biological_processG1/S transition of mitotic cell cycle
K0000086biological_processG2/M transition of mitotic cell cycle
K0000278biological_processmitotic cell cycle
K0000409biological_processregulation of transcription by galactose
K0000776cellular_componentkinetochore
K0000781cellular_componentchromosome, telomeric region
K0000921biological_processseptin ring assembly
K0003677molecular_functionDNA binding
K0003688molecular_functionDNA replication origin binding
K0004842molecular_functionubiquitin-protein transferase activity
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005737cellular_componentcytoplasm
K0006511biological_processubiquitin-dependent protein catabolic process
K0007035biological_processvacuolar acidification
K0007096biological_processregulation of exit from mitosis
K0007346biological_processregulation of mitotic cell cycle
K0008053biological_processmitochondrial fusion
K0010458biological_processexit from mitosis
K0010828biological_processpositive regulation of D-glucose transmembrane transport
K0012505cellular_componentendomembrane system
K0016567biological_processprotein ubiquitination
K0019005cellular_componentSCF ubiquitin ligase complex
K0030466biological_processsilent mating-type cassette heterochromatin formation
K0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
K0031509biological_processsubtelomeric heterochromatin formation
K0031518cellular_componentCBF3 complex
K0031573biological_processmitotic intra-S DNA damage checkpoint signaling
K0043254biological_processregulation of protein-containing complex assembly
K0043291cellular_componentRAVE complex
K0045116biological_processprotein neddylation
K0051382biological_processkinetochore assembly
K0061630molecular_functionubiquitin protein ligase activity
K0065003biological_processprotein-containing complex assembly
K0070072biological_processvacuolar proton-transporting V-type ATPase complex assembly
K0071406biological_processcellular response to methylmercury
K0097602molecular_functioncullin family protein binding
K2000766biological_processnegative regulation of cytoplasmic translation
L0000781cellular_componentchromosome, telomeric region
L0001403biological_processinvasive growth in response to glucose limitation
L0003688molecular_functionDNA replication origin binding
L0004842molecular_functionubiquitin-protein transferase activity
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0006275biological_processregulation of DNA replication
L0006511biological_processubiquitin-dependent protein catabolic process
L0016567biological_processprotein ubiquitination
L0019005cellular_componentSCF ubiquitin ligase complex
L0030466biological_processsilent mating-type cassette heterochromatin formation
L0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
L0031509biological_processsubtelomeric heterochromatin formation
L0031573biological_processmitotic intra-S DNA damage checkpoint signaling
L0032984biological_processprotein-containing complex disassembly
L0043596cellular_componentnuclear replication fork
L0051603biological_processproteolysis involved in protein catabolic process
L1902979biological_processmitotic DNA replication termination
Q0000166molecular_functionnucleotide binding
Q0000278biological_processmitotic cell cycle
Q0003676molecular_functionnucleic acid binding
Q0003677molecular_functionDNA binding
Q0003690molecular_functiondouble-stranded DNA binding
Q0003697molecular_functionsingle-stranded DNA binding
Q0003729molecular_functionmRNA binding
Q0003887molecular_functionDNA-directed DNA polymerase activity
Q0005515molecular_functionprotein binding
Q0005634cellular_componentnucleus
Q0005657cellular_componentreplication fork
Q0006260biological_processDNA replication
Q0006261biological_processDNA-templated DNA replication
Q0006272biological_processleading strand elongation
Q0006281biological_processDNA repair
Q0006284biological_processbase-excision repair
Q0006287biological_processbase-excision repair, gap-filling
Q0006297biological_processnucleotide-excision repair, DNA gap filling
Q0006302biological_processdouble-strand break repair
Q0006303biological_processdouble-strand break repair via nonhomologous end joining
Q0007064biological_processmitotic sister chromatid cohesion
Q0008270molecular_functionzinc ion binding
Q0008310molecular_functionsingle-stranded DNA 3'-5' DNA exonuclease activity
Q0008622cellular_componentepsilon DNA polymerase complex
Q0016740molecular_functiontransferase activity
Q0016779molecular_functionnucleotidyltransferase activity
Q0016787molecular_functionhydrolase activity
Q0031573biological_processmitotic intra-S DNA damage checkpoint signaling
Q0032183molecular_functionSUMO binding
Q0033314biological_processmitotic DNA replication checkpoint signaling
Q0034061molecular_functionDNA polymerase activity
Q0035822biological_processgene conversion
