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7PE9

cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
A0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
A0001006molecular_functionRNA polymerase III type 3 promoter sequence-specific DNA binding
A0001156molecular_functionTFIIIC-class transcription factor complex binding
A0001558biological_processregulation of cell growth
A0001932biological_processregulation of protein phosphorylation
A0001934biological_processpositive regulation of protein phosphorylation
A0002296biological_processT-helper 1 cell lineage commitment
A0003007biological_processheart morphogenesis
A0003179biological_processheart valve morphogenesis
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006112biological_processenergy reserve metabolic process
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006468biological_processprotein phosphorylation
A0006954biological_processinflammatory response
A0006974biological_processDNA damage response
A0007010biological_processcytoskeleton organization
A0007040biological_processlysosome organization
A0007281biological_processgerm cell development
A0007584biological_processresponse to nutrient
A0008361biological_processregulation of cell size
A0009267biological_processcellular response to starvation
A0009408biological_processresponse to heat
A0009791biological_processpost-embryonic development
A0010506biological_processregulation of autophagy
A0010507biological_processnegative regulation of autophagy
A0010592biological_processpositive regulation of lamellipodium assembly
A0010628biological_processpositive regulation of gene expression
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0010831biological_processpositive regulation of myotube differentiation
A0012505cellular_componentendomembrane system
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0016241biological_processregulation of macroautophagy
A0016242biological_processnegative regulation of macroautophagy
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016605cellular_componentPML body
A0018105biological_processpeptidyl-serine phosphorylation
A0019228biological_processneuronal action potential
A0030030biological_processcell projection organization
A0030163biological_processprotein catabolic process
A0030307biological_processpositive regulation of cell growth
A0030425cellular_componentdendrite
A0030838biological_processpositive regulation of actin filament polymerization
A0031295biological_processT cell costimulation
A0031410cellular_componentcytoplasmic vesicle
A0031529biological_processruffle organization
A0031641biological_processregulation of myelination
A0031648biological_processprotein destabilization
A0031667biological_processresponse to nutrient levels
A0031669biological_processcellular response to nutrient levels
A0031670biological_processcellular response to nutrient
A0031929biological_processTOR signaling
A0031931cellular_componentTORC1 complex
A0031932cellular_componentTORC2 complex
A0032516biological_processpositive regulation of phosphoprotein phosphatase activity
A0032868biological_processresponse to insulin
A0032869biological_processcellular response to insulin stimulus
A0032956biological_processregulation of actin cytoskeleton organization
A0033173biological_processcalcineurin-NFAT signaling cascade
A0034198biological_processcellular response to amino acid starvation
A0035264biological_processmulticellular organism growth
A0038202biological_processTORC1 signaling
A0042752biological_processregulation of circadian rhythm
A0042802molecular_functionidentical protein binding
A0043022molecular_functionribosome binding
A0043066biological_processnegative regulation of apoptotic process
A0043200biological_processresponse to amino acid
A0043276biological_processanoikis
A0044877molecular_functionprotein-containing complex binding
A0045335cellular_componentphagocytic vesicle
A0045670biological_processregulation of osteoclast differentiation
A0045727biological_processpositive regulation of translation
A0045792biological_processnegative regulation of cell size
A0045821biological_processpositive regulation of glycolytic process
A0045945biological_processpositive regulation of transcription by RNA polymerase III
A0045948biological_processpositive regulation of translational initiation
A0046777biological_processprotein autophosphorylation
A0046889biological_processpositive regulation of lipid biosynthetic process
A0048266biological_processbehavioral response to pain
A0048511biological_processrhythmic process
A0048709biological_processoligodendrocyte differentiation
A0048714biological_processpositive regulation of oligodendrocyte differentiation
A0048738biological_processcardiac muscle tissue development
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050882biological_processvoluntary musculoskeletal movement
A0051128biological_processregulation of cellular component organization
A0051219molecular_functionphosphoprotein binding
A0051247biological_processpositive regulation of protein metabolic process
A0051496biological_processpositive regulation of stress fiber assembly
A0051549biological_processpositive regulation of keratinocyte migration
A0051647biological_processnucleus localization
A0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0055006biological_processcardiac cell development
A0055013biological_processcardiac muscle cell development
A0060048biological_processcardiac muscle contraction
A0061431biological_processcellular response to methionine
A0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
A0071230biological_processcellular response to amino acid stimulus
A0071233biological_processcellular response to L-leucine
A0071456biological_processcellular response to hypoxia
A0071470biological_processcellular response to osmotic stress
A0080135biological_processregulation of cellular response to stress
A0090559biological_processregulation of membrane permeability
A0106310molecular_functionprotein serine kinase activity
A1900034biological_processregulation of cellular response to heat
