7PLO

H. sapiens replisome-CUL2/LRR1 complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0000166	molecular_function	nucleotide binding
2	0000228	cellular_component	nuclear chromosome
2	0000727	biological_process	double-strand break repair via break-induced replication
2	0000781	cellular_component	chromosome, telomeric region
2	0000785	cellular_component	chromatin
2	0003677	molecular_function	DNA binding
2	0003678	molecular_function	DNA helicase activity
2	0003688	molecular_function	DNA replication origin binding
2	0003697	molecular_function	single-stranded DNA binding
2	0004386	molecular_function	helicase activity
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005664	cellular_component	nuclear origin of replication recognition complex
2	0005694	cellular_component	chromosome
2	0005730	cellular_component	nucleolus
2	0005737	cellular_component	cytoplasm
2	0006260	biological_process	DNA replication
2	0006270	biological_process	DNA replication initiation
2	0006915	biological_process	apoptotic process
2	0008270	molecular_function	zinc ion binding
2	0016787	molecular_function	hydrolase activity
2	0016887	molecular_function	ATP hydrolysis activity
2	0017116	molecular_function	single-stranded DNA helicase activity
2	0019899	molecular_function	enzyme binding
2	0030174	biological_process	regulation of DNA-templated DNA replication initiation
2	0042393	molecular_function	histone binding
2	0042555	cellular_component	MCM complex
2	0043138	molecular_function	3'-5' DNA helicase activity
2	0046872	molecular_function	metal ion binding
2	0071162	cellular_component	CMG complex
2	0090102	biological_process	cochlea development
2	1902975	biological_process	mitotic DNA replication initiation
3	0000166	molecular_function	nucleotide binding
3	0000727	biological_process	double-strand break repair via break-induced replication
3	0000781	cellular_component	chromosome, telomeric region
3	0003677	molecular_function	DNA binding
3	0003678	molecular_function	DNA helicase activity
3	0003697	molecular_function	single-stranded DNA binding
3	0004386	molecular_function	helicase activity
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005658	cellular_component	alpha DNA polymerase:primase complex
3	0005694	cellular_component	chromosome
3	0005730	cellular_component	nucleolus
3	0005737	cellular_component	cytoplasm
3	0006260	biological_process	DNA replication
3	0006270	biological_process	DNA replication initiation
3	0006271	biological_process	DNA strand elongation involved in DNA replication
3	0016020	cellular_component	membrane
3	0016787	molecular_function	hydrolase activity
3	0016887	molecular_function	ATP hydrolysis activity
3	0017116	molecular_function	single-stranded DNA helicase activity
3	0030174	biological_process	regulation of DNA-templated DNA replication initiation
3	0042555	cellular_component	MCM complex
3	0048471	cellular_component	perinuclear region of cytoplasm
3	0071162	cellular_component	CMG complex
3	1902975	biological_process	mitotic DNA replication initiation
4	0000166	molecular_function	nucleotide binding
4	0000727	biological_process	double-strand break repair via break-induced replication
4	0000781	cellular_component	chromosome, telomeric region
4	0003677	molecular_function	DNA binding
4	0003678	molecular_function	DNA helicase activity
4	0003697	molecular_function	single-stranded DNA binding
4	0004386	molecular_function	helicase activity
4	0005515	molecular_function	protein binding
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005694	cellular_component	chromosome
4	0006260	biological_process	DNA replication
4	0006270	biological_process	DNA replication initiation
4	0006271	biological_process	DNA strand elongation involved in DNA replication
4	0016020	cellular_component	membrane
4	0016787	molecular_function	hydrolase activity
4	0016887	molecular_function	ATP hydrolysis activity
4	0017116	molecular_function	single-stranded DNA helicase activity
4	0030174	biological_process	regulation of DNA-templated DNA replication initiation
4	0042555	cellular_component	MCM complex
4	0071162	cellular_component	CMG complex
4	1902975	biological_process	mitotic DNA replication initiation
5	0000166	molecular_function	nucleotide binding
5	0000727	biological_process	double-strand break repair via break-induced replication
5	0000781	cellular_component	chromosome, telomeric region
5	0003677	molecular_function	DNA binding
5	0003678	molecular_function	DNA helicase activity
5	0003688	molecular_function	DNA replication origin binding
5	0003697	molecular_function	single-stranded DNA binding
5	0004386	molecular_function	helicase activity
5	0005515	molecular_function	protein binding
5	0005524	molecular_function	ATP binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005694	cellular_component	chromosome
5	0006260	biological_process	DNA replication
5	0006270	biological_process	DNA replication initiation
5	0016020	cellular_component	membrane
5	0016787	molecular_function	hydrolase activity
5	0016887	molecular_function	ATP hydrolysis activity
5	0017116	molecular_function	single-stranded DNA helicase activity
5	0030174	biological_process	regulation of DNA-templated DNA replication initiation
5	0042555	cellular_component	MCM complex
5	0043138	molecular_function	3'-5' DNA helicase activity
5	0071162	cellular_component	CMG complex
6	0000166	molecular_function	nucleotide binding
6	0000727	biological_process	double-strand break repair via break-induced replication
6	0000781	cellular_component	chromosome, telomeric region
6	0003677	molecular_function	DNA binding
6	0003678	molecular_function	DNA helicase activity
6	0003697	molecular_function	single-stranded DNA binding
6	0004386	molecular_function	helicase activity
6	0005515	molecular_function	protein binding
6	0005524	molecular_function	ATP binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005694	cellular_component	chromosome
6	0006260	biological_process	DNA replication
6	0006270	biological_process	DNA replication initiation
6	0016787	molecular_function	hydrolase activity
6	0016887	molecular_function	ATP hydrolysis activity
6	0030174	biological_process	regulation of DNA-templated DNA replication initiation
6	0042555	cellular_component	MCM complex
6	0042802	molecular_function	identical protein binding
