7PFU

Nucleosome stack of the 4x207 nucleosome array containing H1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0006325	biological_process	chromatin organization
A	0006334	biological_process	nucleosome assembly
A	0030527	molecular_function	structural constituent of chromatin
A	0046982	molecular_function	protein heterodimerization activity
A	0070062	cellular_component	extracellular exosome
B	0000781	cellular_component	chromosome, telomeric region
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0006325	biological_process	chromatin organization
B	0006334	biological_process	nucleosome assembly
B	0016020	cellular_component	membrane
B	0030527	molecular_function	structural constituent of chromatin
B	0032200	biological_process	telomere organization
B	0032991	cellular_component	protein-containing complex
B	0043505	cellular_component	CENP-A containing nucleosome
B	0045653	biological_process	negative regulation of megakaryocyte differentiation
B	0046982	molecular_function	protein heterodimerization activity
B	0061644	biological_process	protein localization to CENP-A containing chromatin
B	0070062	cellular_component	extracellular exosome
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0006325	biological_process	chromatin organization
C	0008285	biological_process	negative regulation of cell population proliferation
C	0030527	molecular_function	structural constituent of chromatin
C	0031507	biological_process	heterochromatin formation
C	0043505	cellular_component	CENP-A containing nucleosome
C	0046982	molecular_function	protein heterodimerization activity
C	0061644	biological_process	protein localization to CENP-A containing chromatin
C	0070062	cellular_component	extracellular exosome
D	0000786	cellular_component	nucleosome
D	0002227	biological_process	innate immune response in mucosa
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005829	cellular_component	cytosol
D	0019731	biological_process	antibacterial humoral response
D	0030527	molecular_function	structural constituent of chromatin
D	0031640	biological_process	killing of cells of another organism
D	0042742	biological_process	defense response to bacterium
D	0046982	molecular_function	protein heterodimerization activity
D	0050829	biological_process	defense response to Gram-negative bacterium
D	0050830	biological_process	defense response to Gram-positive bacterium
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0006325	biological_process	chromatin organization
E	0006334	biological_process	nucleosome assembly
E	0030527	molecular_function	structural constituent of chromatin
E	0046982	molecular_function	protein heterodimerization activity
E	0070062	cellular_component	extracellular exosome
F	0000781	cellular_component	chromosome, telomeric region
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0006325	biological_process	chromatin organization
F	0006334	biological_process	nucleosome assembly
F	0016020	cellular_component	membrane
F	0030527	molecular_function	structural constituent of chromatin
F	0032200	biological_process	telomere organization
F	0032991	cellular_component	protein-containing complex
F	0043505	cellular_component	CENP-A containing nucleosome
F	0045653	biological_process	negative regulation of megakaryocyte differentiation
F	0046982	molecular_function	protein heterodimerization activity
F	0061644	biological_process	protein localization to CENP-A containing chromatin
F	0070062	cellular_component	extracellular exosome
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0006325	biological_process	chromatin organization
G	0008285	biological_process	negative regulation of cell population proliferation
G	0030527	molecular_function	structural constituent of chromatin
G	0031507	biological_process	heterochromatin formation
G	0043505	cellular_component	CENP-A containing nucleosome
G	0046982	molecular_function	protein heterodimerization activity
G	0061644	biological_process	protein localization to CENP-A containing chromatin
G	0070062	cellular_component	extracellular exosome
H	0000786	cellular_component	nucleosome
H	0002227	biological_process	innate immune response in mucosa