A1900181biological_processnegative regulation of protein localization to nucleus
A1901796biological_processregulation of signal transduction by p53 class mediator
A1901838biological_processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
A1903691biological_processpositive regulation of wound healing, spreading of epidermal cells
A1904059biological_processregulation of locomotor rhythm
A1904690biological_processpositive regulation of cytoplasmic translational initiation
A1905672biological_processnegative regulation of lysosome organization
A1905857biological_processpositive regulation of pentose-phosphate shunt
A1990253biological_processcellular response to leucine starvation
A2000785biological_processregulation of autophagosome assembly
C0005515molecular_functionprotein binding
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0006974biological_processDNA damage response
C0007010biological_processcytoskeleton organization
C0010507biological_processnegative regulation of autophagy
C0016020cellular_componentmembrane
C0030307biological_processpositive regulation of cell growth
C0030838biological_processpositive regulation of actin filament polymerization
C0031669biological_processcellular response to nutrient levels
C0031929biological_processTOR signaling
C0031931cellular_componentTORC1 complex
C0031932cellular_componentTORC2 complex
C0032008biological_processpositive regulation of TOR signaling
C0032956biological_processregulation of actin cytoskeleton organization
C0038202biological_processTORC1 signaling
C0043066biological_processnegative regulation of apoptotic process
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0045821biological_processpositive regulation of glycolytic process
C0046889biological_processpositive regulation of lipid biosynthetic process
C0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
C0071456biological_processcellular response to hypoxia
C0071470biological_processcellular response to osmotic stress
C1905857biological_processpositive regulation of pentose-phosphate shunt
E0001932biological_processregulation of protein phosphorylation
E0001938biological_processpositive regulation of endothelial cell proliferation
E0005515molecular_functionprotein binding
E0005794cellular_componentGolgi apparatus
E0005829cellular_componentcytosol
E0007010biological_processcytoskeleton organization
E0009792biological_processembryo development ending in birth or egg hatching
E0010468biological_processregulation of gene expression
E0018105biological_processpeptidyl-serine phosphorylation
E0019901molecular_functionprotein kinase binding
E0030036biological_processactin cytoskeleton organization
E0030307biological_processpositive regulation of cell growth
E0030838biological_processpositive regulation of actin filament polymerization
E0031669biological_processcellular response to nutrient levels
E0031929biological_processTOR signaling
E0031932cellular_componentTORC2 complex
E0032008biological_processpositive regulation of TOR signaling
E0032956biological_processregulation of actin cytoskeleton organization
E0033135biological_processregulation of peptidyl-serine phosphorylation
E0038203biological_processTORC2 signaling
E0042325biological_processregulation of phosphorylation
E0043022molecular_functionribosome binding
E0043066biological_processnegative regulation of apoptotic process
E0043539molecular_functionprotein serine/threonine kinase activator activity
E0050727biological_processregulation of inflammatory response
E0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
E0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
E0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
E0060090molecular_functionmolecular adaptor activity
E2000114biological_processregulation of establishment of cell polarity
G0005515molecular_functionprotein binding
G0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
G0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005794cellular_componentGolgi apparatus
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0007010biological_processcytoskeleton organization
G0019901molecular_functionprotein kinase binding
G0021762biological_processsubstantia nigra development
G0030307biological_processpositive regulation of cell growth
G0031267molecular_functionsmall GTPase binding
G0031410cellular_componentcytoplasmic vesicle
G0031669biological_processcellular response to nutrient levels
G0031932cellular_componentTORC2 complex
G0033138biological_processpositive regulation of peptidyl-serine phosphorylation
G0038203biological_processTORC2 signaling
G0043066biological_processnegative regulation of apoptotic process
G0043325molecular_functionphosphatidylinositol-3,4-bisphosphate binding
G0046580biological_processnegative regulation of Ras protein signal transduction
G0060090molecular_functionmolecular adaptor activity
G0070300molecular_functionphosphatidic acid binding
G0080025molecular_functionphosphatidylinositol-3,5-bisphosphate binding
G1900407biological_processregulation of cellular response to oxidative stress
I0004860molecular_functionprotein kinase inhibitor activity
I0005515molecular_functionprotein binding
I0005764cellular_componentlysosome
I0005765cellular_componentlysosomal membrane
I0006469biological_processnegative regulation of protein kinase activity
I0008289molecular_functionlipid binding
I0010508biological_processpositive regulation of autophagy
I0016020cellular_componentmembrane
I0030291molecular_functionprotein serine/threonine kinase inhibitor activity
I0032007biological_processnegative regulation of TOR signaling
I0035556biological_processintracellular signal transduction
I0045792biological_processnegative regulation of cell size
I0070300molecular_functionphosphatidic acid binding
I1903940biological_processnegative regulation of TORC2 signaling
I1904262biological_processnegative regulation of TORC1 signaling
I2001236biological_processregulation of extrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00307
Number of Residues7
DetailsLECTIN_LEGUME_BETA Legume lectins beta-chain signature. VAVDLDS
ChainResidueDetails
GVAL333-SER339