6	0071162	cellular_component	CMG complex
6	1902969	biological_process	mitotic DNA replication
6	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
7	0000166	molecular_function	nucleotide binding
7	0000727	biological_process	double-strand break repair via break-induced replication
7	0000781	cellular_component	chromosome, telomeric region
7	0000785	cellular_component	chromatin
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0003697	molecular_function	single-stranded DNA binding
7	0004386	molecular_function	helicase activity
7	0005515	molecular_function	protein binding
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005694	cellular_component	chromosome
7	0005730	cellular_component	nucleolus
7	0006260	biological_process	DNA replication
7	0006270	biological_process	DNA replication initiation
7	0006271	biological_process	DNA strand elongation involved in DNA replication
7	0006974	biological_process	DNA damage response
7	0009410	biological_process	response to xenobiotic stimulus
7	0016020	cellular_component	membrane
7	0016787	molecular_function	hydrolase activity
7	0016887	molecular_function	ATP hydrolysis activity
7	0017116	molecular_function	single-stranded DNA helicase activity
7	0030174	biological_process	regulation of DNA-templated DNA replication initiation
7	0042325	biological_process	regulation of phosphorylation
7	0042555	cellular_component	MCM complex
7	0071162	cellular_component	CMG complex
7	0071364	biological_process	cellular response to epidermal growth factor stimulus
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0006259	biological_process	DNA metabolic process
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006281	biological_process	DNA repair
A	0008622	cellular_component	epsilon DNA polymerase complex
A	0016604	cellular_component	nuclear body
A	0031981	cellular_component	nuclear lumen
A	0042276	biological_process	error-prone translesion synthesis
B	0000082	biological_process	G1/S transition of mitotic cell cycle
B	0000166	molecular_function	nucleotide binding
B	0000278	biological_process	mitotic cell cycle
B	0000731	biological_process	DNA synthesis involved in DNA repair
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003682	molecular_function	chromatin binding
B	0003887	molecular_function	DNA-directed DNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005886	cellular_component	plasma membrane
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0006272	biological_process	leading strand elongation
B	0006281	biological_process	DNA repair
B	0006287	biological_process	base-excision repair, gap-filling
B	0006297	biological_process	nucleotide-excision repair, DNA gap filling
B	0006974	biological_process	DNA damage response
B	0008270	molecular_function	zinc ion binding
B	0008310	molecular_function	single-stranded DNA 3'-5' DNA exonuclease activity
B	0008622	cellular_component	epsilon DNA polymerase complex
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0016787	molecular_function	hydrolase activity
B	0034061	molecular_function	DNA polymerase activity
B	0045004	biological_process	DNA replication proofreading
B	0046872	molecular_function	metal ion binding
B	0048568	biological_process	embryonic organ development
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	0071897	biological_process	DNA biosynthetic process
C	0006270	biological_process	DNA replication initiation
D	0000811	cellular_component	GINS complex
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0006260	biological_process	DNA replication
D	0071162	cellular_component	CMG complex
D	1902983	biological_process	DNA strand elongation involved in mitotic DNA replication
E	0000727	biological_process	double-strand break repair via break-induced replication
E	0000811	cellular_component	GINS complex
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0006260	biological_process	DNA replication
E	0071162	cellular_component	CMG complex
F	0000811	cellular_component	GINS complex
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0006260	biological_process	DNA replication
F	0006270	biological_process	DNA replication initiation
F	0071162	cellular_component	CMG complex
G	0000727	biological_process	double-strand break repair via break-induced replication
G	0000811	cellular_component	GINS complex
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0005737	cellular_component	cytoplasm
G	0006260	biological_process	DNA replication
G	0006261	biological_process	DNA-templated DNA replication
G	0071162	cellular_component	CMG complex
H	0000278	biological_process	mitotic cell cycle
H	0003676	molecular_function	nucleic acid binding
H	0003677	molecular_function	DNA binding
H	0003682	molecular_function	chromatin binding
H	0005515	molecular_function	protein binding
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0006261	biological_process	DNA-templated DNA replication
H	0006281	biological_process	DNA repair
H	0043596	cellular_component	nuclear replication fork
I	0000278	biological_process	mitotic cell cycle
I	0003676	molecular_function	nucleic acid binding
I	0003677	molecular_function	DNA binding
I	0003682	molecular_function	chromatin binding
I	0005515	molecular_function	protein binding
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0006261	biological_process	DNA-templated DNA replication
I	0006281	biological_process	DNA repair
I	0043596	cellular_component	nuclear replication fork
J	0000278	biological_process	mitotic cell cycle
J	0003676	molecular_function	nucleic acid binding
J	0003677	molecular_function	DNA binding
J	0003682	molecular_function	chromatin binding
J	0005515	molecular_function	protein binding
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0006261	biological_process	DNA-templated DNA replication
J	0006281	biological_process	DNA repair
J	0043596	cellular_component	nuclear replication fork
K	0000076	biological_process	DNA replication checkpoint signaling
K	0000785	cellular_component	chromatin
K	0002009	biological_process	morphogenesis of an epithelium
K	0003677	molecular_function	DNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0006281	biological_process	DNA repair
K	0006351	biological_process	DNA-templated transcription
K	0006974	biological_process	DNA damage response
K	0007623	biological_process	circadian rhythm