Q0042276biological_processerror-prone translesion synthesis
Q0043596cellular_componentnuclear replication fork
Q0045004biological_processDNA replication proofreading
Q0046872molecular_functionmetal ion binding
Q0051536molecular_functioniron-sulfur cluster binding
Q0051539molecular_function4 iron, 4 sulfur cluster binding
R0003677molecular_functionDNA binding
R0003690molecular_functiondouble-stranded DNA binding
R0003697molecular_functionsingle-stranded DNA binding
R0003887molecular_functionDNA-directed DNA polymerase activity
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005694cellular_componentchromosome
R0005737cellular_componentcytoplasm
R0006260biological_processDNA replication
R0006261biological_processDNA-templated DNA replication
R0008622cellular_componentepsilon DNA polymerase complex
R0030337molecular_functionDNA polymerase processivity factor activity
R0031981cellular_componentnuclear lumen
R0042276biological_processerror-prone translesion synthesis
R0043596cellular_componentnuclear replication fork
R0045005biological_processDNA-templated DNA replication maintenance of fidelity
X0000076biological_processDNA replication checkpoint signaling
X0003674molecular_functionmolecular_function
X0003677molecular_functionDNA binding
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005829cellular_componentcytosol
X0006260biological_processDNA replication
X0006281biological_processDNA repair
X0006974biological_processDNA damage response
X0007064biological_processmitotic sister chromatid cohesion
X0008156biological_processnegative regulation of DNA replication
X0031297biological_processreplication fork processing
X0031298cellular_componentreplication fork protection complex
X0043111biological_processreplication fork arrest
X0043570biological_processmaintenance of DNA repeat elements
X0043596cellular_componentnuclear replication fork
X0051321biological_processmeiotic cell cycle
Y0000076biological_processDNA replication checkpoint signaling
Y0003674molecular_functionmolecular_function
Y0003677molecular_functionDNA binding
Y0005515molecular_functionprotein binding
Y0005634cellular_componentnucleus
Y0005737cellular_componentcytoplasm
Y0006281biological_processDNA repair
Y0006974biological_processDNA damage response
Y0007064biological_processmitotic sister chromatid cohesion
Y0008156biological_processnegative regulation of DNA replication
Y0031297biological_processreplication fork processing
Y0031298cellular_componentreplication fork protection complex
Y0034087biological_processestablishment of mitotic sister chromatid cohesion
Y0043111biological_processreplication fork arrest
Y0043570biological_processmaintenance of DNA repeat elements
Y0043596cellular_componentnuclear replication fork
Y0045132biological_processmeiotic chromosome segregation
Y0051321biological_processmeiotic cell cycle
Functional Information from PROSITE/UniProt
site_idPS00847
Number of Residues9
DetailsMCM_1 MCM family signature. GICCIDEFD
ChainResidueDetails
7GLY519-ASP527
2GLY602-ASP610
5GLY475-ASP483
3GLY468-ASP476
6GLY634-ASP642
4GLY627-ASP635

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues621
DetailsDomain: {"description":"MCM"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues26
DetailsZinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues18
DetailsMotif: {"description":"Arginine finger"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues35
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P33993","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues120
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues24
DetailsRepeat: {"description":"LRR 1"}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues25
DetailsRepeat: {"description":"LRR 2"}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues23
DetailsRepeat: {"description":"LRR 3"}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues24
DetailsRepeat: {"description":"LRR 4"}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues23
DetailsRepeat: {"description":"LRR 5"}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues21
DetailsRepeat: {"description":"LRR 6"}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues24
DetailsRepeat: {"description":"LRR 7"}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues25
DetailsZinc finger: {"description":"CysA-type","evidences":[{"source":"UniProtKB","id":"P15436","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues17
DetailsMotif: {"description":"CysB motif","evidences":[{"source":"UniProtKB","id":"P15436","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI19
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P15436","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI20
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"14747467","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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