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005829	cellular_component	cytosol
H	0019731	biological_process	antibacterial humoral response
H	0030527	molecular_function	structural constituent of chromatin
H	0031640	biological_process	killing of cells of another organism
H	0042742	biological_process	defense response to bacterium
H	0046982	molecular_function	protein heterodimerization activity
H	0050829	biological_process	defense response to Gram-negative bacterium
H	0050830	biological_process	defense response to Gram-positive bacterium
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
K	0000786	cellular_component	nucleosome
K	0003677	molecular_function	DNA binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0006325	biological_process	chromatin organization
K	0006334	biological_process	nucleosome assembly
K	0030527	molecular_function	structural constituent of chromatin
K	0046982	molecular_function	protein heterodimerization activity
K	0070062	cellular_component	extracellular exosome
L	0000781	cellular_component	chromosome, telomeric region
L	0000786	cellular_component	nucleosome
L	0003677	molecular_function	DNA binding
L	0003723	molecular_function	RNA binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005694	cellular_component	chromosome
L	0006325	biological_process	chromatin organization
L	0006334	biological_process	nucleosome assembly
L	0016020	cellular_component	membrane
L	0030527	molecular_function	structural constituent of chromatin
L	0032200	biological_process	telomere organization
L	0032991	cellular_component	protein-containing complex
L	0043505	cellular_component	CENP-A containing nucleosome
L	0045653	biological_process	negative regulation of megakaryocyte differentiation
L	0046982	molecular_function	protein heterodimerization activity
L	0061644	biological_process	protein localization to CENP-A containing chromatin
L	0070062	cellular_component	extracellular exosome
M	0000786	cellular_component	nucleosome
M	0003677	molecular_function	DNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005694	cellular_component	chromosome
M	0006325	biological_process	chromatin organization
M	0008285	biological_process	negative regulation of cell population proliferation
M	0030527	molecular_function	structural constituent of chromatin
M	0031507	biological_process	heterochromatin formation
M	0043505	cellular_component	CENP-A containing nucleosome
M	0046982	molecular_function	protein heterodimerization activity
M	0061644	biological_process	protein localization to CENP-A containing chromatin
M	0070062	cellular_component	extracellular exosome
N	0000786	cellular_component	nucleosome
N	0002227	biological_process	innate immune response in mucosa
N	0003677	molecular_function	DNA binding
N	0005515	molecular_function	protein binding
N	0005615	cellular_component	extracellular space
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005694	cellular_component	chromosome
N	0005829	cellular_component	cytosol
N	0019731	biological_process	antibacterial humoral response
N	0030527	molecular_function	structural constituent of chromatin
N	0031640	biological_process	killing of cells of another organism
N	0042742	biological_process	defense response to bacterium
N	0046982	molecular_function	protein heterodimerization activity
N	0050829	biological_process	defense response to Gram-negative bacterium
N	0050830	biological_process	defense response to Gram-positive bacterium
N	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
O	0000786	cellular_component	nucleosome
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0006325	biological_process	chromatin organization
O	0006334	biological_process	nucleosome assembly
O	0030527	molecular_function	structural constituent of chromatin
O	0046982	molecular_function	protein heterodimerization activity
O	0070062	cellular_component	extracellular exosome
P	0000781	cellular_component	chromosome, telomeric region
P	0000786	cellular_component	nucleosome
P	0003677	molecular_function	DNA binding
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005694	cellular_component	chromosome