K	0008047	molecular_function	enzyme activator activity
K	0009582	biological_process	detection of abiotic stimulus
K	0031297	biological_process	replication fork processing
K	0031298	cellular_component	replication fork protection complex
K	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
K	0035861	cellular_component	site of double-strand break
K	0042127	biological_process	regulation of cell population proliferation
K	0042752	biological_process	regulation of circadian rhythm
K	0042802	molecular_function	identical protein binding
K	0043111	biological_process	replication fork arrest
K	0043596	cellular_component	nuclear replication fork
K	0044770	biological_process	cell cycle phase transition
K	0045892	biological_process	negative regulation of DNA-templated transcription
K	0048511	biological_process	rhythmic process
K	0051301	biological_process	cell division
K	0072711	biological_process	cellular response to hydroxyurea
K	0072719	biological_process	cellular response to cisplatin
K	1904976	biological_process	cellular response to bleomycin
K	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
K	2000781	biological_process	positive regulation of double-strand break repair
L	0000076	biological_process	DNA replication checkpoint signaling
L	0000785	cellular_component	chromatin
L	0003677	molecular_function	DNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0006974	biological_process	DNA damage response
L	0008284	biological_process	positive regulation of cell population proliferation
L	0031297	biological_process	replication fork processing
L	0031298	cellular_component	replication fork protection complex
L	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
L	0033262	biological_process	regulation of nuclear cell cycle DNA replication
L	0043111	biological_process	replication fork arrest
L	0043596	cellular_component	nuclear replication fork
L	0044770	biological_process	cell cycle phase transition
L	0051301	biological_process	cell division
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005829	cellular_component	cytosol
O	0016567	biological_process	protein ubiquitination
O	0035556	biological_process	intracellular signal transduction
O	2000104	biological_process	negative regulation of DNA-templated DNA replication
P	0000122	biological_process	negative regulation of transcription by RNA polymerase II
P	0000151	cellular_component	ubiquitin ligase complex
P	0001222	molecular_function	transcription corepressor binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006351	biological_process	DNA-templated transcription
P	0006367	biological_process	transcription initiation at RNA polymerase II promoter
P	0006368	biological_process	transcription elongation by RNA polymerase II
P	0016567	biological_process	protein ubiquitination
P	0030891	cellular_component	VCB complex
P	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
P	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
P	0031625	molecular_function	ubiquitin protein ligase binding
P	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0065003	biological_process	protein-containing complex assembly
P	0070449	cellular_component	elongin complex
P	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
P	0140958	biological_process	target-directed miRNA degradation
P	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
P	2000104	biological_process	negative regulation of DNA-templated DNA replication
Q	0000076	biological_process	DNA replication checkpoint signaling
Q	0000077	biological_process	DNA damage checkpoint signaling
Q	0000217	molecular_function	DNA secondary structure binding
Q	0003677	molecular_function	DNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005794	cellular_component	Golgi apparatus
Q	0006281	biological_process	DNA repair
Q	0006974	biological_process	DNA damage response
Q	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
Q	0010997	molecular_function	anaphase-promoting complex binding
Q	0033314	biological_process	mitotic DNA replication checkpoint signaling
R	0000122	biological_process	negative regulation of transcription by RNA polymerase II
R	0000151	cellular_component	ubiquitin ligase complex
R	0001222	molecular_function	transcription corepressor binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006351	biological_process	DNA-templated transcription
R	0006357	biological_process	regulation of transcription by RNA polymerase II
R	0006367	biological_process	transcription initiation at RNA polymerase II promoter
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0016567	biological_process	protein ubiquitination
R	0030674	molecular_function	protein-macromolecule adaptor activity
R	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
R	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0070449	cellular_component	elongin complex
R	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
R	0140958	biological_process	target-directed miRNA degradation
R	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
R	2000104	biological_process	negative regulation of DNA-templated DNA replication
S	0000082	biological_process	G1/S transition of mitotic cell cycle
S	0000122	biological_process	negative regulation of transcription by RNA polymerase II
S	0004842	molecular_function	ubiquitin-protein transferase activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005730	cellular_component	nucleolus
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0010498	biological_process	proteasomal protein catabolic process
S	0016567	biological_process	protein ubiquitination
S	0019005	cellular_component	SCF ubiquitin ligase complex
S	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
S	0031461	cellular_component	cullin-RING ubiquitin ligase complex
S	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
S	0031625	molecular_function	ubiquitin protein ligase binding
S	0031981	cellular_component	nuclear lumen
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0072344	biological_process	rescue of stalled ribosome
S	0097193	biological_process	intrinsic apoptotic signaling pathway
S	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
S	0160072	molecular_function	ubiquitin ligase complex scaffold activity
S	0160276	biological_process	negative regulation of beige fat cell differentiation
