Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7PGR

The structure of human neurofibromin isoform 2 in closed conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
F	0000165	biological_process	MAPK cascade
F	0001649	biological_process	osteoblast differentiation
F	0001656	biological_process	metanephros development
F	0001666	biological_process	response to hypoxia
F	0001889	biological_process	liver development
F	0001937	biological_process	negative regulation of endothelial cell proliferation
F	0001952	biological_process	regulation of cell-matrix adhesion
F	0005096	molecular_function	GTPase activator activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005730	cellular_component	nucleolus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0007154	biological_process	cell communication
F	0007265	biological_process	Ras protein signal transduction
F	0007406	biological_process	negative regulation of neuroblast proliferation
F	0007420	biological_process	brain development
F	0007422	biological_process	peripheral nervous system development
F	0007507	biological_process	heart development
F	0008289	molecular_function	lipid binding
F	0008429	molecular_function	phosphatidylethanolamine binding
F	0008542	biological_process	visual learning
F	0014044	biological_process	Schwann cell development
F	0016020	cellular_component	membrane
F	0021510	biological_process	spinal cord development
F	0021897	biological_process	forebrain astrocyte development
F	0021987	biological_process	cerebral cortex development
F	0022011	biological_process	myelination in peripheral nervous system
F	0030036	biological_process	actin cytoskeleton organization
F	0030198	biological_process	extracellular matrix organization
F	0030199	biological_process	collagen fibril organization
F	0030325	biological_process	adrenal gland development
F	0030336	biological_process	negative regulation of cell migration
F	0030424	cellular_component	axon
F	0030425	cellular_component	dendrite
F	0031210	molecular_function	phosphatidylcholine binding
F	0042060	biological_process	wound healing
F	0043065	biological_process	positive regulation of apoptotic process
F	0043087	biological_process	regulation of GTPase activity
F	0043409	biological_process	negative regulation of MAPK cascade
F	0043473	biological_process	pigmentation
F	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
F	0043525	biological_process	positive regulation of neuron apoptotic process
F	0043535	biological_process	regulation of blood vessel endothelial cell migration
F	0043547	biological_process	positive regulation of GTPase activity
F	0045124	biological_process	regulation of bone resorption
F	0045685	biological_process	regulation of glial cell differentiation
F	0045765	biological_process	regulation of angiogenesis
F	0048147	biological_process	negative regulation of fibroblast proliferation
F	0048485	biological_process	sympathetic nervous system development
F	0048593	biological_process	camera-type eye morphogenesis
F	0048715	biological_process	negative regulation of oligodendrocyte differentiation
F	0048745	biological_process	smooth muscle tissue development
F	0048844	biological_process	artery morphogenesis
F	0048853	biological_process	forebrain morphogenesis
F	0050793	biological_process	regulation of developmental process
F	0050890	biological_process	cognition
F	0098978	cellular_component	glutamatergic synapse
F	0099175	biological_process	regulation of postsynapse organization
F	1902531	biological_process	regulation of intracellular signal transduction
N	0000165	biological_process	MAPK cascade
N	0001649	biological_process	osteoblast differentiation
N	0001656	biological_process	metanephros development
N	0001666	biological_process	response to hypoxia
N	0001889	biological_process	liver development
N	0001937	biological_process	negative regulation of endothelial cell proliferation
N	0001952	biological_process	regulation of cell-matrix adhesion
N	0005096	molecular_function	GTPase activator activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005730	cellular_component	nucleolus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0007154	biological_process	cell communication
N	0007265	biological_process	Ras protein signal transduction
N	0007406	biological_process	negative regulation of neuroblast proliferation
N	0007420	biological_process	brain development
N	0007422	biological_process	peripheral nervous system development
N	0007507	biological_process	heart development
N	0008289	molecular_function	lipid binding
N	0008429	molecular_function	phosphatidylethanolamine binding
N	0008542	biological_process	visual learning
N	0014044	biological_process	Schwann cell development
N	0016020	cellular_component	membrane
N	0021510	biological_process	spinal cord development
N	0021897	biological_process	forebrain astrocyte development
N	0021987	biological_process	cerebral cortex development
N	0022011	biological_process	myelination in peripheral nervous system
N	0030036	biological_process	actin cytoskeleton organization
N	0030198	biological_process	extracellular matrix organization
N	0030199	biological_process	collagen fibril organization
N	0030325	biological_process	adrenal gland development
N	0030336	biological_process	negative regulation of cell migration
N	0030424	cellular_component	axon
N	0030425	cellular_component	dendrite
N	0031210	molecular_function	phosphatidylcholine binding
N	0042060	biological_process	wound healing
N	0043065	biological_process	positive regulation of apoptotic process
N	0043087	biological_process	regulation of GTPase activity
N	0043409	biological_process	negative regulation of MAPK cascade
N	0043473	biological_process	pigmentation
N	0043491	biological_process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
N	0043525	biological_process	positive regulation of neuron apoptotic process
N	0043535	biological_process	regulation of blood vessel endothelial cell migration
N	0043547	biological_process	positive regulation of GTPase activity
N	0045124	biological_process	regulation of bone resorption
N	0045685	biological_process	regulation of glial cell differentiation
N	0045765	biological_process	regulation of angiogenesis
N	0048147	biological_process	negative regulation of fibroblast proliferation
N	0048485	biological_process	sympathetic nervous system development
N	0048593	biological_process	camera-type eye morphogenesis
N	0048715	biological_process	negative regulation of oligodendrocyte differentiation
N	0048745	biological_process	smooth muscle tissue development
N	0048844	biological_process	artery morphogenesis
N	0048853	biological_process	forebrain morphogenesis
N	0050793	biological_process	regulation of developmental process
N	0050890	biological_process	cognition
N	0098978	cellular_component	glutamatergic synapse
N	0099175	biological_process	regulation of postsynapse organization
N	1902531	biological_process	regulation of intracellular signal transduction

Functional Information from PROSITE/UniProt

site_id	PS00509
Number of Residues	15
Details	RAS_GTPASE_ACTIV_1 Ras GTPase-activating proteins (rasGAP) domain signature. SaMFLRFINPAIVSP

Chain	Residue	Details
N	SER1407-PRO1421

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	316
Details	Domain: {"description":"CRAL-TRIO","evidences":[{"source":"PROSITE-ProRule","id":"PRU00056","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	514
Details	Region: {"description":"Lipid binding"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Arginine finger; crucial for GTP hydrolysis by stabilizing the transition state","evidences":[{"source":"PROSITE-ProRule","id":"PRU00167","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)