site_idPS00584
Number of Residues14
DetailsPFKB_KINASES_2 pfkB family of carbohydrate kinases signature 2. STsGSGDrihGALL
ChainResidueDetails
ASER247-LEU266

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. MYTGgeDcTARIWDL
ChainResidueDetails
CMET100-LEU114

site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDLRQDervmQ
ChainResidueDetails
ALEU2186-GLN2200

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMvgYILgLgDRHpsN
ChainResidueDetails
ASER2323-ASN2343

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
IMET1
AMET2345
AILE2356
AGLN2167
ALEU2185
AGLU2190
ATYR2225
AGLY2238
ATRP2239
AVAL2240
ATHR2245

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine; by MAPK3 => ECO:0000269|PubMed:35216969
ChainResidueDetails
ISER235
ETHR1295
ETHR1332

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:19446321
ChainResidueDetails
ITHR241
ITHR259

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:19446321, ECO:0007744|PubMed:23186163
ChainResidueDetails
ISER244
ESER1278
ESER1302
ESER1313
ESER1346
ESER1353

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:19446321
ChainResidueDetails
ISER258
ISER263
ISER282
ISER283
ISER297
ISER298

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:19446321, ECO:0000269|PubMed:22017875
ChainResidueDetails
ISER265

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q570Y9
ChainResidueDetails
ISER280
ESER1411

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CK1 => ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877
ChainResidueDetails
ISER286

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CK1 => ECO:0000269|PubMed:19446321, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877
ChainResidueDetails
ISER287

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by SYK => ECO:0000269|PubMed:34634301
ChainResidueDetails
ITYR289

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CK1 => ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:22017877
ChainResidueDetails
ISER291

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MTOR => ECO:0000269|PubMed:19446321, ECO:0000269|PubMed:22017875
ChainResidueDetails
ISER293
ISER299

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by MTOR => ECO:0000269|PubMed:22017875
ChainResidueDetails
ITHR295

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:21576368, ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER2481

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PDB entries from 2024-07-24

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