S	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
S	2000104	biological_process	negative regulation of DNA-templated DNA replication
T	0000082	biological_process	G1/S transition of mitotic cell cycle
T	0000122	biological_process	negative regulation of transcription by RNA polymerase II
T	0000165	biological_process	MAPK cascade
T	0000209	biological_process	protein polyubiquitination
T	0004842	molecular_function	ubiquitin-protein transferase activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005794	cellular_component	Golgi apparatus
T	0005813	cellular_component	centrosome
T	0005829	cellular_component	cytosol
T	0006281	biological_process	DNA repair
T	0006283	biological_process	transcription-coupled nucleotide-excision repair
T	0006289	biological_process	nucleotide-excision repair
T	0006355	biological_process	regulation of DNA-templated transcription
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0006513	biological_process	protein monoubiquitination
T	0006879	biological_process	intracellular iron ion homeostasis
T	0006974	biological_process	DNA damage response
T	0007283	biological_process	spermatogenesis
T	0007346	biological_process	regulation of mitotic cell cycle
T	0008270	molecular_function	zinc ion binding
T	0008283	biological_process	cell population proliferation
T	0010506	biological_process	regulation of autophagy
T	0010564	biological_process	regulation of cell cycle process
T	0010824	biological_process	regulation of centrosome duplication
T	0014033	biological_process	neural crest cell differentiation
T	0016567	biological_process	protein ubiquitination
T	0016740	molecular_function	transferase activity
T	0019005	cellular_component	SCF ubiquitin ligase complex
T	0019788	molecular_function	NEDD8 transferase activity
T	0030174	biological_process	regulation of DNA-templated DNA replication initiation
T	0030510	biological_process	regulation of BMP signaling pathway
T	0030891	cellular_component	VCB complex
T	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
T	0031297	biological_process	replication fork processing
T	0031461	cellular_component	cullin-RING ubiquitin ligase complex
T	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
T	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
T	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
T	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
T	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
T	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
T	0031625	molecular_function	ubiquitin protein ligase binding
T	0032006	biological_process	regulation of TOR signaling
T	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
T	0032480	biological_process	negative regulation of type I interferon production
T	0032814	biological_process	regulation of natural killer cell activation
T	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
T	0034599	biological_process	cellular response to oxidative stress
T	0034644	biological_process	cellular response to UV
T	0040029	biological_process	epigenetic regulation of gene expression
T	0042110	biological_process	T cell activation
T	0042127	biological_process	regulation of cell population proliferation
T	0042752	biological_process	regulation of circadian rhythm
T	0042770	biological_process	signal transduction in response to DNA damage
T	0042981	biological_process	regulation of apoptotic process
T	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
T	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0043687	biological_process	post-translational protein modification
T	0044314	biological_process	protein K27-linked ubiquitination
T	0044877	molecular_function	protein-containing complex binding
T	0045116	biological_process	protein neddylation
T	0045732	biological_process	positive regulation of protein catabolic process
T	0045995	biological_process	regulation of embryonic development
T	0046627	biological_process	negative regulation of insulin receptor signaling pathway
T	0046872	molecular_function	metal ion binding
T	0050727	biological_process	regulation of inflammatory response
T	0051298	biological_process	centrosome duplication
T	0051726	biological_process	regulation of cell cycle
T	0060090	molecular_function	molecular adaptor activity
T	0060173	biological_process	limb development
T	0060271	biological_process	cilium assembly
T	0060964	biological_process	regulation of miRNA-mediated gene silencing
T	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
T	0061630	molecular_function	ubiquitin protein ligase activity
T	0061663	molecular_function	NEDD8 ligase activity
T	0062197	biological_process	cellular response to chemical stress
T	0070936	biological_process	protein K48-linked ubiquitination
T	0071230	biological_process	cellular response to amino acid stimulus
T	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
T	0080135	biological_process	regulation of cellular response to stress
T	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
T	0090734	cellular_component	site of DNA damage
T	0097602	molecular_function	cullin family protein binding
T	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
T	0160240	biological_process	RNA polymerase II transcription initiation surveillance
T	0160276	biological_process	negative regulation of beige fat cell differentiation
T	1900076	biological_process	regulation of cellular response to insulin stimulus
T	1901524	biological_process	regulation of mitophagy
T	1901525	biological_process	negative regulation of mitophagy
T	1901987	biological_process	regulation of cell cycle phase transition
T	1902412	biological_process	regulation of mitotic cytokinesis
T	1902499	biological_process	positive regulation of protein autoubiquitination
T	1902883	biological_process	negative regulation of response to oxidative stress
T	1904178	biological_process	negative regulation of adipose tissue development
T	1904263	biological_process	positive regulation of TORC1 signaling
T	1904415	biological_process	regulation of xenophagy
T	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
T	2000001	biological_process	regulation of DNA damage checkpoint
T	2000036	biological_process	regulation of stem cell population maintenance
T	2000104	biological_process	negative regulation of DNA-templated DNA replication