P	0006325	biological_process	chromatin organization
P	0006334	biological_process	nucleosome assembly
P	0016020	cellular_component	membrane
P	0030527	molecular_function	structural constituent of chromatin
P	0032200	biological_process	telomere organization
P	0032991	cellular_component	protein-containing complex
P	0043505	cellular_component	CENP-A containing nucleosome
P	0045653	biological_process	negative regulation of megakaryocyte differentiation
P	0046982	molecular_function	protein heterodimerization activity
P	0061644	biological_process	protein localization to CENP-A containing chromatin
P	0070062	cellular_component	extracellular exosome
Q	0000786	cellular_component	nucleosome
Q	0003677	molecular_function	DNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005694	cellular_component	chromosome
Q	0006325	biological_process	chromatin organization
Q	0008285	biological_process	negative regulation of cell population proliferation
Q	0030527	molecular_function	structural constituent of chromatin
Q	0031507	biological_process	heterochromatin formation
Q	0043505	cellular_component	CENP-A containing nucleosome
Q	0046982	molecular_function	protein heterodimerization activity
Q	0061644	biological_process	protein localization to CENP-A containing chromatin
Q	0070062	cellular_component	extracellular exosome
R	0000786	cellular_component	nucleosome
R	0002227	biological_process	innate immune response in mucosa
R	0003677	molecular_function	DNA binding
R	0005515	molecular_function	protein binding
R	0005615	cellular_component	extracellular space
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005694	cellular_component	chromosome
R	0005829	cellular_component	cytosol
R	0019731	biological_process	antibacterial humoral response
R	0030527	molecular_function	structural constituent of chromatin
R	0031640	biological_process	killing of cells of another organism
R	0042742	biological_process	defense response to bacterium
R	0046982	molecular_function	protein heterodimerization activity
R	0050829	biological_process	defense response to Gram-negative bacterium
R	0050830	biological_process	defense response to Gram-positive bacterium
R	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
S	0000122	biological_process	negative regulation of transcription by RNA polymerase II
S	0000786	cellular_component	nucleosome
S	0000791	cellular_component	euchromatin
S	0000792	cellular_component	heterochromatin
S	0003677	molecular_function	DNA binding
S	0003690	molecular_function	double-stranded DNA binding
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005694	cellular_component	chromosome
S	0006325	biological_process	chromatin organization
S	0006334	biological_process	nucleosome assembly
S	0006357	biological_process	regulation of transcription by RNA polymerase II
S	0030261	biological_process	chromosome condensation
S	0030527	molecular_function	structural constituent of chromatin
S	0031490	molecular_function	chromatin DNA binding
S	0031492	molecular_function	nucleosomal DNA binding
S	0042826	molecular_function	histone deacetylase binding
S	0045910	biological_process	negative regulation of DNA recombination
U	0000122	biological_process	negative regulation of transcription by RNA polymerase II
U	0000786	cellular_component	nucleosome
U	0000791	cellular_component	euchromatin
U	0000792	cellular_component	heterochromatin
U	0003677	molecular_function	DNA binding
U	0003690	molecular_function	double-stranded DNA binding
U	0003723	molecular_function	RNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005694	cellular_component	chromosome
U	0006325	biological_process	chromatin organization
U	0006334	biological_process	nucleosome assembly
U	0006357	biological_process	regulation of transcription by RNA polymerase II
U	0030261	biological_process	chromosome condensation
U	0030527	molecular_function	structural constituent of chromatin
U	0031490	molecular_function	chromatin DNA binding
U	0031492	molecular_function	nucleosomal DNA binding
U	0042826	molecular_function	histone deacetylase binding
U	0045910	biological_process	negative regulation of DNA recombination