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LAAGsiNgLIIVWNV

Chain	Residue	Details
H	LEU245-VAL259

---

site_id	PS00847
Number of Residues	9
Details	MCM_1 MCM family signature. GVVCIDEFD

Chain	Residue	Details
5	GLY440-ASP448
6	GLY455-ASP463
4	GLY569-ASP577
7	GLY440-ASP448
3	GLY404-ASP412
2	GLY582-ASP590

---

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. IKkcIevLIDKqYIeRsqasadeYsYvA

Chain	Residue	Details
S	ILE718-ALA745

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	826
Details	Domain: {"description":"MCM"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	26
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	15
Details	Motif: {"description":"Arginine finger"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32453425","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XTX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	7
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	31
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32453425","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6XTX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Glen H.","Brunton V.G.","Frame M.C."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P25206","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P97311","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	43
Details	Region: {"description":"Interaction with RAD17","evidences":[{"source":"PubMed","id":"15538388","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	32
Details	Zinc finger: {"description":"CysA-type","evidences":[{"source":"UniProtKB","id":"P15436","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	17
Details	Motif: {"description":"CysB motif","evidences":[{"source":"UniProtKB","id":"P15436","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P15436","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	57
Details	Region: {"description":"Important for GINS complex assembly"}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P59328","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	76
Details	Region: {"description":"Interaction with TIMELESS","evidences":[{"source":"PubMed","id":"23359676","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	21
Details	Repeat: {"description":"LRR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	21
Details	Repeat: {"description":"LRR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	21
Details	Repeat: {"description":"LRR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	21
Details	Repeat: {"description":"LRR 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	21
Details	Repeat: {"description":"LRR 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	21
Details	Repeat: {"description":"LRR 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	21
Details	Repeat: {"description":"LRR 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	7
Details	Motif: {"description":"PCNA-interacting protein (PIP)","evidences":[{"source":"PubMed","id":"27401717","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	60
Details	Domain: {"description":"Cullin neddylation","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)","evidences":[{"source":"PubMed","id":"10092517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10597293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	45
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z8B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---