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA21-VAL27

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG92-GLY114

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P15865

Chain	Residue	Details
U	SER1
S	SER1
N	PRO1
R	PRO1

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P43274

Chain	Residue	Details
U	LYS16
S	LYS16
N	GLU2
R	GLU2

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
U	THR17
H	LYS11
H	LYS15
H	LYS16
H	LYS20
H	LYS23
H	LYS43
H	LYS85
N	LYS5
N	LYS11
N	LYS15
S	THR17
N	LYS16
N	LYS20
N	LYS23
N	LYS43
N	LYS85
R	LYS5
R	LYS11
R	LYS15
R	LYS16
R	LYS20
D	LYS15
R	LYS23
R	LYS43
R	LYS85
D	LYS16
D	LYS20
D	LYS23
D	LYS43
D	LYS85
H	LYS5

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:3782055

Chain	Residue	Details
U	LYS25
S	LYS25
N	SER6
R	SER6
M	LYS9
M	LYS95
Q	LYS9
Q	LYS95

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P43274

Chain	Residue	Details
U	LYS33
P	LYS8
P	LYS16
P	LYS44
S	LYS33
N	LYS12
R	LYS12
F	LYS16
F	LYS44
L	LYS8
L	LYS16
L	LYS44

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P43274

Chain	Residue	Details
U	SER35
L	LYS31
L	LYS77
L	LYS91
P	LYS12
P	LYS31
P	LYS77
P	LYS91
S	SER35
N	SER14
R	SER14
F	LYS12
F	LYS31
F	LYS77
F	LYS91
L	LYS12

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	MOD_RES: N6-(beta-hydroxybutyryl)lysine => ECO:0000250|UniProtKB:P43277

Chain	Residue	Details
U	LYS51
S	LYS105
U	LYS63
U	LYS84
U	LYS89
U	LYS105
S	LYS51
S	LYS63
S	LYS84
S	LYS89

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Citrulline => ECO:0000250|UniProtKB:P43274

Chain	Residue	Details
U	ARG53
R	LYS34
R	LYS116
R	LYS120
S	ARG53
D	LYS120
H	LYS34
H	LYS116
H	LYS120
N	LYS34
N	LYS116
N	LYS120

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
U	THR145
Q	LYS118
Q	LYS119
Q	LYS125
S	THR145
N	GLU35
R	GLU35
G	LYS119
G	LYS125
M	LYS118
M	LYS119
M	LYS125

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: ADP-ribosylserine => ECO:0000269|PubMed:27723750

Chain	Residue	Details
U	SER149
S	SER149
N	SER36
R	SER36
K	LYS14
K	LYS56
O	LYS14
O	LYS56

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692

Chain	Residue	Details
U	SER186
S	SER186
H	LYS46
H	LYS108
N	LYS46
N	LYS108
R	LYS46
R	LYS108

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine; alternate => ECO:0000269|PubMed:24681537

Chain	Residue	Details
D	LYS57
H	LYS57
N	LYS57
R	LYS57
M	LYS119
Q	LYS119

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Dimethylated arginine => ECO:0000250|UniProtKB:Q96A08

Chain	Residue	Details
D	ARG79
H	ARG79
N	ARG79
R	ARG79

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q96A08

Chain	Residue	Details
D	ARG86
D	ARG92
H	ARG86
H	ARG92
N	ARG86
N	ARG92
R	ARG86
R	ARG92

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q00729

Chain	Residue	Details
D	THR115
H	THR115
N	THR115
R	THR115
L	LYS91
P	LYS91

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250|UniProtKB:P62807

Chain	Residue	Details
D	SER112
P	LYS20
P	LYS59
P	LYS79
H	SER112
N	SER112
R	SER112
F	LYS59
F	LYS79
L	LYS20
L	LYS59
L	LYS79

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P58876

Chain	Residue	Details
D	LYS5
H	LYS5
N	LYS5
R	LYS5

---

site_id	SWS_FT_FI18
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:16713563

Chain	Residue	Details
A	SER57
D	LYS120
K	SER57
H	LYS120
N	LYS120
R	LYS120

---

site_id	SWS_FT_FI19
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:Q5QNW6

Chain	Residue	Details
D	LYS20
H	LYS20
N	LYS20
R	LYS20

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:21726816

Chain	Residue	Details
D	LYS34
H	LYS34
N	LYS34
R	LYS34

---

site_id	SWS_FT_FI21
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
A	SER86
E	SER86
K	SER86
O	SER86

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	THR107
E	THR107
K	THR107
O	THR107

---

site_id	SWS_FT_FI23
Number of Residues	4
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297

Chain	Residue	Details
A	LYS115
E	LYS115
K	LYS115
O	LYS115

---

site_id	SWS_FT_FI24
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:27436229

Chain	Residue	Details
A	LYS122
E	LYS122
K	LYS122
O	LYS122

---

site_id	SWS_FT_FI25
Number of Residues	4
Details	LIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806

Chain	Residue	Details
A	LYS18
E	LYS18
K	LYS18
O	LYS18

---

site_id	SWS_FT_FI26
Number of Residues	4
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:21076176

Chain	Residue	Details
A	ALA110
E	ALA110
K	ALA110
O	ALA110

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